James McCaw

Development of an influenza pandemic decision support tool linking situational analytics to national response policy.

Freya M Shearer, Robert Moss, David J Price, Alexander E Zarebski, Peter G Ballard, Jodie McVernon, Joshua V Ross, James M McCaw

Journal article  |  2021  |  Epidemics: the journal of infectious disease dynamics

National influenza pandemic plans have evolved substantially over recent decades, as has the scientific research that underpins th..

Promoting Resilience While Mitigating Disease Transmission: An Australian COVID-19 Study

Freya M Shearer, Niamh Meagher, Katitza Marinkovic Chavez, Lauren Carpenter, Alana Pirrone, Phoebe Quinn, Eva Alisic, James M McCaw, Colin MacDougall, David J Price, Lisa Gibbs

Book Chapter  |  2021

Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..

Modelling the Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics

Ke Li, Pengxing Cao, James M McCaw

Journal article  |  2021  |  VIRUSES-BASEL

MUC1 belongs to the family of cell surface (cs-) mucins. Experimental evidence indicates that its presence reduces in vivo influen..

Constructing an ethical framework for priority allocation of pandemic vaccines

J Fielding, SG Sullivan, F Beard, K Macartney, J Williams, A Dawson, GL Gilbert, P Massey, K Crooks, R Moss, JM McCaw, J McVernon

Journal article  |  2021  |  VACCINE

BACKGROUND: Allocation of scarce resources during a pandemic extends to the allocation of vaccines when they eventually become ava..

Modelling within-host macrophage dynamics in influenza virus infection

Ke Li, James M McCaw, Pengxing Cao

Journal article  |  2021  |  JOURNAL OF THEORETICAL BIOLOGY

Human respiratory disease associated with influenza virus infection is of significant public health concern. Macrophages, as part ..

Antibody Dynamics for Plasmodium vivax Malaria: A Mathematical Model.

Somya Mehra, James M McCaw, Mark B Flegg, Peter G Taylor, Jennifer A Flegg

Journal article  |  2021  |  Bulletin of Mathematical Biology

Malaria is a mosquito-borne disease that, despite intensive control and mitigation initiatives, continues to pose an enormous publ..

Coronavirus Disease Model to Inform Transmission -Reducing Measures and Health System Preparedness, Australia

Robert Moss, James Wood, Damien Brown, Freya M Shearer, Andrew J Black, Kathryn Glass, Allen C Cheng, James M McCaw, Jodie McVernon

Journal article  |  2020  |  EMERGING INFECTIOUS DISEASES

The ability of health systems to cope with coronavirus disease (COVID-19) cases is of major concern. In preparation, we used clini..

Estimation of the force of infection and infectious period of skin sores in remote Australian communities using interval-censored data

Michael J Lydeamore, Patricia T Campbell, David J Price, Yue Wu, Adrian J Marcato, Will Cuningham, Jonathan R Carapetis, Ross M Andrews, Malcolm McDonald, Jodie McVernon, Steven YC Tong, James M McCaw

Journal article  |  2020  |  PLoS Computational Biology

Prevalence of impetigo (skin sores) remains high in remote Australian Aboriginal communities, Fiji, and other areas of socio-econo..

Influencing public health policy with data-informed mathematical models of infectious diseases: Recent developments and new challenges

Amani Alahmadi, Sarah Belet, Andrew Black, Deborah Cromer, Jennifer A Flegg, Thomas House, Pavithra Jayasundara, Jonathan M Keith, James M McCaw, Robert Moss, Joshua Ross, Freya M Shearer, Thein Than Tun Sai, James Walker, Lisa White, Jason M Whyte, Ada WC Yan, Alexander E Zarebski

Journal article  |  2020  |  EPIDEMICS

Modern data and computational resources, coupled with algorithmic and theoretical advances to exploit these, allow disease dynamic..