James Beeson

Strengthening routine immunization in Papua New Guinea: a cross-sectional provincial assessment of front-line services

Christopher J Morgan, Olga PM Saweri, Nicholas Larme, Elizabeth Peach, Pele Melepia, Lucy Au, Michelle JL Scoullar, Mohammad Salim Reza, Lisa M Vallely, Barbara McPake, James G Beeson

Journal article  |  2020  |  BMC Public Health

BACKGROUND: Routine immunization programs face many challenges in settings such as Papua New Guinea with dispersed rural populatio..

Complement in malaria immunity and vaccines

Liriye Kurtovic, Michelle J Boyle, D Herbert Opi, Alexander T Kennedy, Wai-Hong Tham, Linda Reiling, Jo-Anne Chan, James G Beeson

Journal article  |  2020  |  Immunological Reviews

Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a major global health priority, although this..

Induction and Kinetics of Complement-Fixing Antibodies Against Plasmodium vivax Merozoite Surface Protein 3 alpha and Relationship With Immunoglobulin G Subclasses and Immunoglobulin M

Damian A Oyong, Danny W Wilson, Bridget E Barber, Timothy William, Jianlin Jiang, Mary R Galinski, Freya JI Fowkes, Matthew J Grigg, James G Beeson, Nicholas M Anstey, Michelle J Boyle

Journal article  |  2019  |  The Journal of Infectious Diseases

BACKGROUND: Complement-fixing antibodies are important mediators of protection against Plasmodium falciparum malaria. However, com..

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten, et al.

Journal article  |  2019  |  The Journal of Infectious Diseases

BACKGROUND: Antibodies to the blood-stages of malaria enhance parasite-clearance and antimalarial efficacy. The antibody subclass ..

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

Jo-Anne Chan, David Wetzel, Linda Reiling, Kazutoyo Miura, Damien R Drew, Paul R Gilson, David A Anderson, Jack S Richards, Carole A Long, Manfred Suckow, Volker Jenzelewski, Takafumi Tsuboi, Michelle J Boyle, Michael Piontek, James G Beeson

Journal article  |  2019  |  PLOS ONE

The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS..

Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha

David Wetzel, Jo-Anne Chan, Manfred Suckow, Andreas Barbian, Michael Weniger, Volker Jenzelewski, Linda Reiling, Jack S Richards, David A Anderson, Betty Kouskousis, Catherine Palmer, Eric Hanssen, Gerhard Schembecker, Juliane Merz, James G Beeson, Michael Piontek

Journal article  |  2019  |  PLOS ONE

IgM in human immunity to Plasmodium falciparum malaria

MJ Boyle, JA Chan, I Handayuni, L Reiling, G Feng, A Hilton, L Kurtovic, D Oyong, KA Piera, BE Barber, T William, DP Eisen, G Minigo, C Langer, DR Drew, F de Labastida Rivera, FH Amante, TN Williams, S Kinyanjui, K Marsh, et al.

Journal article  |  2019  |  Science Advances

RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study

Carlota Dobano, Itziar Ubillos, Chenjerai Jairoce, Ben Gyan, Marta Vidal, Alfons Jimenez, Rebeca L Santano, David Dosoo, Augusto J Nhabomba, Aintzane Ayestaran, Ruth Aguilar, Nana Aba Williams, Nuria Diez-Padrisa, David Lanar, Virander Chauhan, Chetan Chitnis, Sheetij Dutta, Deepak Gaur, Evelina Angov, Kwaku Poku Asante, et al.

Journal article  |  2019  |  BMC Medicine

Understanding the interactions between iron supplementation, infectious disease and adverse birth outcomes is essential to guide public health recommendations

Freya JI Fowkes, Eliza Davidson, Paul A Agius, James G Beeson

Journal article  |  2019  |  BMC Medicine

Antibody Reactivity to Merozoite Antigens in Ghanaian Adults Correlates With Growth Inhibitory Activity Against Plasmodium falciparum in Culture

Henrietta E Mensah-Brown, Harvey Aspeling-Jones, Rupert K Delimini, Kwaku Poku Asante, Emmanuel Amlabu, Saikou Y Bah, James G Beeson, Gavin J Wright, David J Conway, Gordon A Awandare

Journal article  |  2019  |  Open Forum Infectious Diseases

Background: Plasmodium falciparum uses a repertoire of merozoite-stage proteins for invasion of erythrocytes. Antibodies against s..

Targeting malaria parasite invasion of red blood cells as an antimalarial strategy

Amy L Burns, Madeline G Dans, Juan M Balbin, Tania F de Koning-Ward, Paul R Gilson, James G Beeson, Michelle J Boyle, Danny W Wilson

Journal article  |  2019  |  FEMS Microbiology Reviews

Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resis..

UNINTENDED PREGNANCY AND FAMILY PLANNING USE AMONG ANTENATAL ATTENDEES IN EAST NEW BRITAIN, PAPUA NEW GUINEA

Elizabeth Peach, Chris Morgan, Michelle Scoullar, Freya Fowkes, Elissa Kennedy, Stanley Luchters, Andrew Vallely, Lisa Vallely, Angela Kelly, Leanne Robinson, Brendan Crabb, Peter Siba, William Pomat, JG Beeson

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

Carlota Dobano, Rebeca Santano, Marta Vidal, Alfons Jimenez, Chenjerai Jairoce, Itziar Ubillos, David Dosoo, Ruth Aguilar, Nana Aba Williams, Nuria Diez-Padrisa, Aintzane Ayestaran, Clarissa Valim, Kwaku Poku Asante, Seth Owusu-Agyei, David Lanar, Virander Chauhan, Chetan Chitnis, Sheetij Dutta, Evelina Angov, Benoit Gamain, et al.

Journal article  |  2019  |  Frontiers in Immunology

Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein

Natalie J Kingston, Liriye Kurtovic, Renae Walsh, Carina Joe, George Lovrecz, Stephen Locarnini, James G Beeson, Hans J Netter

Journal article  |  2019  |  Vaccine

Dendritic Cell Responses and Function in Malaria

Xi Zen Yap, Rachel J Lundie, James G Beeson, Meredith O'Keeffe

Journal article  |  2019  |  Frontiers in Immunology

Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children

Jo-Anne Chan, Michelle J Boyle, Kerryn A Moore, Linda Reiling, Zaw Lin, Wina Hasang, Marion Avril, Laurens Manning, Ivo Mueller, Moses Laman, Timothy Davis, Joseph D Smith, Stephen J Rogerson, Julie A Simpson, Freya JI Fowkes, James G Beeson

Journal article  |  2019  |  The Journal of Infectious Diseases

Acquisition of Antibodies Against Endothelial Protein C Receptor-Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Severe Malaria

Janavi S Rambhatla, Louise Turner, Laurens Manning, Moses Laman, Timothy ME Davis, James G Beeson, Ivo Mueller, Jonathan Warrel, Thor G Theander, Thomas Lavstsen, Stephen J Rogerson

Journal article  |  2019  |  The Journal of Infectious Diseases

The salt between the beans: a qualitative study of the role of auxiliary midwives in a hard-to-reach area of Myanmar

Kyu Kyu Than, Stanley Luchters, Khaing Nwe Tin, Thazin La, James Beeson, Alison Morgan

Journal article  |  2019  |  BMC Health Services Research

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

Journal article  |  2019  |  BMC Medicine

Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection

Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson

Journal article  |  2019  |  Scientific Reports

Targets of complement-fixing antibodies in protective immunity against malaria in children

Linda Reiling, Michelle J Boyle, Michael T White, Danny W Wilson, Gaoqian Feng, Rupert Weaver, D Herbert Opi, Kristina EM Persson, Jack S Richards, Peter M Siba, Freya JI Fowkes, Eizo Takashima, Takafumi Tsuboi, Ivo Mueller, James G Beeson

Journal article  |  2019  |  Nature Communications

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Xi Zen Yap, Rachel J Lundie, Gaoqian Feng, Joanne Pooley, James G Beeson, Meredith O'Keeffe

Journal article  |  2019  |  Frontiers in Immunology

The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

Priyanka Barua, James G Beeson, Kenneth Maleta, Per Ashorn, Stephen J Rogerson

Journal article  |  2019  |  Malaria Journal

Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections

Lotus L van den Hoogen, Jona Walk, Tate Oulton, Isaie J Reuling, Linda Reiling, James G Beeson, Ross L Coppel, Susheel K Singh, Simon J Draper, Teun Bousema, Chris Drakeley, Robert Sauerwein, Kevin KA Tetteh

Journal article  |  2019  |  Frontiers in Microbiology

Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria

Jo-Anne Chan, Damien R Drew, Linda Reiling, Ashley Lisboa-Pinto, Bismarck Dinko, Colin J Sutherland, Arlene E Dent, Kiprotich Chelimo, James W Kazura, Michelle J Boyle, James G Beeson

Journal article  |  2019  |  Frontiers in Immunology

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G Beeson, Liriye Kurtovic, Carlota Dobano, D Herbert Opi, Jo-Anne Chan, Gaoqian Feng, Michael F Good, Linda Reiling, Michelle J Boyle

Journal article  |  2019  |  Science Translational Medicine

Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination.

