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Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Dru..
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents..
Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the ..
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the ind..
Displaying the 21 most recent scholarly works by Kym Lowes.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.
Journal article | 2019 | Nature Chemical Biology
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy
Journal article | 2019 | Cell Reports
Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity
Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.
Journal article | 2017 | Gastroenterology
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity
Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs
Journal article | 2017 | Journal of Medicinal Chemistry
Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V
Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs
Journal article | 2016 | Bioorganic & Medicinal Chemistry
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy
Journal article | 2016 | Cell Death & Disease
Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes
Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman
Journal article | 2015 | Nature Structural & Molecular Biology
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz, Stephen K Tahir, Lisa D Belmont, Paul Nimmer, Yu Xiao, Xiaoju Max Ma, Kym N Lowes, Peter Kovar, Jun Chen, Sha Jin, Morey Smith, John Xue, Haichao Zhang, Anatol Oleksijew, Terrance J Magoc, Kedar S Vaidya, et al.
Journal article | 2015 | Science Translational Medicine
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.
Journal article | 2015 | Nature Communications
Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax
Brad E Sleebs, Michelle Gazdik, Matthew T O'Neill, Pravin Rajasekaran, Sash Lopaticki, Kurt Lackovic, Kym Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey
Journal article | 2014 | Journal of Medicinal Chemistry
Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites
Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Guenther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey
Journal article | 2014 | PLoS Biology
Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L
Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.
Journal article | 2013 | Journal of Medicinal Chemistry
Structure-guided design of a selective BCL-X-L inhibitor
Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.
Journal article | 2013 | Nature Chemical Biology
Engineering a multimodal nerve conduit for repair of injured peripheral nerve
AF Quigley, KJ Bulluss, ILB Kyratzis, K Gilmore, T Mysore, KSU Schirmer, EL Kennedy, M O'Shea, YB Truong, SL Edwards, G Peeters, P Herwig, JM Razal, TE Campbell, KN Lowes, MJ Higgins, SE Moulton, MA Murphy, MJ Cook, GM Clark, et al.
Journal article | 2013 | Journal of Neural Engineering
Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines.
Lily S Subrata, Kim N Lowes, John K Olynyk, George CT Yeoh, Elizabeth A Quail, Lawrence J Abraham
Journal article | 2005 | Liver International
BACKGROUND: Lymphotoxin-beta (LT-beta) plays an important role in inflammation and its promoter contains a functional nuclear fact..
Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C.
KN Lowes, EJ Croager, LJ Abraham, JK Olynyk, GCT Yeoh
Journal article | 2003 | Gut
BACKGROUND: Bipotent liver progenitor (oval) cells with the ability to differentiate into hepatocytes and biliary epithelium have ..
Oval cell numbers in human chronic liver diseases are directly related to disease severity.
KN Lowes, BA Brennan, GC Yeoh, JK Olynyk
Journal article | 1999 | The American Journal of Pathology
The risk of developing hepatocellular carcinoma is significantly increased in patients with genetic hemochromatosis, alcoholic liv..
Medical Biology (W.E.H.I.)