Andrew Brooks

Harnessing HLA-E-restricted CD8 T lymphocytes for adoptive cell therapy of patients with severe COVID-19.

Nadia Caccamo, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli

Journal article  |  2020  |  British Journal of Haematology

SARS-CoV-2 is spreading worldwide, and is a pandemic virus that has infected almost 5 million individuals and causing 300.000 deat..

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

CM Fernandes Monteiro, DC Walton, Y Cristiano, BJ Levvey, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

A Potential Role for NKG2C gamma delta T Cells as a Cellular Therapy in Combating Post-Lung Transplant Cytomegalovirus Infection

S Stankovic, MS Davey, EM Shaw, Y Cristiano, GI Snell, GP Westall, AG Brooks, LC Sullivan

Conference Proceedings  |  2020  |  The Journal of Heart and Lung Transplantation

HLA-E-restricted CD8( ) T Lymphocytes Efficiently Control Mycobacterium tuberculosis and HIV-1 Coinfection

Marco Pio La Manna, Valentina Orlando, Teresa Prezzemolo, Paola Di Carlo, Antonio Cascio, Giovanni Delogu, Guido Poli, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli, Nadia Caccamo

Journal article  |  2020  |  American Journal of Respiratory Cell and Molecular Biology

We investigated the contribution of human leukocyte antigen A2 (HLA-A2) and HLA-E-restricted CD8+ T cells in patients with Mycobac..

IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages

Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading

Journal article  |  2020  |  Virology

Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..

Enrichment of Cytomegalovirus-induced NKG2C( ) Natural Killer Cells in the Lung Allograft

Christopher M Harpur, Sanda Stankovic, Abbie Kanagarajah, Jacqueline ML Widjaja, Bronwyn J Levvey, Yvonne Cristiano, Greg I Snell, Andrew G Brooks, Glen P Westall, Lucy C Sullivan

Journal article  |  2019  |  Transplantation

BACKGROUND: In lung transplant recipients, immunosuppressive medications result in impaired antiviral immunity and a propensity fo..

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo

Joel Z Ma, Wy Ching Ng, Luke Zappia, Linden J Gearing, Moshe Olshansky, Kym Pham, Karey Cheong, Arthur Hsu, Stephen J Turner, Odilia Wijburg, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2019  |  Journal of Virology

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Christopher M Harpur, Yu Kato, Shinta T Dewi, Sanda Stankovic, Darryl N Johnson, Sammy Bedoui, Paul G Whitney, Mireille H Lahoud, Irina Caminschi, William R Heath, Andrew G Brooks, Thomas Gebhardt

Journal article  |  2019  |  The Journal of Immunology

Broadening our knowledge of the differences between HIV-2 and HIV-1 innate sensing: HIV-2 infected cells selectively express B7-H6 and engage NKp30 on natural killer cells

Marc Dalod, Andrew Brooks

Journal article  |  2019  |  AIDS

The complex existence of gamma delta T cells following transplantation: the good, the bad and the simply confusing

Lucy C Sullivan, Evangeline M Shaw, Sanda Stankovic, Gregory I Snell, Andrew G Brooks, Glen P Westall

Journal article  |  2019  |  Clinical & Translational Immunology

Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice

Eva Fuglsang, Angela Pizzolla, Lukasz Krych, Dennis S Nielsen, Andrew G Brooks, Hanne Frokiaer, Patrick C Reading

Journal article  |  2018  |  Frontiers in Cellular and Infection Microbiology

Activating killer-cell immunoglobulin-like receptor haplotype influences clinical outcome following HLA-matched sibling haematopoietic stem cell transplantation

Susan L Heatley, Charles G Mullighan, Kathleen Doherty, Silke Danner, Geraldine M O'Connor, Uwe Hahn, Jeff Szer, Anthony Schwarer, Kenneth Bradstock, Lucy C Sullivan, Peter G Bardy, Andrew G Brooks

Journal article  |  2018  |  HLA

THE ALLOTYPIC ARCHITECTURE OF HLA-B57 ALLOTYPES ALTERS PEPTIDE CONFORMATION TO REGULATE INHIBITION OF NK CELL ACTIVATION THROUGH KIR3DL1

Andrew G Brooks, Philippa M Saunders, Philip Pymm, Jacqueline ML Widjaja, Jie Lin, Jamie Rossjohn, Julian P Vivian

Conference Proceedings  |  2018  |  HLA

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Maureen P Martin, Vivek Naranbhai, Patrick R Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L Brumme, Jonathan M Carlson, Steven M Wolinsky, James J Goedert, Bruce D Walker, Florencia P Segal, Steven G Deeks, David W Haas, Stephen A Migueles, Mark Connors, Nelson Michael, Jacques Fellay, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

Induction and Measurement of Cytotoxic T Lymphocyte Activity.

John Wonderlich, Gene Shearer, Alexandra Livingstone, Andrew Brooks, Mark J Soloski, Matthew M Presby

Journal article  |  2018  |  Current Protocols in Immunology

Cytotoxic T cells (CTLs) are important immune effector cells in the adaptive immune response. It has been well documented that CTL..

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alpha beta T cell receptors

Lucy C Sullivan, Nicholas G Walpole, Carine Farenc, Gabriella Pietra, Matthew JW Sum, Craig S Clements, Eleanor J Lee, Travis Beddoe, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Stephanie Gras, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2017  |  Journal of Biological Chemistry

Host Cell Restriction Factors that Limit Influenza A Infection

Fernando Villalon-Letelier, Andrew G Brooks, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2017  |  Viruses

The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule

Jesse I Mobbs, Patricia T Illing, Nadine L Dudek, Andrew G Brooks, Daniel G Baker, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian

Journal article  |  2017  |  Journal of Biological Chemistry

Resident memory CD8( ) T cells in the upper respiratory tract prevent pulmonary influenza virus infection

Angela Pizzolla, Thi HO Nguyen, Jeffrey M Smith, Andrew G Brooks, Katherine Kedzierska, William R Heath, Patrick C Reading, Linda M Wakim

Journal article  |  2017  |  SCIENCE IMMUNOLOGY

Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells

Angela Pizzolla, Zhongfang Wang, Joanna R Groom, Katherine Kedzierska, Andrew G Brooks, Patrick C Reading, Linda M Wakim

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Phillip Pymm, Patricia T Illing, Sri H Ramarathinam, Geraldine M O'Connor, Victoria A Hughes, Corinne Hitchen, David A Price, Bosco K Ho, Daniel W McVicar, Andrew G Brooks, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian

