Kaylene Simpson

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma.

Jovana R Gotovac, David SH Liu, Michael J Yates, Julia V Milne, Arthi A Macpherson, Kaylene J Simpson, Guy D Eslick, Catherine Mitchell, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2020  |  The Journal of Pathology

Efficacious therapeutic approaches are urgently needed to improve outcomes in patients with oesophageal adenocarcinoma (OAC). Howe..

Requirement for cleavage factor IIm in the control of alternative polyadenylation in breast cancer cells

Rachael E Turner, Lee M Henneken, Marije Liem-Weits, Paul F Harrison, Angavai Swaminathan, Robert Vary, Iva Nikolic, Kaylene J Simpson, David R Powell, Traude H Beilharz, Bernhard Dichtl

Journal article  |  2020  |  RNA

Alternative polyadenylation (APA) determines stability, localization and translation potential of the majority of mRNA in eukaryot..

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells.

Vuk Bortnik, Michelle Wu, Bryan Julcher, Ana Salinas, Iva Nikolic, Kaylene J Simpson, Nigel Aj McMillan, Adi Idris

Journal article  |  2020  |  Journal of Microbiology, Immunology and Infection

Human papilloma viruses (HPV) are the main culprit in cervical and oropharyngeal cancers. HPV positive (+) cancers are regarded as..

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer

Laura A Baker, Holly Holliday, Daniel Roden, Christoph Krisp, Sunny Z Wu, Simon Junankar, Aurelien A Serandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan, Andrew MK Law, Andrea McFarland, Peter T Simpson, Sunil Lakhani, Eoin Dodson, Christina Selinger, Lyndal Anderson, Goli Samimi, Neville F Hacker, Elgene Lim, et al.

Journal article  |  2020  |  Breast Cancer Research

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

Michael F Sharp, Vince J Murphy, Sylvie Van Twest, Winnie Tan, Jennii Lui, Kaylene J Simpson, Andrew J Deans, Wayne Crismani

Journal article  |  2020  |  Scientific Reports

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription...

Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Ekaterina Ivanova, Pamela M Pollock, Shivashankar H Nagaraj, Adrian P Wiegmans, Izhak Haviv, Kaylene J Simpson, Erik W Thompson

Journal article  |  2020  |  Cancers

BACKGROUND: Breast cancer (BC) is a heterogeneous disease for which the commonly used chemotherapeutic agents primarily include th..

Lysosomal degradation products induce Coxiella burnetii virulence

Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death and Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

FGFR3 signaling and function in triple negative breast cancer

Nicole J Chew, Elizabeth V Nguyen, Shih-Ping Su, Karel Novy, Howard C Chan, Lan K Nguyen, Jennii Luu, Kaylene J Simpson, Rachel S Lee, Roger J Daly

Journal article  |  2020  |  Cell Communication and Signaling

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S Lee, Samuel J Rodgers, Fuyi Li, Cheng Huang, Ralf B Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K Brown, Christina A Mitchell, Kaylene J Simpson, Roger J Daly

Journal article  |  2019  |  Nature Communications

Society of Biomolecular Imaging and Informatics Special Issue

Myles Fennell, Kaylene J Simpson

Journal article  |  2019  |  ASSAY and Drug Development Technologies

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, Nadine Hein, Jun Chen, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, Thomas John Gonda, Richard B Pearson, Johan Flygare, Katherine M Hannan, Amee J George, Ross Hannan

Conference Proceedings  |  2018  |  Blood

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Cuiping Xia, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane JF Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Journal article  |  2018  |  PLOS Genetics

Society of Biomolecular Imaging and Informatics Special Issue

Myles Fennell, Kaylene J Simpson

Journal article  |  2018  |  ASSAY and Drug Development Technologies

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips

Journal article  |  2018  |  Cancer Discovery

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer

Hui-Ming Lin, Iva Nikolic, Jessica Yang, Lesley Castillo, Niantao Deng, Chia-Ling Chan, Nicole K Yeung, Eoin Dodson, Benjamin Elsworth, Calan Spielman, Brian Y Lee, Zoe Boyer, Kaylene J Simpson, Roger J Daly, Lisa G Horvath, Alexander Swarbrick

Journal article  |  2018  |  Scientific Reports

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer

Hui-Ming Lin, Iva Nikolic, Jessica Yang, Lesley Castillo, Niantao Deng, Chia-Ling Chan, Nicole Yeung, Eoin Dodson, Benjamin Elsworth, Calan Spielman, Brian Lee, Zoe Boyer, Kaylene Simpson, Roger Daly, Lisa Horvath, Alexander Swarbrick

Journal article  |  2018

Abstract Docetaxel and cabazitaxel are taxane chemotherapy treatments for metastatic castration-resistant prostate cancer (CRPC). ..