Bryan Greenhouse, Jennifer Daily, Caterina Guinovart, Bronner Goncalves, James Beeson, David Bell, Michelle A Chang, Justin M Cohen, Xavier Ding, Gonzalo Domingo, Thomas P Eisele, Patrick J Lammie, Alfredo Mayor, Nicolas Merienne, Wuelto Monteiro, John Painter, Isabel Rodriguez, Michael White, Chris Drakeley, Ivo Mueller, et al.

Journal article  |  2019  |  Gates Open Research

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to a..

THE EFFECTIVENESS OF REPELLENT DELIVERED THROUGH VILLAGE HEALTH VOLUNTEERS ON MALARIA INCIDENCE IN SOUTHEAST MYANMAR: A STEPPED-WEDGE CLUSTER-RANDOMIZED CONTROLLED TRIAL

Paul Agius, Win Han Oo, Naanki Pasricha, Katherine O'Flaherty, Kyaw Zayar Aung, Aung Thi, Myat Mon Thein, Nyi Nyi Zaw, Htin Kyaw Thu, Wai Yan Min Htay, Aung Paing Soe, Nicole Romero, Zahra Razook, Alyssa Barry, Angela Devine, Julie Simpson, Brendan S Crabb, James G Beeson, Julia Cutts, Freya J Fowkes

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol

Win Han Oo, Julia C Cutts, Paul A Agius, Kyaw Zayar Aung, Poe Poe Aung, Thi Aung, Nyi Nyi Zaw, Htin Kyaw Thu, Wai Yan Min Htay, Ricardo Ataide, Katherine O'Flaherty, Ai Pao Yawn, Aung Paing Soe, James G Beeson, Brendan Crabb, Naanki Pasricha, Freya JI Fowkes

Journal article  |  2018  |  BMC Infectious Diseases

KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization

Gathoni Kamuyu, James Tuju, Rinter Kimathi, Kennedy Mwai, James Mburu, Nelson Kibinge, Marisa Chong Kwan, Sam Hawkings, Reuben Yaa, Emily Chepsat, James M Njunge, Timothy Chege, Fatuma Guleid, Micha Rosenkranz, Christopher K Kariuki, Roland Frank, Samson M Kinyanjui, Linda M Murungi, Philip Bejon, Anna Farnert, et al.

Journal article  |  2018  |  Frontiers in Immunology

Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia

Damian A Oyong, Enny Kenangalem, Jeanne R Poespoprodjo, James G Beeson, Nicholas M Anstey, Ric N Price, Michelle J Boyle

Journal article  |  2018  |  JCI Insight

Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study

Freya JI Fowkes, Kerryn A Moore, D Herbert Opi, Julie A Simpson, Freya Langham, Danielle I Stanisic, Alice Ura, Christopher L King, Peter M Siba, Ivo Mueller, Stephen J Rogerson, James G Beeson

Journal article  |  2018  |  BMC Medicine

Multiple morbidities in pregnancy: Time for research, innovation, and action

James G Beeson, Caroline SE Homer, Christopher Morgan, Clara Menendez

Journal article  |  2018  |  PLOS Medicine

Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites

Oliver Lythl, Gema Vizcay-Barrena, Katherine E Wright, Silvia Haase, Franziska Mohring, Adrian Nejer, Isabelle G Henshall, George W Ashdown, Lawrence H Bannister, Damien R Drew, James G Beeson, Roland A Fleck, Robert W Moon, Danny W Wilson, Jake Baum

Journal article  |  2018  |  Scientific Reports

The Complement System Contributes to Functional Antibody Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites

Marije C Behet, Liriye Kurtovic, Geert-Jan van Gemert, Celine M Haukes, Rianne Siebelink-Stoter, Wouter Graumans, Marga G van de Vegte-Bolmer, Anja Scholzen, Jeroen D Langereis, Dimitri A Diavatopoulos, James G Beeson, Robert W Sauerwein

Journal article  |  2018  |  Infection and Immunity

Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains

Gaoqian Feng, Michelle J Boyle, Nadia Cross, Jo-Anne Chan, Linda Roiling, Faith Osier, Danielle Stanisic, Ivo Mueller, Robin F Anders, James S McCarthy, Jack S Richards, James G Beeson

Journal article  |  2018  |  The Journal of Infectious Diseases

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial

Prasanna Jagannathan, Abel Kakuru, Jaffer Okiring, Mary K Muhindo, Paul Natureeba, Miriam Nakalembe, Bishop Opira, Peter Olwoch, Felistas Nankya, Isaac Ssewanyana, Kevin Tetteh, Chris Drakeley, James Beeson, Linda Reiling, Tamara D Clark, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Erika Wallender, Francesca Aweeka, Mary Prahl, et al.

Journal article  |  2018  |  PLOS Medicine

Factors influencing the induction of high affinity antibodies to Plasmodium falciparum merozoite antigens and how affinity changes over time

Muyideen K Tijani, Sreenivasulu B Reddy, Christine Langer, James G Beeson, Mats Wahlgren, Roseangela I Nwuba, Kristina EM Persson

Journal article  |  2018  |  Scientific Reports

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG(1-4), IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies

Itziar Ubillos, Alfons Jimenez, Marta Vidal, Paul W Bowyer, Deepak Gaur, Sheetij Dutta, Benoit Gamain, Ross Coppel, Virander Chauhan, David Lanar, Chetan Chitnis, Evelina Angov, James Beeson, David Cavanagh, Joseph J Campo, Ruth Aguilar, Carlota Dobano

Journal article  |  2018  |  Malaria Journal

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Liriye Kurtovic, Marije C Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E Dent, Ivo Mueller, James W Kazura, Robert W Sauerwein, Freya JI Fowkes, James G Beeson

Journal article  |  2018  |  BMC Medicine

Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures

Andrew J Guy, Vashti Irani, James G Beeson, Benjamin Webb, Andrej Sali, Jack S Richards, Paul A Ramsland

Journal article  |  2018  |  Scientific Reports

Combating low birth weight due to malaria infection in pregnancy

James G Beeson, Michelle JL Scoullar, Philippe Boeuf

Journal article  |  2018  |  Science Translational Medicine

Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure

Aida Valmaseda, Eusebio Macete, Augusto Nhabomba, Caterina Guinovart, Pedro Aide, Azucena Bardaji, Quique Bassat, Tacilta Nhampossa, Sonia Maculuve, Aina Casellas, Llorenc Quinto, Sergi Sanz, Alfons Jimenez, Gaoqian Feng, Christine Langer, Linda Reiling, K Sony Reddy, Alok Pandey, Chetan E Chitnis, Virander S Chauhan, et al.

Journal article  |  2018  |  Clinical Infectious Diseases

Effect of nutrient supplementation on the acquisition of humoral immunity to Plasmodium falciparum in young Malawian children

Priyanka Barua, Upeksha P Chandrasiri, James G Beeson, Kathryn G Dewey, Kenneth Maleta, Per Ashorn, Stephen J Rogerson

Journal article  |  2018  |  Malaria Journal

Establishment of a yeast-based VLP platform for antigen presentation

David Wetzel, Theresa Rolf, Manfred Suckow, Andreas Kranz, Andreas Barbian, Jo-Anne Chan, Joachim Leitsch, Michael Weniger, Volker Jenzelewski, Betty Kouskousis, Catherine Palmer, James G Beeson, Gerhard Schembecker, Juliane Merz, Michael Piontek

Journal article  |  2018  |  Microbial Cell Factories

Functional Conservation of the AMA1 Host-Cell Invasion Ligand Between P. falciparum and P. vivax: A Novel Platform to Accelerate Vaccine and Drug Development

Damien R Drew, Paul R Sanders, Gretchen Weiss, Paul R Gilson, Brendan S Crabb, James G Beeson

Journal article  |  2018  |  The Journal of Infectious Diseases

Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

Mirja Hommel, Jo-Anne Chan, Alexandra J Umbers, Christine Langer, Stephen J Rogerson, Joseph D Smith, James G Beeson

Journal article  |  2018  |  Parasites & Vectors

The potential of task shifting selected maternal interventions to auxiliary midwives in Myanmar: a mixed-method study

Kyu Kyu Than, Khaing Nwe Tin, Thazin La, Kyaw Soe Thant, Theingi Myint, James G Beeson, Stanley Luchters, Alison Morgan

Journal article  |  2018  |  BMC Public Health

Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Grace E Weber, Michael T White, Anna Babakhanyan, Peter Odada Sumba, John Vulule, Dylan Ely, Chandy John, Evelina Angov, David Lanar, Sheetij Dutta, David L Narum, Toshihiro Horii, Alan Cowman, James Beeson, Joseph Smith, James W Kazura, Arlene E Dent

Journal article  |  2017  |  Scientific Reports

Patterns of protective associations differ for antibodies to &ITP&IT. &ITfalciparum&IT-infected erythrocytes and merozoites in immunity against malaria in children

Jo-Anne Chan, Danielle Stanisic, Michael F Duffy, Leanne J Robinson, Enmoore Lin, James W Kazura, Christopher L King, Peter M Siba, Freya J Fowkes, Ivo Mueller, James G Beeson