Journal article  |  2017  |  Nature Structural & Molecular Biology

Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus

Angela Pizzolla, Jeffery M Smith, Andrew G Brooks, Patrick C Reading

Journal article  |  2017  |  Journal of Leukocyte Biology

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C

Lucy C Sullivan, Richard Berry, Natasha Sosnin, Jacqueline ML Widjaja, Felix A Deuss, Gautham R Balaji, Nicole L LaGruta, Michiko Mirams, Joseph A Trapani, Jamie Rossjohn, Andrew G Brooks, Daniel M Andrews

Journal article  |  2016  |  Journal of Biological Chemistry

DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

Leah Gillespie, Kathleen Gerstenberg, Fernanda Ana-Sosa-Batiz, Matthew S Parsons, Rubaiyea Farrukee, Mark Krabbe, Kirsten Spann, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2016  |  JOURNAL OF VIROLOGY

Neutralizing inhibitors in the airways of naive ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses

Emma R Job, Angela Pizzolla, Thomas Nebl, Kirsty R Short, Yi-Mo Deng, Louise Carolan, Karen L Laurie, Andrew G Brooks, Patrick C Reading

Journal article  |  2016  |  Virology

Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition

Philippa M Saunders, Phillip Pymm, Gabriella Pietra, Victoria A Hughes, Corinne Hitchen, Geraldine M O'Connor, Fabrizio Loiacono, Jacqueline Widjaja, David A Price, Michela Falco, Maria Cristina Mingari, Lorenzo Moretta, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks, Julian P Vivian

Journal article  |  2016  |  Journal of Experimental Medicine

Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN

Leah Gillespie, Paula Roosendahl, Wy Ching Ng, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2016  |  Scientific Reports

The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus

Wy Ching Ng, Sarah L Londrigan, Najla Nasr, Anthony L Cunningham, Stuart Turville, Andrew G Brooks, Patrick C Reading

Journal article  |  2016  |  JOURNAL OF VIROLOGY

Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

Sarah L Londrigan, Kirsty R Short, Joel Ma, Leah Gillespie, Steven P Rockman, Andrew G Brooks, Patrick C Reading

Journal article  |  2015  |  JOURNAL OF VIROLOGY

Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1

Sanda Stankovic, Christopher M Harpur, Bethany L Macleod, Paul G Whitney, Thomas Gebhardt, Andrew G Brooks

Journal article  |  2015  |  The Journal of Immunology

Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection

Sarah L Londrigan, Michelle D Tate, Emma R Job, Jessica M Moffat, Linda M Wakim, Christopher A Gonelli, Damien FJ Purcell, Andrew G Brooks, Jose A Villadangos, Patrick C Reading, Justine D Mintern

Journal article  |  2015  |  PLOS ONE

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4( ) and CD8( ) T Cell Activation to Localized Viral Infection (vol 43, pg 554, 2015)

Jyh Liang Hor, Paul G Whitney, Ali Zaid, Andrew G Brooks, William R Heath, Scott N Mueller

Journal article  |  2015  |  Immunity

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4( ) and CD8( ) T Cell Activation to Localized Viral Infection

Jyh Liang Hor, Paul G Whitney, Ali Zaid, Andrew G Brooks, William R Heath, Scott N Mueller

Journal article  |  2015  |  Immunity

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

Philippa M Saunders, Julian P Vivian, Geraldine M O'Connor, Lucy C Sullivan, Phillip Pymm, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2015  |  Immunological Reviews

The Presence of HLA-E-Restricted, CMV-Specific CD8( ) T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection

Lucy C Sullivan, Glen P Westall, Jacqueline ML Widjaja, Nicole A Mifsud, Thi HO Nguyen, Aislin C Meehan, Tom C Kotsimbos, Andrew G Brooks

Journal article  |  2015  |  PLOS ONE

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1 (vol 89, pg 5213, 2015)

Geraldine M O'Connor, Julian P Vivian, Emma Gostick, Phillip Pymm, Bernard AP Lafont, David A Price, Jamie Rossjohn, Andrew G Brooks, Daniel W McVicar

Journal article  |  2015  |  Journal of Virology

Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1

Geraldine M O'Connor, Julian P Vivian, Emma Gostick, Phillip Pymm, Bernard AP Lafont, David A Price, Jamie Rossjohn, Andrew G Brooks, Daniel W McVicar

Journal article  |  2015  |  Journal of Virology

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

Shoeib Moradi, Richard Berry, Phillip Pymm, Corinne Hitchen, Simone A Beckham, Matthew CJ Wilce, Nicholas G Walpole, Craig S Clements, Hugh H Reid, Matthew A Perugini, Andrew G Brooks, Jamie Rossjohn, Julian P Vivian

Journal article  |  2015  |  Journal of Biological Chemistry

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

Nadia Caccamo, Gabriella Pietra, Lucy C Sullivan, Andrew G Brooks, Teresa Prezzemolo, Marco P La Manna, Diana Di Liberto, Simone A Joosten, Krista E van Meijgaarden, Paola Di Carlo, Lucina Titone, Lorenzo Moretta, Maria C Mingari, Tom HM Ottenhoff, Francesco Dieli

Journal article  |  2015  |  European Journal of Immunology

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

Jessica Li, Fatma Ahmet, Lucy C Sullivan, Andrew G Brooks, Stephen J Kent, Robert De Rose, Andres M Salazar, Caetano Reis e Sousa, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  European Journal of Immunology

The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope

Philippa M Saunders, Julian P Vivian, Nikola Baschuk, Travis Beddoe, Jacqueline Widjaja, Geraldine M O'Connor, Corinne Hitchen, Phillip Pymm, Daniel M Andrews, Stephanie Gras, Daniel W McVicar, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2015  |  The Journal of Immunology

The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins

Richard Berry, Julian P Vivian, Felix A Deuss, Gautham R Balaji, Philippa M Saunders, Jie Lin, Dene R Littler, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2014  |  Journal of Biological Chemistry

Distinct APC Subtypes Drive Spatially Segregated CD4 and CD8 T-Cell Effector Activity during Skin Infection with HSV-1

Bethany L Macleod, Sammy Bedoui, Jyh Liang Hor, Scott N Mueller, Tiffany A Russell, Natasha A Hollett, William R Heath, David C Tscharke, Andrew G Brooks, Thomas Gebhardt

Journal article  |  2014  |  PLoS Pathogens

Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity

Geraldine M O'Connor, Julian P Vivian, Jacqueline M Widjaja, John S Bridgeman, Emma Gostick, Bernard AP Lafont, Stephen K Anderson, David A Price, Andrew G Brooks, Jamie Rossjohn, Daniel W McVicar

Journal article  |  2014  |  Journal of Immunology

The Ly49 natural killer cell receptors: a versatile tool for viral self-discrimination

Richard Berry, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2014  |  Immunology & Cell Biology

