Sarah-Jane Dawson

A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study.

Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C Tebbutt, Michael Michael, Emma Link, Stephen Q Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J Solomon, Grant A McArthur, Rodney J Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai

Journal article  |  2023  |  Clin Cancer Res

PURPOSE: BRAF V600E mutant metastatic colorectal cancer represents a significant clinical problem, with combination approaches bei..

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

Christina E Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Kah Lok Chan, Charles C Bell, Omer Gilan, Yih-Chih Chan, Sarah Popp, Daniel J Gough, Melanie A Eckersley-Maslin, Sarah-Jane Dawson, Paul J Lehner, Kate D Sutherland, Patricia Ernst, Gerard M McGeehan, Enid YN Lam, Marian L Burr, Mark A Dawson

Journal article  |  2023  |  NATURE CELL BIOLOGY

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at bivalent promoters is essential for normal ..

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid YN Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, et al.

Journal article  |  2022  |  CANCER CELL

There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expre..

Clinical validation and implementation of droplet digital PCR for the detection of BRAF mutations from cell-free DNA

Rainer Arnolda, Kerry Howlett, Timmy Chan, Jeanette Raleigh, Athena Hatzimihalis, Anthony Bell, Andrew Fellowes, Shahneen Sandhu, Grant A Mcarthur, Stephen B Fox, Sarah-jane Dawson, Chelsee Hewitt, Kate Jones, Stephen Q Wong

Journal article  |  2022  |  PATHOLOGY

Droplet digital PCR (ddPCR) has been demonstrated in many research studies to be a sensitive method in the analysis of circulating..

Alpelisib Monotherapy for PI3K-Altered Pretreated Advanced Breast Cancer A Phase II Study

Peter Savas, Louisa L Lo, Stephen J Luen, Elizabeth F Blackley, Jason Callahan, Kate Moodie, Courtney T van Geelen, Yi-An Ko, Chen-Fang Weng, Lironne Wein, Maria Joao Silva, Andjelija Zivanovic Bujak, Miriam M Yeung, Sarah Ftouni, Rodney J Hicks, Prudence A Francis, Chee Khoon Lee, Sarah-Jane Dawson, Sherene Loi

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: There is limited knowledge on the benefit of the α-subunit-specific PI3K inhibitor alpelisib in later lines of therapy..

1670P Circulating tumor DNA (ctDNA) dynamics of response and resistance in BRAF V600E mutant (mt) metastatic colorectal (mCRC) and other cancers: Data from EVICT (erlotinib and vemurafenib in combination trial)

L Tan, B Tran, J Tie, E Link, SQ Wong, S Chandrashekar, J Guinto, B Markman, S Ananda, NC Tebbutt, M Michael, BJ Solomon, G McArthur, P Gibbs, S-J Dawson, J Desai

Journal article  |  2022  |  Annals of Oncology

Potential Clinical Utility of a Targeted Circulating Tumor DNA Assay in Esophageal Adenocarcinoma

Carlos S Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q Wong, Bonnie Z Zhang, Kenji M Fujihara, Lynn Chong, Michael W Hii, Sarah-Jane Dawson, Wayne A Phillips, Cuong P Duong, Nicholas J Clemons

Journal article  |  2022  |  ANNALS OF SURGERY

OBJECTIVE: To explore the clinical utility of circulating tumor DNA (ctDNA) in esophageal adenocarcinoma (EAC) by developing a cos..

Clinical implications of prospective genomic profiling of metastatic breast cancer patients (vol 22, 91, 2020)

Courtney T van Geelen, Peter Savas, Zhi Ling Teo, Stephen J Luen, Chen-Fang Weng, Yi-An Ko, Keilly S Kuykhoven, Franco Caramia, Roberto Salgado, Prudence A Francis, Sarah-Jane Dawson, Stephen B Fox, Andrew Fellowes, Sherene Loi

Journal article  |  2022  |  BREAST CANCER RESEARCH

Following publication of the original article [1], the authors identified some errors in Fig. 4. The correct figure is given below..

Abstract 476: Predicting response to treatment in early breast cancer using dynamic integrative multi-omic profiling

Stephen-John Sammut, Mireia Crispin-Ortuzar, Suet-Feung Chin, Elena Provenzano, Wei Cope, Ali Dariush, Sarah-Jane Dawson, Paul D Pharoah, Florian Markowetz, Oscar M Rueda, Helena M Earl, Carlos Caldas

Journal article  |  2022  |  Cancer Research

Abstract Aim: We recently published the first machine learning framework that integrates multi-omic data derived fr..

DETECTION phase II/III trial: Circulating tumor DNA–guided therapy for stage IIB/C melanoma after surgical resection.

Rebecca Lee, Dominic G Rothwell, Richard Jackson, Nigel Smith, Stephen Q Wong, Noel Kelso, George Burghel, Chelsee Hewitt, Harry Clarke, Jackie Mitchell, Kate Jones, Andrew Muinonen-Martin, Samra Turajlic, Philippa Gail Corrie, Richard Marais, Mark R Middleton, Sarah-Jane Dawson, Shahneen Sandhu, Caroline Dive, Paul Lorigan

Conference Proceedings  |  2022  |  Journal of Clinical Oncology

TPS9603 Background: Circulating tumor DNA (ctDNA; the tumor derived fraction of circulating free DNA in the blood) is a well reco..