Pasi Korhonen

Genome-wide exploration reveals distinctive northern and southern variants of Clonorchis sinensis in the Far East

Liina Kinkar, Pasi K Korhonen, Urmas Saarma, Tao Wang, Xing-Quan Zhu, Ivon Harliwong, Bicheng Yang, J Lynn Fink, Daxi Wang, Bill CH Chang, Galina N Chelomina, Anson V Koehler, Neil D Young, Robin B Gasser

Journal article  |  2023  |  MOLECULAR ECOLOGY RESOURCES

Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis-a neglected tropical disease (NTD) affecting ~35 milli..

The redlegged earth mite draft genome provides new insights into pesticide resistance evolution and demography in its invasive Australian range

Joshua A Thia, Pasi K Korhonen, Neil D Young, Robin B Gasser, Paul A Umina, Qiong Yang, Owain Edwards, Tom Walsh, Ary A Hoffmann

Journal article  |  2022  |  JOURNAL OF EVOLUTIONARY BIOLOGY

Genomic data provide valuable insights into pest management issues such as resistance evolution, historical patterns of pest invas..

Proteomic analysis of Sarcoptes scabiei reveals that proteins differentially expressed between eggs and female adult stages are involved predominantly in genetic information processing, metabolism and/or host-parasite interactions

Tao A Wang, Robin Gasser, Pasi R Korhonen, Neil D Young, Ching-Seng Ang, Nicholas Williamson, Guangxu Ma, Gangi Samarawickrama, Deepani Fernando, Katja Fischer

Journal article  |  2022  |  PLOS NEGLECTED TROPICAL DISEASES

Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a hig..

Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

Aya CC Taki, Tao Wang, Nghi NN Nguyen, Ching-Seng Ang, Michael GG Leeming, Shuai Nie, Joseph JJ Byrne, Neil DD Young, Yuanting Zheng, Guangxu Ma, Pasi KK Korhonen, Anson VV Koehler, Nicholas AA Williamson, Andreas Hofmann, Bill CH Chang, Cecile Haeberli, Jennifer Keiser, Abdul Jabbar, Brad EE Sleebs, Robin BB Gasser

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. T..

Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control

Pasi K Korhonen, Tao Wang, Neil D Young, Gangi R Samarawickrama, Deepani D Fernando, Guangxu Ma, Robin B Gasser, Katja Fischer

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Here, we explored transcriptomic differences among early egg (Ee), late egg (Le) and adult female (Af) stages of the scabies mite,..

Chromosome-scale Echinococcus granulosus (genotype G1) genome reveals the Eg95 gene family and conservation of the EG95-vaccine molecule

Pasi K Korhonen, Liina Kinkar, Neil D Young, Huimin Cai, Marshall W Lightowlers, Charles Gauci, Abdul Jabbar, Bill CH Chang, Tao Wang, Andreas Hofmann, Anson Koehler, Junhua Li, Jiandong Li, Daxi Wang, Jiefang Yin, Huanming Yang, David J Jenkins, Urmas Saarma, Teivi Laurimae, Mohammad Rostami-Nejad, et al.

Journal article  |  2022  |  COMMUNICATIONS BIOLOGY

Cystic echinococcosis is a socioeconomically important parasitic disease caused by the larval stage of the canid tapeworm Echinoco..

"Escalibur"-A practical pipeline for the de novo analysis of nucleotide variation in nonmodel eukaryotes

Pasi K Korhonen, Babak Shaban, Noel G Faux, Liina Kinkar, Bill CH Chang, Daxi Wang, Bicheng Yang, Neil D Young, Robin B Gasser

Journal article  |  2022  |  MOLECULAR ECOLOGY RESOURCES

The revolution in genomics has enabled large-scale population genetic investigations of a wide range of organisms, but there has b..

Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium

Neil D Young, Andreas J Stroehlein, Tao Wang, Pasi K Korhonen, Margaret Mentink-Kane, J Russell Stothard, David Rollinson, Robin B Gasser

Journal article  |  2022  |  NATURE COMMUNICATIONS

Some snails act as intermediate hosts (vectors) for parasitic flatworms (flukes) that cause neglected tropical diseases, such as s..

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

Andreas J Stroehlein, Pasi K Korhonen, V Vern Lee, Stuart A Ralph, Margaret Mentink-Kane, Hong You, Donald P McManus, Louis-Albert Tchuem Tchuente, J Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M Emery, Bonnie L Webster, Paul J Brindley, David Rollinson, Bill CH Chang, Robin B Gasser, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases..

Harnessing model organism genomics to underpin the machine learning-based prediction of essential genes in eukaryotes-Biotechnological implications

Tulio L Campos, Pasi K Korhonen, Andreas Hofmann, Robin B Gasser, Neil D Young

Journal article  |  2022  |  BIOTECHNOLOGY ADVANCES

The availability of high-quality genomes and advances in functional genomics have enabled large-scale studies of essential genes i..