The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus

Wy Ching Ng, Stella Liong, Michelle D Tate, Tatsuro Irimura, Kaori Denda-Nagai, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2014  |  JOURNAL OF VIROLOGY

Distinct APC subtypes drive spatially segregated CD4 and CD8 T-cell effector activity during skin infection with HSV-1

BL Macleod, S Bedoui, JL Hor, SN Mueller, TA Russell, NA Hollett, WR Heath, DC Tscharke, AG Brooks, T Gebhardt

Journal article  |  2014  |  PLoS Pathogens

A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice

Emma R Job, Barbara Bottazzi, Kirsty R Short, Yi-Mo Deng, Alberto Mantovani, Andrew G Brooks, Patrick C Reading

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY

Anti-HIV Antibody-Dependent Activation of NK Cells Impairs NKp46 Expression

Matthew S Parsons, Chi-Chang Tang, Sinthujan Jegaskanda, Robert J Center, Andrew G Brooks, Ivan Stratov, Stephen J Kent

Journal article  |  2014  |  Journal of Immunology

Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

Sinthujan Jegaskanda, Karen L Laurie, Thakshila H Amarasena, Wendy R Winnall, Marit Kramski, Robert De Rose, Ian G Barr, Andrew G Brooks, Patrick C Reading, Stephen J Kent

Journal article  |  2013  |  JOURNAL OF INFECTIOUS DISEASES

HLA Peptide Length Preferences Control CD8( ) T Cell Responses

Melissa J Rist, Alex Theodossis, Nathan P Croft, Michelle A Neller, Andrew Welland, Zhenjun Chen, Lucy C Sullivan, Jacqueline M Burrows, John J Miles, Rebekah M Brennan, Stephanie Gras, Rajiv Khanna, Andrew G Brooks, James McCluskey, Anthony W Purcell, Jamie Rossjohn, Scott R Burrows

Journal article  |  2013  |  Journal of Immunology

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Onisha Patel, Lars Kjer-Nielsen, Jerome Le Nours, Sidonia BG Eckle, Richard Birkinshaw, Travis Beddoe, Alexandra J Corbett, Ligong Liu, John J Miles, Bronwyn Meehan, Rangsima Reantragoon, Maria L Sandoval-Romero, Lucy C Sullivan, Andrew G Brooks, Zhenjun Chen, David P Fairlie, James McCluskey, Jamie Rossjohn

Journal article  |  2013  |  Nature Communications

Targeting of a natural killer cell receptor family by a viral immunoevasin

Richard Berry, Natasha Ng, Philippa M Saunders, Julian P Vivian, Jie Lin, Felix A Deuss, Alexandra J Corbett, Catherine A Forbes, Jacqueline M Widjaja, Lucy C Sullivan, Adrian D McAlister, Matthew A Perugini, Melissa J Call, Anthony A Scalzo, Mariapia A Degli-Esposti, Jerome D Coudert, Travis Beddoe, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2013  |  Nature Immunology

Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses

Emma R Job, Barbara Bottazzi, Brad Gilbertson, Kathryn M Edenborough, Lorena E Brown, Alberto Mantovani, Andrew G Brooks, Patrick C Reading

Journal article  |  2013  |  PLOS ONE

Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells

Susan L Heatley, Gabriella Pietra, Jie Lin, Jacqueline ML Widjaja, Christopher M Harpur, Sue Lester, Jamie Rossjohn, Jeff Szer, Anthony Schwarer, Kenneth Bradstock, Peter G Bardy, Maria Cristina Mingari, Lorenzo Moretta, Lucy C Sullivan, Andrew G Brooks

Journal article  |  2013  |  Journal of Biological Chemistry

Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses

Emma R Job, Yi-Mo Deng, Kenneth K Barfod, Michelle D Tate, Natalie Caldwell, Scott Reddiex, Sebastian Maurer-Stroh, Andrew G Brooks, Patrick C Reading

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

Non-classical MHC Class I molecules regulating natural killer cell function

Mark J Smyth, Lucy C Sullivan, Andrew G Brooks, Daniel M Andrews

Journal article  |  2013  |  ONCOIMMUNOLOGY

Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies

Sinthujan Jegaskanda, Emma R Job, Marit Kramski, Karen Laurie, Gamze Isitman, Robert de Rose, Wendy R Winnall, Ivan Stratov, Andrew G Brooks, Patrick C Reading, Stephen J Kent

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

Contribution of Thy1( ) NK cells to protective IFN-gamma production during Salmonella Typhimurium infections

Andreas Kupz, Timothy A Scott, Gabrielle T Belz, Daniel M Andrews, Marie Greyer, Andrew M Lew, Andrew G Brooks, Mark J Smyth, Roy Curtiss, Sammy Bedoui, Richard A Strugnell

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks, Mark J Smyth

Journal article  |  2012  |  Nature Immunology

Degenerate Recognition of MHC Class I Molecules with Bw4 and Bw6 Motifs by a Killer Cell Ig-like Receptor 3DL Expressed by Macaque NK Cells

Sebastien M Maloveste, Dan Chen, Emma Gostick, Julian P Vivian, Ronald J Plishka, Ranjini Iyengar, Robin L Kruthers, Alicia Buckler-White, Andrew G Brooks, Jamie Rossjohn, David A Price, Bernard AP Lafont

Journal article  |  2012  |  Journal of Immunology

The fate of influenza A virus after infection of human macrophages and dendritic cells

Kirsty R Short, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2012  |  Journal of General Virology

DEC-205 is a cell surface receptor for CpG oligonucleotides

Mireille H Lahoud, Fatma Ahmet, Jian-Guo Zhang, Simone Meuter, Antonia N Policheni, Susie Kitsoulis, Chin-Nien Lee, Meredith O'Keeffe, Lucy C Sullivan, Andrew G Brooks, Richard Berry, Jamie Rossjohn, Justine D Mintern, Javier Vega-Ramos, Jose A Villadangos, Nicos A Nicola, Michel C Nussenzweig, Katryn J Stacey, Ken Shortman, William R Heath, et al.