Journal article  |  2017  |  European Journal of Immunology

Impaired placental autophagy in placental malaria

Kris Genelyn Dimasuay, Lan Gong, Fredrick Rosario, Emma McBryde, Tim Spelman, Jocelyn Glazier, Stephen J Rogerson, James G Beeson, Thomas Jansson, Rodney J Devenish, Philippe Boeuf

Journal article  |  2017  |  PLOS ONE

Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development

Michelle J Boyle, Mark Skidmore, Benjamin Dickerman, Lynsay Cooper, Anthony Devlin, Edwin Yates, Paul Horrocks, Craig Freeman, Wengang Chai, James G Beeson

Journal article  |  2017  |  Antimicrobial Agents and Chemotherapy

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission

Alistair RD McLean, Danielle Stanisic, Rose McGready, Kesinee Chotivanich, Caroline Clapham, Francesca Baiwog, Mupawjay Pimanpanarak, Peter Siba, Ivo Mueller, Christopher L King, Francois Nosten, James G Beeson, Stephen Rogerson, Julie A Simpson, Freya JI Fowkes

Journal article  |  2017  |  PLOS ONE

Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children

Cleopatra K Mugyenyi, Salenna R Elliott, Xi Zen Yap, Gaoqian Feng, Philippe Boeuf, Gregory Fegan, Faith FH Osier, Freya JI Fowkes, Marion Avril, Thomas N Williams, Kevin Marsh, James G Beeson

Journal article  |  2017  |  The Journal of Infectious Diseases

Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study

Ricardo Ataide, Rosanna Powell, Kerryn Moore, Alistair McLean, Aung Pyae Phyo, Shalini Nair, Marina White, Tim J Anderson, James G Beeson, Julie A Simpson, Francois Nosten, Freya JI Fowkes

Journal article  |  2017  |  The Journal of Infectious Diseases

Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion

Muyideen K Tijani, Oluwatoyin A Babalola, Alex B Odaibo, Chiaka I Anumudu, Adanze O Asinobi, Olajumoke A Morenikeji, Michael C Asuzu, Christine Langer, Linda Reiling, James G Beeson, Mats Wahlgren, Roseangela I Nwuba, Kristina EM Persson

Journal article  |  2017  |  PLOS ONE

Dichotomous miR expression and immune responses following primary blood-stage malaria

Julie G Burel, Simon H Apte, Penny L Groves, Michelle J Boyle, Christine Langer, James G Beeson, James S McCarthy, Denise L Doolan

Journal article  |  2017  |  JCI Insight

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites

Sarah C Charnaud, Matthew WA Dixon, Catherine Q Nie, Lia Chappell, Paul R Sanders, Thomas Nebl, Eric Hanssen, Matthew Berriman, Jo-Anne Chan, Adam J Blanch, James G Beeson, Julian C Rayner, Jude M Przyborski, Leann Tilley, Brendan S Crabb, Paul R Gilson

Journal article  |  2017  |  PLOS ONE

Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates

Aida Valmaseda, Quique Bassat, Pedro Aide, Pau Cistero, Alfons Jimenez, Aina Casellas, Sonia Machevo, Ruth Aguilar, Betuel Sigauque, Virander S Chauhan, Christine Langer, James Beeson, Chetan Chitnis, Pedro L Alonso, Deepak Gaur, Alfredo Mayor

Journal article  |  2017  |  Scientific Reports

Determinants of knowledge of critical danger signs, safe childbirth and immediate newborn care practices among auxiliary midwives: a cross sectional survey in Myanmar

Kyu Kyu Than, Alison Morgan, Duc Pham Minh, James G Beeson, Stanley Luchters

Journal article  |  2017  |  BMJ Open

Prevention of postpartum haemorrhage by community-based auxiliary midwives in hard-to-reach areas of Myanmar: a qualitative inquiry into acceptability and feasibility of task shifting

Kyu Kyu Than, Yasmin Mohamed, Victoria Oliver, Theingi Myint, Thazin La, James G Beeson, Stanley Luchters

Journal article  |  2017  |  BMC Pregnancy and Childbirth

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

Fiona J McCallum, Kristina EM Persson, Freya JI Fowkes, Linda Reiling, Cleopatra K Mugyenyi, Jack S Richards, Julie A Simpson, Thomas N Williams, Paul R Gilson, Anthony N Hodder, Paul R Sanders, Robin F Anders, David L Narum, Chetan Chitnis, Brendan S Crabb, Kevin Marsh, James G Beeson

Journal article  |  2017  |  Journal of Leukocyte Biology

Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort

Ricardo Ataide, Elizabeth A Ashley, Rosanna Powell, Jo-Anne Chan, Michael J Malloy, Katherine O'Flaherty, Eizo Takashima, Christine Langer, Takafumi Tsuboi, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, et al.

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

The potential benefit of scaling up malaria prevention to reduce low birth weight in Africa

James G Beeson, Julie A Simpson

Journal article  |  2017  |  PLOS Medicine

Plasmodium vivax vaccine research - we've only just begun.

Wai-Hong Tham, James G Beeson, Julian C Rayner

Journal article  |  2017  |  International Journal for Parasitology

Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause ..

Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

Kris Genelyn Dimasuay, Elizabeth H Aitken, Fredrick Rosario, Madi Njie, Jocelyn Glazier, Stephen J Rogerson, Freya JI Fowkes, James G Beeson, Theresa Powell, Thomas Jansson, Philippe Boeuf

Journal article  |  2017  |  BMC Medicine

Antibody Responses to Plasmodium falciparum and Plasmodium vivax and Prospective Risk of Plasmodium spp. Infection Postpartum

Alistair RD McLean, Machteld Boel, Rose McGready, Ricardo Ataide, Damien Drew, Takafumi Tsuboi, James G Beeson, Francois Nosten, Julie A Simpson, Freya JI Fowkes

Journal article  |  2017  |  The American Journal of Tropical Medicine and Hygiene

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion

Swapna Johnson, Raphael Rahmani, Damien R Drew, Melanie J Williams, Mark Wilkinson, Yan Hong Tan, Johnny X Huang, Christopher J Tonkin, James G Beeson, Jake Baum, Brian J Smith, Jonathan B Baell

Journal article  |  2016  |  Journal of Medicinal Chemistry

Evaluating Complement-Mediated Humoral Immunity to P. falciparum Blood Stages

MJ Boyle, L Reiling, JG Beeson

Journal article  |  2016  |  EBioMedicine

Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation

Upeksha P Chandrasiri, Freya JI Fowkes, James G Beeson, Jack S Richards, Steve Kamiza, Kenneth Maleta, Per Ashorn, Stephen J Rogerson

Journal article  |  2016  |  Malaria Journal

Functional Antibodies and Protection against Blood-Stage Malaria

Andrew Teo, Gaoqian Feng, Graham V Brown, James G Beeson, Stephen J Rogerson

Journal article  |  2016  |  Trends in Parasitology

A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

Jo-Anne Chan, Katherine B Howell, Christine Langer, Alexander G Maier, Wina Hasang, Stephen J Rogerson, Michaela Petter, Joanne Chesson, Danielle I Stanisic, Michael F Duffy, Brian M Cooke, Peter M Siba, Ivo Mueller, Peter C Bull, Kevin Marsh, Freya JI Fowkes, James G Beeson

Journal article  |  2016  |  Cellular and Molecular Life Sciences

Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

Geqing Wang, Nyssa Drinkwater, Damien R Drew, Christopher A MacRaild, David K Chalmers, Biswaranjan Mohanty, San Sui Lim, Robin F Anders, James G Beeson, Philip E Thompson, Sheena McGowan, Jamie S Simpson, Raymond S Norton, Martin J Scanlon

Journal article  |  2016  |  Journal of Molecular Biology

A malaria vaccine in children with HIV

James G Beeson, Freya JI Fowkes

Journal article  |  2016  |  The Lancet Infectious Diseases

E-Poster Abstracts

Conference Proceedings  |  2016  |  Australian and New Zealand Journal of Obstetrics and Gynaecology

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

Damien R Drew, Danny W Wilson, Salenna R Elliott, Nadia Cross, Ulrich Terheggen, Anthony N Hodder, Peter M Siba, Kiprotich Chelimo, Arlene E Dent, James W Kazura, Ivo Mueller, James G Beeson

Journal article  |  2016  |  BMC Medicine

The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria

Rupert Weaver, Linda Reiling, Gaoqian Feng, Damien R Drew, Ivo Mueller, Peter M Siba, Takafumi Tsuboi, Jack S Richards, Freya JI Fowkes, James G Beeson

Journal article  |  2016  |  Scientific Reports

Infectivity of Plasmodium falciparum in Malaria-Naive Individuals Is Related to Knob Expression and Cytoadherence of the Parasite

Danielle I Stanisic, John Gerrard, James Fink, Paul M Griffin, Xue Q Liu, Lana Sundac, Silvana Sekuloski, Ingrid B Rodriguez, Jolien Pingnet, Yuedong Yang, Yaoqi Zhou, Katharine R Trenholme, Claire YT Wang, Hazel Hackett, Jo-Anne A Chan, Christine Langer, Eric Hanssen, Stephen L Hoffman, James G Beeson, James S McCarthy, et al.

