Andrew Brooks

The Role of the HLA Class I alpha 2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1 Philippa

Philippa M Saunders, Bruce J MacLachlan, Jacqueline Widjaja, Shu Cheng Wong, Clare VL Oates, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2021  |  The Journal of Immunology

HLA class I molecules that represent ligands for the inhibitory killer cell Ig-like receptor (KIR) 3DL1 found on NK cells are cate..

Estradiol Enhances Antiviral CD4( ) Tissue-Resident Memory T Cell Responses following Mucosal Herpes Simplex Virus 2 Vaccination through an IL-17-Mediated Pathway

Puja Bagri, Ramtin Ghasemi, Joshua JC McGrath, Danya Thayaparan, Emma Yu, Andrew G Brooks, Martin R Staempfli, Charu Kaushic

Journal article  |  2021  |  Journal of Virology

Estradiol (E2) is a sex hormone which has been shown to be protective against sexually transmitted infections such as herpes simpl..

Cytomegalovirus replication is associated with enrichment of distinct g 8 T cell subsets following lung transplantation: A novel therapeutic approach?

Sanda Stankovic, Martin S Davey, Evangeline M Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J Levvey, Jamie Rossjohn, Glen P Westall, Gregory I Snell, Andrew G Brooks, Lucy C Sullivan

Journal article  |  2020  |  Journal of Heart and Lung Transplantation

BACKGROUND: Anti-viral treatments to control cytomegalovirus (CMV) after lung transplantation (LTx) are associated with toxicity a..

Harnessing HLA-E-restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID-19

Nadia Caccamo, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli

Journal article  |  2020  |  British Journal of Haematology

SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deat..

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of the United States of America

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

CM Fernandes Monteiro, DC Walton, Y Cristiano, BJ Levvey, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

A Potential Role for NKG2C gamma delta T Cells as a Cellular Therapy in Combating Post-Lung Transplant Cytomegalovirus Infection

S Stankovic, MS Davey, EM Shaw, Y Cristiano, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

HLA-E-restricted CD8( ) T Lymphocytes Efficiently Control Mycobacterium tuberculosis and HIV-1 Coinfection

Marco Pio La Manna, Valentina Orlando, Teresa Prezzemolo, Paola Di Carlo, Antonio Cascio, Giovanni Delogu, Guido Poli, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli, Nadia Caccamo

Journal article  |  2020  |  American Journal of Respiratory Cell and Molecular Biology

We investigated the contribution of human leukocyte antigen A2 (HLA-A2) and HLA-E-restricted CD8+ T cells in patients with Mycobac..

IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages

Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading

Journal article  |  2020  |  Virology

Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..

Enrichment of Cytomegalovirus-induced NKG2C( ) Natural Killer Cells in the Lung Allograft

Christopher M Harpur, Sanda Stankovic, Abbie Kanagarajah, Jacqueline ML Widjaja, Bronwyn J Levvey, Yvonne Cristiano, Greg I Snell, Andrew G Brooks, Glen P Westall, Lucy C Sullivan

Journal article  |  2019  |  Transplantation

BACKGROUND: In lung transplant recipients, immunosuppressive medications result in impaired antiviral immunity and a propensity fo..