David Barit

Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis.

P Harraka, Tony Wightman, Sarah Akom, Kieran Sandhu, Deb Colville, Andrew Catran, David Langsford, Timothy Pianta, David Barit, Frank Ierino, Alison Skene, Heather Mack, Judy Savige

Journal article  |  2022  |  Sci Rep

Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration..

Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

P Harraka, H Mack, D Colville, D Barit, D Langsford, T Pianta, F Ierino, Judy Savige

Journal article  |  2022  |  SCIENTIFIC REPORTS

Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropat..

Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment

Ye Ji Ham, Eleanor Nicklason, Tony Wightman, Sarah Akom, Kieran Sandhu, Philip Harraka, Deb Colville, Andrew Catran, David Barit, David Langsford, Tim Pianta, Andrew Foote, Russell Buchanan, Heather Mack, Judy Savige

Journal article  |  2022  |  KIDNEY INTERNATIONAL REPORTS

INTRODUCTION: Complement has been implicated in systemic lupus erythematosus (SLE) pathogenesis on the basis of the associations w..

BONE SCINTIGRAPHY AS A MODALITY TO MONITOR DISEASE ACTIVITY OF CALCIPHYLAXIS IN A PATIENT WITH END-STAGE KIDNEY DISEASE SECONDARY TO DIABETIC NEPHROPATHY

J Chua, A Hannah, D Barit, D Langsford

Conference Proceedings  |  2018  |  NEPHROLOGY

PRIMARY CENTRAL NERVOUS SYSTEM POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE: AN UNCOMMON DIAGNOSTIC DILEMMA

Dov Degen, John Kanellis, Peter Hughes, David Barit, Francesco Ierino

Journal article  |  2016  |  NEPHROLOGY

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy.

Vicki Thallas-Bonke, Jay C Jha, Stephen P Gray, David Barit, Hermann Haller, Harald HHW Schmidt, Melinda T Coughlan, Mark E Cooper, Josephine M Forbes, Karin AM Jandeleit-Dahm

Journal article  |  2014  |  Physiol Rep

Current treatments for diabetic nephropathy (DN) only result in slowing its progression, thus highlighting a need to identify nove..

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jay C Jha, Stephen P Gray, David Barit, Jun Okabe, Assam El-Osta, Tamehachi Namikoshi, Vicki Thallas-Bonke, Kirstin Wingler, Cedric Szyndralewiez, Freddy Heitz, Rhian M Touyz, Mark E Cooper, Harald HHW Schmidt, Karin A Jandeleit-Dahm

Journal article  |  2014  |  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedica..

Role of Nox2 in diabetic kidney disease

Young-Hyun You, Shinichi Okada, San Ly, Karin Jandeleit-Dahm, David Barit, Tamehachi Namikoshi, Kumar Sharma

Journal article  |  2013  |  AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

NADPH oxidase (Nox) isoforms have been implicated in contributing to diabetic microvascular complications, but the functional role..

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

Christoph Kleinschnitz, Henrike Grund, Kirstin Wingler, Melanie E Armitage, Emma Jones, Manish Mittal, David Barit, Tobias Schwarz, Christian Geis, Peter Kraft, Konstanze Barthel, Michael K Schuhmann, Alexander M Herrmann, Sven G Meuth, Guido Stoll, Sabine Meurer, Anja Schrewe, Lore Becker, Valerie Gailus-Durner, Helmut Fuchs, et al.

Journal article  |  2010  |  PLOS BIOLOGY

Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contrain..

Blood pressure lowering and outcomes in type 2 diabetes: Implications of the blood pressure-lowering arm of the advance trial

RJ MacIsaac, D Barit, G Jerums

Journal article  |  2009  |  Current Hypertension Reviews

This review focuses on trials that have examined the relationship between blood pressure (BP) lowering strategies and cardiovascul..