Kym Lowes

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

Trent D Ashton, Madeline G Dans, Paola Favuzza, Anna Ngo, Adele M Lehane, Xinxin Zhang, Deyun Qiu, Bikash Chandra Maity, Nirupam De, Kyra A Schindler, Tomas Yeo, Heekuk Park, Anne-Catrin Uhlemann, Alisje Churchyard, Jake Baum, David A Fidock, Kate E Jarman, Kym N Lowes, Delphine Baud, Stephen Brand, et al.

Journal article  |  2023  |  JOURNAL OF MEDICINAL CHEMISTRY

There is an urgent need to populate the antimalarial clinical portfolio with new candidates because of resistance against frontlin..

Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.

Petar PS Calic, Natalie B Vinh, Chaille T Webb, Tess R Malcolm, Anna Ngo, Kym Lowes, Nyssa Drinkwater, Sheena McGowan, Peter J Scammells

Journal article  |  2023  |  Eur J Med Chem

Malaria remains a global health threat and growing resistance to artemisinin-based therapies calls for therapeutic agents with nov..

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

Julie Healer, Jennifer KK Thompson, Karen LL Mackwell, Cecille DD Browne, Benjamin AA Seager, Anna Ngo, Kym NN Lowes, Sarah EE Silk, David Pulido, Lloyd DW King, Jayne MM Christen, Amy RR Noe, Vinayaka Kotraiah, Paul JJ Masendycz, Rajkannan Rajagopalan, Leanne Lucas, Marianne MM Stanford, Lorraine Soisson, Carter Diggs, Robin Miller, et al.

Journal article  |  2022  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

BACKGROUND: RH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth..

The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria

Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Zhiyu Lei, Dongmei Zhan, Nicholas Murgolo, Christopher W Boyce, Marissa Vavrek, Jennifer Thompson, Anna Ngo, Kate E Jarman, Johnathan Robbins, Justin Boddey, Brad E Sleebs, Kym N Lowes, Alan F Cowman, David B Olsen, John A McCauley

Journal article  |  2022  |  ACS MEDICINAL CHEMISTRY LETTERS

Drug resistance to first-line antimalarials-including artemisinin-is increasing, resulting in a critical need for the discovery of..

Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

Anthony N Hodder, Janni Christensen, Stephen Scally, Tony Triglia, Anna Ngo, Richard W Birkinshaw, Brodie Bailey, Paola Favuzza, Melanie H Dietrich, Wai-Hong Tham, Peter E Czabotar, Kym Lowes, Zhuyan Guo, Nicholas Murgolo, Manuel de Lera Ruiz, John A McCauley, Brad E Sleebs, David Olsen, Alan F Cowman

Journal article  |  2022  |  STRUCTURE

Plasmepsins IX (PMIX) and X (PMX) are essential aspartyl proteases for Plasmodium spp. egress, invasion, and development. WM4 and ..

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

Dale J Calleja, Nathan Kuchel, Bernadine GC Lu, Richard W Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P Cooney, Liana Mackiewicz, Amanda E Au, Yu Q Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E Jarman, Melissa J Call, Bernhard C Lechtenberg, Peter E Czabotar, Marc Pellegrini, Susan A Charman, et al.

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalizati..

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Annette Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus JA Kersten, Andre L Samson, Mark F van Delft, David CS Huang, Helene Jousset Sabroux, Guillaume Lessene, John Silke, James M Murphy

Journal article  |  2022  |  CELL DEATH & DISEASE

Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed line..

Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity

Trent D Ashton, Anna Ngo, Paola Favuzza, Hayley E Bullen, Maria R Gancheva, Ornella Romeo, Molly Parkyn Schneider, Nghi Nguyen, Ryan WJ Steel, Sandra Duffy, Kym N Lowes, Helene Jousset Sabroux, Vicky M Avery, Justin A Boddey, Danny W Wilson, Alan F Cowman, Paul R Gilson, Brad E Sleebs

Journal article  |  2021  |  BIOORGANIC CHEMISTRY

Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has..

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Brodie L Bailey, William Nguyen, Anna Ngo, Christopher D Goodman, Maria R Gancheva, Paola Favuzza, Laura M Sanz, Francisco-Javier Gamo, Kym N Lowes, Geoffrey I McFadden, Danny W Wilson, Benoit Laleu, Stephen Brand, Paul F Jackson, Alan F Cowman, Brad E Sleebs

Journal article  |  2021  |  BIOORGANIC CHEMISTRY

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported..

Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion

William Nguyen, Madeline G Dans, Anna Ngo, Maria R Gancheva, Ornella Romeo, Sandra Duffy, Tania F de Koning-Ward, Kym N Lowes, Helene Jousset Sabroux, Vicky M Avery, Danny W Wilson, Paul R Gilson, Brad E Sleebs

Journal article  |  2021  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The emerging resistance to combination therapies comprised of artemisinin derivatives has driven a need to identify new antimalari..