Journal article  |  2016  |  Infection and Immunity

Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period

Alistair RD McLean, Machteld E Boel, Rose McGready, Ricardo Ataide, Damien Drew, Takafumi Tsuboi, James G Beeson, Francois Nosten, Julie A Simpson, Freya JI Fowkes

Journal article  |  2016  |  Scientific Reports

The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact

Phillipe Boeuf, Heidi E Drummer, Jack S Richards, Michelle JL Scoullar, James G Beeson

Journal article  |  2016  |  BMC Medicine

Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending Opsonizing Immunity

Danika L Hill, Danny W Wilson, Natalia G Sampaio, Emily M Eriksson, Victoria Ryg-Cornejo, GL Abby Harrison, Alessandro D Uboldi, Leanne J Robinson, James G Beeson, Peter Siba, Alan F Cowman, Diana S Hansen, Ivo Mueller, Louis Schofield

Journal article  |  2016  |  Infection and Immunity

Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

James G Beeson, Damien R Drew, Michelle J Boyle, Gaoqian Feng, Freya JI Fowkes, Jack S Richards

Journal article  |  2016  |  FEMS Microbiology Reviews

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

Bankala Krishnarjuna, Dean Andrew, Christopher A MacRaild, Rodrigo AV Morales, James G Beeson, Robin F Anders, Jack S Richards, Raymond S Norton

Journal article  |  2016  |  Scientific Reports

Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting

SC Charnaud, R McGready, A Herten-Crabb, R Powell, A Guy, C Langer, JS Richards, PR Gilson, K Chotivanich, T Tsuboi, DL Narum, M Pimanpanarak, JA Simpson, JG Beeson, F Nosten, FJI Fowkes

Journal article  |  2016  |  Scientific Reports

Immunity to malaria in an era of declining malaria transmission

Freya JI Fowkes, Philippe Boeuf, James G Beeson

Journal article  |  2016  |  Parasitology

Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort

Arlene E Dent, Indu Malhotra, Xuelie Wang, Denise Babineau, Kee Thai Yeo, Timothy Anderson, Rhonda J Kimmel, Evelina Angov, David E Lanar, David Narum, Sheetij Dutta, Jack Richards, James G Beeson, Brendan S Crabb, Alan F Cowman, Toshihiro Horii, Eric Muchiri, Peter L Mungai, Christopher L King, James W Kazura

Journal article  |  2016  |  Clinical and Vaccine Immunology

High resolution FTIR imaging provides automated discrimination and detection of single malaria parasite infected erythrocytes on glass

David Perez-Guaita, Dean Andrew, Philip Heraud, James Beeson, David Anderson, Jack Richards, Bayden R Wood

Journal article  |  2016  |  Faraday Discussions

CD14 hi CD16 monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so (vol 13, 154, 2015)

Jingling Zhou, Gaoqian Feng, James Beeson, P Mark Hogarth, Stephen J Rogerson, Yan Yan, Anthony Jaworowski

Journal article  |  2015  |  BMC Medicine

Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions

Andrew J Guy, Vashti Irani, Christopher A MacRaild, Robin F Anders, Raymond S Norton, James G Beeson, Jack S Richards, Paul A Ramsland

Journal article  |  2015  |  PLOS ONE

Acquisition of Functional Antibodies That Block the Binding of Erythrocyte-Binding Antigen 175 and Protection Against Plasmodium falciparum Malaria in Children

Vashti Irani, Paul A Ramsland, Andrew J Guy, Peter M Siba, Ivo Mueller, Jack S Richards, James G Beeson

Journal article  |  2015  |  Clinical Infectious Diseases

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

Vashti Irani, Andrew J Guy, Dean Andrew, James G Beeson, Paul A Ramsland, Jack S Richards

Journal article  |  2015  |  Molecular Immunology

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya

Sarah H Atkinson, Sophie M Uyoga, Andrew E Armitage, Shivani Khandwala, Cleopatra K Mugyenyi, Philip Bejon, Kevin Marsh, James G Beeson, Andrew M Prentice, Hal Drakesmith, Thomas N Williams

Journal article  |  2015  |  EBioMedicine

Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities

Danica A Helb, Kevin KA Tetteh, Philip L Felgner, Jeff Skinner, Alan Hubbard, Emmanuel Arinaitwe, Harriet Mayanja-Kizza, Isaac Ssewanyana, Moses R Kamya, James G Beeson, Jordan Tappero, David L Smith, Peter D Crompton, Philip J Rosenthal, Grant Dorsey, Christopher J Drakeley, Bryan Greenhouse

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Malaria eradication and elimination: views on how to translate a vision into reality

Marcel Tanner, Brian Greenwood, Christopher JM Whitty, Evelyn K Ansah, Ric N Price, Arjen M Dondorp, Lorenz von Seidlein, J Kevin Baird, James G Beeson, Freya JI Fowkes, Janet Hemingway, Kevin Marsh, Faith Osier

Journal article  |  2015  |  BMC Medicine

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

Danny W Wilson, Christopher D Goodman, Brad E Sleebs, Greta E Weiss, Nienke WM de Jong, Fiona Angrisano, Christine Langer, Jake Baum, Brendan S Crabb, Paul R Gilson, Geoffrey I McFadden, James G Beeson

Journal article  |  2015  |  BMC Biology

CD14(hi)CD16 monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so

Jingling Zhou, Gaoqian Feng, James Beeson, P Mark Hogarth, Stephen J Rogerson, Yan Yan, Anthony Jaworowski

Journal article  |  2015  |  BMC Medicine

Background With more than 600,000 deaths from malaria, mainly of children under five years old and caused by infection with Plasmo..

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens

Sreenivasulu B Reddy, Robin F Anders, Nadia Cross, Ivo Mueller, Nicolas Senn, Danielle I Stanisic, Peter M Siba, Mats Wahlgren, Fred Kironde, James G Beeson, Kristina EM Persson

Journal article  |  2015  |  BMC Microbiology

Malaria and immunity during pregnancy and postpartum: a tale of two species

ARD Mclean, R Ataide, JA Simpson, JG Beeson, FJI Fowkes

Journal article  |  2015  |  Parasitology

The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial

Upeksha P Chandrasiri, Freya JI Fowkes, Jack S Richards, Christine Langer, Yue-Mei Fan, Steve M Taylor, James G Beeson, Kathryn G Dewey, Kenneth Maleta, Per Ashorn, Stephen J Rogerson

Journal article  |  2015  |  Malaria Journal

Maximizing antimalarial efficacy and the importance of dosing strategies

James G Beeson, Philippe Boeuf, Freya JI Fowkes

Journal article  |  2015  |  BMC Medicine

Plasmodium vivax Malaria Challenges in diagnosis, treatment and elimination

James G Beeson, Cindy S Chu, Jack S Richards, Francois Nosten, Freya JI Fowkes

Journal article  |  2015  |  The Pediatric Infectious Disease Journal

Risk factors for malaria and adverse birth outcomes in a prospective cohort of pregnant women resident in a high malaria transmission area of Papua New Guinea

Danielle I Stanisic, Kerryn A Moore, Francesca Baiwog, Alice Ura, Caroline Clapham, Christopher L King, Peter M Siba, James G Beeson, Ivo Mueller, Freya J Fowkes, Stephen J Rogerson

Journal article  |  2015  |  Transactions of The Royal Society of Tropical Medicine and Hygiene

Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria

Michelle J Boyle, Linda Reiling, Gaoqian Feng, Christine Langer, Faith H Osier, Harvey Aspeling-Jones, Yik Sheng Cheng, Janine Stubbs, Kevin KA Tetteh, David J Conway, James S McCarthy, Ivo Muller, Kevin Marsh, Robin F Anders, James G Beeson

Journal article  |  2015  |  Immunity

Conformational Dynamics and Antigenicity in the Disordered Malaria Antigen Merozoite Surface Protein 2

Christopher A MacRaild, Milan Zachrdla, Dean Andrew, Bankala Krishnarjuna, Jiri Novacek, Lukas Zidek, Vladimir Sklenar, Jack S Richards, James G Beeson, Robin F Anders, Raymond S Norton

Journal article  |  2015  |  PLOS ONE

PfRH5 as a candidate vaccine for Plasmodium falciparum malaria

Damien R Drew, James G Beeson

Journal article  |  2015  |  Trends in Parasitology

Acquisition of Antibodies against Plasmodium falciparum Merozoites and Malaria Immunity in Young Children and the Influence of Age, Force of Infection, and Magnitude of Response

Danielle I Stanisic, Freya JI Fowkes, Melanie Koinari, Sarah Javati, Enmoore Lin, Benson Kiniboro, Jack S Richards, Leanne J Robinson, Louis Schofield, James W Kazura, Christopher L King, Peter Zimmerman, Ingrid Felger, Peter M Siba, Ivo Mueller, James G Beeson

Journal article  |  2015  |  Infection and Immunity

Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria

Hodan Ahmed Ismail, Muyideen K Tijani, Christine Langer, Linda Reiling, Michael T White, James G Beeson, Mats Wahlgren, Roseangela Nwuba, Kristina EM Persson

Journal article  |  2014  |  Malaria Journal

Use of Immunodampening To Overcome Diversity in the Malarial Vaccine Candidate Apical Membrane Antigen 1

Karen S Harris, Christopher G Adda, Madhavi Khore, Damien R Drew, Antonina Valentini-Gatt, Freya JI Fowkes, James G Beeson, Sheetij Dutta, Robin F Anders, Michael Foley

Journal article  |  2014  |  Infection and Immunity

Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women

Andrew Teo, Wina Hasang, Louise M Randall, Gaoqian Feng, Lauren Bell, Holger Unger, Christine Langer, James G Beeson, Peter M Siba, Ivo Mueller, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

Journal article  |  2014  |  Journal of Infectious Diseases

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines

Ulrich Terheggen, Damien R Drew, Anthony N Hodder, Nadia J Cross, Cleopatra K Mugyenyi, Alyssa E Barry, Robin F Anders, Sheetij Dutta, Faith HA Osier, Salenna R Elliott, Nicolas Senn, Danielle I Stanisic, Kevin Marsh, Peter M Siba, Ivo Mueller, Jack S Richards, James G Beeson

Journal article  |  2014  |  BMC Medicine

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

Jo-Anne Chan, Freya JI Fowkes, James G Beeson

Journal article  |  2014  |  Cellular and Molecular Life Sciences

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Shane M Devine, San Sui Lim, Lndu R Chandrashekaran, Christopher A MacRaild, Damien R Drew, Cael O Debono, Raymond Lam, Robin F Anders, James G Beeson, Martin J Scanlon, Peter J Scammells, Raymond S Norton

Journal article  |  2014  |  Med. Chem. Commun.

