Paul Yeh

Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Carlos S Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q Wong, Bonnie Z Zhang, Kenji M Fujihara, Lynn Chong, Michael W Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGERY

OBJECTIVE: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cos..

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

Ella R Thompson, Tamia Nguyen, Yamuna Kankanige, John F Markham, Mary Ann Anderson, Sasanka M Handunnetti, Rachel Thijssen, Paul Sung-Hao Yeh, Constantine S Tam, John F Seymour, Andrew W Roberts, David A Westerman, Piers Blombery

Journal article  |  2022  |  BLOOD ADVANCES

The genomic landscape of resistance to targeted agents (TAs) used as monotherapy in chronic lymphocytic leukemia (CLL) is complex ..

Abstract 539: Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  Cancer Research

Abstract Background: Circulating tumor DNA (ctDNA) has clinical utility in monitoring treatment response and in the..

Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease.

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  CANCER RESEARCH

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nila J Dharan, Paul Yeh, Mark Bloch, Miriam M Yeung, David Baker, Jerick Guinto, Norman Roth, Sarah Ftouni, Katherine Ognenovska, Don Smith, Jennifer F Hoy, Ian Woolley, Catherine Pell, David J Templeton, Neil Fraser, Nectarios Rose, Jolie Hutchinson, Kathy Petoumenos, Sarah-Jane Dawson, Mark N Polizzotto, et al.

Journal article  |  2021  |  NATURE MEDICINE

People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and..

Clonal independence of JAK2 and CALR or MPL mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing

Ella R Thompson, Tamia Nguyen, Yamuna Kankanige, Paul Yeh, Michael Ingbritsen, Michelle McBean, Timothy Semple, Gisela Mir Arnau, Kate Burbury, Nora Lee, Amit Khot, David Westerman, Piers Blombery

Journal article  |  2021  |  HAEMATOLOGICA

Age-related clonal haematopoiesis is more prevalent in older adults with HIV: the ARCHIVE study

Mark Dawson, Nila Dharan, Paul Yeh, Mark Bloch, Miriam Yeung, David Baker, Jerick Guinto, Norman Roth, Sarah Ftouni, Katherine Ognenovska, Don Smith, Jennifer Hoy, Ian Woolley, Catherine Pell, David Templeton, Neil Fraser, Nectarios Rose, Jolie Hutchinson, Kathy Petoumenos, Sarah-Jane Dawson, et al.

Journal article  |  2020

People with HIV have higher rates of certain comorbidities, particularly cardiovascular disease and some malignancies, than people..

High Clonal Complexity of Resistance Mechanisms Occurring at Progression after Single-Agent Targeted Therapy Strategies in Chronic Lymphocytic Leukemia

Ella R Thompson, Tamia Nguyen, Yamuna Kankanige, Mary Ann Anderson, Sasanka M Handunnetti, Rachel Thijssen, Paul Sung-Hao Yeh, Constantine S Tam, John F Seymour, Andrew W Roberts, David Alan Westerman, Piers Blombery

Conference Proceedings  |  2020  |  BLOOD

Progression of chronic lymphocytic leukemia (CLL) on venetoclax (VEN) and BTK inhibitors (BTKi) is associated with acquired genomi..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  NATURE

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

BTK Leu528Trp-a Potential Secondary Resistance Mechanism Specific for Patients with Chronic Lymphocytic Leukemia Treated with the Next Generation BTK Inhibitor Zanubrutinib

Sasanka M Handunnetti, Chloe Pek Sang Tang, Nguyen Tamia, Xing Zhou, Ella Thompson, Hanzi Sun, Haimei Xing, Bo Zhang, Yin Guo, Lesley Ann Sutton, Paolo Ghia, Richard Rosenquist, Lydia Scarfo, Silvia Bonfiglio, John F Seymour, Mary Ann Anderson, Andrew W Roberts, David CS Huang, Ye Liu, Chan Y Cheah, et al.

Conference Proceedings  |  2019  |  BLOOD

One of the most common secondary resistance mechanisms to ibrutinib (IBR, a first-generation, irreversible Bruton's tyrosine kinas..