James Beeson

Recent clinical trials inform the future for malaria vaccines

Liriye Kurtovic, Linda Reiling, D Herbert Opi, James G Beeson

Journal article  |  2021  |  Communications Medicine

Multi-functional antibody profiling for malaria vaccine development and evaluation.

D Herbert Opi, Liriye Kurtovic, Jo-Anne Chan, Jessica L Horton, Gaoqian Feng, James G Beeson

Journal article  |  2021  |  Expert Rev Vaccines

IntroductionA vaccine would greatly accelerate current global efforts towards malaria elimination. While a partially efficacious v..

839A novel approach to investigating poor growth in a longitudinal study of infants in PNG

Clarissa Moreira, Michelle Scoullar, Elizabeth Peach, Ruth Fidelis, Pele Melepeia, William Pomat, Peter Siba, Brendan Crabb, Leanne Robinson, Paul Agius, James Beeson

Journal article  |  2021  |  International Journal of Epidemiology

Abstract Background Children in Papua New Guinea (PNG) experience high rates o..

Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

D Herbert Opi, Michelle J Boyle, Alistair RD McLean, Linda Reiling, Jo-Anne Chan, Danielle Stanisic, Alice Ura, Ivo Mueller, Freya J Fowkes, Stephen J Rogerson, James G Beeson

Journal article  |  2021  |  BMC MEDICINE

BACKGROUND: The pathogenesis of malaria in pregnancy (MiP) involves accumulation of P. falciparum-infected red blood cells (pRBCs)..

O16.1 High burden of reproductive tract infections and poor sexual and reproductive health in pregnancy and postpartum in Papua New Guinea

M Scoullar, P Boeuf, E Peach, E Kearney, R Fidelis, K Tokmun, P Melepia, C Bradshaw, A Elijah, G Fehler, P Siba, S Erskine, E Mokany, E Kennedy, A Umbers, S Luchters, L Robinson, N Wong, A Vallely, S Badman, et al.

Conference Proceedings  |  2021  |  Female reproductive health for STIs and HIV

Iron Deficiency Is Associated With Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children.

Caroline K Bundi, Angela Nalwoga, Lawrence Lubyayi, John Muthii Muriuki, Reagan M Mogire, Herbert Opi, Alexander J Mentzer, Cleopatra K Mugyenyi, Jedida Mwacharo, Emily L Webb, Philip Bejon, Thomas N Williams, Joseph K Gikunju, James G Beeson, Alison M Elliott, Francis M Ndungu, Sarah H Atkinson

Journal article  |  2021  |  Clin Infect Dis

BACKGROUND: Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan A..

High Antibodies to VAR2CSA in Response to Malaria Infection Are Associated With Improved Birthweight in a Longitudinal Study of Pregnant Women

Alistair RD McLean, D Herbert Opi, Danielle Stanisic, Julia C Cutts, Gaoqian Feng, Alice Ura, Ivo Mueller, Stephen J Rogerson, James G Beeson, Freya J Fowkes

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Introduction: Pregnant women have an increased risk of P. falciparum infection, which is associated with low birth weight and pret..

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes

Journal article  |  2021  |  BMC MEDICINE

BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..

HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women

Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel Gonzalez, Chenjerai Jairoce, M Nelia Manaca, Miquel Vazquez-Santiago, Reyes Balcells, Anifa Vala, Maria Ruperez, Pau Cistero, Laura Fuente-Soro, Evelina Angov, Ross L Coppel, Benoit Gamain, David Cavanagh, James G Beeson, Arsenio Nhacolo, Esperanca Sevene, John J Aponte, et al.

Journal article  |  2021  |  JOURNAL OF INFECTION

OBJECTIVES: Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main ..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  NATURE COMMUNICATIONS

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..