Sarah-Jane Dawson

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan, Inmaculada Rioja, Kathy Knezevic, Matthew J Bell, Miriam M Yeung, Nicola R Harker, Enid YN Lam, Chun-wa Chung, Paul Bamborough, Massimo Petretich, Marjeta Urh, Stephen J Atkinson, Anna K Bassil, Emma J Roberts, Dane Vassiliadis, Marian L Burr, Alex GS Preston, Christopher Wellaway, Thilo Werner, James R Gray, et al.

Journal article  |  2020  |  Science

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins enable chromatin binding to facilitate tran..

Longitudinal monitoring of ctDNA in patients with melanoma and brain metastases treated with immune checkpoint inhibitors.

Jenny H Lee, Alexander M Menzies, Matteo S Carlino, Ashleigh C McEvoy, Shahneen Sandhu, Alison M Weppler, Russell J Diefenbach, Sarah-Jane Dawson, Richard F Kefford, Michael J Millward, Zeyad Al-Ogaili, Thien Tra, Elin S Gray, Stephen Q Wong, Richard A Scolyer, Georgina V Long, Helen Rizos

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Brain involvement occurs in majority of patients with metastatic melanoma. The potential of circulating tumor DNA (ctDNA)..

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Kevin Ebata, Brian B Tuch, Satoshi Yoda, Justin F Gainor, Lecia V Sequist, Geoffrey R Oxnard, Oliver Gautschi, Alexander Drilon, Vivek Subbiah, Christine Khoo, Edward Y Zhu, Michele Nguyen, Dahlia Henry, Kevin R Condroski, Gabrielle R Kolakowski, et al.

Journal article  |  2020  |  Journal of Thoracic Oncology

INTRODUCTION: Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) h..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  Nature

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

Prospective testing of circulating tumour DNA in metastatic breast cancer facilitates clinical trial enrollment and precision oncology

AZ Bujak, C-F Weng, M-J Silva, M Yeung, L Lo, S Ftouni, C Litchfield, A Ko, K Kuykhoven, C van Geelen, S Chandrashekar, MA Dawson, S Loi, SQ Wong, S-J Dawson

Conference Proceedings  |  2019  |  ANNALS OF ONCOLOGY

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Charles C Bell, Katie A Fenne, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson, et al.

Journal article  |  2019  |  Nature Communications

Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

L Tan, S Sandhu, RJ Lee, J Li, J Callahan, S Ftouni, N Dhomen, P Middlehurst, A Wallace, J Raleigh, A Hatzimihalis, MA Henderson, M Shackleton, A Haydon, V Mar, DE Gyorki, D Oudit, MA Dawson, RJ Hicks, P Lorigan, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: The advent of effective adjuvant therapies for patients with resected melanoma has highlighted the need to stratify pa..

Characterizing the Cancer Genome in Blood

Sarah-Jane Dawson

Journal article  |  2019  |  Cold Spring Harbor Perspectives in Medicine

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

Massimo Cristofanilli, Jean-Yves Pierga, James Reuben, Alfred Rademaker, Andrew A Davis, Dieter J Peeters, Tanja Fehm, Franco Nole, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Mario Giuliano, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Angela Fernandez de lascoiti, Leticia de Mattos-Arruda, et al.

Journal article  |  2019  |  Critical Reviews in Oncology/Hematology

Circulating tumor DNA for disease monitoring in the era of CAR T-cell therapy

Piers Blombery, Sarah-Jane Dawson

Journal article  |  2019  |  Leukemia & Lymphoma

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Clinical Implications and Biomarkers of Clonal Evolution

Sarah-Jane Dawson

Conference Proceedings  |  2018  |  Blood

Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients

Bente Risberg, Dana WY Tsui, Heather Biggs, Andrea Ruiz-Valdepenas Martin de Almagro, Sarah-Jane Dawson, Charlotte Hodgkin, Linda Jones, Christine Parkinson, Anna Piskorz, Francesco Marass, Dineika Chandrananda, Elizabeth Moore, James Morris, Vincent Plagnol, Nitzan Rosenfeld, Carlos Caldas, James D Brenton, Davina Gale