Immunological markers of Plasmodium vivax exposure and immunity: a systematic review and meta-analysis

Julia C Cutts, Rosanna Powell, Paul A Agius, James G Beeson, Julie A Simpson, Freya JI Fowkes

Journal article  |  2014  |  BMC Medicine

PTEX is an essential nexus for protein export in malaria parasites

Brendan Elsworth, Kathryn Matthews, Catherine Q Nie, Ming Kalanon, Sarah C Charnaud, Paul R Sanders, Scott A Chisholm, Natalie A Counihan, Philip J Shaw, Paco Pino, Jo-Anne Chan, Mauro F Azevedo, Stephen J Rogerson, James G Beeson, Brendan S Crabb, Paul R Gilson, Tania F de Koning-Ward

Journal article  |  2014  |  Nature

Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria

Faith HA Osier, Gaoqian Feng, Michelle J Boyle, Christine Langer, Jingling Zhou, Jack S Richards, Fiona J McCallum, Linda Reiling, Anthony Jaworowski, Robin F Anders, Kevin Marsh, James G Beeson

Journal article  |  2014  |  BMC Medicine

Correlates of protection for plasmodium falciparum malaria vaccine development: Current knowledge and future research

JG Beeson, FJI Fowkes, L Reiling, FH Osier, DR Drew, GV Brown

Book Chapter  |  2014

Sequential Processing of Merozoite Surface Proteins during and after Erythrocyte Invasion by Plasmodium falciparum

Michelle J Boyle, Christine Langer, Jo-Anne Chan, Anthony N Hodder, Ross L Coppel, Robin F Anders, James G Beeson

Journal article  |  2014  |  Infection and Immunity

Research priorities for the development and implementation of serological tools for malaria surveillance.

Salenna R Elliott, Freya JI Fowkes, Jack S Richards, Linda Reiling, Damien R Drew, James G Beeson

Journal article  |  2014  |  F1000Prime Reports

Surveillance is a key component of control and elimination programs. Malaria surveillance has been typically reliant on case repor..

Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1

Sheetij Dutta, Lisa S Dlugosz, Damien R Drew, Xiopeng Ge, Diouf Ababacar, Yazmin I Rovira, J Kathleen Moch, Meng Shi, Carole A Long, Michael Foley, James G Beeson, Robin F Anders, Kazutoyo Miura, J David Haynes, Adrian H Batchelor

Journal article  |  2013  |  PLoS Pathogens

Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines

Freya JI Fowkes, Julie A Simpson, James G Beeson

Journal article  |  2013  |  BMC Medicine

T-Helper Cell 2-Driven Immunity in Pregnancy as a Determinant of Antiplasmodial Antibody Half-life Through Regulation of Fc-Receptor-Mediated Clearance Reply

Freya JI Fowkes, James G Beeson

Journal article  |  2013  |  J. Infect. Dis.

Acquired Antibodies to Merozoite Antigens in Children from Uganda with Uncomplicated or Severe Plasmodium falciparum Malaria

Hodan Ahmed Ismail, Ulf Ribacke, Linda Reiling, Johan Normark, Tom Egwang, Fred Kironde, James G Beeson, Mats Wahlgren, Kristina EM Persson

Journal article  |  2013  |  Clinical and Vaccine Immunology

Erythrocyte-Binding Antigens of Plasmodium falciparum Are Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity

Kristina EM Persson, Freya JI Fowkes, Fiona J McCallum, Nimmo Gicheru, Linda Reiling, Jack S Richards, Danny W Wilson, Sash Lopaticki, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article  |  2013  |  J. Immunol.

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

Jack S Richards, Thangavelu U Arumugam, Linda Reiling, Julie Healer, Anthony N Hodder, Freya JI Fowkes, Nadia Cross, Christine Langer, Satoru Takeo, Alex D Uboldi, Jennifer K Thompson, Paul R Gilson, Ross L Coppel, Peter M Siba, Christopher L King, Motomi Torii, Chetan E Chitnis, David L Narum, Ivo Mueller, Brendan S Crabb, et al.

Journal article  |  2013  |  Journal of Immunology

Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria

Cleopatra K Mugyenyi, Salenna R Elliott, Fiona J McCallum, Robin F Anders, Kevin Marsh, James G Beeson

Journal article  |  2013  |  PLoS One

Defining the Timing of Action of Antimalarial Drugs against Plasmodium falciparum

Danny W Wilson, Christine Langer, Christopher D Goodman, Geoffrey I McFadden, James G Beeson

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Antibody Boosting and Longevity Following Tetanus Immunization During Pregnancy

Freya JI Fowkes, Rose McGready, Simon Johnstone-Robertson, Francois Nosten, James G Beeson

Journal article  |  2013  |  Clinical Infectious Diseases

PfEMP1 as a target of human immunity and a vaccine candidate against malaria

James G Beeson, Jo-Anne Chan, Freya JI Fowkes

Journal article  |  2013  |  Expert Rev. Vaccines

Does Malaria Affect Placental Development? Evidence from In Vitro Models

Alexandra J Umbers, Danielle I Stanisic, Maria Ome, Regina Wangnapi, Sarah Hanieh, Holger W Unger, Leanne J Robinson, Elvin Lufele, Francesca Baiwog, Peter M Siba, Christopher L King, James G Beeson, Ivo Mueller, John D Aplin, Jocelyn D Glazier, Stephen J Rogerson

Journal article  |  2013  |  PLoS One

New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology

Michelle J Boyle, Danny W Wilson, James G Beeson

Journal article  |  2013  |  International Journal for Parasitology

Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum

Brendan J McMorran, Laura Wieczorski, Karen E Drysdale, Jo-Anne Chan, Hong Ming Huang, Clare Smith, Chalachew Mitiku, James G Beeson, Gaetan Burgio, Simon J Foote

Journal article  |  2012  |  Science

Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria

Damien R Drew, Anthony N Hodder, Danny W Wilson, Michael Foley, Ivo Mueller, Peter M Siba, Arlene E Dent, Alan F Cowman, James G Beeson

Journal article  |  2012  |  PLoS ONE

Antigenic Characterization of an Intrinsically Unstructured Protein, Plasmodium falciparum Merozoite Surface Protein 2

Christopher G Adda, Christopher A MacRaild, Linda Reiling, Kaye Wycherley, Michelle J Boyle, Vivian Kienzle, Paul Masendycz, Michael Foley, James G Beeson, Raymond S Norton, Robin F Anders

Journal article  |  2012  |  Infection and Immunity

New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women

Freya JI Fowkes, Rose McGready, Nadia J Cross, Mirja Hommel, Julie A Simpson, Salenna R Elliott, Jack S Richards, Kurt Lackovic, Jacher Viladpai-Nguen, David Narum, Takafumi Tsuboi, Robin F Anders, Francois Nosten, James G Beeson

Journal article  |  2012  |  Journal of Infectious Diseases

Malaria Parasite Signal Peptide Peptidase is an ER-Resident Protease Required for Growth but not for Invasion

Danushka S Marapana, Danny W Wilson, Elizabeth S Zuccala, Chaitali D Dekiwadia, James G Beeson, Stuart A Ralph, Jake Baum

Journal article  |  2012  |  Traffic

The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria

Linda Reiling, Jack S Richards, Freya JI Fowkes, Danny W Wilson, Watcharee Chokejindachai, Alyssa E Barry, Wai-Hong Tham, Janine Stubbs, Christine Langer, John Donelson, Pascal Michon, Livingstone Tavul, Brendan S Crabb, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article  |  2012  |  PLoS One

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article  |  2012  |  Journal of Clinical Investigation

DOES MALARIA AFFECT PLACENTAL DEVELOPMENT? EVIDENCE FROM AN IN VITRO MODEL

Alexandra Umbers, Danielle Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher King, James Beeson, Stephen Rogerson

