Wesley Thevathasan

Cortex leads the thalamic centromedian nucleus in generalized epileptic discharges in Lennox-Gastaut syndrome

Linda J Dalic, Aaron EL Warren, James C Young, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John S Archer

Journal article  |  2020  |  EPILEPSIA

Objective We aimed to assess the roles of the cortex and thalamus (centromedian nucleus [CM]) during epileptic activity in Lennox‐..

Targeting the centromedian thalamic nucleus for deep brain stimulation

Aaron EL Warren, Linda J Dalic, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John Archer

Journal article  |  2020  |  JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

OBJECTIVES: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain dis..

Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Adolfo Ramirez-Zamora, James Giordano, Aysegul Gunduz, Jose Alcantara, Jackson N Cagle, Stephanie Cernera, Parker Difuntorum, Robert S Eisinger, Julieth Gomez, Sarah Long, Brandon Parks, Joshua K Wong, Shannon Chiu, Bhavana Patel, Warren M Grill, Harrison C Walker, Simon J Little, Ro'ee Gilron, Gerd Tinkhauser, Wesley Thevathasan, et al.

Journal article  |  2020  |  FRONTIERS IN HUMAN NEUROSCIENCE

The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and u..

Tailoring Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Evoked Resonant Neural Activity

Wesley Thevathasan, Nicholas C Sinclair, Kristian J Bulluss, Hugh J McDermott

Journal article  |  2020  |  FRONTIERS IN HUMAN NEUROSCIENCE

Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity

Nicholas C Sinclair, Hugh J McDermott, James B Fallon, Thushara Perera, Peter Brown, Kristian J Bulluss, Wesley Thevathasan

Journal article  |  2019  |  NEUROBIOLOGY OF DISEASE

Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited unders..

What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?

Wesley Thevathasan, Elena Moro

Journal article  |  2019  |  NEUROBIOLOGY OF DISEASE

Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) is an experimental treatment for Parkinson's disease (PD) which offers..

On the neural basis of deep brain stimulation evoked resonant activity

Nicholas C Sinclair, James B Fallon, Kristian J Bulluss, Wesley Thevathasan, Hugh J McDermott

Journal article  |  2019  |  BIOMEDICAL PHYSICS & ENGINEERING EXPRESS

Objective: Deep brain stimulation can be a remarkably effective treatment for Parkinson's disease and other conditions; however, a..

SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION EVOKED RESONANT NEURAL ACTIVITY PREDICTS CLINICAL RESPONSE TO DBS

San San Xu, Nicholas C Sinclair, Kristian J Bulluss, Thushara Perera, Wee-Lih Lee, Hugh J McDermott, Wesley Theathasan

Conference Proceedings  |  2019  |  JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IntroductionDBS can improve motor deficit in Parkinson’s disease (PD) patients. Existing devices have limitations due to electrode..

An Instrumented Pull Test to Characterize Postural Responses

Joy Tan, Wesley Thevathasan, Jennifer McGinley, Peter Brown, Thushara Perera

Journal article  |  2019  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Impairment of postural reflexes, termed postural instability, is a common and disabling deficit in Parkinson's disease. To assess ..

Alternate Subthalamic Nucleus Deep Brain Stimulation Parameters to Manage Motor Symptoms of Parkinson's Disease: Systematic Review and Meta-analysis

Zachary J Conway, Peter A Silburn, Wesley Thevathasan, Karen O' Maley, Geraldine A Naughton, Michael H Cole

Journal article  |  2019  |  MOVEMENT DISORDERS CLINICAL PRACTICE

Background: The use of alternate frequencies, amplitudes, and pulse widths to manage motor symptoms in Parkinson's disease (PD) pa..