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens

Leonie A Cluse, Iva Nikolic, Deborah Knight, Piyush B Madhamshettiwar, Jennii Luu, Karla J Cowley, Timothy Semple, Gisela Mir Arnau, Jake Shortt, Ricky W Johnstone, Kaylene J Simpson

Book Chapter  |  2018  |  Methods in Molecular Biology

Discovering cancer vulnerabilities using high-throughput micro-RNA screening

Iva Nikolic, Benjamin Elsworth, Eoin Dodson, Sunny Z Wu, Cathryn M Gould, Pieter Mestdagh, Glenn M Marshall, Lisa G Horvath, Kaylene J Simpson, Alexander Swarbrick

Journal article  |  2017  |  Nucleic Acids Research

Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

Sarah Preston, Yaqing Jiao, Jonathan B Baell, Jennifer Keiser, Simon Crawford, Anson V Koehler, Tao Wang, Moana M Simpson, Ray M Kaplan, Karla J Cowley, Kaylene J Simpson, Andreas Hofmann, Abdul Jabbar, Robin B Gasser

Journal article  |  2017  |  International Journal for Parasitology: Drugs and Drug Resistance

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4

William G Darby, Megan S Grace, Kaylene J Simpson, Owen L Woodman, Peter McIntyre

Journal article  |  2017  |  ASSAY and Drug Development Technologies

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

J Manent, S Banerjee, R de Matos Simoes, T Zoranovic, C Mitsiades, JM Penninger, KJ Simpson, PO Humbert, HE Richardson

Journal article  |  2017  |  Oncogene

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.

Journal article  |  2017  |  Science Signaling

Society of Biomolecular Imaging and Informatics Special Issue

Myles Fennell, Kaylene J Simpson

Journal article  |  2017  |  ASSAY and Drug Development Technologies

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

Yaqing Jiao, Sarah Preston, Anson V Koehler, Andreas J Stroehlein, Bill CH Chang, Kaylene J Simpson, Karla J Cowley, Michael J Palmer, Benoit Laleu, Timothy NC Wells, Abdul Jabbar, Robin B Gasser

Journal article  |  2017  |  PARASITES & VECTORS

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  Cell Death & Differentiation

Signalome-wide assessment of host cell response to hepatitis C virus

Gholamreza Haqshenas, Jianmin Wu, Kaylene J Simpson, Roger J Daly, Hans J Netter, Thomas F Baumert, Christian Doerig

Journal article  |  2017  |  Nature Communications

A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson

Conference Proceedings  |  2017  |  Synthetic Lethality and Viability

Knocking down the obstacles to functional genomics data sharing

Kaylene J Simpson, Jennifer A Smith

Journal article  |  2017  |  Scientific Data

Data Descriptor: Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology

Steven P Williams, Cathryn M Gould, Cameron J Nowell, Tara Karnezis, Marc G Achen, Kaylene J Simpson, Steven A Stacker

Journal article  |  2017  |  Scientific Data

SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium

Ann F Hoffman, Kaylene J Simpson, Peter Horvath, Carrie Lovitt, Serena Silver, Evan Easton, Daniel V LaBarbera, Melissa Mendez, Mark E Rothenberg, Jan Seldin, Judi Wardwell-Swanson, Myles Fennell

Journal article  |  2017  |  ASSAY and Drug Development Technologies

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour

Rasika Kumarasingha, Avinash V Karpe, Sarah Preston, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Jennii Luu, Kaylene J Simpson, Jillian M Shaw, Robin B Gasser, David J Beale, Paul D Morrison, Enzo A Palombo, Peter R Boag

Journal article  |  2016  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Society of Biomolecular Imaging and Informatics Special Issue, October 2016

Myles Fennell, Kaylene J Simpson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization

Lorey K Smith, Daniel W Thomas, Kaylene J Simpson, Patrick O Humbert

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion

Chwan Hong Foo, Christina L Rootes, Karla Cowley, Glenn A Marsh, Cathryn M Gould, Celine Deffrasnes, Christopher J Cowled, Reuben Klein, Sarah J Riddell, Deborah Middleton, Kaylene J Simpson, Lin-Fa Wang, Andrew GD Bean, Cameron R Stewart

Journal article  |  2016  |  PLOS Pathogens

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence

Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Society of Biomolecular Imaging and Informatics Special Issue

Myles Fennell, Kaylene J Simpson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Interview with Kaylene Simpson, PhD

Andrew D Napper, Kaylene Simpson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

KJ Falkenberg, A Newbold, CM Gould, J Luu, JA Trapani, GM Matthews, KJ Simpson, RW Johnstone

Journal article  |  2016  |  Cell Death & Differentiation

Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation

Nicholas S Eyre, Rachel J Hampton-Smith, Amanda L Aloia, James S Eddes, Kaylene J Simpson, Peter Hoffmann, Michael R Beard

Journal article  |  2016  |  Virology

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection

Celine Deffrasnes, Glenn A Marsh, Chwan Hong Foo, Christina L Rootes, Cathryn M Gould, Julian Grusovin, Paul Monaghan, Michael K Lo, S Mark Tompkins, Timothy E Adams, John W Lowenthal, Kaylene J Simpson, Cameron R Stewart, Andrew GD Bean, Lin-Fa Wang

Journal article  |  2016  |  PLOS PATHOGENS

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

Bhaskar Dutta, Alaleh Azhir, Louis-Henri Merino, Yongjian Guo, Swetha Revanur, Piyush B Madhamshettiwar, Ronald N Germain, Jennifer A Smith, Kaylene J Simpson, Scott E Martin, Eugen Beuhler, Iain DC Fraser

Journal article  |  2016  |  Nature Communications

Colloquium: SBI2 HCS/HCA Informatics and Data Analysis - Best Practices and Unmet Needs September 15, 2015

Douglas Bowman, Myles Fennell, Kaylene J Simpson

Journal article  |  2015  |  ASSAY and Drug Development Technologies

Society of Biomolecular Imaging and Informatics Special Issue, November 2015

Myles Fennell, Kaylene J Simpson

Journal article  |  2015  |  ASSAY and Drug Development Technologies

Society of Biomolecular Imaging and Informatics Special Issue

Myles Fennell, Kaylene J Simpson

Journal article  |  2015  |  ASSAY and Drug Development Technologies

High-Content Assay for Measuring Intracellular Growth of Leishmania in Human Macrophages

Michael J Dagley, Eleanor C Saunders, Kaylene J Simpson, Malcolm J McConville

Journal article  |  2015  |  ASSAY and Drug Development Technologies

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley

Journal article  |  2015  |  Clinical Cancer Research

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Sally J Davis, Karen E Sheppard, Michael S Anglesio, Joshy George, Nadia Traficante, Sian Fereday, Maria P Intermaggio, Usha Menon, Aleksandra Gentry-Maharaj, Jan Lubinski, Jacek Gronwald, Celeste Leigh Pearce, Malcolm C Pike, Anna Wu, Stefan Kommoss, Jacobus Pfisterer, Andreas du Bois, Felix Hilpert, Susan J Ramus, David DL Bowtell, et al.

Journal article  |  2015  |  MOLECULAR CANCER THERAPEUTICS

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin-Deficient Cells

Bryony J Telford, Augustine Chen, Henry Beetham, James Frick, Tom P Brew, Cathryn M Gould, Andrew Single, Tanis Godwin, Kaylene J Simpson, Parry Guilford

Journal article  |  2015  |  Molecular Cancer Therapeutics

Whole-Genome Multiparametric Screening to Identify Modulators of Epithelial-to-Mesenchymal Transition

Nur Akmarina BM Said, Cathryn M Gould, Kurt Lackovic, Kaylene J Simpson, Elizabeth D Williams

Journal article  |  2014  |  ASSAY and Drug Development Technologies

A high-throughput, multiplex cell death assay using an RNAi screening approach.

Katrina J Falkenberg, Darren N Saunders, Kaylene J Simpson

Journal article  |  2014  |  Cold Spring Harbor Protocols

This protocol outlines a high-throughput, multiplex cell death assay and its use in conjunction with a genome-scale siRNA screen t..

High-throughput approaches to measuring cell death.