Journal article  |  2018  |  The Journal of Molecular Diagnostics

Phase II trial of alternating osimertinib with gefitinib in patients with EGFR-T790M mutation positive advanced non-small cell lung cancer (Oscillate)

Antony Mersiades, Nick Pavlakis, Steven Kao, Tom John, Chee Khoon Lee, Sarah-Jane Dawson, Stephen Wong, Lavinia Tan, Sonia Yip, Chris Brown, Ann Livingstone, Yvonne Cheung, Hannora Jurkovic, Martin Stockler

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Circulating tumour DNA analysis predicts relapse following resection in stage II and III melanoma

L Tan, SK Sandhu, R Lee, J Li, J Callahan, J Raleigh, A Hatzimihalis, P Middlehurst, M Henderson, M Shackleton, A Haydon, D Gyorki, D Oudit, RJ Hicks, P Lorigan, GA McArthur, R Marais, SQ Wong, S-J Dawson

Conference Proceedings  |  2018  |  Annals of Oncology

The impact of circulating tumor cells (CTCs) detection in metastatic breast cancer (MBC): Implications of "indolent" stage IV disease (Stage IVindolent)

Andrew A Davis, Jean-Yves Pierga, Luc Yves Dirix, Stefan Michiels, Alfred Rademaker, James M Reuben, Tanja N Fehm, Elisabetta Munzone, Mario Giuliano, Jose Vidal-Martinez, Dimitrios Mavroudis, Salvatore Grisanti, Daniele Giulio Generali, Jose Angel Garcia-Saenz, Justin Stebbing, Sarah-Jane Dawson, Paola Gazzaniga, Francois-Clement Bidard, Massimo Cristofanilli

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Plasma and tumor genomic correlates of response to BYL719 in PI3KCA mutated metastatic ER-positive breast cancer (ER /HER2-BC).

Sarah-Jane Dawson, Lironne Wein, Maria Joao Silva, Stephen James Luen, Courtney VanGeelen, Kate Moodie, Peter Savas, Chen-Fang Weng, Andjelija Zivanovic Bujak, Miriam M Yeung, Sarah Ftouni, Keilly Kuykhoven, Rodney J Hicks, Prudence A Francis, Chee Khoon Lee, Sherene Loi

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

The value of cell-free DNA for molecular pathology

Caitlin M Stewart, Prachi D Kothari, Florent Mouliere, Richard Mair, Saira Somnay, Ryma Benayed, Ahmet Zehir, Britta Weigelt, Sarah-Jane Dawson, Maria E Arcila, Michael F Berger, Dana WY Tsui

Journal article  |  2018  |  The Journal of Pathology

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts

Journal article  |  2018  |  New England Journal of Medicine

Circulating Tumor DNA Guides Prognosis in Metastatic Triple-Negative Breast Cancer

Andjelija Zivanovic Bujak, Sarah-Jane Dawson

Journal article  |  2018  |  Journal of Clinical Oncology

OSCILLATE - Phase 2 Trial of Alternating Osimertinib with Gefitinib in Patients with EGFR-T790M Mutation Positive Advanced NSCLC

B Solomon, P Kok, A Livingstone, S Yip, C Brown, S Dawson, S Wong, N Pavlakis, M Stockler

Conference Proceedings  |  2017  |  JOURNAL OF THORACIC ONCOLOGY

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

Click chemistry enables preclinical evaluation of targeted epigenetic therapies

Dean S Tyler, Johanna Vappiani, Tatiana Caneque, Enid YN Lam, Aoife Ward, Omer Gilan, Yih-Chih Chan, Antje Hienzsch, Anna Rutkowska, Thilo Werner, Anne J Wagner, Dave Lugo, Richard Gregory, Cesar Ramirez Molina, Neil Garton, Christopher R Wellaway, Susan Jackson, Laura MacPherson, Margarida Figueiredo, Sabine Stolzenburg, et al.

Journal article  |  2017  |  Science

Wet or Dry? Do Liquid Biopsy Techniques Compete with or Complement PET for Disease Monitoring in Oncology?

Stephen Q Wong, Richard W Tothill, Sarah-Jane Dawson, Rodney J Hicks

Journal article  |  2017  |  Journal of Nuclear Medicine

Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.

Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Combination ibrutinib (Ibr) and venetoclax (Ven) for the treatment of mantle cell lymphoma (MCL): Primary endpoint assessment of the phase 2 AIM study.

Constantine Si Lun Tam, Andrew Warwick Roberts, Mary Ann Anderson, Sarah-Jane Dawson, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David A Westerman, Rishu Agarwal, Christiane Pott, Martin H Dreyling, Mark A Dawson, John Francis Seymour

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Reversion of BRCA1/2 Germline Mutations Detected in Circulating Tumor DNA From Patients With High-Grade Serous Ovarian Cancer

Elizabeth L Christie, Sian Fereday, Ken Doig, Swetansu Pattnaik, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2017  |  Journal of Clinical Oncology

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

Paul Yeh, Michael Dickinson, Sarah Ftouni, Tane Hunter, Devbarna Sinha, Stephen Q Wong, Rishu Agarwal, Ravikiran Vedururu, Kenneth Doig, Chun Yew Fong, Piers Blombery, David Westerman, Mark A Dawson, Sarah-Jane Dawson

Journal article  |  2017  |  Blood

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, et al.

Journal article  |  2017  |  Nature Communications

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE"

Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi

Journal article  |  2016  |  PLOS Medicine

Blood Worth Bottling: Circulating Tumor DNA as a Cancer Biomarker

Elizabeth L Christie, Sarah-Jane Dawson, David DL Bowtell

Journal article  |  2016  |  Cancer Research

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Omer Gilan, Enid YN Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro, Gerard Joberty, Aoife Ward, Meike Wiese, Chun Yew Fong, Sarah Ftouni, Dean Tyler, Kym Stanley, Laura MacPherson, Chen-Fang Weng, Yih-Chih Chan, Margherita Ghisi, David Smil, Christopher Carpenter, Peter Brown, Neil Garton, et al.

Journal article  |  2016  |  Nature Structural & Molecular Biology

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

Bernard Pereira, Suet-Feung Chin, Oscar M Rueda, Hans-Kristian Moen Vollan, Elena Provenzano, Helen A Bardwell, Michelle Pugh, Linda Jones, Roslin Russell, Stephen-John Sammut, Dana WY Tsui, Bin Liu, Sarah-Jane Dawson, Jean Abraham, Helen Northen, John F Peden, Abhik Mukherjee, Gulisa Turashvili, Andrew R Green, Steve McKinney, et al.

Journal article  |  2016  |  Nature Communications

Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays

Fiona M Blows, Hamid R Ali, Sarah-J Dawson, John Le Quesne, Elena Provenzano, Carlos Caldas, Paul DP Pharoah

Journal article  |  2016  |  Applied Immunohistochemistry & Molecular Morphology

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

Muhammed Murtaza, Sarah-Jane Dawson, Katherine Pogrebniak, Oscar M Rueda, Elena Provenzano, John Grant, Suet-Feung Chin, Dana WY Tsui, Francesco Marass, Davina Gale, H Raza Ali, Pankti Shah, Tania Contente-Cuomo, Hossein Farahani, Karey Shumansky, Zoya Kingsbury, Sean Humphray, David Bentley, Sohrab P Shah, Matthew Wallis, et al.

Journal article  |  2015  |  Nature Communications

BET inhibitor resistance emerges from leukaemia stem cells

Chun Yew Fong, Omer Gilan, Enid YN Lam, Alan F Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G Ramsay, Steven W Lane, Omar Abdel-Wahab, Tony Kouzarides, et al.

Journal article  |  2015  |  Nature

PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes

HR Ali, S-E Glont, FM Blows, E Provenzano, S-J Dawson, B Liu, L Hiller, J Dunn, CJ Poole, S Bowden, HM Earl, PDP Pharoah, C Caldas

Journal article  |  2015  |  Annals of Oncology

Large B-cell lymphoma: is the future written in the blood?

