Ben Gu

Leukocyte Surface Biomarkers Implicate Deficits of Innate Immunity in Late‐onset Alzheimer’s Disease

Yihan Li, Xin Huang, Christopher Fowler, James D Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Yen Ying Lim, Paul Maruff, Jacobo E Mintzer, Vincent Dore, Christopher Rowe, Jurgen Fripp, James S Wiley, Colin L Masters, Ben J Gu

Journal article  |  2022  |  Alzheimer's & Dementia

P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration.

Candace Drysdale, Keunha Park, Kirstan A Vessey, Xin Huang, Emily Caruso, Yihan Li, Joelyn Wong, James S Wiley, Erica Fletcher, Robyn H Guymer, Ben J Gu

Journal article  |  2022  |  Purinergic Signal

We have shown deficits in monocyte phagocytosis from patients with age-related macular degeneration (AMD). Cell membrane fluidity ..

Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease

Xin Huang, Yihan Li, Christopher Fowler, James D Doecke, Yen Ying Lim, Candace Drysdale, Vicky Zhang, Keunha Park, Brett Trounson, Kelly Pertile, Rebecca Rumble, John W Pickering, Robert A Rissman, Floyd Sarsoza, Sara Abdel-Latif, Yong Lin, Vincent Dore, Victor Villemagne, Christopher C Rowe, Jurgen Fripp, et al.

Journal article  |  2022  |  ALZHEIMERS & DEMENTIA

INTRODUCTION: Blood-based diagnostics and prognostics in sporadic Alzheimer's disease (AD) are important for identifying at-risk i..

Topographical Distribution and Phenotype of Resident Meibomian Gland Orifice Immune Cells (MOICs) in Mice and the Effects of Topical Benzalkonium Chloride (BAK)

Ching Yi Wu, Mengliang Wu, Xin Huang, Ben J Gu, Carole Maldonado-Codina, Philip B Morgan, Laura E Downie, Holly R Chinnery

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Meibomian gland orifices (MGOs) are located along the eyelid margin and secrete meibum into the tear film. The profile of resident..

Identification of Leukocyte Surface P2X7 as a Biomarker Associated with Alzheimer's Disease

Yihan Li, Xin Huang, Christopher Fowler, Yen Y Lim, Simon M Laws, Noel Faux, James D Doecke, Brett Trounson, Kelly Pertile, Rebecca Rumble, Vincent Dore, Victor L Villemagne, Christopher C Rowe, James S Wiley, Paul Maruff, Colin L Masters, Ben J Gu

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer's disease (AD) has shown altered immune responses in the periphery. We studied P2X7 (a proinflammatory receptor and a sc..

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer's disease

Xian-Le Bu, Pu-Yang Sun, Dong-Yu Fan, Jun Wang, Hao-Lun Sun, Yuan Cheng, Gui-Hua Zeng, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Ying-Ying Shen, Luke A Miles, Paul Maruff, Ben J Gu, Christopher J Fowler, Colin L Masters, Yan-Jiang Wang

Journal article  |  2022  |  SCIENCE ADVANCES

CD22 has been suggested to contribute to Alzheimer's disease (AD) pathogenesis by inhibiting microglial amyloid β (Aβ) phagocytosi..

Flow Cytometry Identifies an Early Stage of Platelet Apoptosis Produced by Agonists of the P2X1 and P2X7 Receptors

Joelyn Wong, Ben J Gu, Harry Teoh, Malgorzata Krupa, Mastura Monif, Mark Slee, James S Wiley

Journal article  |  2022  |  PLATELETS

Platelets express P2X1 receptors and our data also show the expression of P2X7 receptors. We studied the role of both receptors in..

Genomics of Alzheimer's disease implicates the innate and adaptive immune systems

Yihan Li, Simon M Laws, Luke A Miles, James S Wiley, Xin Huang, Colin L Masters, Ben J Gu

Journal article  |  2021  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterised by cognitive impairment, behavioural alteration, and..

Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

Journal article  |  2021  |  FRONTIERS IN MEDICINE

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

Regulation of the Acute Sickness Response by the P2RX7 Receptor

Hui Li, Erin Cvejic, Ben Gu, Ute Vollmer-Conna, Ian Hickie, Denis Wakefield, Tracey Davenport, James Wiley, Andrew R Lloyd

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: The acute sickness response to infection is a stereotyped set of illness manifestations initiated by proinflammatory s..