Darren N Saunders, Katrina J Falkenberg, Kaylene J Simpson

Journal article  |  2014  |  Cold Spring Harbor Protocols

Cell death is integral to developmental and disease processes, and high-throughput screening (HTS) has been instrumental both for ..

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

D Brasacchio, T Noori, C House, AJ Brennan, KJ Simpson, O Susanto, PI Bird, RW Johnstone, JA Trapani

Journal article  |  2014  |  Cell Death & Differentiation

Functional Genomics Down Under: RNAi Screening in the Victorian Centre for Functional Genomics

Daniel W Thomas, Cathryn M Gould, Yanny Handoko, Kaylene J Simpson

Journal article  |  2014  |  Combinatorial Chemistry & High Throughput Screening

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

Katrina J Falkenberg, Cathryn M Gould, Ricky W Johnstone, Kaylene J Simpson

Journal article  |  2014  |  Scientific Data

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

Amee J George, Brooke W Purdue, Cathryn M Gould, Daniel W Thomas, Yanny Handoko, Hongwei Qian, Gregory A Quaife-Ryan, Kylie A Morgan, Kaylene J Simpson, Walter G Thomas, Ross D Hannan

Journal article  |  2013  |  JOURNAL OF CELL SCIENCE

Synthetic lethality between CCNE1 amplification and loss of BRCA1

Dariush Etemadmoghadam, Barbara A Weir, George Au-Yeung, Kathryn Alsop, Gillian Mitchell, Joshy George, Sally Davis, Alan D D'Andrea, Kaylene Simpson, William C Hahn, David DL Bowtell

Journal article  |  2013  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer

Sally J Davis, Karen E Sheppard, Richard B Pearson, Ian G Campbell, Kylie L Gorringe, Kaylene J Simpson

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

Strategies and Challenges for Systematically Mapping Biologically Significant Molecular Pathways Regulating Carcinoma Epithelial-Mesenchymal Transition

Nur Akmarina BM Said, Kaylene J Simpson, Elizabeth D Williams

Journal article  |  2013  |  Cells Tissues Organs

Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

Ghassan Mouneimne, Scott D Hansen, Laura M Selfors, Lara Petrak, Michele M Hickey, Lisa L Gallegos, Kaylene J Simpson, James Lim, Frank B Gertler, John H Hartwig, R Dyche Mullins, Joan S Brugge

Journal article  |  2012  |  Cancer Cell

Optimized PCR Conditions and Increased shRNA Fold Representation Improve Reproducibility of Pooled shRNA Screens

Zaklina Strezoska, Abel Licon, Josh Haimes, Katie Jansen Spayd, Kruti M Patel, Kevin Sullivan, Katarzyna Jastrzebski, Kaylene J Simpson, Devin Leake, Anja van Brabant Smith, Annaleen Vermeulen

Journal article  |  2012  |  PLoS One

Comparative high-throughput RNAi screening methodologies in C-elegans and mammalian cells

Kaylene J Simpson, Gregory M Davis, Peter R Boag

Journal article  |  2012  |  New Biotechnology

Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

Victoria A Meliopoulos, Lauren E Andersen, Katherine F Birrer, Kaylene J Simpson, John W Lowenthal, Andrew GD Bean, John Stambas, Cameron R Stewart, S Mark Tompkins, Victor W van Beusechem, Iain Fraser, Musa Mhlanga, Samantha Barichievy, Queta Smith, Devin Leake, Jon Karpilow, Amy Buck, Ghil Jona, Ralph A Tripp

Journal article  |  2012  |  FASEB Journal

Psidin, a conserved protein that regulates protrusion dynamics and cell migration

Ji Hoon Kim, Aeri Cho, Hongyan Yin, Dorothy A Schafer, Ghassan Mouneimne, Kaylene J Simpson, Kim-Vy Nguyen, Joan S Brugge, Denise J Montell

Journal article  |  2011  |  Genes & Development

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown

Journal article  |  2011  |  Oncogene

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

Peter Storz, Heike Doeppler, John A Copland, Kaylene J Simpson, Alex Toker

Journal article  |  2009  |  Molecular and Cellular Biology

Posttranscriptional Regulation of the Breast Cancer Susceptibility Gene BRCA1 by the RNA Binding Protein HuR

