Paul Klauser

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.

Daniella Dwir, Basilio Giangreco, Lijing Xin, Liliane Tenenbaum, Jan-Harry Cabungcal, Pascal Steullet, Audrey Goupil, Martine Cleusix, Raoul Jenni, Abdelwahed Chtarto, Philipp S Baumann, Paul Klauser, Philippe Conus, Rabindra Tirouvanziam, Michel Cuenod, Kim Q Do

Journal article  |  2020  |  Molecular Psychiatry

Various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction,..

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky

Journal article  |  2020  |  Molecular Psychiatry

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..

The 2019 ESCAP research academy workshop: how novel technologies are impacting child and adolescent psychiatry.

Paul Klauser, Johannes Hebebrand, Laura A Kehoe, Mercedes Huscsava, Alexis Revet

Journal article  |  2020  |  European Child & Adolescent Psychiatry

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study.

Emeline Mullier, Timo Roine, Alessandra Griffa, Lijing Xin, Philipp S Baumann, Paul Klauser, Martine Cleusix, Raoul Jenni, Yasser Alemàn-Gómez, Rolf Gruetter, Philippe Conus, Kim Q Do, Patric Hagmann

Journal article  |  2019  |  International Journal of Neuropsychopharmacology

BACKGROUND: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment..

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients.

Philipp S Baumann, Paul Klauser, Alessandra Griffa, Philippe Golay, Julie Palix, Luis Alameda, Valérie Moulin, Patric Hagmann, Kim Q Do, Philippe Conus

Journal article  |  2019  |  Early Intervention in Psychiatry

AIM: Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behav..

Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging.

Alessandra Griffa, Philipp S Baumann, Paul Klauser, Emeline Mullier, Martine Cleusix, Raoul Jenni, Martijn P van den Heuvel, Kim Q Do, Philippe Conus, Patric Hagmann

Journal article  |  2019  |  Translational Psychiatry

Early in the course of psychosis, alterations in brain connectivity accompany the emergence of psychiatric symptoms and cognitive ..

Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis.

Luis Alameda, Margot Fournier, Ines Khadimallah, Alessandra Griffa, Martine Cleusix, Raoul Jenni, Carina Ferrari, Paul Klauser, Philipp S Baumann, Michel Cuenod, Patric Hagmann, Philippe Conus, Kim Q Do

Journal article  |  2018  |  Proceedings of the National Academy of Sciences of USA

Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly throu..

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial.

Paul Klauser, Lijing Xin, Margot Fournier, Alessandra Griffa, Martine Cleusix, Raoul Jenni, Michel Cuenod, Rolf Gruetter, Patric Hagmann, Philippe Conus, Philipp S Baumann, Kim Q Do

Journal article  |  2018  |  Translational Psychiatry

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. P..

Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, OA Andreassen, C Arango, N Banaj, S Bouix, CA Bousman, RM Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, et al.

Journal article  |  2018  |  Molecular Psychiatry

CHILDHOOD TRAUMA ENGAGES OXIDATIVE STRESS, HIPPOCAMPUS ALTERATIONS, AND POORER CLINICAL OUTCOME IN EARLY PSYCHOSIS PATIENTS

Luis Alameda, Margot Fournier, Ines Khadimallah, Philippe S Baumann, Martine Cleusix, Alessandra Griffa, Paul Klauser, Raoul Jenni, Michel Cuenod, Patric Hagmann, Philippe Conus, Kim Do

Conference Proceedings  |  2018  |  SCHIZOPHRENIA BULLETIN