Man Lyang Kim

Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells

Man Lyang Kim, Melinda Y Hardy, Laura E Edgington-Mitchell, Sri H Ramarathinam, Shan Zou Chung, Amy K Russell, Iain Currie, Brad E Sleebs, Anthony W Purcell, Jason A Tye-Din, Ian P Wicks

Journal article  |  2021  |  ISCIENCE

Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understo..

Dysregulated IL-1-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychloroquine

Man Lyang Kim, William J Martin, Gabriela Minigo, Joanne L Keeble, Alexandra L Garnham, Guido Pacini, Gordon K Smyth, Terence P Speed, Jonathan Carapetis, Ian P Wicks

Journal article  |  2018  |  CIRCULATION

BACKGROUND: Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection..

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide ..

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1 beta

Man Lyang Kim, Jae Jin Chae, Yong Hwan Park, Dominic De Nardo, Roslynn A Stirzaker, Hyun-Ja Ko, Hazel Tye, Louise Cengia, Ladina DiRago, Donald Metcalf, Andrew W Roberts, Daniel L Kastner, Andrew M Lew, Dena Lyras, Benjamin T Kile, Ben A Croker, Seth L Masters

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with inc..