Journal article  |  2012  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus

Sarah L Londrigan, Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2012  |  Journal of Leukocyte Biology

MHC Class Ib-Restricted CD8 T Cells Differ in Dependence on CD4 T Cell Help and CD28 Costimulation over the Course of Mouse Polyomavirus Infection

Amelia R Hofstetter, Mandy L Ford, Lucy C Sullivan, Jarad J Wilson, Annette Hadley, Andrew G Brooks, Aron E Lukacher

Journal article  |  2012  |  Journal of Immunology

Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques

Sinthujan Jegaskanda, Jeanette C Reece, Robert De Rose, John Stambas, Lucy Sullivan, Andrew G Brooks, Stephen J Kent, Amy Sexton

Journal article  |  2012  |  PLoS One

Neutrophils sustain effective CD8( ) T-cell responses in the respiratory tract following influenza infection

Michelle D Tate, Andrew G Brooks, Patrick C Reading, Justine D Mintern

Journal article  |  2012  |  Immunology and Cell Biology

A Structural Basis for Antigen Presentation by the MHC Class Ib Molecule, Qa-1(b)

Li Zeng, Lucy C Sullivan, Julian P Vivian, Nicholas G Walpole, Christopher M Harpur, Jamie Rossjohn, Craig S Clements, Andrew G Brooks

Journal article  |  2012  |  Journal of Immunology

Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

Wy Ching Ng, Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2012  |  JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8( ) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery

Lei Shong Lau, Daniel Fernandez Ruiz, Gayle M Davey, Tania F de Koning-Ward, Anthony T Papenfuss, Francis R Carbone, Andrew G Brooks, Brendan S Crabb, William R Heath

Journal article  |  2011  |  Journal of Infectious Diseases

V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

Onisha Patel, Daniel G Pellicci, Adam P Uldrich, Lucy C Sullivan, Mugdha Bhati, Melissa McKnight, Stewart K Richardson, Amy R Howell, Thierry Mallevaey, Jingjing Zhang, Romain Bedel, Gurdyal S Besra, Andrew G Brooks, Lars Kjer-Nielsen, James McCluskey, Steven A Porcelli, Laurent Gapin, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2011  |  Proceedings of the National Academy of Sciences

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Julian P Vivian, Renee C Duncan, Richard Berry, Geraldine M O'Connor, Hugh H Reid, Travis Beddoe, Stephanie Gras, Philippa M Saunders, Maya A Olshina, Jacqueline ML Widjaja, Christopher M Harpur, Jie Lin, Sebastien M Maloveste, David A Price, Bernard AP Lafont, Daniel W McVicar, Craig S Clements, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2011  |  Nature

Live Attenuated Influenza-SIV Vaccines: Efficacy Against Mucosal Challenge in Macaques

SJ Kent, S Jegaskanda, J Reece, T Ameresena, A Sexton, C Fernandez, J Stambas, A Brooks, R De Rose

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Different patterns of peripheral migration by memory CD4( ) and CD8( ) T cells

Thomas Gebhardt, Paul G Whitney, Ali Zaid, Laura K Mackay, Andrew G Brooks, William R Heath, Francis R Carbone, Scott N Mueller

Journal article  |  2011  |  Nature

Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice

Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Journal of Immunology

A semi-invariant V(alpha)10( ) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Adam P Uldrich, Onisha Patel, Garth Cameron, Daniel G Pellicci, E Bridie Day, Lucy C Sullivan, Konstantinos Kyparissoudis, Lars Kjer-Nielsen, Julian P Vivian, Benjamin Cao, Andrew G Brooks, Spencer J Williams, Petr Illarionov, Gurdyal S Besra, Stephen J Turner, Steven A Porcelli, James McCluskey, Mark J Smyth, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2011  |  Nature Immunology

Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice

Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Virology

Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice

Michelle D Tate, Emma R Job, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Virology

Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus

Michelle D Tate, Heidi C Schilter, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Viral Immunology

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

Kwok S Wun, Garth Cameron, Onisha Patel, Siew Siew Pang, Daniel G Pellicci, Lucy C Sullivan, Santosh Keshipeddy, Mary H Young, Adam P Uldrich, Meena S Thakur, Stewart K Richardson, Amy R Howell, Petr A Illarionov, Andrew G Brooks, Gurdyal S Besra, James McCluskey, Laurent Gapin, Steven A Porcelli, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2011  |  Immunity

The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice

Michelle D Tate, Lisa J Ioannidis, Ben Croker, Lorena E Brown, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  PLoS One

Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection

Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Immunology and Cell Biology

N-Linked Glycosylation Facilitates Sialic Acid-Independent Attachment and Entry of Influenza A Viruses into Cells Expressing DC-SIGN or L-SIGN

Sarah L Londrigan, Stuart G Turville, Michelle D Tate, Yi-Mo Deng, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Journal of Virology

Immunoreceptor intramembrane assembly How opposites attract

Travis Beddoe, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2011  |  Immunology & Cell Biology

Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus

Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2011  |  Microbes and Infection

Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity

Amelia R Hofstetter, Lucy C Sullivan, Aron E Lukacher, Andrew G Brooks

Journal article  |  2011  |  Current Opinion in Immunology

Gr-1( ) cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1

Magdalena Wojtasiak, Danielle L Pickett, Michelle D Tate, Sammy Bedoui, Emma R Job, Paul G Whitney, Andrew G Brooks, Patrick C Reading

Journal article  |  2010  |  Virology

Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies

Emma R Job, Yi-Mo Deng, Michelle D Tate, Barbara Bottazzi, Erika C Crouch, Melinda M Dean, Alberto Mantovani, Andrew G Brooks, Patrick C Reading

Journal article  |  2010  |  Journal of Immunology

Depletion of Gr-1( ), but not Ly6G( ), immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection

Magdalena Wojtasiak, Danielle L Pickett, Michelle D Tate, Sarah L Londrigan, Sammy Bedoui, Andrew G Brooks, Patrick C Reading

Journal article  |  2010  |  Journal of General Virology

Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice

Patrick C Reading, Paul G Whitney, Danielle L Pickett, Michelle D Tate, Andrew G Brooks

Journal article  |  2010  |  Immunology and Cell Biology

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

Michelle D Tate, Danielle L Pickett, Nico van Rooijen, Andrew G Brooks, Patrick C Reading

Journal article  |  2010  |  Journal of Virology

Allelic polymorphism in the T cell receptor and its impact on immune responses

Stephanie Gras, Zhenjun Chen, John J Miles, Yu Chih Liu, Melissa J Bell, Lucy C Sullivan, Lars Kjer-Nielsen, Rebekah M Brennan, Jacqueline M Burrows, Michelle A Neller, Rajiv Khanna, Anthony W Purcell, Andrew G Brooks, James McCluskey, Jamie Rossjohn, Scott R Burrows

Journal article  |  2010  |  Journal of Experimental Medicine

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Scott R Burrows, Zhenjun Chen, Julia K Archbold, Fleur E Tynan, Travis Beddoe, Lars Kjer-Nielsen, John J Miles, Rajiv Khanna, Denis J Moss, Yu Chih Liu, Stephanie Gras, Lyudmila Kostenko, Rebekah M Brennan, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Natural Killer Cell Activation in the Lung Allograft Early Posttransplantation

Aislin C Meehan, Lucy C Sullivan, Nicole A Mifsud, Andrew G Brooks, Greg I Snell, Tom C Kotsimbos, Glen P Westall