Conference Proceedings  |  2012  |  PLACENTA

PERSPECTIVES The missing pieces

Brendan S Crabb, James G Beeson, Rogerio Amino, Robert Menard, Andy Waters, Elizabeth A Winzeler, Mats Wahlgren, David A Fidock, Solomon Nwaka

Journal article  |  2012  |  Nature

Plasmodium vivax Adherence to Placental Glycosaminoglycans

Kesinee Chotivanich, Rachanee Udomsangpetch, Rossarin Suwanarusk, Sasithon Pukrittayakamee, Polrat Wilairatana, James G Beeson, Nicholas PJ Day, Nicholas J White

Journal article  |  2012  |  PLoS One

Intermittent Preventive Treatment for Malaria in Papua New Guinean Infants Exposed to Plasmodium falciparum and P. vivax: A Randomized Controlled Trial

Nicolas Senn, Patricia Rarau, Danielle I Stanisic, Leanne Robinson, Celine Barnadas, Doris Manong, Mary Salib, Jonah Iga, Nandao Tarongka, Serej Ley, Anna Rosanas-Urgell, John J Aponte, Peter A Zimmerman, James G Beeson, Louis Schofield, Peter Siba, Stephen J Rogerson, John C Reeder, Ivo Mueller

Journal article  |  2012  |  PLoS Medicine

High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria

Sreenivasulu B Reddy, Robin F Anders, James G Beeson, Anna Farnert, Fred Kironde, Sharon Kuhlman Berenzon, Mats Wahlgren, Sara Linse, Kristina EM Persson

Journal article  |  2012  |  PLoS One

Antibody to P. falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use

Elizabeth H Aitken, Bernard Mbewe, Mari Luntamo, Teija Kulmala, James G Beeson, Per Ashorn, Stephen J Rogerson

Journal article  |  2012  |  PLoS One

New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women.

FJI Fowkes, R McGready, NJ Cross, M Hommel, JA Simpson, SR Elliott, JS Richards, K Lackovic, J Viladpai-Nguen, D Narum, T Tsuboi, RF Anders, F Nosten, JG Beeson

Journal article  |  2012  |  Journal of Infectious Diseases

Quantifying the Importance of MSP1-19 as a Target of Growth-Inhibitory and Protective Antibodies against Plasmodium falciparum in Humans

Danny W Wilson, Freya JI Fowkes, Paul R Gilson, Salenna R Elliott, Livingstone Tavul, Pascal Michon, Elija Dabod, Peter M Siba, Ivo Mueller, Brendan S Crabb, James G Beeson

Journal article  |  2011  |  PLoS One

Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen

Thangavelu U Arumugam, Satoru Takeo, Tsutomu Yamasaki, Amporn Thonkukiatkul, Kazutoyo Miura, Hitoshi Otsuki, Hong Zhou, Carole A Long, Jetsumon Sattabongkot, Jennifer Thompson, Danny W Wilson, James G Beeson, Julie Healer, Brendan S Crabb, Alan F Cowman, Motomi Torii, Takafumi Tsuboi

Journal article  |  2011  |  Infect. Immun.

A Phase 1 Trial of MSP2-C1, a Blood-Stage Malaria Vaccine Containing 2 Isoforms of MSP2 Formulated with Montanide (R) ISA 720

James S McCarthy, Joanne Marjason, Suzanne Elliott, Paul Fahey, Gilles Bang, Elissa Malkin, Eveline Tierney, Hayley Aked-Hurditch, Christopher Adda, Nadia Cross, Jack S Richards, Freya JI Fowkes, Michelle J Boyle, Carole Long, Pierre Druilhe, James G Beeson, Robin F Anders

Journal article  |  2011  |  PLoS ONE

IgG against Plasmodium falciparum variant surface antigens and growth inhibitory antibodies in Mozambican children receiving intermittent preventive treatment with sulfadoxine-pyrimethamine

Diana Quelhas, Alfons Jimenez, Llorenc Quinto, Elisa Serra-Casas, Alfredo Mayor, Pau Cistero, Laura Puyol, Danny W Wilson, Jack S Richards, Tacilta Nhampossa, Eusebio Macete, Pedro Aide, Inacio Mandomando, Sergi Sanz, John J Aponte, Pedro L Alonso, James G Beeson, Clara Menendez, Carlota Dobano

Journal article  |  2011  |  Immunobiology

Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

Sash Lopaticki, Alexander G Maier, Jennifer Thompson, Danny W Wilson, Wai-Hong Tham, Tony Triglia, Alex Gout, Terence P Speed, James G Beeson, Julie Healer, Alan F Cowman

Journal article  |  2011  |  Infection and Immunity

Placental Malaria-Associated Inflammation Disturbs the Insulin-like Growth Factor Axis of Fetal Growth Regulation

Alexandra J Umbers, Philippe Boeuf, Caroline Clapham, Danielle I Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher L King, James G Beeson, Jocelyn Glazier, Stephen J Rogerson

Journal article  |  2011  |  Journal of Infectious Diseases

Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates.

Marion Avril, Marianne J Hathaway, Anand Srivastava, Sébastien Dechavanne, Mirja Hommel, James G Beeson, Joseph D Smith, Benoît Gamain

Journal article  |  2011  |  PLoS ONE

The high molecular weight, multidomain VAR2CSA protein mediating adhesion of Plasmodium falciparum-infected erythrocytes in the pl..

Intermittent Preventive Treatment to Reduce the Burden of Malaria in Children: New Evidence on Integration and Delivery

James G Beeson, Stephen J Rogerson, Ivo Mueller, Jack S Richards, Freya JI Fowkes

Journal article  |  2011  |  PLoS Medicine

Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte

David T Riglar, Dave Richard, Danny W Wilson, Michelle J Boyle, Chaitali Dekiwadia, Lynne Turnbull, Fiona Angrisano, Danushka S Marapana, Kelly L Rogers, Cynthia B Whitchurch, James G Beeson, Alan F Cowman, Stuart A Ralph, Jake Baum

Journal article  |  2011  |  Cell Host & Microbe

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum Malaria

Linda Reiling, Jack S Richards, Freya JI Fowkes, Alyssa E Barry, Tony Triglia, Watcharee Chokejindachai, Pascal Michon, Livingstone Tavul, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article  |  2010  |  Journal of Immunology

LONGITUDINAL PATTERNS OF ANTIBODY RESPONSES AND PLASMODIUM SPP. INFECTION DURING PREGNANCY

Freya J Fowkes, Rose McGready, Mirja Hommel, Nadia J Cross, Julie A Simpson, Kurt Lackovic, Jack S Richards, Samuel J Viladpai-nguen, Marion Avril, Joseph D Smith, David L Narum, Robin F Anders, Francois Nosten, James G Beeson

Conference Proceedings  |  2010  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

QUANTIFYING INVASION INHIBITORY ANTIBODIES TO AMA1 IN HUMAN POPULATIONS USING TRANSGENIC PLASMODIUM FALCIPARUM: IMPLICATIONS FOR VACCINE DESIGN

Damien R Drew, Danny W Wilson, Nadia J Cross, Salenna R Elliot, Ivo Muller, Livingstone Tavul, Danielle I Stanisic, Nicolas Senn, Jack Tairaka, Peter M Siba, Julie Healer, Alan F Cowman, Anthony Hodder, James G Beeson

Conference Proceedings  |  2010  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

QUANTIFYING THE IMPORTANCE OF PFEMP1 AND OTHER ANTIGENS EXPRESSED ON THE SURFACE OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES AS TARGETS OF PROTECTIVE ANTIBODIES AGAINST MALARIA

Katherine Howell, Jo-Anne Chan, Linda Reiling, Ricardo Ataide, Fiona McCallum, Peter C Bull, Alexander G Maier, Joanne Chesson, George Warimwe, Stephen J Rogerson, Alan F Cowman, Kevin Marsh, James G Beeson

Conference Proceedings  |  2010  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Association between Naturally Acquired Antibodies to Erythrocyte-Binding Antigens of Plasmodium falciparum and Protection from Malaria and High-Density Parasitemia

Jack S Richards, Danielle I Stanisic, Freya JI Fowkes, Livingstone Tavul, Elijah Dabod, Jennifer K Thompson, Sanjeev Kumar, Chetan E Chitnis, David L Narum, Pascal Michon, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson

Journal article  |  2010  |  Clinical Infectious Diseases

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

Wai-Hong Tham, Danny W Wilson, Sash Lopaticki, Christoph Q Schmidt, Patience B Tetteh-Quarcoo, Paul N Barlow, Dave Richard, Jason E Corbin, James G Beeson, Alan F Cowman

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Minimal Association of Common Red Blood Cell Polymorphisms with Plasmodium falciparum Infection and Uncomplicated Malaria in Papua New Guinean School Children

Enmoore Lin, Livingstone Tavul, Pascal Michon, Jack S Richards, Elijah Dabod, James G Beeson, Christopher L King, Peter A Zimmerman, Ivo Mueller

Journal article  |  2010  |  The American Journal of Tropical Medicine and Hygiene

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

Michelle J Boyle, Danny W Wilson, Jack S Richards, David T Riglar, Kevin KA Tetteh, David J Conway, Stuart A Ralph, Jake Baum, James G Beeson

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites

Michelle J Boyle, Jack S Richards, Paul R Gilson, Wengang Chai, James G Beeson

Journal article  |  2010  |  Blood

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays

Danny W Wilson, Brendan S Crabb, James G Beeson

Journal article  |  2010  |  Malaria Journal

Using an Improved Phagocytosis Assay to Evaluate the Effect of HIV on Specific Antibodies to Pregnancy-Associated Malaria

Ricardo Ataide, Wina Hasang, Danny W Wilson, James G Beeson, Victor Mwapasa, Malcolm E Molyneux, Steven R Meshnick, Stephen J Rogerson

Journal article  |  2010  |  PLoS One

Antibodies to Chondroitin Sulfate A- Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment

Elizabeth H Aitken, Bernard Mbewe, Mari Luntamo, Ken Maleta, Teija Kulmala, Marc-James Friso, Freya JI Fowkes, James G Beeson, Per Ashorn, Stephen J Rogerson

Journal article  |  2010  |  Journal of Infectious Diseases

Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.

