Ruwan Epa

Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma, Palika Abayakoon, Ruwan Epa, Yi Jin, James P Lingford, Tomohiro Shimada, Masahiro Nakano, Janice W-Y Mui, Akira Ishihama, Ethan D Goddard-Borger, Gideon J Davies, Spencer J Williams

Journal article  |  2021  |  ACS CENTRAL SCIENCE

The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on Earth and is metabolized by bacteria..

A Sulfoglycolytic Entner-Doudoroff Pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li, Ruwan Epa, Nichollas E Scott, Dominik Skoneczny, Mahima Sharma, Alexander JD Snow, James P Lingford, Ethan D Goddard-Borger, Gideon J Davies, Malcolm J McConville, Spencer J Williams

Journal article  |  2020  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Rhizobia are nitrogen-fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as free-living ..

Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase

Mahima Sharma, Palika Abayakoon, James P Lingford, Ruwan Epa, Alan John, Yi Jin, Ethan D Goddard-Borger, Gideon J Davies, Spencer J Williams

Journal article  |  2020  |  ACS CATALYSIS

2,3-Dihydroxypropanesulfonate (DHPS) is a major sulfur species in the biosphere. One important route for the production of DHPS is..

Comprehensive Synthesis of Substrates, Intermediates, and Products of the Sulfoglycolytic Embden-Meyerhoff-Parnas Pathway

Palika Abayakoon, Ruwan Epa, Marija Petricevic, Christopher Bengt, Janice W-Y Mui, Phillip L van der Peet, Yunyang Zhang, James P Lingford, Jonathan M White, Ethan D Goddard-Borger, Spencer J Williams

Journal article  |  2019  |  JOURNAL OF ORGANIC CHEMISTRY

Sulfoglycolysis is a metabolic pathway dedicated to the catabolism of the sulfosugar sulfoquinovose (SQ) into smaller organosulfur..

Synthesis and Structural Investigation of Some Electron-Rich Nitroaromatics

Jonathan M White, Colin E Skene, John Deadman, Ruwan Epa, Sarah Foenander, Kyle Hamer, Thomas Fellowes, Shea Fern Lim, Sebastian M Marcuccio, Roger F Martin

Journal article  |  2019  |  AUSTRALIAN JOURNAL OF CHEMISTRY

2,4-Difluoro-, 2,4,6-Trifluoro-, and 2,3,4,6,tetrafluoronitrobenzenes undergo nucleophilic aromatic substitution, once, twice, and..

Improved Hiyama cross-coupling reactions using HOMSi®

SM Marcuccio, R Epa, M Moslmani, AB Hughes

Journal article  |  2011  |  Tetrahedron Letters

Various parameters in the Hiyama cross-coupling reaction of HOMSi® reagents with ethyl bromobenzoate were studied. These included ..

A New Process for Synthesis of Apricitabine, 2-(R)-Hydroxymethyl-4-(R)-(cytosin-1 '-yl)-1,3-oxathiolane, an Anti-HIV NRTI

Sebastian M Marcuccio, Ruwan Epa, Jonathan M White, John J Deadman

Journal article  |  2011  |  ORGANIC PROCESS RESEARCH & DEVELOPMENT

Apricitabine is a novel inhibitor of the HIV virus reverse transcriptase polymerase which is currently in clinical development for..

The p75 neurotrophin receptor enhances TrkA signalling by binding to Shc and augmenting its phosphorylation

WR Epa, K Markovska, GL Barrett

Journal article  |  2004  |  JOURNAL OF NEUROCHEMISTRY

Nerve growth factor (NGF) is an important neuronal survival factor, especially during development. Optimal sensitivity of the surv..

Interactions between fibroblast growth factors and Notch regulate neuronal differentiation

CH Faux, AM Turnley, R Epa, R Cappai, PF Bartlett

Journal article  |  2001  |  JOURNAL OF NEUROSCIENCE

The differentiation of precursor cells into neurons has been shown to be influenced by both the Notch signaling pathway and growth..

Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons

KS Lowry, SS Murray, EJ Coulson, R Epa, PF Bartlett, G Barrett, SS Cheema

Journal article  |  2001  |  JOURNAL OF NEUROSCIENCE RESEARCH

The 75 kD low-affinity neurotrophin receptor (p75(NTR)) is expressed in developing and axotomised spinal motor neurons. There is n..