Journal article  |  2010  |  Transplantation

The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide

Nicholas G Walpole, Lars Kjer-Nielsen, Lyudmila Kostenko, James McCluskey, Andrew G Brooks, Jamie Rossjohn, Craig S Clements

Journal article  |  2010  |  Journal of Molecular Biology

T Cell Allorecognition via Molecular Mimicry

Whitney A Macdonald, Zhenjun Chen, Stephanie Gras, Julia K Archbold, Fleur E Tynan, Craig S Clements, Mandvi Bharadwaj, Lars Kjer-Nielsen, Philippa M Saunders, Matthew CJ Wilce, Fran Crawford, Brian Stadinsky, David Jackson, Andrew G Brooks, Anthony W Purcell, John W Kappler, Scott R Burrows, Jamie Rossjohn, James McCluskey

Journal article  |  2009  |  Immunity

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

Michelle D Tate, Yi-Mo Deng, Jessica E Jones, Gary P Anderson, Andrew G Brooks, Patrick C Reading

Journal article  |  2009  |  Journal of Immunology

Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice

Patrick C Reading, Danielle L Pickett, Michelle D Tate, Paul G Whitney, Emma R Job, Andrew G Brooks

Journal article  |  2009  |  Respiratory Research

A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules

Amy Sexton, Paul G Whitney, Siow-Feng Chong, Alexander N Zelikin, Angus PR Johnston, Robert De Rose, Andrew G Brooks, Frank Caruso, Stephen J Kent

Journal article  |  2009  |  ACS NANO

Killer Ig-Like Receptor Ligand Mismatch Directs NK Cell Expansion In Vitro

Mingus JJ Rose, Andrew G Brooks, Lisbeth A Stewart, Thi H Nguyen, Anthony P Schwarer

Journal article  |  2009  |  Journal of Immunology

Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the V beta 8.2 and V beta 7 Semi-invariant NKT T Cell Receptors

Daniel G Pellicci, Onisha Patel, Lars Kjer-Nielsen, Siew Siew Pang, Lucy C Sullivan, Konstantinos Kyparissoudis, Andrew G Brooks, Hugh H Reid, Stephanie Gras, Isabelle S Lucet, Ruide Koh, Mark J Smyth, Thierry Mallevaey, Jennifer L Matsuda, Laurent Gapin, James McCluskey, Dale I Godfrey, Jamie Rossjohn

Journal article  |  2009  |  Immunity

Cross-presentation of viral and self antigens by skin-derived CD103( ) dendritic cells

Sammy Bedoui, Paul G Whitney, Jason Waithman, Liv Eidsmo, Linda Wakim, Irina Caminschi, Rhys S Allan, Magdalena Wojtasiak, Ken Shortman, Francis R Carbone, Andrew G Brooks, William R Heath

Journal article  |  2009  |  Nature Immunology

The Shaping of T Cell Receptor Recognition by Self-Tolerance

Stephanie Gras, Scott R Burrows, Lars Kjer-Nielsen, Craig S Clements, Yu Chih Liu, Lucy C Sullivan, Melissa J Bell, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2009  |  Immunity

RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION

Susan Heatley, Lucy Sullivan, Gabriella Pietra, Jie Lin, Jason Jordan, Maria Cristina Mingari, Lorenzo Moretta, Andrew Brooks

Conference Proceedings  |  2009  |  Human Immunology

THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION

Susan Heatley, Charles Mullighan, Lucy Sullivan, Andrew Brooks, Peter Bardy

Conference Proceedings  |  2009  |  Human Immunology

Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs

Erik Rollman, Rosemarie D Mason, Jie Lin, Andrew G Brooks, Stephen J Kent

Journal article  |  2008  |  Journal of Medical Primatology

The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity

LC Sullivan, CS Clements, J Rossjohn, AG Brooks

Journal article  |  2008  |  Tissue Antigens

Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D

Peter D Tran, Dale Christiansen, Adam Winterhalter, Andrew Brooks, Mark Gorrell, Benjamin G Lilienfeld, Joerg D Seebach, Mauro Sandrin, Alexandra Sharland

Journal article  |  2008  |  Xenotransplantation

The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice

Michelle D Tate, Andrew G Brooks, Patrick C Reading

Journal article  |  2008  |  Respiratory Research

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors

Hilary L Hoare, Lucy C Sullivan, Craig S Clements, Lauren K Ely, Travis Beddoe, Kate N Henderson, Jie Lin, Hugh H Reid, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2008  |  Journal of Molecular Biology

Application of CD27 as a marker for distinguishing human NK cell subsets

Anabel Silva, Daniel M Andrews, Andrew G Brooks, Mark J Smyth, Yoshihiro Hayakawa

Journal article  |  2008  |  International Immunology

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

Emma J Petrie, Craig S Clements, Jie Lin, Lucy C Sullivan, Darryl Johnson, Trevor Huyton, Annie Heroux, Hilary L Hoare, Travis Beddoe, Hugh H Reid, Matthew CJ Wilce, Andrew G Brooks, Jamie Rossjohn

Journal article  |  2008  |  Journal of Experimental Medicine

Antiviral activity of the long chain pentraxin PTX3 against influenza viruses

Patrick C Reading, Silvia Bozza, Brad Gilbertson, Michelle Tate, Silvia Moretti, Emma R Job, Erika C Crouch, Andrew G Brooks, Lorena E Brown, Barbara Bottazzi, Luigina Romani, Alberto Mantovani

Journal article  |  2008  |  Journal of Immunology

Inhibition of Influenza Viruses By Proteins of the Innate Immune System

P READING, E JOB, M TATE, A BROOKS, B Bottazzi, A Mantovani

Conference Proceedings  |  2008  |  Options for the Control of Influenza VI

The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition

Lucy C Sullivan, Craig S Clements, Travis Beddoe, Darryl Johnson, Hilary L Hoare, Jie Lin, Trevor Huyton, Emma J Hopkins, Hugh H Reid, Mafthew CJ Wilce, Juraj Kabat, Francisco Borrego, John E Coligan, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2007  |  Immunity

CD8( ) T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection

GP Westall, AG Brooks, T Kotsimbos

Journal article  |  2007  |  Transplant Immunology

Killing kinetics of simian immunodeficiency virus-specific CD8( ) T cells: implications for HIV vaccine strategies

Erik Rollman, Miranda Z Smith, Andrew G Brooks, Damian FJ Purcell, Bartek Zuber, Ian A Ramshaw, Stephen J Kent

Journal article  |  2007  |  Journal of Immunology

IL48, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type I infection

Patrick C Reading, Paul G Whitney, Daniel P Barr, Magdalena Wojtasiak, Justine D Mintern, Jason Waithman, Andrew G Brooks

