Kym Lowes

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Journal article  |  2019  |  Cell Reports

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  Gastroenterology

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs

Journal article  |  2017  |  Journal of Medicinal Chemistry

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2016  |  Bioorganic & Medicinal Chemistry

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy

Journal article  |  2016  |  Cell Death & Disease

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article  |  2015  |  Nature Structural & Molecular Biology

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz, Stephen K Tahir, Lisa D Belmont, Paul Nimmer, Yu Xiao, Xiaoju Max Ma, Kym N Lowes, Peter Kovar, Jun Chen, Sha Jin, Morey Smith, John Xue, Haichao Zhang, Anatol Oleksijew, Terrance J Magoc, Kedar S Vaidya, et al.

Journal article  |  2015  |  Science Translational Medicine

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.

Journal article  |  2015  |  Nature Communications

The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Matthew T O'Neill, Sash Lopaticki, Kym N Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2015  |  MedChemComm

Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P-falciparum and P-vivax

Brad E Sleebs, Michelle Gazdik, Matthew T O'Neill, Pravin Rajasekaran, Sash Lopaticki, Kurt Lackovic, Kym Lowes, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article  |  2014  |  Journal of Medicinal Chemistry

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Guenther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey

Journal article  |  2014  |  PLoS Biology

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

Engineering a multimodal nerve conduit for repair of injured peripheral nerve

AF Quigley, KJ Bulluss, ILB Kyratzis, K Gilmore, T Mysore, KSU Schirmer, EL Kennedy, M O'Shea, YB Truong, SL Edwards, G Peeters, P Herwig, JM Razal, TE Campbell, KN Lowes, MJ Higgins, SE Moulton, MA Murphy, MJ Cook, GM Clark, et al.

Journal article  |  2013  |  Journal of Neural Engineering

beta TrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

Elinor Dehan, Florian Bassermann, Daniele Guardavaccaro, Gaia Vasiliver-Shamis, Michael Cohen, Kym N Lowes, Michael Dustin, David CS Huang, Jack Taunton, Michele Pagano

Journal article  |  2009  |  Mol. Cell

Therapeutic DNA delivery to skeletal muscle

Anita Quigley, Kyrn Lowes, Andrew J Kornberg, Mark J Cook, Robert Kapsa

Journal article  |  2006  |  Current Genomics

Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines.

Lily S Subrata, Kim N Lowes, John K Olynyk, George CT Yeoh, Elizabeth A Quail, Lawrence J Abraham

Journal article  |  2005  |  Liver International

BACKGROUND: Lymphotoxin-beta (LT-beta) plays an important role in inflammation and its promoter contains a functional nuclear fact..

Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C.

KN Lowes, EJ Croager, LJ Abraham, JK Olynyk, GCT Yeoh

Journal article  |  2003  |  Gut

BACKGROUND: Bipotent liver progenitor (oval) cells with the ability to differentiate into hepatocytes and biliary epithelium have ..

Oval cell-mediated liver regeneration: Role of cytokines and growth factors

KN Lowes, EJ Croager, JK Olynyk, LJ Abraham, GCT Yeoh

Journal article  |  2003  |  Journal of Gastroenterology and Hepatology

Oval cell numbers in human chronic liver diseases are directly related to disease severity.

KN Lowes, BA Brennan, GC Yeoh, JK Olynyk

Journal article  |  1999  |  The American Journal of Pathology

The risk of developing hepatocellular carcinoma is significantly increased in patients with genetic hemochromatosis, alcoholic liv..