More than 800 million women and children worldwide are anaemic, with the majority of this burden falling in low income countries. However, anaemia also affects 4.5 per cent of Australians.
Very little progress has been made in alleviating the global burden of anaemia over recent decades.
Our lab aims to address this problem through a combination of approaches, including:
- innovative field trials to develop evidence which can be used for public health policies
- translational studies which apply cutting edge methods to samples from these studies to make new insights
- experimental laboratory projects to uncover fundamental processes in iron metabolism.
Find out more about Sant-Rayn Pasricha's experience
Sant-Rayn Pasricha's highlights
Sant-Rayn Pasricha's selected work
Defining The Impact Of Universal Iron Interventions In Young Children: A Randomized Contro..
Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus..
Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnanc..
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibitio..
Displaying the most recent project by Sant-Rayn Pasricha.
Displaying the 71 most recent scholarly works by Sant-Rayn Pasricha.
Balancing Safety and Potential for Impact in Universal Iron Interventions.
Andrew J Baldi, Leila M Larson, Sant-Rayn Pasricha
Journal article | 2020 | Nestle Nutrition Institute Workshop Series
Almost 300 million children under 5 years of age are anemic worldwide. International policymakers recommend universal distribution..
Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.
Anne M Williams, Chandresh N Ladva, Juan S Leon, Ben A Lopman, Vin Tangpricha, Ralph D Whitehead, Andrew E Armitage, Katherine Wray, Alireza Morovat, Sant-Rayn Pasricha, David Thurnham, Sherry A Tanumihardjo, Setti Shahab-Ferdows, Lindsay Allen, Rafael C Flores-Ayala, Parminder S Suchdev
Journal article | 2019 | The American Journal of Clinical Nutrition
BACKGROUND: To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-p..
Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia
Amat Bah, Abdul Khalie Muhammad, Rita Wegmuller, Hans Verhoef, Morgan M Goheen, Saikou Sanyang, Ebrima Danso, Ebrima A Sise, Sant-Rayn Pasricha, Andrew E Armitage, Hal Drakesmith, James H Cross, Sophie E Moore, Carla Cerami, Andrew M Prentice
Journal article | 2019 | The Lancet Global Health
BACKGROUND: WHO recommends daily iron supplementation for pregnant women, but adherence is poor because of side-effects, effective..
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Sarah Gooding, Sam WZ Olechnowicz, Emma Morris, Andrew E Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J Mead, Karthik Ramasamy, Hal Drakesmith, Claire M Edwards
Journal article | 2019 | Nature Communications
Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain...
Use and interpretation of hemoglobin concentrations for assessing anemia status in individuals and populations: results from a WHO technical meeting
Maria Nieves Garcia-Casal, Sant-Rayn Pasricha, Andrea J Sharma, Juan Pablo Pena-Rosas
Book | 2019 | Annals of the New York Academy of Sciences
Anemia is an important public health problem that negatively affects health of individuals and economic potential of populations. ..
Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants
Andrew E Armitage, Schadrac C Agbla, Modupeh Betts, Ebrima A Sise, Momodou W Jallow, Ellen Sambou, Bakary Darboe, Archibald Worwui, George M Weinstock, Martin Antonio, Sant-Rayn Pasricha, Andrew M Prentice, Hal Drakesmith, Momodou K Darboe, Brenda Anna Kwambana-Adams
Journal article | 2019 | Haematologica
Iron deficiency and iron deficiency anemia are highly prevalent in low-income countries, especially among young children. Hepcidin..
Agreement Between Venous and Capillary Haemoglobin Concentrations in Bangladeshi Children (P10-105-19).
Leila Larson, Mohammed Imrul Hasan, Sabine Braat, Andrew Baldi, Mohammad Saiful Alam, Beverley-Ann Biggs, Jena Hamadani, Sant-Rayn Pasricha
Journal article | 2019 | Current Developments in Nutrition
Objectives: There are concerns that capillary haemoglobin (Hb) concentrations do not agree with venous Hb, which has implications ..
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin
PJ Lim, TL Duarte, J Arezes, D Garcia-Santos, A Hamdi, SR Pasricha, AE Armitage, H Mehta, S Wideman, AG Santos, A Santos-Gonçalves, A Morovat, JR Hughes, E Soilleux, CY Wang, AL Bayer, P Klenerman, CB Willberg, RC Hartley, MP Murphy, et al.
