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Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death us..
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting ..
Displaying the 29 most recent scholarly works by Jarrod Sandow.
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Sarah Theresa Boyle, Valentina Poltavets, Jasreen Kular, Natasha Theresa Pyne, Jarrod John Sandow, Alexander Charles Lewis, Kendelle Joan Murphy, Natasha Kolesnikoff, Paul Andre Bartholomew Moretti, Melinda Nay Tea, Vinay Tergaonkar, Paul Timpson, Stuart Maxwell Pitson, Andrew Ian Webb, Robert John Whitfield, Angel Francisco Lopez, Marina Kochetkova, Michael Susithiran Samuel
Journal article | 2020 | Nature Cell Biology
It is well accepted that cancers co-opt the microenvironment for their growth. However, the molecular mechanisms that underlie can..
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe PC Smith, Andrew I Webb, Peter E Czabotar, Shohei Koide, James M Murphy
Journal article | 2020 | Proceedings of the National Academy of Sciences
The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosph..
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matthias Geyer, Nathanael S Gray, Stephin J Vervoort, et al.
Journal article | 2020 | Science Advances
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.
Journal article | 2019 | Science
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..
Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1
Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon
Journal article | 2019 | Cancers
Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.
Journal article | 2019 | Nature Chemical Biology
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy
Journal article | 2019 | Cell Reports
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association
Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams
Journal article | 2019 | Cell Reports
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou, Grant Dewson
Journal article | 2019 | The EMBO Journal
Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex
Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.
Journal article | 2019 | Nature
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.
Journal article | 2018 | Nature Communications
Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte
Danushka S Marapana, Laura F Dagley, Jarrod J Sandow, Thomas Nebl, Tony Triglia, Michal Pasternak, Benjamin K Dickerman, Brendan S Crabb, Paul R Gilson, Andrew Webb, Justin A Boddey, Alan F Cowman
Journal article | 2018 | Nature Microbiology
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy
Journal article | 2018 | Nature Communications
Role of the beta Common (beta c) Family of Cytokines in Health and Disease
Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.
Journal article | 2018 | Cold Spring Harbor Perspectives in Biology
Discovery and Validation of Novel Protein Biomarkers in Ovarian Cancer Patient Urine
Jarrod J Sandow, Adam Rainczuk, Giuseppe Infusini, Ming Makanji, Maree Bilandzic, Amy L Wilson, Nicole Fairweather, Peter G Stanton, Daniel Garama, Daniel Gough, Thomas W Jobling, Andrew I Webb, Andrew N Stephens
Journal article | 2018 | PROTEOMICS - Clinical Applications
Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
Michael D Stutz, Samar Ojaimi, Cody Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J Sandow, Andrew I Webb, John Silke, Warren S Alexander, Marc Pellegrini
Journal article | 2018 | Cell Death & Differentiation
Role of salt bridges in the dimer interface of 14-3-3 zeta in dimer dynamics, N-terminal alpha-helical order, and molecular chaperone activity
Joanna M Woodcock, Katy L Goodwin, Jarrod J Sandow, Carl Coolen, Matthew A Perugini, Andrew I Webb, Stuart M Pitson, Angel F Lopez, John A Carver
Journal article | 2018 | Journal of Biological Chemistry
Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death
Jarrod J Sandow, Giuseppe Infusini, Aliaksei Z Holik, Gabriela Brumatti, Tessa V Averink, Paul G Ekert, Andrew I Webb
Journal article | 2017 | PROTEOMICS - Clinical Applications
High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression
Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore, Richard J D'Andrea, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw
Journal article | 2017 | Blood Advances
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.
Journal article | 2015 | Nature Communications
HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert
Journal article | 2013 | Oncotarget
Hoxb8 regulates expression of microRNAs to control cell death and differentiation
M Salmanidis, G Brumatti, N Narayan, BD Green, JA van den Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert
Journal article | 2013 | Cell Death & Differentiation
Signalling by the beta c family of cytokines
Timothy R Hercus, Urmi Dhagat, Winnie LT Kan, Sophie E Broughton, Tracy L Nero, Michelle Perugini, Jarrod J Sandow, Richard J D'Andrea, Paul G Ekert, Timothy Hughes, Michael W Parker, Angel F Lopez
Journal article | 2013 | Cytokine & Growth Factor Reviews
Medical Biology (W.E.H.I.)