Marion Avril, Megan M Cartwright, Marianne J Hathaway, Mirja Hommel, Salenna R Elliott, Kathryn Williamson, David L Narum, Patrick E Duffy, Michal Fried, James G Beeson, Joseph D Smith

Journal article  |  2010  |  Infection and Immunity

Pregnancy-associated malaria is a severe clinical syndrome associated with the sequestration of Plasmodium falciparum-infected ery..

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women

Mirja Hommel, Salenna R Elliott, Viju Soma, Greg Kelly, Freya JI Fowkes, Joanne M Chesson, Michael F Duffy, Joseph Bockhorst, Marion Avril, Ivo Mueller, Andrew Raiko, Danielle I Stanisic, Stephen J Rogerson, Joseph D Smith, James G Beeson

Journal article  |  2010  |  Infection and Immunity

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

Freya JI Fowkes, Jack S Richards, Julie A Simpson, James G Beeson

Journal article  |  2010  |  PLoS Medicine

PFEMP1 IS THE MAJOR TARGET OF ANTIBODIES TO THE SURFACE OF PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES THAT ARE ASSOCIATED WITH PROTECTION FROM MALARIA

Katherine Howell, Joanne M Chesson, Linda Reiling, Peter C Bull, George Warimwe, Alan F Cowman, Kevin Marsh, James G Beeson

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

ACQUISITION OF ANTIBODIES TO THE PFRH2 INVASION LIGANDS OF PLASMODIUM FALCIPARUM AND THEIR ASSOCIATION WITH PROTECTION FROM MALARIA

Linda Reiling, Jack S Richards, Tony Triglia, Watcharee Chokejindachai, John E Donelson, Elijah Dabod, Pascal Michon, Livingstone Tavul, Alan F Cowman, Ivo Mueller, James G Beeson

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

LIMITED GLOBAL DIVERSITY OF ANTIBODY EPITOPES EXPRESSED BY PLACENTAL BINDING PLASMODIUM FALCIPARUM VARIANTS

Mirja Hommel, Salenna R Elliott, Greg Kelly, Freya J Fowkes, Michael F Duffy, Joanne Chesson, Danielle I Stanisic, Ivo Mueller, Marion Avril, Viju Soma, Joseph D Smith, Stephen J Rogerson, James G Beeson

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

THE RELATIONSHIP BETWEEN ANTI-MEROZOITE ANTIBODIES AND PROTECTION FROM PLASMODIUM FALCIPARUM MALARIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Freya J Fowkes, Jack S Richards, Julie A Simpson, James G Beeson

Conference Proceedings  |  2009  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Strain-Specific Duffy Binding Protein Antibodies Correlate with Protection against Infection with Homologous Compared to Heterologous Plasmodium vivax Strains in Papua New Guinean Children

Jennifer L Cole-Tobian, Pascal Michon, Moses Biasor, Jack S Richards, James G Beeson, Ivo Mueller, Christopher L King

Journal article  |  2009  |  Infection and Immunity

The future for blood-stage vaccines against malaria

Jack S Richards, James G Beeson

Journal article  |  2009  |  Immunology and Cell Biology

Cellular Tumor Necrosis Factor, Gamma Interferon, and Interleukin-6 Responses as Correlates of Immunity and Risk of Clinical Plasmodium falciparum Malaria in Children from Papua New Guinea

Leanne J Robinson, Marthe C D'Ombrain, Danielle I Stanisic, Jack Taraika, Nicholas Bernard, Jack S Richards, James G Beeson, Livingstone Tavul, Pascal Michon, Ivo Mueller, Louis Schofield

Journal article  |  2009  |  Infection and Immunity

Antibodies to Reticulocyte Binding Protein-Like Homologue 4 Inhibit Invasion of Plasmodium falciparum into Human Erythrocytes

Wai-Hong Tham, Danny W Wilson, Linda Reiling, Lin Chen, James G Beeson, Alan F Cowman

Journal article  |  2009  |  Infect. Immun.

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

Christopher J Tonkin, Celine K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman

Journal article  |  2009  |  PLoS Biology

Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

Danielle I stanisic, Jack S Richards, Fiona J McCallum, Pascal Michon, Christopher L King, Sonja Schoepflin, Paul R Gilson, Vincent J Murphy, Robin F Anders, Ivo Mueller, James G Beeson

Journal article  |  2009  |  Infection and Immunity

Reticulocyte-binding protein homologue 5-An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

Jake Baum, Lin Chen, Julie Healer, Sash Lopaticki, Michelle Boyle, Tony Triglia, Florian Ehlgen, Stuart A Ralph, James G Beeson, Alan F Cowman

Journal article  |  2009  |  International Journal for Parasitology

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Anthony N Hodder, Alexander G Maier, Melanie Rug, Monica Brown, Mirja Hommel, Ivan Pantic, Marina Puig-de-Morales-Marinkovic, Brian Smith, Tony Triglia, James Beeson, Alan F Cowman

Journal article  |  2009  |  Mol. Microbiol.

Recent insights into humoral and cellular immune responses against malaria.

James G Beeson, Faith HA Osier, Christian R Engwerda

Journal article  |  2008  |  Trends in Parasitology

Effective immunity to malaria has been clearly demonstrated among individuals naturally exposed to malaria, and can be induced by ..

Antibody-Mediated Growth Inhibition of Plasmodium falciparum: Relationship to Age and Protection from Parasitemia in Kenyan Children and Adults

Arlene E Dent, Elke S Bergmann-Leitner, Danny W Wilson, Daniel J Tisch, Rhonda Kimmel, John Vulule, Peter Odada Sumba, James G Beeson, Evelina Angov, Ann M Moormann, James W Kazura

Journal article  |  2008  |  PLoS ONE

Acquisition of Growth-Inhibitory Antibodies against Blood-Stage Plasmodium falciparum

Fiona J McCallum, Kristina EM Persson, Cleopatra K Mugyenyi, Freya JI Fowkes, Julie A Simpson, Jack S Richards, Thomas N Williams, Kevin Marsh, James G Beeson

Journal article  |  2008  |  PLoS One

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

Alexander G Maier, Melanie Rug, Matthew T O'Neill, Monica Brown, Srabasti Chakravorty, Tadge Szestak, Joanne Chesson, Yang Wu, Katie Hughes, Ross L Coppel, Chris Newbold, James G Beeson, Alister Craig, Brendan S Crabb, Alan F Cowman

Journal article  |  2008  |  Cell

Estimating the burden of global mortality in children aged <5 years by pathogen-specific causes.

Salenna R Elliott, James G Beeson

Journal article  |  2008  |  Clinical Infectious Diseases

Characteristics of Plasmodium falciparum-infected-erythrocyte adhesion to chondroitin sulfate.

James G Beeson

Journal article  |  2008  |  Infection and Immunity

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development

Tania F de Koning-Ward, Damien R Drew, Joanne A Chesson, James G Beeson, Brendan S Crabb

Journal article  |  2008  |  Molecular and Biochemical Parasitology

Polymorphic and conserved targets of antibodies against Plasmodium falciparum during pregnancy.

James G Beeson, Salenna R Elliott, Mirja Hommel

Journal article  |  2008  |  The Journal of Infectious Diseases

Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line

Francisca Yosaatmadja, Katherine T Andrews, Michael F Duffy, Graham V Brown, James G Beeson, Stephen J Rogerson

Journal article  |  2008  |  Malaria Journal

Characterization of VAR2CSA- deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line

F Yosaatmadja, undefined Andrews, M Duffy, GV Brown, JG Beeson, SJ Rogerson

Journal article  |  2008  |  Malaria Journal

The role of proteins exported to the Plasmodium falciparum-infected erythrocyte.

Alexander G Maier, Melanie Rug, Monica Brown, Matthew T O'Neill, Shribasti Chakravorty, Tadge Szestak, Joanne Chesson, Yang Wu, Katie Hughes, Ross Coppel, Chris Newbold, James Beeson, Alister Craig, Brendan S Crabb, Alan F Cowman

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Antibodies against the erythrocyte binding antigens and reticulocyte binding homologues of Plasmodium falciparum have a strong association with protection against clinical malaria.

JS Richards, DI Stanisic, D Wilson, L Reiling, CL King, AF Cowman, P Michon, I Mueller, JG Beeson

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Antibody levels to variant surface antigens of pregnancy-associated Plasmodium falciparum malaria in Malawian women receiving intermittent preventive treatment.

