James Beeson

Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration.

Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K Singh, James G Beeson, Kevin KA Tetteh, Immo Kleinschmidt, Umberto D'Alessandro, Chris Drakeley

Journal article  |  2020  |  BMC Medicine

BACKGROUND: As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool to monito..

Epitope masking may limit antibody boosting to malaria vaccines

Liriye Kurtovic, Michelle J Boyle, James G Beeson

Journal article  |  2020  |  Immunology & Cell Biology

We discuss the study by McNamara et al., who report that low levels of antigen-specific antibodies in serum can limit the boosting..

Retargeting azithromycin analogues to have dual-modality antimalarial activity

Amy L Burns, Brad E Sleebs, Ghizal Siddiqui, Amanda E De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G Beeson, Darren J Creek, Christopher D Goodman, Geoffrey I McFadden, Danny W Wilson

Journal article  |  2020  |  BMC Biology

BACKGROUND: Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug t..

Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and transmission settings in The Gambia

Lindsey Wu, Julia Mwesigwa, Muna Affara, Mamadou Bah, Simon Correa, Tom Hall, Susheel K Singh, James G Beeson, Kevin KA Tetteh, Immo Kleinschmidt, Umberto D'Alessandro, Chris Drakeley

Journal article  |  2020  |  BMC Medicine

BACKGROUND: As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission...

Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity.

Swapna Varghese, Raphaël Rahmani, Damien R Drew, James G Beeson, Jake Baum, Brian J Smith, Jonathan B Baell

Journal article  |  2020  |  ChemMedChem

Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effect..

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha, et al.

Journal article  |  2020  |  PLoS Medicine

BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..

Identifying and combating the impacts of COVID-19 on malaria

Stephen J Rogerson, James G Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A Simpson, Ric N Price

Journal article  |  2020  |  BMC MEDICINE

BACKGROUND: The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disru..

Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children.

Caroline K Bundi, Angela Nalwoga, Lawrence Lubyayi, John Muthii Muriuki, Reagan M Mogire, Herbert Opi, Alexander J Mentzer, Cleopatra K Mugyenyi, Jedida Mwacharo, Emily L Webb, Philip Bejon, Thomas N Williams, Joseph K Gikunju, James G Beeson, Alison M Elliott, Francis M Ndungu, Sarah H Atkinson

Journal article  |  2020  |  Clinical Infectious Diseases

BACKGROUND: Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan A..

Antibody responses to the RTS,S/AS01(E) vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique

Lina Sanchez, Marta Vidal, Chenjerai Jairoce, Ruth Aguilar, Itziar Ubillos, Inocencia Cuamba, Augusto J Nhabomba, Nana Aba Williams, Nuria Diez-Padrisa, David Cavanagh, Evelina Angov, Ross L Coppel, Deepak Gaur, James G Beeson, Sheetij Dutta, Pedro Aide, Joseph J Campo, Gemma Moncunill, Carlota Dobano

Journal article  |  2020  |  npj Vaccines

Selection of Antibody Responses Associated WithPlasmodium falciparumInfections in the Context of Malaria Elimination

Lotus L van den Hoogen, Gillian Stresman, Jacquelin Presume, Ithamare Romilus, Gina Mondelus, Tamara Elisme, Alexandre Existe, Karen ES Hamre, Ruth A Ashton, Thomas Druetz, Vena Joseph, James G Beeson, Susheel K Singh, Jacques Boncy, Thomas P Eisele, Michelle A Chang, Jean F Lemoine, Kevin KA Tetteh, Eric Rogier, Chris Drakeley

Journal article  |  2020  |  Frontiers in Immunology

In our aim to eliminate malaria, more sensitive tools to detect residual transmission are quickly becoming essential. Antimalarial..