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Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Dise..
Displaying the 5 most recent projects by Peng Lei.
Internal Research Grant
Displaying the 48 most recent scholarly works by Peng Lei.
Molecular regulatory network of PD-1/PD-L1 in non-small cell lung cancer.
Zhu Lingling, Liu Jiewei, Wang Li, Yan Danli, Zhou Jie, Li Wen, Pu Dan, Peng Lei, Zhou Qinghua
Journal article | 2020 | Pathology - Research and Practice
Lung cancer remains the most common cancer and the leading cause of cancer death worldwide. Despite effective chemotherapy and mol..
Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease.
Scott Ayton, Peng Lei, Ambili T Appukuttan, Thibault Renoir, Simote Foliaki, Feng Chen, Paul A Adlard, Anthony J Hannan, Ashley I Bush
Journal article | 2020 | Neurotherapeutics
There is currently no disease-modifying treatment for Huntington's disease (HD), which is characterized by chorea motor impairment..
MKP-1 reduces A beta generation and alleviates cognitive impairments in Alzheimer's disease models
Yehong Du, Yexiang Du, Yun Zhang, Zhilin Huang, Min Fu, Junjie Li, Yayan Pang, Peng Lei, Yu Tian Wang, Weihong Song, Guiqiong He, Zhifang Dong
Journal article | 2019 | Signal Transduction and Targeted Therapy
Diagnostics and Treatments of Iron-Related CNS Diseases
Huan Xiong, Qing-Zhang Tuo, Yu-Jie Guo, Peng Lei
Book Chapter | 2019 | Advances in Experimental Medicine and Biology
Iron has been proposed to be responsible for neuronal loss in several diseases of the central nervous system, including Alzheimer'..
Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues
Tao Tan, Lin Xia, Kailing Tu, Jie Tang, Senlin Yin, Lunzhi Dai, Peng Lei, Biao Dong, Hongbo Hu, Yong Fan, Yang Yu, Dan Xie
Journal article | 2018 | BMC Genomics
BACKGROUNDS: Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health..
Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke
Qing-Zhang Tuo, Zhen-Yu Liuyang, Peng Lei, Xiong Yan, Yang-Ping Shentu, Jia-Wei Liang, Huan Zhou, Lei Pei, Yan Xiong, Tong-Yao Hou, Xin-Wen Zhou, Qun Wang, Jian-Zhi Wang, Xiao-Chuan Wang, Rong Liu
Journal article | 2018 | Cell Death & Disease
CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 c..
The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau
Lin-Lin Shen, Noralyn B Manucat-Tan, Shi-Hao Gao, Wei-Wei Li, Fan Zeng, Chi Zhu, Jun Wang, Xian-Le Bu, Yu-Hui Liu, Chang-Yue Gao, Zhi-Qiang Xu, Larisa Bobrovskaya, Peng Lei, Jin-Tai Yu, Weihong Song, Hua-Dong Zhou, Xiu-Qing Yao, Xin-Fu Zhou, Yan-Jiang Wang
Journal article | 2018 | Molecular Psychiatry
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic ..
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment
Liang Ouyang, Lan Zhang, Shouyue Zhang, Dahong Yao, Yuqian Zhao, Guan Wang, Leilei Fu, Peng Lei, Bo Liu
Journal article | 2018 | Journal of Medicinal Chemistry
UNC-51-like kinase 1 (ULK1), the yeast Atg1 ortholog, is the sole serine-threonine kinase and initiating enzyme in autophagy, whic..
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, et al.
Journal article | 2017 | Molecular Psychiatry
Tat-haFGF(14-154) Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1 alpha/XBP1 Pathway
Tian Meng, Qin Cao, Peng Lei, Ashley I Bush, Qi Xiang, Zhijian Su, Xiang He, Jack T Rogers, Ing-Ming Chiu, Qihao Zhang, Yadong Huang
Journal article | 2017 | Molecular Therapy - Nucleic Acids
The Copper bis(thiosemicarbazone) Complex Cu-II(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
Mikko T Huuskonen, Qing-zhang Tuo, Sanna Loppi, Hiramani Dhungana, Paula Korhonen, Lachlan E McInnes, Paul S Donnelly, Alexandra Grubman, Sara Wojciechowski, Katarina Lejavova, Yuriy Pomeshchik, Laura Periviita, Lotta Kosonen, Martina Giordano, Frederick R Walker, Rong Liu, Ashley I Bush, Jari Koistinaho, Tarja Malm, Anthony R White, et al.
Journal article | 2017 | Neurotherapeutics
Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3 beta Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease
Peng-hui Yang, Jian-xiu Zhu, Ya-dong Huang, Xian-ying Zhang, Peng Lei, Ashley I Bush, Qi Xiang, Zhi-jian Su, Qi-hao Zhang
Journal article | 2016 | Neurodegenerative Diseases
Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of beta-Amyloid Toxicity and Are Mediated by Tau
Xuling Li, Peng Lei, Qingzhang Tuo, Scott Ayton, Qiao-Xin Li, Steve Moon, Irene Volitakis, Rong Liu, Colin L Masters, David I Finkelstein, Ashley I Bush
Journal article | 2015 | Neurotherapeutics
Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of beta-Amyloid Precursor Protein
Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush
Journal article | 2015 | Journal of Neuroscience
A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2 under physiologically relevant conditions
Bruce X Wong, Scott Ayton, Linh Q Lam, Peng Lei, Paul A Adlard, Ashley I Bush, James A Duce
Journal article | 2014 | Biochimica et Biophysica Acta (BBA) - General Subjects
An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
Dominic J Hare, Peng Lei, Scott Ayton, Blaine R Roberts, Rudolf Grimm, Jessica L George, David P Bishop, Alison D Beavis, Sarah J Donovan, Gawain McColl, Irene Volitakis, Colin L Masters, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip A Doble
Journal article | 2014 | Chemical Science
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush
Journal article | 2012 | Nature Medicine
Florey Department Of Neuroscience And Mental Health
Themis Dept Access
Florey Department Of Neuroscience And Mental Health
University of Melbourne