Elizabeth Aitken, Bernard Mbewe, Marc-James Friso, Francisca Yosaatmadja, James Beeson, Per Ashorn, Stephen J Rogerson

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies

Kristina EM Persson, Fiona J McCallum, Linda Reiling, Nicole A Lister, Janine Stubbs, Alan F Cowman, Kevin Marsh, James G Beeson

Journal article  |  2008  |  Journal of Clinical Investigation

Antibodies to variant surface antigens expressed by P-falciparum-infected erythrocytes that adhere ICAM-1.

Joanne Chesson, Jonathon S Richards, Danielle I Stanisic, Ivo Mueller, James G Beeson

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Towards a vaccine against Plasmodium vivax malaria

James G Beeson, Brendan S Crabb

Journal article  |  2007  |  PLoS Medicine

Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface

Sarah Frankland, Salenna R Elliott, Francisca Yosaatmadja, James G Beeson, Stephen J Rogerson, Akinola Adisa, Leann Tilley

Journal article  |  2007  |  Eukaryotic Cell

Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity

James G Beeson, Katherine T Andrews, Michelle Boyle, Michael F Duffy, Ee Ken Choong, Tim J Byrne, Joanne M Chesson, Alexander M Lawson, Wengang Chai

Journal article  |  2007  |  Journal of Biological Chemistry

Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

James G Beeson, Francis Ndungu, EM Persson, Joanne M Chesson, Greg L Kelly, Sophie Uyoga, Sandra L Hallamore, Thomas N Williams, John C Reeder, Graham V Brown, Kevin Marsh

Journal article  |  2007  |  American Journal of Tropical Medicine and Hygiene

The risk of malarial infections and disease in Papua New Guinean children

Pascal Michon, Jennifer L Cole-Tobian, Elijah Dabod, Sonja Schoepflin, Jennifer Igu, Melinda Susapu, Nandao Tarongka, Peter A Zimmerman, John C Reeder, James G Beeson, Louis Schofield, Christopher L King, Ivo Mueller

Journal article  |  2007  |  The American Journal of Tropical Medicine and Hygiene

Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface

Alexander G Maier, Melanie Rug, Matthew T O'Neill, James G Beeson, Matthias Marti, John Reeder, Alan F Cowman

Journal article  |  2007  |  Blood

Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies

Kristina EM Persson, Chee T Lee, Kevin Marsh, James G Beeson

Journal article  |  2006  |  Journal of Clinical Microbiology

Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies

JG Beeson, EJ Mann, TJ Byrne, A Caragounis, SR Elliott, GV Brown, SJ Rogerson

Journal article  |  2006  |  Journal of Infectious Diseases

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

TS Voss, J Healer, AJ Marty, MF Duffy, JK Thompson, JG Beeson, JC Reeder, BS Crabb, AF Cowman

Journal article  |  2006  |  Nature

Targets of protective antibodies to malaria during pregnancy

JG Beeson, SJ Rogerson, SR Elliott, MF Duffy

Journal article  |  2005  |  Journal of Infectious Diseases

Promising functional readouts of immunity in a blood-stage malaria vaccine trial

BS Crabb, JG Beeson

Journal article  |  2005  |  PLoS Medicine

Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity

SR Elliott, AK Brennan, JG Beeson, E Tadesse, ME Molyneux, GV Brown, SJ Rogerson

Journal article  |  2005  |  Infection and Immunity

Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype

MF Duffy, TJ Byrne, SR Elliott, DW Wilson, SJ Rogerson, JG Beeson, R Noviyanti, GV Brown

Journal article  |  2005  |  Molecular Microbiology

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa

SR Elliott, MF Duffy, TJ Byrne, JG Beeson, EJ Mann, DW Wilson, SJ Rogerson, GV Brown

Journal article  |  2005  |  Infection and Immunity

The immunology and pathogenesis of malaria during pregnancy

JG Beeson, PE Duffy

Book  |  2005  |  Current Topics in Microbiology and Immunology

Clinical features and pathogenesis of severe malaria

CL Mackintosh, JG Beeson, K Marsh

Journal article  |  2004  |  Trends in Parasitology

Malaria in pregnancy and the endemicity spectrum: what can we learn?

F Nosten, SJ Rogerson, JG Beeson, R McGready, TK Mutabingwa, B Brabin

Journal article  |  2004  |  Trends in Parasitology

Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection

AM Mount, V Mwapasa, SR Elliott, JG Beeson, E Tadesse, VM Lema, ME Molyneux, SR Meshnick, SJ Rogerson

Journal article  |  2004  |  The Lancet

Phenotypes of Plasmodium falciparum from the peripheral blood of pregnant women

JG Beeson, SJ Rogerson

Journal article  |  2004  |  Infection and Immunity

Antibodies to variant surface antigens of Plasmodium falciparum - Infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets

JG Beeson, EJ Mann, SR Elliott, VM Lema, E Tadesse, ME Molyneux, GV Brown, SJ Rogerson

Journal article  |  2004  |  Journal of Infectious Diseases

Plasmodium falciparum-infected erythrocytes demonstrate dual specificity for adhesion to hyaluronic acid and chondroitin sulfate a and have distinct adhesive properties

JG Beeson, GV Brown

Journal article  |  2004  |  Journal of Infectious Diseases

An alternative agglutination assay to measure antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes

EJ Mann, SJ Rogerson, JG Beeson

Journal article  |  2003  |  Transactions of the Royal Society of Tropical Medicine and Hygiene

Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta

JG Beeson, N Amin, M Kanjala, SJ Rogerson

Journal article  |  2002  |  Infection and Immunity

Evaluating specific adhesion of Plasmodium falciparum-infected erythrocytes to immobilised hyaluronic acid with comparison to binding of mammalian cells

JG Beeson, SJ Rogerson, GV Brown

Journal article  |  2002  |  International Journal for Parasitology

The structural motif in chondroitin sulfate for adhesion of Plasmodium falciparum-infected erythrocytes comprises disaccharide units of 4-O-sulfated and non-sulfated N-acetylgalactosamine linked to glucuronic acid

WG Chai, JG Beeson, AM Lawson

Journal article  |  2002  |  Journal of Biological Chemistry

Expanding the paradigms of placental malaria

JG Beeson, BM Cooke, JA Rowe, SJ Rogerson

Journal article  |  2002  |  Trends in Parasitology

Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation

JG Beeson, GV Brown

Journal article  |  2002  |  Cellular and Molecular Life Sciences

Of mothers and malaria

JG BEESON

Journal article  |  2002  |  Trends in Parasitology

Parasite adhesion and immune evasion in placental malaria

JG Beeson, JC Reeder, SJ Rogerson, GV Brown

Journal article  |  2001  |  Trends in Parasitology

Sticky rings: challenging the cytoadherence dogma.

BM Cooke, JG Beeson, SJ Rogerson

Journal article  |  2001  |  Trends in Parasitology

New agents to combat malaria

JG Beeson, PA Winstanley, GI McFadden, GV Brown

Journal article  |  2001  |  Nature Medicine

Inhibition of adhesion of Plasmodium falciparum-infected erythrocytes by structurally defined hyaluronic acid dodecasaccharides

WG Chai, JG Beeson, H Kogelberg, GV Brown, AM Lawson

Journal article  |  2001  |  Infection and Immunity

Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite

JC Reeder, AN Hodder, JG Beeson, GV Brown

Journal article  |  2000  |  Infection and Immunity

Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

JG Beeson, SJ Rogerson, BM Cooke, JC Reeder, WG Chai, AM Lawson, ME Molyneux, GV Brown

Journal article  |  2000  |  Nature Medicine

Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women

SJ Rogerson, JG Beeson, CG Mhango, FK Dzinjalamala, ME Molyneux

Journal article  |  2000  |  Infection and Immunity

The placenta in malaria: mechanisms of infection, disease and foetal morbidity

SJ Rogerson, JG Beeson

Conference Proceedings  |  1999  |  Annals of Tropical Medicine and Parasitology

Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties

JG Beeson, GV Brown, ME Molyneux, C Mhango, F Dzinjalamala, SJ Rogerson

Conference Proceedings  |  1999  |  The Journal of Infectious Diseases

The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1

JC Reeder, AF Cowman, KM Davern, JG Beeson, JK Thompson, SJ Rogerson, GV Brown

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Inhibition of binding of malaria-infected erythrocytes by a tetradecasaccharide fraction from chondroitin sulfate A

JG Beeson, WG Chai, SJ Rogerson, AM Lawson, GV Brown

Journal article  |  1998  |  Infection and Immunity

Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies.

JG Beeson, ER Shelton, HW Chan, FH Gage

Journal article  |  1994  |  The Journal of Comparative Neurology

The beta-amyloid or A4 protein is found deposited in neuritic plaques and neurofibrillary tangles in Alzheimer's disease (AD) affe..

Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain.

JG Beeson, ER Shelton, HW Chan, FH Gage

Journal article  |  1994  |  The Journal of Comparative Neurology

Alzheimer's disease (AD) is characterized by the extensive deposition of the 42-amino-acid beta-amyloid or A4 protein in neuritic ..