Melody Li

Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow

GDC Mendis, G Berecki, E Morrisroe, S Pachernegg, M Li, M Varney, PB Osborne, CA Reid, S Halgamuge, S Petrou

Journal article  |  2019  |  SCIENTIFIC REPORTS

Determining the mechanism of action (MOA) of novel or naturally occurring compounds mostly relies on assays tailored for individua..

Functional consequences of the CAPOS mutation E818K of Na ,K -ATPase

Christian P Roenn, Melody Li, Vivien R Schack, Ian C Forster, Rikke Holm, Mads S Toustrup-Jensen, Jens P Andersen, Steven Petrou, Bente Vilsen

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) syndrome is caused by the singl..

Lack of response to quinidine in KCNT1-related neonatal epilepsy

Adam L Numis, Umesh Nair, Anita N Datta, Tristan T Sands, Michael S Oldham, Akash Patel, Melody Li, Elena Gazina, Steven Petrou, Maria Roberta Cilio

Journal article  |  2018  |  EPILEPSIA

OBJECTIVE: To evaluate the clinical efficacy and safety of quinidine in patients with KCNT1-related epilepsy of infancy with migra..

Characterization of a Novel Knock-in Mouse Model of KCNT1 Epileptic Encephalopathy

Lisseth Burbano, Melody Li, Nikola Jancovski, Kay Richards, Elena Gazina, Snezana Maljevic, Christopher Reid, Steven Petrou

Conference Proceedings  |  2018  |  NEUROLOGY

Gain-of-function HCN2 variants in genetic epilepsy

Melody Li, Snezana Maljevic, A Marie Phillips, Slave Petrovski, Michael S Hildebrand, Rosemary Burgess, Therese Mount, Federico Zara, Pasquale Striano, Julian Schubert, Holger Thiele, Peter Nuernberg, Michael Wong, Judith L Weisenberg, Liu Lin Thio, Holger Lerche, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou, Christopher A Reid

Journal article  |  2018  |  HUMAN MUTATION

Genetic generalized epilepsy (GGE) is a common epilepsy syndrome that encompasses seizure disorders characterized by spike-and-wav..

Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine

Saul A Mullen, Patrick W Carney, Annie Roten, Michael Ching, Paul A Lightfoot, Leonid Churilov, Umesh Nair, Melody Li, Samuel F Berkovic, Steven Petrou, Ingrid E Scheffer

Journal article  |  2018  |  NEUROLOGY

OBJECTIVE: To evaluate quinidine as a precision therapy for severe epilepsy due to gain of function mutations in the potassium cha..

Gabapentin Modulates HCN4 Channel Voltage-Dependence

Han-Shen Tae, Kelly M Smith, A Marie Phillips, Kieran A Boyle, Melody Li, Ian C Forster, Robert J Hatch, Robert Richardson, David I Hughes, Brett A Graham, Steven Petrou, Christopher A Reid

Journal article  |  2017  |  FRONTIERS IN PHARMACOLOGY

Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-ac..

KCTD12 modulation of GABA(B) receptor function

Melody Li, Carol J Milligan, Haiyan Wang, Andrew Walker, Leonid Churilov, Andrew J Lawrence, Christopher A Reid, Seth C Hopkins, Steven Petrou

Journal article  |  2017  |  PHARMACOLOGY RESEARCH & PERSPECTIVES

The molecular composition and functional diversity of native GABAB receptors (GABABR) are still poorly understood, thus hindering ..

Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy

Mark A Corbett, Susannah T Bellows, Melody Li, Renee Carroll, Silvana Micallef, Gemma L Carvill, Candace T Myers, Katherine B Howell, Snezana Maljevic, Holger Lerche, Elena V Gazina, Heather C Mefford, Melanie Bahlo, Samuel F Berkovic, Steven Petrou, Ingrid E Scheffer, Jozef Gecz

Journal article  |  2016  |  NEUROLOGY

OBJECTIVE: To identify the genetic basis of a family segregating episodic ataxia, infantile seizures, and heterogeneous epilepsies..

Quinidine in the Treatment of KCNT1-Positive Epilepsies

Mohamad A Mikati, Yong-hui Jiang, Michael Carboni, Vandana Shashi, Slave Petrovski, Rebecca Spillmann, Carol J Milligan, Melody Li, Annette Grefe, Allyn McConkie, Samuel Berkovic, Ingrid Scheffer, Saul Mullen, Melanie Bonner, Steven Petrou, David Goldstein

Journal article  |  2015  |  ANNALS OF NEUROLOGY

We report 2 patients with drug-resistant epilepsy caused by KCNT1 mutations who were treated with quinidine. Both mutations manife..