Andrew Brooks

IFITM proteins that restrict the early stages of respiratory virus infection do not influence late-stage replication.

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B Tessema, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2021  |  J Virol

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

Shoeib Moradi, Sanda Stankovic, Geraldine M O'Connor, Phillip Pymm, Bruce J MacLachlan, Camilla Faoro, Christelle Retiere, Lucy C Sullivan, Philippa M Saunders, Jacqueline Widjaja, Shea Cox-Livingstone, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2021  |  NATURE COMMUNICATIONS

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of na..

Natural killer cell receptors regulate responses of HLA-E-restricted T cells

Lucy C Sullivan, Thi HO Nguyen, Christopher M Harpur, Sanda Stankovic, Abbie R Kanagarajah, Marios Koutsakos, Philippa M Saunders, Zhangying Cai, James A Gray, Jacqueline ML Widjaja, Jie Lin, Gabriella Pietra, Maria Cristina Mingari, Lorenzo Moretta, Jerome Samir, Fabio Luciani, Glen P Westall, Karl J Malmberg, Katherine Kedzierska, Andrew G Brooks

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen (HLA)-E-restricted CD8+ T cell responses. These..

The Role of the HLA Class I alpha 2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1 Philippa

Philippa M Saunders, Bruce J MacLachlan, Jacqueline Widjaja, Shu Cheng Wong, Clare VL Oates, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

HLA class I molecules that represent ligands for the inhibitory killer cell Ig-like receptor (KIR) 3DL1 found on NK cells are cate..

Estradiol Enhances Antiviral CD4( ) Tissue-Resident Memory T Cell Responses following Mucosal Herpes Simplex Virus 2 Vaccination through an IL-17-Mediated Pathway

Puja Bagri, Ramtin Ghasemi, Joshua JC McGrath, Danya Thayaparan, Emma Yu, Andrew G Brooks, Martin R Staempfli, Charu Kaushic

Journal article  |  2021  |  JOURNAL OF VIROLOGY

Estradiol (E2) is a sex hormone which has been shown to be protective against sexually transmitted infections such as herpes simpl..

Cytomegalovirus replication is associated with enrichment of distinct g 8 T cell subsets following lung transplantation: A novel therapeutic approach?

Sanda Stankovic, Martin S Davey, Evangeline M Shaw, Anouk von Borstel, Yvonne Cristiano, Bronwyn J Levvey, Jamie Rossjohn, Glen P Westall, Gregory I Snell, Andrew G Brooks, Lucy C Sullivan

Journal article  |  2020  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

BACKGROUND: Anti-viral treatments to control cytomegalovirus (CMV) after lung transplantation (LTx) are associated with toxicity a..

Harnessing HLA-E-restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID-19

Nadia Caccamo, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli

Journal article  |  2020  |  BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deat..

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

CM Fernandes Monteiro, DC Walton, Y Cristiano, BJ Levvey, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

PURPOSE: The long-term success of lung transplantation (LTx) is limited by CLAD. The complement-independent pathway of ABMR, drive..