Journal article  |  2007  |  Journal of Immunology

Porcine cells express more than one functional ligand for the human NK cell activating receptor NKG2D

Peter Tran, Dale Christiansen, Adam Winterhalter, Andrew Brooks, Mark Gorrell, Benjamin G Lilienfeld, Joerg D Seebach, Mauro Sandrin, Alexandra Sharland

Conference Proceedings  |  2007  |  XENOTRANSPLANTATION

A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection

Daniel P Barr, Gabrielle T Belz, Patrick C Reading, Magdalena Wojtasiak, Paul G Whitney, William R Heath, Francis R Carbone, Andrew G Brooks

Journal article  |  2007  |  European Journal of Immunology

Glycosylation as a target for recognition of influenza viruses by the innate immune system

Patrick C Reading, Michelle D Tate, Danielle L Pickett, Andrew G Brooks

Journal article  |  2007  |  Advances in Experimental Medicine and Biology

Glycosylation as a target for recognition of influenza viruses by the innate immune system

PC Reading, MD Tate, DL Pickett, AG Brooks

Conference Proceedings  |  2007  |  Advances in Experimental Medicine and Biology

MHC class I allele frequencies in pigtail macaques of diverse origin

Bridget F Pratt, David H O'Connor, Bernard AP Lafont, Joseph L Mankowski, Caroline S Fernandez, Retno Triastuti, Andrew G Brooks, Stephen J Kent, Miranda Z Smith

Journal article  |  2006  |  IMMUNOGENETICS

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Balasubramanian Krishnamurthy, Nadine L Dudek, Mark D McKenzie, Anthony W Purcell, Andrew G Brooks, Shane Gellert, Peter G Colman, Leonard C Harrison, Andrew M Lew, Helen E Thomas, Thomas WH Kay

Journal article  |  2006  |  Journal of Clinical Investigation

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism

Ming-Lee Lin, Yifan Zhan, Stephen L Nutt, Jason Brady, Magdalena Wojtasiak, Andrew G Brooks, Andrew M Lew

Journal article  |  2006  |  Xenotransplantation

A structural perspective on MHC class lb molecules in adaptive immunity

Lucy C Sullivan, Hilary L Hoare, James McCluskey, Jamie Rossjohn, Andrew G Brooks

Journal article  |  2006  |  Trends in Immunology (formerly Immunology Today)

Induction and measurement of cytotoxic T lymphocyte activity.

John Wonderlich, Gene Shearer, Alexandra Livingstone, Andrew Brooks

Journal article  |  2006  |  Current Protocols in Immunology

Cytotoxic T lymphocytes (CTL) kill target cells on the basis of cell-surface antigen recognition and are important in the host res..

NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection

PC Reading, PG Whitney, DP Barr, MJ Smyth, AG Brooks

Journal article  |  2006  |  European Journal of Immunology

The human cytomegalovirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope

M Vales-Gomez, A Winterhalter, P Roda-Navarro, A Zimmermann, L Boyle, H Hengel, A Brooks, HT Reyburn

Journal article  |  2006  |  Cellular Microbiology

CMV-Specific CD8( ) T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation

G Westall, T Kotsimbos, A Brooks

Journal article  |  2006  |  American Journal of Transplantation

Structural basis for a major histocompatibility complex class Ib-restricted T cell response

HL Hoare, LC Sullivan, G Pietra, CS Clements, EJ Lee, LK Ely, T Beddoe, M Falco, L Kjer-Nielsen, HH Reid, J McCluskey, L Moretta, J Rossjohn, AG Brooks

Journal article  |  2006  |  NATURE IMMUNOLOGY

Assays for T cell function. Induction and Measurement of Cytotoxic T Lymphocyte Activity

J Wonderlich, A Livingstone, A BROOKS

Book Chapter  |  2006

T-cell grit: large clonal expansions of virus-specific CD8( ) T cells can dominate in the peripheral circulation for at least 18 years

JJ Miles, SL Silins, AG Brooks, JE Davis, I Misko, SR Burrows

Journal article  |  2005  |  Blood

Recognition of the non-classical MHC class I molecule, HLA-E, by the adaptive immune system

H Hoare, LC Sullivan, G Pietra, C Clements, T Beddoe, E Lee, L Kjer-Nielsen, H Reid, J McCluskey, L Moretta, J Rossjohn, AG Brooks

Conference Proceedings  |  2005  |  Tissue Antigens

Neutrophil recruitment and activation following intranasal infection with different influenza viruses

MD Tate, AG Brooks, PC Reading

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

The role of peptide in the recognition of HLA-E by cytomegalovirus-specific CD8 T cells

LC Sullivan, EJ Lee, T Beddoe, HL Hoare, L Kjer-Nielsen, G Pietra, L Moretta, J Rossjohn, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Soluble MICA and reduced expression of NKG2D in preclinical type-1 diabetics

AC Winterhalter, LC Harrison, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

NK cells mediate control of viral replication in the nerves following HSV-1 flank zosteriform infection

M Wojtasiak, PG Whitney, DP Barr, PC Reading, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Identification of CD4 T cell epitopes important for the recognition of HSV-1 in C57BI/6 mice

SE Flynn, M Wojtasiak, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection

PG Whitney, PC Reading, DP Barr, M Wojtasiak, MJ Smyth, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Plasmacytoid and conventional dendritic cells mediate rapid cytokine-dependent activation of NK cells to herpes simplex virus type 1

DP Barr, PC Reading, M Wojtasiak, PG Whitney, GT Belz, AG Brooks

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

Insights into effective SIV gag-specific CD8 T cell responses and fitness costs of viral escape

MZ Smith, CJ Batten, CS Fernandez, R De Rose, I Stratov, DH O'Connor, D Watkins, J Lin, AG Brooks, MP Davenport, SJ Kent

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells

DG Pellicci, KJL Hammond, J Coquet, K Kyparissoudis, AG Brooks, K Kedzierska, R Keating, S Turner, S Berzins, MJ Smyth, DI Godfrey

Journal article  |  2005  |  Journal of Immunology

The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion

MZ Smith, CS Fernandez, A Chung, CJ Dale, R De Rose, J Lin, AG Brooks, KC Krebs, DI Watkins, DH O'Connor, MP Davenport, SJ Kent

Journal article  |  2005  |  Journal of Medical Primatology

Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface

CS Clements, L Kjer-Nielsen, L Kostenko, HL Hoare, MA Dunstone, E Moses, K Freed, AG Brooks, J Rossjohn, J McCluskey

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes

MZ Smith, CJ Dale, R De Rose, I Stratov, CS Fernandez, AG Brooks, J Weinfurter, K Krebs, C Riek, DI Watkins, DH O'Connor, SJ Kent

