Patricia Costa

Features of intracranial hemorrhage in cerebral venous thrombosis

K Afifi, G Bellanger, PJ Buyck, SM Zuurbier, CG Esperon, MA Barboza, P Costa, I Escudero, D Renard, R Lemmens, N Hinteregger, F Fazekas, J Jimenez Conde, E Giralt-Steinhauer, S Hiltunen, A Arauz, A Pezzini, J Montaner, J Putaala, C Weimar, et al.

Journal article  |  2020  |  JOURNAL OF NEUROLOGY

BACKGROUND: Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. AIM: To identify clinical and imaging fea..

The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Nguyen Linh, Marcos Perini, Christopher Christophi

Journal article  |  2018  |  BMC CANCER

BACKGROUND: The Kallikrein-Kinin System (KKS) has been found to play a role in tumor progression in several cancers. The KKS metab..

Blockade of the renin-angiotensin system inhibits growth of colorectal cancer liver metastases in the regenerating liver

Shir Lin Koh, EI Ager, PLN Costa, C Malcontenti-Wilson, V Muralidharan, C Christophi

Journal article  |  2014  |  CLINICAL & EXPERIMENTAL METASTASIS

Partial hepatectomy (PH), the preferred option for selected patients with colorectal cancer liver metastases (CRCLM), is associate..

Tumour growth stimulation following partial hepatectomy in mice is associated with increased upregulation of c-Met

Nadia Harun, Patricia Costa, C Christophi

Journal article  |  2014  |  CLINICAL & EXPERIMENTAL METASTASIS

Hepatic resection is the preferred option for curative treatment of colorectal liver metastasis (CLM). However, this is associated..

Comparison of Two Syngeneic Orthotopic Murine Models of Pancreatic Adenocarcinoma

Mehrdad Nikfarjam, Dannel Yeo, Hong He, Graham Baldwin, Theodora Fifis, Patricia Costa, Bryan Tan, Eunice Yang, Shu Wen Wen, Christopher Christophi

Journal article  |  2013  |  JOURNAL OF INVESTIGATIVE SURGERY

BACKGROUND: Pancreatic adenocarcinoma has an extremely poor prognosis. The use of appropriate in vivo models is essential in devis..

Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor

Theodora Fifis, Linh Nguyen, Cathy Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Jurstine Daruwalla, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Mark Waltham, Erik W Thompson, Christopher Christophi

Journal article  |  2013  |  CANCER MEDICINE

Epithelial to mesenchymal transition (EMT) is considered an important mechanism in tumor resistance to drug treatments; however, i..

Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments

Nguyen Linh, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi

Journal article  |  2012  |  BMC CANCER

BACKGROUND: Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thi..

Captopril inhibits colorectal cancer liver metastases following 70% partial hepatectomy in a mouse model

Shir Lin Koh, EI Ager, C Malcontenti-Wilson, PL Costa, V Muralidharan, C Christophi

Conference Proceedings  |  2012  |  CANCER RESEARCH

Abstract Background: Blockade of the renin-angiotensin system (RAS) with the angiotensin-converting enzyme inhibito..

Spatial morphological and molecular differences within solid tumours may contribute to the failure of vascular disruptive agent treatments

L Nguyen, T Fifis, C Malcontenti-Wilson, undefined Chan, PL Costa, M Nikfarjam, V Muralidharan, C Christophi

Journal article  |  2012  |  BMC Cancer