Journal article | 2019 | Nature Metabolism
Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children
Andrew M Prentice, Amat Bah, Momodou W Jallow, Amadou T Jallow, Saikou Sanyang, Ebrima A Sise, Kabiru Ceesay, Ebrima Danso, Andrew E Armitage, Sant-Rayn Pasricha, Hal Drakesmith, Miriam Wathuo, Noah Kessler, Carla Cerami, Rita Wegmuelleri
Journal article | 2019 | Science Advances
Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice
Irene Artuso, Mariateresa Pettinato, Antonella Nai, Alessia Pagani, Ugo Sardo, Benjamin Billore, Maria Rosa Lidonnici, Cavan Bennett, Giacomo Mandelli, Sant-Rayn Pasricha, Giuliana Ferrari, Clara Camaschella, Leon Kautz, Laura Silvestri
Journal article | 2019 | Haematologica
Erythroferrone inhibits the induction of hepcidin by BMP6
Joao Arezes, Niall Foy, Kirsty McHugh, Anagha Sawant, Doris Quinkert, Virginie Terraube, Alette Brinth, May Tam, Edward R LaVallie, Stephen Taylor, Andrew E Armitage, Sant-Rayn Pasricha, Orla Cunningham, Matthew Lambert, Simon J Draper, Reema Jasuja, Hal Drakesmithm
Journal article | 2018 | Blood
Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania
Nathaniel Lee, Julie Makani, Furahini Tluway, Abel Makubi, Andrew E Armitage, Sant-Rayn Pasricha, Hal Drakesmith, Andrew M Prentice, Sharon E Cox
Journal article | 2018 | EBioMedicine
Hepatic iron is the major determinant of serum ferritin in NAFLD patients
John D Ryan, Andrew E Armitage, Jeremy F Cobbold, Rajarshi Banerjee, Oscar Borsani, Paola Dongiovanni, Stefan Neubauer, Reza Morovat, Lai Mun Wang, Sant-Rayn Pasricha, Silvia Fargion, Jane Collier, Eleanor Barnes, Hal Drakesmith, Luca Valenti, Michael Pavlides
Journal article | 2018 | Liver International
Benefits and risks of Iron interventions in children (BRISC): protocol for a three-arm parallel-group randomised controlled field trial in Bangladesh
Mohammed Imrul Hasan, Sheikh Jamal Hossain, Sabine Braat, Michael John Dibley, Jane Fisher, Sally Grantham-McGregor, Fahmida Tofail, Julie A Simpson, Shams Ei Arifeen, Jena Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha
Journal article | 2017 | BMJ Open
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Sant-Rayn Pasricha, Pei Jin Lim, Tiago L Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, Joao Arezes, Kirsty McHugh, Sarah Gooding, Joe N Frost, Katherine Wray, Ana Santos, Graca Porto, Emmanouela Repapi, Nicki Gray, Simon J Draper, Neil Ashley, et al.
Journal article | 2017 | Nature Communications
Urolithiasis is prevalent and associated with reduced bone mineral density in beta-thalassaemia major
Phillip Wong, Frances Milat, Peter J Fuller, Peter G Kerr, James CG Doery, Danielle H Oh, Dana Jackson, Matthew T Gillespie, Donald K Bowden, Sant-Rayn Pasricha, Ken K Lau
Journal article | 2017 | Internal Medicine Journal
Postdonation iron replacement for maintaining iron stores in female whole blood donors in routine donor practice: results of two feasibility studies in Australia
Sant-Rayn Pasricha, Denese C Marks, Hannah Salvin, Tania Brama, Anthony J Keller, Joanne Pink, Joanna Speedy
Journal article | 2017 | Transfusion
Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia
Amat Bah, Sant-Rayn Pasricha, Momodou W Jallow, Ebrima A Sise, Rita Wegmuller, Andrew E Armitage, Hal Drakesmith, Sophie E Moore, Andrew M Prentice
Journal article | 2017 | The Journal of Nutrition
Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study
Katherine Wray, Angela Allen, Emma Evans, Chris Fisher, Anuja Premawardhena, Lakshman Perera, Rexan Rodrigo, Gayan Goonathilaka, Lebbe Ramees, Craig Webster, Andrew E Armitage, Andrew M Prentice, David J Weatherall, Hal Drakesmith, Sant-Rayn Pasricha
Journal article | 2017 | American Journal of Hematology
A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron
Amat Bah, Rita Wegmuller, Carla Cerami, Lindsay Kendall, Sant-Rayn Pasricha, Sophie E Moore, Andrew M Prentice
Journal article | 2016 | BMC Pregnancy and Childbirth
Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material
Lisa N van der Vorm, Jan CM Hendriks, Coby M Laarakkers, Siem Klaver, Andrew E Armitage, Alison Bamberg, Anneke J Geurts-Moespot, Domenico Girelli, Matthias Herkert, Outi Itkonen, Robert J Konrad, Naohisa Tomosugi, Mark Westerman, Sukhvinder S Bansal, Natascia Campostrini, Hal Drakesmith, Marianne Fillet, Gordana Olbina, Sant-Rayn Pasricha, Kelly R Pitts, et al.
Journal article | 2016 | Clinical Chemistry
Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia
Andrew E Armitage, Pei Jin Lim, Joe N Frost, Sant-Rayn Pasricha, Elizabeth J Soilleux, Emma Evans, Alireza Morovat, Ana Santos, Rebeca Diaz, Daniel Biggs, Benjamin Davies, Uzi Gileadi, Peter A Robbins, Samira Lakhal-Littleton, Hal Drakesmith
Journal article | 2016 | Journal of Innate Immunity
Integration to Implementation and the Micronutrient Forum: A Coordinated Approach for Global Nutrition. Case Study Application: Safety and Effectiveness of Iron Interventions
Daniel J Raiten, Lynnette M Neufeld, Luz-Maria De-Regil, Sant-Rayn Pasricha, Ian Darnton-Hill, Richard Hurrell, Laura E Murray-Kolb, K Madhavan Nair, Terry Wefwafwa, Roland Kupka, Modou Cheyassin Phall, Fayrouz A Sakr Ashour
Journal article | 2016 | Advances in Nutrition
Hepcidin is suppressed by erythropoiesis in hemoglobin E beta-thalassemia and beta-thalassemia trait
Emma Jones, Sant-Rayn Pasricha, Angela Allen, Patricia Evans, Chris A Fisher, Katherine Wray, Anuja Premawardhena, Dyananda Bandara, Ashok Perera, Craig Webster, Pamela Sturges, Nancy F Olivieri, Timothy St Pierre, Andrew E Armitage, John B Porter, David J Weatherall, Hal Drakesmith
Journal article | 2015 | Blood
Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections
Andrew E Armitage, Andrea R Stacey, Eleni Giannoulatou, Elizabeth Marshall, Pamela Sturges, Kamaljit Chatha, Nicola MG Smith, XiaoJie Huang, XiaoNing Xu, Sant-Rayn Pasricha, Ning Li, Hao Wu, Craig Webster, Andrew M Prentice, Pierre Pellegrino, Ian Williams, Phillip J Norris, Hal Drakesmith, Persephone Borrow
Journal article | 2014 | Proceedings of the National Academy of Sciences
Expression of the Iron Hormone Hepcidin Distinguishes Different Types of Anemia in African Children
Sant-Rayn Pasricha, Sarah H Atkinson, Andrew E Armitage, Shivani Khandwala, Jacobien Veenemans, Sharon E Cox, Lucy A Eddowes, Theodore Hayes, Conor P Doherty, Ayse Y Demir, Edwin Tijhaar, Hans Verhoef, Andrew M Prentice, Hal Drakesmith
Journal article | 2014 | Science Translational Medicine
Is Serial Testing Required to Diagnose Imported Malaria in the Era of Rapid Diagnostic Tests?
Janet M Pasricha, Surender Juneja, Joseph Manitta, Susan Whitehead, Ellen Maxwell, Wai-Keong Goh, Sant-Rayn Pasricha, Damon P Eisen
Journal article | 2013 | American Journal of Tropical Medicine and Hygiene
Vitamin B-12, folate, iron, and vitamin A concentrations in rural Indian children are associated with continued breastfeeding, complementary diet, and maternal nutrition
Sant-Rayn Pasricha, Arun S Shet, James F Black, H Sudarshan, NS Prashanth, Beverley-Ann Biggs
Journal article | 2011 | American Journal of Clinical Nutrition
Diagnosis and management of iron deficiency anaemia: a clinical update
Sant-Rayn S Pasricha, Stephen C Flecknoe-Brown, Katrina J Allen, Peter R Gibson, Lawrence P McMahon, John K Olynyk, Simon D Roger, Helen F Savoia, Ramdas Tampi, Amanda R Thomson, Erica M Wood, Kathryn L Robinson
Journal article | 2010 | Medical Journal of Australia
Baseline Iron Indices as Predictors of Hemoglobin Improvement in Anemic Vietnamese Women Receiving Weekly Iron-Folic Acid Supplementation and Deworming
Sant-Rayn Pasricha, Gerard J Casey, Q Phuc Tran, Seema Mihrshahi, Lachlan MacGregor, Antonio Montresor, Tien Nong, Beverley-Ann Biggs
Journal article | 2009 | American Journal of Tropical Medicine and Hygiene
A Multicenter Phase 2 Study of Risk-adjusted Salvage Chemotherapy Incorporating Vinorelbine and Gemcitabine for Relapsed and Refractory Lymphoma
Sant-Rayn Pasricha, Andrew Grigg, John Catalano, Michael Leahy, Craig Underhill, Chris Arthur, James D'Rozario, Ray Lowenthal, Kate Reed, Andrew Spencer
Journal article | 2008 | Cancer
Anemia, iron deficiency, meat consumption, and hookworm infection in women of reproductive age in northwest Vietnam
Sant-Rayn Pasricha, Sonia R Caruana, Tran Q Phuc, Gerard J Casey, Damien Jolley, Sally Kingsland, Nong T Tien, Lachlan MacGregor, Antonio Montresor, Beverley-Ann Biggs
Journal article | 2008 | American Journal of Tropical Medicine and Hygiene
Displaying the most recent news article by Sant-Rayn Pasricha.
Honours, Awards and Fellowships
Victoria Fellowship, awarded to emerging leaders in science and technology
FRACP - Fellow of the Royal Australasian College of Physicians
FRCPA - Fellow of the Royal College of Pathologists of Australasia
Medical Biology (W.E.H.I.)
Haematology Society of Australia and New Zealand
Doctor of Philosophy
University of Melbourne
Masters of Public Health
University of Melbourne
Bachelor of Medicine/ Bachelor of Surgery
University of Melbourne