Amber Alsop

Mcl-1 and Bcl-x(L) sequestration of Bak confers differential resistance to BH3-only proteins

Colin Hockings, Amber E Alsop, Stephanie C Fennell, Erinna F Lee, W Douglas Fairlie, Grant Dewson, Ruth M Kluck

Journal article  |  2018  |  Cell Death & Differentiation

BAK alpha 6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Mark Xiang Li, Iris KL Tan, Stephen B Ma, Colin Hockings, Tobias Kratina, Michael A Dengler, Amber E Alsop, Ruth M Kluck, Grant Dewson

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  Cell Death & Differentiation

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

Rachel T Uren, Martin O'Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck

Journal article  |  2017  |  eLife

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Sweta Iyer, Khatira Anwari, Amber E Alsop, Wai Shan Yuen, David CS Huang, John Carroll, Nicholas A Smith, Brian J Smith, Grant Dewson, Ruth M Kluck

Journal article  |  2016  |  NATURE COMMUNICATIONS

Dissociation of Bak alpha 1 helix from the core and latch domains is required for apoptosis

Amber E Alsop, Stephanie C Fennell, Ray C Bartolo, Iris KL Tan, Grant Dewson, Ruth M Kluck

Journal article  |  2015  |  Nature Communications

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies

Journal article  |  2014  |  Nature Medicine

Reconstruction of the ancestral marsupial karyotype from comparative gene maps

Janine E Deakin, Margaret L Delbridge, Edda Koina, Nerida Harley, Amber E Alsop, Chenwei Wang, Vidushi S Patel, Jennifer A Marshall Graves

Journal article  |  2013  |  BMC Evolutionary Biology

Cyclin E facilitates dysplastic hepatocytes to bypass G(1)/S checkpoint in hepatocarcinogenesis

Sharon Pok, Victoria Wen, Nicholas Shackel, Amber Alsop, Pawan Pyakurel, Aude Fahrer, Geoffrey C Farrell, Narci C Teoh

Journal article  |  2013  |  Journal of Gastroenterology and Hepatology

Bak apoptotic function is not directly regulated by phosphorylation

VH Tran, R Bartolo, D Westphal, A Alsop, G Dewson, RM Kluck

Journal article  |  2013  |  Cell Death & Disease

Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer

Elizabeth P Murchison, Ole B Schulz-Trieglaff, Zemin Ning, Ludmil B Alexandrov, Markus J Bauer, Beiyuan Fu, Matthew Hims, Zhihao Ding, Sergii Ivakhno, Caitlin Stewart, Bee Ling Ng, Wendy Wong, Bronwen Aken, Simon White, Amber Alsop, Jennifer Becq, Graham R Bignell, R Keira Cheetham, William Cheng, Thomas R Connor, et al.

Journal article  |  2012  |  Cell

Genome analysis of the platypus reveals unique signatures of evolution (vol 453, pg 175, 2008)

Wesley C Warren, LaDeana W Hillier, Jennifer A Marshall Graves, Ewan Birney, Chris P Ponting, Frank Grutzner, Katherine Belov, Webb Miller, Laura Clarke, Asif T Chinwalla, Shiaw-Pyng Yang, Andreas Heger, Devin P Locke, Pat Miethke, Paul D Waters, Frederic Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, et al.

Journal article  |  2008  |  Nature

Defensins and the convergent evolution of platypus and reptile venom genes

Camilla M Whittington, Anthony T Papenfuss, Paramjit Bansal, Allan M Torres, Emily SW Wong, Janine E Deakin, Tina Graves, Amber Alsop, Kyriena Schatzkamer, Colin Kremitzki, Chris P Ponting, Peter Temple-Smith, Wesley C Warren, Philip W Kuchel, Katherine Belov

Journal article  |  2008  |  Genome Res.

Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes

Frederic Veyrunes, Paul D Waters, Pat Miethke, Willem Rens, Daniel McMillan, Amber E Alsop, Frank Gruetzner, Janine E Deakin, Camilla M Whittington, Kyriena Schatzkamer, Colin L Kremitzki, Tina Graves, Malcolm A Ferguson-Smith, Wes Warren, Jennifer A Marshall Graves

Journal article  |  2008  |  Genome Res.

