Amber Alsop

Mcl-1 and Bcl-x(L) sequestration of Bak confers differential resistance to BH3-only proteins

Colin Hockings, Amber E Alsop, Stephanie C Fennell, Erinna F Lee, W Douglas Fairlie, Grant Dewson, Ruth M Kluck

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

The prosurvival Bcl-2 family proteins Mcl-1 and Bcl-xL inhibit apoptosis by sequestering BH3-only proteins such as Bid and Bim (MO..

BAK alpha 6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Mark Xiang Li, Iris KL Tan, Stephen B Ma, Colin Hockings, Tobias Kratina, Michael A Dengler, Amber E Alsop, Ruth M Kluck, Grant Dewson

Journal article  |  2017  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and B..

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

PCAF and ADA3 associate within the same macromolecular complexes to control the transcription of many genes, including some that r..

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

Rachel T Uren, Martin O'Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck

Journal article  |  2017  |  ELIFE

During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitocho..

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Sweta Iyer, Khatira Anwari, Amber E Alsop, Wai Shan Yuen, David CS Huang, John Carroll, Nicholas A Smith, Brian J Smith, Grant Dewson, Ruth M Kluck

Journal article  |  2016  |  NATURE COMMUNICATIONS

During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2-α5 hydrophobic groove; Bax is also activated vi..

Dissociation of Bak alpha 1 helix from the core and latch domains is required for apoptosis

Amber E Alsop, Stephanie C Fennell, Ray C Bartolo, Iris KL Tan, Grant Dewson, Ruth M Kluck

Journal article  |  2015  |  NATURE COMMUNICATIONS

During apoptosis, Bak permeabilizes mitochondria after undergoing major conformational changes, including poorly defined N-termina..

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies

Journal article  |  2014  |  NATURE MEDICINE

Loss of function of the tumor suppressor gene PRDM1 (also known as BLIMP1) or deregulated expression of the oncogene BCL6 occurs i..

Reconstruction of the ancestral marsupial karyotype from comparative gene maps

Janine E Deakin, Margaret L Delbridge, Edda Koina, Nerida Harley, Amber E Alsop, Chenwei Wang, Vidushi S Patel, Jennifer A Marshall Graves

Journal article  |  2013  |  BMC EVOLUTIONARY BIOLOGY

BACKGROUND: The increasing number of assembled mammalian genomes makes it possible to compare genome organisation across mammalian..

Cyclin E facilitates dysplastic hepatocytes to bypass G(1)/S checkpoint in hepatocarcinogenesis

Sharon Pok, Victoria Wen, Nicholas Shackel, Amber Alsop, Pawan Pyakurel, Aude Fahrer, Geoffrey C Farrell, Narci C Teoh

Journal article  |  2013  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND AND AIM: By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hep..

Bak apoptotic function is not directly regulated by phosphorylation

VH Tran, R Bartolo, D Westphal, A Alsop, G Dewson, RM Kluck

Journal article  |  2013  |  CELL DEATH & DISEASE

During apoptosis, Bak and Bax permeabilize the mitochondrial outer membrane by undergoing major conformational change and oligomer..