Ben Gu

A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function

Kristen K Skarratt, Ben J Gu, Michael D Lovelace, Carol J Milligan, Leanne Stokes, Rachel Glover, Steven Petrou, James S Wiley, Stephen J Fuller

Journal article  |  2020  |  The FASEB Journal

P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types. Brief exposure to ATP induces the opening of a..

Assays to Measure Purinoceptor Pore Dilation

Ben J Gu, Pavan Avula, James S Wiley

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

The P2X7 receptor is a classic purinoceptor/ion channel. After activated by ATP, it opens a cation selective channel, which dilate..

P2X7 receptor signaling during adult hippocampal neurogenesis

Hannah C Leeson, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Ben J Gu, Michael W Weible

Journal article  |  2019  |  Neural Regeneration Research

Targeting P2X7 receptors as a means for treating retinal disease

Erica L Fletcher, Anna Y Wang, Andrew I Jobling, Matthew V Rutar, Ursula Greferath, Ben Gu, Kirstan A Vessey

Journal article  |  2019  |  Drug Discovery Today

Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. Th..

The local and systemic effects following subthreshold nanosecond laser treatment to the posterior retina

Quan Findlay, Andrew Ian Jobling, Kirstan Anne Vessey, Ursula Greferath, Pavan Avula, Ben Gu, Robyn H Guymer, Erica L Fletcher

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells

Hannah C Leeson, Tailoi Chan-Ling, Michael D Lovelace, Jeremy D Brownlie, Michael W Weible, Ben J Gu

Journal article  |  2019  |  Journal of Visualized Experiments

INNATE IMMUNITY IN ENDOPHTHALMITIS: THE ROLE OF PHAGOCYTOSIS AND THE P2X7 RECEPTOR

Andrew Hurley, Rosie Dawkins, Ben Gu, Xin Huang, Penelope Allen

Conference Proceedings  |  2018  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis

Hannah C Leeson, Maria A Kasherman, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Kelly M Toppinen, Ben J Gu, Michael W Weible

Journal article  |  2018  |  Stem Cells

P2X7 as a scavenger receptor for innate phagocytosis in the brain

Ben J Gu, James S Wiley

Journal article  |  2018  |  British Journal of Pharmacology

The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases

Amber Ou, Ben J Gu, James S Wiley

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease