Sarah-Jane Dawson

Custom workflows to improve joint variant calling from multiple related tumour samples: FreeBayesSomatic and Strelka2Pass.

S Hollizeck, SQ Wong, B Solomon, D Chandranada, S-J Dawson

Journal article  |  2021  |  Bioinformatics

SUMMARY: This work describes two novel workflows for variant calling that extend the widely used algorithms of Strelka2 and FreeBa..

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies..

Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER breast cancer with KAT6A dysregulation

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M Avery, Miriam S Butler, Michelle A Camerino, et al.

Conference Proceedings  |  2021  |  Experimental and Molecular Therapeutics

First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER plus breast cancer with KAT6A dysregulation.

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M Avery, Miriam S Butler, Michelle A Camerino, et al.

Conference Proceedings  |  2021  |  CANCER RESEARCH

Abstract 539: Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  Clinical Research (Excluding Clinical Trials)

Utility of circulating tumor DNA in esophageal cancer: A potential prognostic biomarker in tumor staging, monitoring of treatment response and detection of recurrent disease.

Carlos Suhady Cabalag, Michael Yates, Mariana B Corrales, Paul Yeh, Stephen Q Wong, Bonnie Zhang, Kenji M Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Conference Proceedings  |  2021  |  CANCER RESEARCH

Detection of cell-free microbial DNA using a contaminant-controlled analysis framework

Enrique Zozaya-Valdes, Stephen Q Wong, Jeanette Raleigh, Athena Hatzimihalis, Sarah Ftouni, Anthony T Papenfuss, Shahneen Sandhu, Mark A Dawson, Sarah-Jane Dawson

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The human microbiome plays an important role in cancer. Accumulating evidence indicates that commensal microbiome-deri..

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nila J Dharan, Paul Yeh, Mark Bloch, Miriam M Yeung, David Baker, Jerick Guinto, Norman Roth, Sarah Ftouni, Katherine Ognenovska, Don Smith, Jennifer F Hoy, Ian Woolley, Catherine Pell, David J Templeton, Neil Fraser, Nectarios Rose, Jolie Hutchinson, Kathy Petoumenos, Sarah-Jane Dawson, Mark N Polizzotto, et al.

Journal article  |  2021  |  NATURE MEDICINE

People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and..

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Ismael A Vergara, Christopher P Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J Young, Stephen Q Wong, Andrew Colebatch, Daniel L Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origi..

Alternating Osimertinib and Gefitinib as Second-Line Treatment for EGFR-Mutated NSCLC Harbouring a T790M Resistance Mutation (OSCILLATE)

B Solomon, A Mersiades, C Brown, S Dawson, S Wong, L Tan, S Yip, Y Cheung, H Jurkovic, M Walker, S Kao, CK Lee, G Newnham, K O'Byrne, S Parakh, K Jasas, V Bray, M Stockler, T John, N Pavlakis

Conference Proceedings  |  2021  |  JOURNAL OF THORACIC ONCOLOGY