Sarah-Jane Dawson, John F Seymour

Journal article  |  2015  |  The Lancet Oncology

Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium

William J Howat, Fiona M Blows, Elena Provenzano, Mark N Brook, Lorna Morris, Patrycja Gazinska, Nicola Johnson, Leigh-Anne McDuffus, Jodi Miller, Elinor J Sawyer, Sarah Pinder, Carolien HM van Deurzen, Louise Jones, Reijo Sironen, Daniel Visscher, Carlos Caldas, Frances Daley, Penny Coulson, Annegien Broeks, Joyce Sanders, et al.

Journal article  |  2015  |  The Journal of Pathology: Clinical Research

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

M Ignatiadis, S-J Dawson

Journal article  |  2014  |  Annals of Oncology

Association between CD8 T-cell infiltration and breast cancer survival in 12 439 patients

HR Ali, E Provenzano, S-J Dawson, FM Blows, B Liu, M Shah, HM Earl, CJ Poole, L Hiller, JA Dunn, SJ Bowden, C Twelves, JMS Bartlett, SMA Mahmoud, E Rakha, IO Ellis, S Liu, D Gao, TO Nielsen, PDP Pharoah, et al.

Journal article  |  2014  |  Annals of Oncology

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

Francois-Clement Bidard, Dieter J Peeters, Tanja Fehm, Franco Nole, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Daniele Generali, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Angela Fernandez de Lascoiti, Leticia De Mattos-Arruda, Michail Ignatiadis, Ronald Lebofsky, Steven J van Laere, Franziska Meier-Stiegen, et al.

Journal article  |  2014  |  The Lancet Oncology

Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression

Hisani N Horne, Mark E Sherman, Montserrat Garcia-Closas, Paul D Pharoah, Fiona M Blows, Xiaohong R Yang, Stephen M Hewitt, Catherine M Conway, Jolanta Lissowska, Louise A Brinton, Ludmila Prokunina-Olsson, Sarah-Jane Dawson, Carlos Caldas, Douglas F Easton, Stephen J Chanock, Jonine D Figueroa

Journal article  |  2014  |  Breast Cancer Research and Treatment

Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Massimo Cristofanilli, Paolo Fortina

Journal article  |  2013  |  New England Journal of Medicine

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Muhammed Murtaza, Sarah-Jane Dawson, Dana WY Tsui, Davina Gale, Tim Forshew, Anna M Piskorz, Christine Parkinson, Suet-Feung Chin, Zoya Kingsbury, Alvin SC Wong, Francesco Marass, Sean Humphray, James Hadfield, David Bentley, Tan Min Chin, James D Brenton, Carlos Caldas, Nitzan Rosenfeld

Journal article  |  2013  |  Nature

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Sarah-Jane Dawson, Dana WY Tsui, Muhammed Murtaza, Heather Biggs, Oscar M Rueda, Suet-Feung Chin, Mark J Dunning, Davina Gale, Tim Forshew, Betania Mahler-Araujo, Sabrina Rajan, Sean Humphray, Jennifer Becq, David Halsall, Matthew Wallis, David Bentley, Carlos Caldas, Nitzan Rosenfeld

Journal article  |  2013  |  New England Journal of Medicine

A new genome-driven integrated classification of breast cancer and its implications

Sarah-Jane Dawson, Oscar M Rueda, Samuel Aparicio, Carlos Caldas

Journal article  |  2013  |  The EMBO Journal

Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

HR Ali, M Irwin, L Morris, S-J Dawson, FM Blows, E Provenzano, B Mahler-Araujo, PD Pharoah, NA Walton, JD Brenton, C Caldas

Journal article  |  2013  |  British Journal of Cancer

Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue

John Le Quesne, Julia Jones, Joanna Warren, Sarah-Jane Dawson, H Raza Ali, Helen Bardwell, Fiona Blows, Paul Pharoah, Carlos Caldas

Journal article  |  2012  |  The Journal of Pathology

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

Tim Forshew, Muhammed Murtaza, Christine Parkinson, Davina Gale, Dana WY Tsui, Fiona Kaper, Sarah-Jane Dawson, Anna M Piskorz, Mercedes Jimenez-Linan, David Bentley, James Hadfield, Andrew P May, Carlos Caldas, James D Brenton, Nitzan Rosenfeld