Journal article  |  2005  |  Journal of Virology

Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals

M Wojtasiak, CM Jones, LC Sullivan, AC Winterhalter, FR Carbone, AG Brooks

Journal article  |  2004  |  International Immunology

The production and purification of the human T-cell receptors, the CD3 epsilon gamma and CD3 epsilon delta heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

MA Dunstone, LB Kjer-Nielsen, L Kostenko, AW Purcell, AG Brooks, J Rossjohn, J McCluskey

Journal article  |  2004  |  Acta Crystallographica Section D - Biological Crystallography

Natural HLA class 1 polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

D Zernich, AW Purcell, WA Macdonald, L Kjer-Nielsen, LK Ely, N Laham, T Crockford, NA Mifsud, M Bharadwaj, L Chang, BD Tait, R Holdsworth, AG Brooks, SP Bottomley, T Beddoe, CA Peh, J Rossjohn, J McCluskey

Journal article  |  2004  |  JOURNAL OF EXPERIMENTAL MEDICINE

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

GT Belz, CM Smith, L Kleinert, P Reading, A Brooks, K Shortman, FR Carbone, WR Heath

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3

L Kjer-Nielsen, MA Dunstone, L Kostenko, LK Ely, T Beddoe, NA Mifsud, AW Purcell, AG Brooks, J McCluskey, J Rossjohn

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

Impact of natural HLA class I polymorphism and the pathway of antigen presentation

D Zernich, AW Purcell, WA Macdonald, L Kjer-Nielsen, LK Ely, N Laham, T Crockford, A Mifsud, BD Tait, R Holdsworth, AG Brooks, SP Bottomley, T Beddoe, CA Peh, J Rossjohn, J McCluskey

Conference Proceedings  |  2004  |  GENES AND IMMUNITY

The 2.1 angstrom crystal structure of the human T cell receptor CD3E Gamma heterodimer complexed to the therapeutic MAB OKT3

L Kjer-Nielsen, MA Dunstone, L Kostenko, LK Ely, T Beddoe, N Mifsud, AW Purcell, AG Brooks, J Rossjohn, J McCluskey

Conference Proceedings  |  2004  |  GENES AND IMMUNITY

Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands

M Ulbrecht, S Maier, V Hofmeister, CS Falk, AG Brooks, MT McMaster, EH Weiss

Journal article  |  2004  |  Human Immunology

Herpes simplex virus-specific CD8( ) T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation

A van Lint, M Ayers, AG Brooks, RM Coles, WR Heath, FR Carbone

Journal article  |  2004  |  Journal of Immunology

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

L Chang, L Kjer-Nielsen, S Flynn, AG Brooks, SI Mannering, MC Honeyman, LC Harrison, J McCluskey, AW Purcell

Journal article  |  2003  |  Tissue Antigens

Genetic control of NKT cell numbers maps to major diabetes and lupus loci

LM Esteban, T Tsoutsman, MA Jordan, D Roach, LD Poulton, A Brooks, OV Naidenko, S Sidobre, DI Godfrey, AG Baxter

Journal article  |  2003  |  Journal of Immunology

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition

WA Macdonald, AW Purcell, NA Misfud, LK Ely, DS Williams, LN Chang, J Gorman, CS Clements, L Kjer-Nielsen, DM Koelle, SR Burrows, BD Tait, R Holdsworth, AG Brooks, GO Lovrecz, L Lu, J Rossjohn, J McCluskey

Journal article  |  2003  |  JOURNAL OF EXPERIMENTAL MEDICINE

Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide

DG Pellicci, AP Uldrich, K Kyparissoudis, NY Crowe, AG Brooks, KJL Hammond, S Sidobre, M Kronenberg, MJ Smyth, DI Godfrey

Journal article  |  2003  |  European Journal of Immunology

Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes

RM Coles, CM Jones, AG Brooks, PU Cameron, WR Heath, FR Carbone

Journal article  |  2003  |  European Journal of Immunology

A structural basis for the selection of dominant alpha beta T cell receptors in antiviral immunity

L Kjer-Nielsen, CS Clements, AW Purcell, AG Brooks, JC Whisstock, SR Burrows, J McCluskey, J Rossjohn

Journal article  |  2003  |  Immunity

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

CS Clements, L Kjer-Nielsen, WA MacDonald, AG Brooks, AW Purcell, J McCluskey, J Rossjohn

Journal article  |  2002  |  Acta Crystallographica Section D - Biological Crystallography

The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization

L Kjer-Nielsen, CS Clements, AG Brooks, AW Purcell, MR Fontes, J McCluskey, J Rossjohn

Journal article  |  2002  |  Journal of Immunology

The 1.5 angstrom crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

L Kjer-Nielsen, CS Clements, AG Brooks, AW Purcell, J McCluskey, J Rossjohn

Journal article  |  2002  |  STRUCTURE

The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance

Lars Kjer-Nielsen, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2002  |  Structure

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.

Lars Kjer-Nielsen, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2002  |  Structure

Despite a potential repertoire of >10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a l..

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim

GM Davey, C Kurts, JFAP Miller, P Bouillet, A Strasser, AG Brooks, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex

W Macdonald, DS Williams, CS Clements, JJ Gorman, L Kjer-Nielsen, AG Brooks, J McCluskey, J Rossjohn, AW Purcell

Journal article  |  2002  |  FEBS Letters

Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal

J Kabat, F Borrego, A Brooks, JE Coligan

Journal article  |  2002  |  The Journal of Immunology

The human NKG2A chain of the CD94/NKG2A receptor contains two immunoreceptor Tyr-based inhibitory motifs (ITIMs) in its cytoplasmi..

Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1

RM Coles, SN Mueller, WR Heath, FR Carbone, AG Brooks

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

Prime-boost immunization generates a high frequency, high-avidity CD8( ) cytotoxic T lymphocyte population

MJ Estcourt, AJ Ramsay, A Brooks, SA Thomson, CJ Medveckzy, IA Ramshaw

Journal article  |  2002  |  International Immunology

Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3

S Radaev, B Rostro, AG Brooks, M Colonna, PD Sun

Journal article  |  2001  |  IMMUNITY

Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules

JC Boyington, AG Brooks, PD Sun

Journal article  |  2001  |  Immunological Reviews

Analysis of the role that each NKG2A ITIM motif plays in CD94/NKG2A signal initiation

J Kabat, A Brooks, F Borrego, PP Posh, DK Kim, R Valas, JE Coligan

Journal article  |  2001  |  FASEB JOURNAL

Peptide-MHC class I tetrameric complexes display exquisite ligand specificity

SR Burrows, N Kienzle, A Winterhalter, M Bharadwaj, JD Altman, A Brooks

Journal article  |  2000  |  The Journal of Immunology

Crystal structure of the exctracellular domain of a human Fc gamma RIII

YH Zhang, CC Boesen, S Radaev, AG Brooks, WH Fridman, C Sautes-Fridman, PD Sun

Journal article  |  2000  |  Immunity

Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells

N Kienzle, M Buck, SL Silins, SR Burrows, DJ Moss, A Winterhalter, A Brooks, R Khanna

Journal article  |  2000  |  The Journal of Immunology

The activation of CTLs is dependent on the recognition of MHC-bound peptide present on the surface of APCs. We give evidence in th..

Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand

JC Boyington, SA Motyka, P Schuck, AG Brooks, PD Sun

Journal article  |  2000  |  Nature

Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1

ME Wallace, M Bryden, SC Cose, RM Coles, TN Schumacher, A Brooks, FR Carbone

Journal article  |  2000  |  Immunity

The enormous diversity of the T cell pool makes it difficult to determine whether inherent biases in the naive TCR repertoire can ..

Reconstitution of bacterial expressed human CD94: The importance of the stem region for dimer formation

JC Boyington, AN Raiz, AG Brooks, A Patamawenu, PD Sun

Journal article  |  2000  |  Protein Expression and Purification

Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection

CM Jones, SC Cose, RM Coles, AC Winterhalter, AG Brooks, WR Heath, FR Carbone

Journal article  |  2000  |  Journal of Virology

Aberrant development of thymocytes in mice lacking laminin-2.

WJ Magner, AC Chang, J Owens, MJ Hong, A Brooks, JE Coligan

Journal article  |  2000  |  Developmental Immunology

In previous in vitro studies, we proposed a role for the extracellular matrix component, laminin-2, and its integrin receptor, VLA..

Natural killer cell recognition of HLA class I molecules.

AG Brooks, JC Boyington, PD Sun

Journal article  |  2000  |  Reviews in Immunogenetics

Human NK cells express multiple receptors that interact with HLA class I molecules. These receptors belong to one of two major pro..

Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers

JP Zou, LA Morford, C Chougnet, AR Dix, AG Brooks, N Torres, JD Shuman, JE Coligan, WH Brooks, TL Roszman, GM Shearer

Journal article  |  1999  |  Journal of Immunology

Patients with gliomas exhibit deficient in vitro and in vivo T cell immune activity, and human glioblastoma culture supernatants (..

Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2

GA Snyder, AG Brooks, PD Sun

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors

JC Boyington, AN Riaz, A Patamawenu, JE Coligan, AG Brooks, PD Sun

Journal article  |  1999  |  Immunity

The crystal structure of the extracellular domain of CD94, a component of the CD94/NKG2 NK cell receptor, has been determined to 2..

Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells

AG Brooks, F Borrego, PE Posch, A Patamawenu, CJ Scorzelli, M Ulbrecht, EH Weiss, JE Coligan

Journal article  |  1999  |  Journal of Immunology

The CD94/NKG2 receptors expressed by subpopulations of NK cells and T cells have been implicated as receptors for a broad range of..

HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors

PE Posch, F Borrego, AG Brooks, JE Coligan

Journal article  |  1998  |  Journal of Biomedical Science

Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis

F Borrego, M Ulbrecht, EH Weiss, JE Coligan, AG Brooks

Journal article  |  1998  |  Journal of Experimental Medicine

Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in mo..

HLA-E Is the Ligand for the Natural Killer Cell CD94/NKG2 Receptors

Phillip E Posch, Francisco Borrego, Andrew G Brooks, John E Coligan

Journal article  |  1998  |  Journal of Biomedical Science

Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis

F Zappacosta, F Borrego, AG Brooks, KC Parker, JE Coligan

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

HLA class I molecules bind peptides derived from proteins degraded in the cytoplasm and display them for surveillance by the immun..

NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor

AG Brooks, PE Posch, CJ Scorzelli, F Borrego, JE Coligan

Journal article  |  1997  |  Journal of Experimental Medicine

CD94 is a C-type lectin expressed by natural killer (NK) cells and a subset of T cells. Blocking studies using anti-CD94 mAbs have..

Antigen processing and presentation by a murine myoblast cell line

MJ Garlepp, W Chen, H Tabarias, M Baines, A Brooks, J McCluskey

Journal article  |  1995  |  Clinical & Experimental Immunology

PEPTIDE BINDING TO MHC CLASS-I MOLECULES - IMPLICATIONS FOR ANTIGENIC PEPTIDE PREDICTION

KC PARKER, M SHIELDS, M DIBRINO, JE COLIGAN

Journal article  |  1995  |  Immunologic Research

The human mayor histocompatibility complex class I molecule HLA-A2 preferentially binds peptides that contain Leu at P2 and Val or..

ANTIGEN PRESENTATION AND ASSEMBLY BY MOUSE I-A(K) CLASS-II MOLECULES IN HUMAN APC CONTAINING DELETED OR MUTATED HLA DM GENES

AG BROOKS, PL CAMPBELL, P REYNOLDS, AM GAUTAM, J MCCLUSKEY

Journal article  |  1994  |  Journal of Immunology

Effects of IL-4 depletion on the antibody response to Pseudomonas aeruginosa lipopolysaccharide in mice.

MB Fauntleroy, R Asofsky, PJ Baker, T Hraba, A Brooks, P Stashak, CE Taylor

Journal article  |  1993  |  Immunobiology

These studies were done to examine the role of interleukin-4 (IL-4) in the generation of isotype specific antibody responses of mi..

CLASS-II-RESTRICTED PRESENTATION OF A HEN EGG LYSOZYME DETERMINANT DERIVED FROM ENDOGENOUS ANTIGEN SEQUESTERED IN THE CYTOPLASM OR ENDOPLASMIC-RETICULUM OF THE ANTIGEN PRESENTING CELLS

AG BROOKS, J MCCLUSKEY

Journal article  |  1993  |  Journal of Immunology

CLASS-II-RESTRICTED PRESENTATION OF AN ENDOGENOUSLY DERIVED IMMUNODOMINANT T-CELL DETERMINANT OF HEN EGG LYSOZYME

A BROOKS, S HARTLEY, L KJERNIELSEN, J PERERA, CC GOODNOW, A BASTEN, J MCCLUSKEY

Journal article  |  1991  |  Proceedings of the National Academy of Sciences

Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.

CE Taylor, PW Stashak, G Caldes, B Prescott, TE Chused, A Brooks, PJ Baker

Journal article  |  1983  |  The Journal of Experimental Medicine

The transfer of B lymphocytes from mice immunized with type III pneumococcal polysaccharide (SSS-III) results in antigen-specific ..