Genome analysis of the platypus reveals unique signatures of evolution

Wesley C Warren, LaDeana W Hillier, Jennifer A Marshall Graves, Ewan Birney, Chris P Ponting, Frank Grutzner, Katherine Belov, Webb Miller, Laura Clarke, Asif T Chinwalla, Shiaw-Pyng Yang, Andreas Heger, Devin P Locke, Pat Miethke, Paul D Waters, Frederic Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, et al.

Journal article  |  2008  |  Nature

Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.

Amber E Alsop, Karen Taylor, Jieqing Zhang, Hani Gabra, Adam JW Paige, Paul AW Edwards

Journal article  |  2008  |  Genes, Chromosomes and Cancer

Homozygous deletions in cancer cells have been thought to harbor tumor suppressor genes. We show that the 25 and 50 kb homozygous ..

Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus)

Daniel McMillan, Pat Miethke, Amber E Alsop, Willem Rens, Patricia O'Brien, Vladimir Trifonov, Frederic Veyrunes, Kyriena Schatzkamer, Colin L Kremitzki, Tina Graves, Wesley Warren, Frank Grutzner, Malcolm A Ferguson-Smith, Jennifer A Marshall Graves

Journal article  |  2007  |  Chromosome Res.

Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting

S Suzuki, R Ono, T Narita, AJ Pask, G Shaw, C Wang, T Kohda, AE Alsop, JA Marshall Graves, Y Kohara, F Ishino, MB Renfree, T Kaneko-Ishino

Journal article  |  2007  |  PLoS Genetics

DMRT gene cluster analysis in the platypus: New insights into genomic organization and regulatory regions

Nisrine El-Mogharbel, Matthew Wakefield, Janine E Deakin, Enkhjargal Tsend-Ayush, Frank Grutzner, Amber Alsop, Tariq Ezaz, Jennifer A Marshall Graves

Journal article  |  2007  |  Genomics

High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation.

JCM Pole, C Courtay-Cahen, MJ Garcia, KA Blood, SL Cooke, AE Alsop, DML Tse, C Caldas, PAW Edwards

Journal article  |  2006  |  Oncogene

The short arm of chromosome 8, 8p, is often rearranged in carcinomas, typically showing distal loss by unbalanced translocation. W..

Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines.

Amber E Alsop, Andrew E Teschendorff, Paul AW Edwards

Journal article  |  2006  |  Cancer Genetics and Cytogenetics

Chromosome 18 is frequently rearranged in carcinomas. We explored the distribution of breakpoints affecting chromosome 18 by mappi..

Assignment of BReast Cancer Associated 1 (BRCA1) to tammar wallaby (Macropus eugenii) chromosome 2q3 by in situ hybridization

MJ Wakefield, AE Alsop

Journal article  |  2006  |  Cytogenet. Genome Res.

Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization

ML Delbridge, MC Wallis, PJ Kirby, AE Alsop, F Grutzner, JAM Graves

Journal article  |  2006  |  Cytogenet. Genome Res.

Characterizing the chromosomes of the Australian model marsupial Macropus eugenii (tammar wallaby)

AE Alsop, P Miethke, R Rofe, E Koina, N Sankovic, JE Deakin, H Haines, RW Rapkins, JAM Graves

Journal article  |  2005  |  Chromosome Res.

A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.

José Adélaïde, Huai-En Huang, Anne Murati, Amber E Alsop, Béatrice Orsetti, Marie-Joëlle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Céline Basset, Céline Courtay-Cahen, Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul AW Edwards, Max Chaffanet

Journal article  |  2003  |  Genes Chromosomes Cancer

The 8p11-21 region is a frequent target of alterations in breast cancer and other carcinomas. We surveyed 34 breast tumor cell lin..

Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.

MJ O'Hare, J Bond, C Clarke, Y Takeuchi, AJ Atherton, C Berry, J Moody, AR Silver, DC Davies, AE Alsop, AM Neville, PS Jat

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Reports differ as to whether reconstitution of telomerase activity alone is sufficient for immortalization of different types of h..