Jodi M Saunus, Juliet D French, Stacey L Edwards, Dianne J Beveridge, Esme C Hatchell, Sarah A Wagner, Sandra R Stein, Andrew Davidson, Kaylene J Simpson, Glenn D Francis, Peter J Leedman, Melissa A Brown

Journal article  |  2008  |  Cancer Research

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

Kaylene J Simpson, Laura M Selfors, James Bui, Angela Reynolds, Devin Leake, Anastasia Khvorova, Joan S Brugge

Journal article  |  2008  |  Nature Cell Biology

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1

Mariana Melani, Kaylene J Simpson, Joan S Brugge, Denise Montell

Journal article  |  2008  |  Current Biology

Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma

DI Bellovin, KJ Simpson, T Danilov, E Maynard, DL Rimm, P Oettgen, AM Mercurio

Journal article  |  2006  |  Oncogene

Generation of a functional mammary gland from a single stem cell

M Shackleton, F Vaillant, KJ Simpson, J Stingl, GK Smyth, ML Asselin-Labat, L Wu, GJ Lindeman, JE Visvader

Journal article  |  2006  |  Nature

The alpha 6 beta 4 integrin maintains the survival of human breast carcinoma cells in vivo

EA Lipscomb, KJ Simpson, SR Lyle, JE Ring, AS Dugan, AM Mercurio

Journal article  |  2005  |  Cancer Research

Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

KJ Simpson, AS Dugan, AM Mercurio

Journal article  |  2004  |  Cancer Research

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

KJ Simpson, MR Wati, AJ Deans, GJ Lindeman, MA Brown

Journal article  |  2004  |  International Journal of Developmental Biology

Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary gland

AJ Deans, KJ Simpson, MK Trivett, MA Brown, GA McArthur

Journal article  |  2004  |  Oncogene

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

Kaylene J Simpson

Journal article  |  2004  |  International Journal of Developmental Biology

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

MA Brown, H Nicolai, K Howe, T Katagiri, E Lalani, KJ Simpson, NW Manning, A Deans, P Chen, KK Khanna, MR Wati, BL Griffiths, CF Xu, GWH Stamp, E Solomon

Journal article  |  2002  |  Transgenic Research

The comparative biology of whey proteins

KJ Simpson, KR Nicholas

Journal article  |  2002  |  Journal of Mammary Gland Biology and Neoplasia

Differential expression of the whey acidic protein gene during lactation in the brushtail possum (Trichosurus vulpecula)

J Demmer, SJ Stasiuk, MR Grigor, KJ Simpson, KR Nicholas

Journal article  |  2001  |  Biochimica et Biophysica Acta-Gene Structure & Expression

The gene for a novel member of the whey acidic protein family encodes three four-disulfide core domains and is asynchronously expressed during lactation

KJ Simpson, S Ranganathan, JA Fisher, PA Janssens, DC Shaw, KR Nicholas

Journal article  |  2000  |  Journal of Biological Chemistry

The whey acidic protein family: A new signature motif and three-dimensional structure by comparative modeling

S Ranganathan, KJ Simpson, DC Shaw, KR Nicholas

Journal article  |  1999  |  Journal of Molecular Graphics and Modelling

Autocrine inhibition of milk secretion in the lactating tammar wallaby (Macropus eugenii)

KAK Hendry, KJ Simpson, KR Nicholas, CJ Wilde

Journal article  |  1998  |  Journal of Molecular Endocrinology

Developmentally-regulated expression of a putative protease inhibitor gene in the lactating mammary gland of the tammar wallaby, Macropus eugenii

K Simpson, D Shaw, K Nicholas

Journal article  |  1998  |  Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Molecular characterisation and hormone-dependent expression of the porcine whey acidic protein gene

KJ Simpson, P Bird, D Shaw, K Nicholas

Journal article  |  1998  |  Journal of Molecular Endocrinology

The Tammar Wallaby: A Model to Study Putative Autocrine-Induced Changes in Milk Composition

Kevin Nicholas, Kaylene Simpson, Michael Wilson, Josephine Trott, Denis Shaw

Journal article  |  1997  |  Journal of Mammary Gland Biology and Neoplasia

Transformation of a grain legume (Lupinus angustifolius L.) via Agrobacterium tumefaciens-mediated gene transfer to shoot apices

A Pigeaire, D Abernethy, PM Smith, K Simpson, N Fletcher, CY Lu, CA Atkins, E Cornish

Journal article  |  1997  |  Molecular Breeding