Thibault Renoir

Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington?s disease transgenic mice

Farheen Farzana, Malcolm J McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J Hannan, Danny M Hatters, Berin A Boughton

Journal article  |  2023  |  NEUROBIOLOGY OF DISEASE

In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the mutant h..

Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon

Anita JL Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony JJ Hannan, Lincon AA Stamp, Marlene MM Hao, Joel CC Bornstein

Journal article  |  2023  |  BIOMOLECULES

Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic ..

Environmental enrichment and exercise housing protocols for mice.

Chloe J Love, Carolina Gubert, Thibault Renoir, Anthony J Hannan

Journal article  |  2022  |  STAR Protoc

Here, we present a protocol that allows comparison of the effects of the standard home cage, environmentally enriched home cage wi..

Phosphoproteomic dysregulation in Huntington's disease mice is rescued by environmental enrichment

Isaline Mees, Shanshan Li, Harvey Tran, Ching-Seng Ang, Nicholas A Williamson, Anthony J Hannan, Thibault Renoir

Journal article  |  2022  |  BRAIN COMMUNICATIONS

Huntington's disease is a fatal autosomal-dominant neurodegenerative disorder, characterized by neuronal cell dysfunction and loss..

Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington's disease mice

Carolina Gubert, Jocelyn M Choo, Chloe J Love, Saritha Kodikara, Bethany A Masson, Jamie JM Liew, Yiwen Wang, Geraldine Kong, Vinod K Narayana, Thibault Renoir, Kim-Anh Le Cao, Geraint B Rogers, Anthony J Hannan

Journal article  |  2022  |  BRAIN COMMUNICATIONS

Huntington's disease is a neurodegenerative disorder involving psychiatric, cognitive and motor symptoms. Huntington's disease is ..

Loss-of-function and gain-of-function studies refute the hypothesis that tau protein is causally involved in the pathogenesis of Huntington's disease

Isaline Mees, Shanshan Li, Leah C Beauchamp, Kevin J Barnham, Mathias Dutschmann, Anthony J Hannan, Thibault Renoir

Journal article  |  2022  |  HUMAN MOLECULAR GENETICS

Tubulin-associated unit (Tau) is a microtubule-associated protein, whose abnormal phosphorylation and deposition in the brain char..

Quantitative Phosphoproteomics Reveals Extensive Protein Phosphorylation Dysregulation in the Cerebral Cortex of Huntington's Disease Mice Prior to Onset of Symptoms

Isaline Mees, Harvey Tran, Anne Roberts, Larissa Lago, Shanshan Li, Blaine R Roberts, Anthony J Hannan, Thibault Renoir

Journal article  |  2022  |  MOLECULAR NEUROBIOLOGY

Protein phosphorylation plays a role in many important cellular functions such as cellular plasticity, gene expression, and intrac..

Gene-environment-gut interactions in Huntington's disease mice are associated with environmental modulation of the gut microbiome

Carolina Gubert, Chloe Jane Love, Saritha Kodikara, Jamie Jie Mei Liew, Thibault Renoir, Kim-Anh Le Cao, Anthony John Hannan

Journal article  |  2022  |  ISCIENCE

Gut dysbiosis in Huntington's disease (HD) has recently been reported using microbiome profiling in R6/1 HD mice and replicated in..

Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice

Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoir

Journal article  |  2021  |  BRAIN STRUCTURE & FUNCTION

Deficits in hippocampal cellular and synaptic plasticity are frequently associated with cognitive and mood disorders, and indeed c..

Small Non-coding RNAs Are Dysregulated in Huntington's Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention

Celine Dubois, Geraldine Kong, Harvey Tran, Shanshan Li, Terence Y Pang, Anthony J Hannan, Thibault Renoir

Journal article  |  2021  |  MOLECULAR NEUROBIOLOGY

Huntington's disease (HD) is a neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin gene. Trans..