Journal article  |  2012  |  Science Translational Medicine

Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer

HR Ali, S-J Dawson, FM Blows, E Provenzano, PD Pharoah, C Caldas

Journal article  |  2012  |  British Journal of Cancer

A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer

H Raza Ali, Sarah-Jane Dawson, Fiona M Blows, Elena Provenzano, Samuel Leung, Torsten Nielsen, Paul D Pharoah, Carlos Caldas

Journal article  |  2012  |  JOURNAL OF PATHOLOGY

Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Kristen N Stevens, Celine M Vachon, Adam M Lee, Susan Slager, Timothy Lesnick, Curtis Olswold, Peter A Fasching, Penelope Miron, Diana Eccles, Jane E Carpenter, Andrew K Godwin, Christine Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K Schmidt, Angela Cox, Simon S Cross, Elinor Sawyer, Arndt Hartmann, Matthias W Beckmann, et al.

Journal article  |  2011  |  Cancer Research

Comparison of methods for handling missing data on immunohistochemical markers in survival analysis of breast cancer

AMG Ali, S-J Dawson, FM Blows, E Provenzano, IO Ellis, L Baglietto, D Huntsman, C Caldas, PD Pharoah

Journal article  |  2011  |  British Journal of Cancer

Intraperitoneal distribution imaging in ovarian cancer patients

SJ Dawson, RJ Hicks, V Johnston, D Allen, T Jobling, M Quinn, D Rischin

Journal article  |  2011  |  Internal Medicine Journal

Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance

H Raza Ali, Sarah-Jane Dawson, Fiona M Blows, Elena Provenzano, Paul D Pharoah, Carlos Caldas

Journal article  |  2011  |  BREAST CANCER RESEARCH

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

S-J Dawson, N Makretsov, FM Blows, KE Driver, E Provenzano, J Le Quesne, L Baglietto, G Severi, GG Giles, CA McLean, G Callagy, AR Green, I Ellis, K Gelmon, G Turashvili, S Leung, S Aparicio, D Huntsman, C Caldas, P Pharoah

Journal article  |  2010  |  British Journal of Cancer

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

Fiona M Blows, Kristy E Driver, Marjanka K Schmidt, Annegien Broeks, Flora E van Leeuwen, Jelle Wesseling, Maggie C Cheang, Karen Gelmon, Torsten O Nielsen, Carl Blomqvist, Paivi Heikkila, Tuomas Heikkinen, Heli Nevanlinna, Lars A Akslen, Louis R Begin, William D Foulkes, Fergus J Couch, Xianshu Wang, Vicky Cafourek, Janet E Olson, et al.

Journal article  |  2010  |  PLoS Medicine

Molecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival

SJ Dawson, SW Duffy, FM Blows, KE Driver, E Provenzano, J LeQuesne, DC Greenberg, P Pharoah, C Caldas, GC Wishart

Journal article  |  2009  |  BRITISH JOURNAL OF CANCER

Triple negative breast cancers: clinical and prognostic implications.

SJ Dawson, E Provenzano, C Caldas

Journal article  |  2009  |  European Journal of Cancer

Triple negative breast cancers are defined by the absence of oestrogen, progesterone and HER2 expression. Most triple negative can..

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer

SJ Dawson, M Michael, J Biagi, KF Foo, M Jefford, SY Ngan, T Leong, A Hui, AD Milner, RJS Thomas, JR Zalcberg

Journal article  |  2007  |  Investigational New Drugs

Central nervous system metastases in women with HER-2 positive metastatic breast cancer after treatment with trastuzumab

SJ Dawson, NF Ranieri, RD Snyder, SA McLachlan, WI Burns, GM Newnham, PA Francis, AJ Dowling

Journal article  |  2006  |  Asia-Pacific Journal of Clinical Oncology

Hypocalcemia associated with bone metastases in a patient with salivary-gland carcinoma

SJ Dawson, RML Murray, D Rischin

Journal article  |  2006  |  Nature Clinical Practice Oncology

Cerebral metastases in breast cancer

H Rouse, SJ Dawson

Journal article  |  2005  |  New England Journal of Medicine

Cerebral metastases in breast cancer

H Rouse, SJ Dawson

Journal article  |  2005  |  New England Journal of Medicine