Andrew Brooks

Mouse guanylate-binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo.

Melkamu B Tessema, Daniel Enosi Tuipulotu, Clare V Oates, Andrew G Brooks, Si Ming Man, Sarah L Londrigan, Patrick C Reading

Journal article  |  2023  |  Immunol Cell Biol

Many interferon (IFN)-stimulated genes are upregulated within host cells following infection with influenza and other viruses. Whi..

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Fernando Villalon-Letelier, Rubaiyea Farrukee, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict..

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines (vol 49, 971, 2019)

Nadia Caccamo, Gabriella Pietra, Lucy C Sullivan, Andrew G Brooks, Teresa Prezzemolo, Marco P La Manna, Diana Di Liberto, Simone A Joosten, Krista E van Meijgaarden, Paola Di Carlo, Lucina Titone, Lorenzo Moretta, Maria C Mingari, Tom HM Ottenhoff, Francesco Dieli

Journal article  |  2022  |  EUROPEAN JOURNAL OF IMMUNOLOGY

CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells ..

340.2: HLA-C Mismatching Improves Outcomes Following Lung Transplantation

Lucy Sullivan, Steven Hiho, Gregory I Snell, Bronwyn J Levvey, Andrew G Brooks, Glen P Westall

Journal article  |  2022  |  Transplantation

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets

Lara SU Schwab, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Anshupa Sahu, Yi-Mo Deng, Jean Moselen, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Intracellular RIG-I receptors represent key innate sensors of RNA virus infection, and RIG-I activation results in the induction o..

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection

Lara SU Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF INFECTIOUS DISEASES

Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Tre..

Permanent Loss of Human Leukocyte Antigen E-restricted CD8 T Stem Memory Cells in Human Tuberculosis.

Mojtaba Shekarkar Azgomi, Marco P La Manna, Lucy C Sullivan, Andrew G Brooks, Paola Di Carlo, Francesco Dieli, Nadia Caccamo

Journal article  |  2022  |  Am J Respir Cell Mol Biol

Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

Lara SU Schwab, Fernando Villalon-Letelier, Melkamu B Tessema, Sarah L Londrigan, Andrew G Brooks, Aeron Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies u..

Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model

Melkamu B Tessema, Rubaiyea Farrukee, Christopher E Andoniou, Mariapia A Degli-Esposti, Clare Oates, James B Barnes, Linda M Wakim, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Myxovirus resistance (Mx) proteins are dynamin-like GTPases that are inducible by interferons (IFNs) following virus infections. M..