Ross Bathgate

The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.

Fariha Alam, Tracey A Gaspari, Barbara K Kemp-Harper, Edward Low, Aaron Aw, Dorota Ferens, Iresha Spizzo, Ann-Maree Jefferis, Praveen Praveen, Robert E Widdop, Ross AD Bathgate, Mohammed Akhter Hossain, Chrishan S Samuel

Journal article  |  2023  |  Biomed Pharmacother

The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and ..

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1)

Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A Robson, Ross AD Bathgate, Daniel J Scott, Paul R Gooley, Joshua J Ziarek

Journal article  |  2023  |  CELL REPORTS

Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allos..

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).

Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Jiahui Yan, Yibing Wang, Qi Zhu, Fenghui Zhao, Chenghao Li, Chuan-Wei Chen, Xiaoqing Cai, Ross AD Bathgate, Chun Shen, H Eric Xu, Dehua Yang, Hong Liu, Ming-Wei Wang

Journal article  |  2023  |  Nat Commun

Members of the insulin superfamily regulate pleiotropic biological processes through two types of target-specific but structurally..

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.

Stephane Illiano, Bruno Poirier, Claire Minoletti, Olivier Pasquier, Laurence Riva, Xavier Chenede, Isabelle Menguy, Michel Guillotel, Philippe Prigent, Stéphane Le Claire, Florence Gillot, Gilbert Thill, François Lo Presti, Alain Corbier, Jean-Christophe Le Bail, Patrick Grailhe, Edith Monteagudo, Raffaele Ingenito, Elisabetta Bianchi, Christophe Philippo, et al.

Journal article  |  2022  |  Sci Rep

Despite beneficial effects in acute heart failure, the full therapeutic potential of recombinant relaxin-2 has been hampered by it..

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design

Annunziata D'Ercole, Silvia Nistri, Lorenzo Pacini, Alfonso Carotenuto, Federica Santoro, Anna Maria Papini, Ross AD Bathgate, Daniele Bani, Paolo Rovero

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a card..

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross AD Bathgate

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The mo..

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

Guangyao Lin, Yang Feng, Xiaoqing Cai, Caihong Zhou, Lijun Shao, Yan Chen, Linhai Chen, Qing Liu, Qingtong Zhou, Ross AD Bathgate, Dehua Yang, Ming-Wei Wang

Journal article  |  2021  |  MOLECULES

Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogen..

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

Stephen PH Alexander, Arthur Christopoulos, Anthony P Davenport, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Maria Pia Abbracchio, Wayne Alexander, Khaled Al-hosaini, Magnus Baeck, Nicholas M Barnes, Ross Bathgate, Jean-Martin Beaulieu, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise..

Spawning induction of the high-value white teatfish sea cucumber, Holothuria fuscogilva, using recombinant relaxin-like gonad stimulating peptide (RGP)

Josephine Nocillado, Nguyen Dinh Quang Duy, Hoang Dinh Chieu, Luke Turner, Ross AD Bathgate, Tianfang Wang, Mohammed Akhter Hossain, Nguyen Van Hung, Nguyen Huu Ninh, Scott F Cummins, Abigail Elizur

Journal article  |  2021  |  AQUACULTURE

We have previously shown in Holothuria leucospilota the maturation-inducing role of the neurohormone relaxin-like gonad-stimulatin..

Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2

Ashish Sethi, Shoni Bruell, Tim Ryan, Fei Yan, Mohammad Hossein Tanipour, Yee-Foong Mok, Chris Draper-Joyce, Yogesh Khandokar, Riley D Metcalfe, Michael DW Griffin, Daniel J Scott, Mohammad Akhter Hossain, Emma J Petrie, Ross AD Bathgate, Paul R Gooley

Journal article  |  2021  |  JOURNAL OF MOLECULAR BIOLOGY

Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 an..