Kaylene Simpson

Genome-wide screening identifies cell cycle control as a synthetic lethal pathway with SRSF2P95H mutation.

Jane Jialu Xu, Alistair M Chalk, Iva Nikolic, Kaylene Simpson, Monique F Smeets, Carl Walkley

Journal article  |  2021  |  Blood Adv

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approac..

CX-5461 sensitises DNA damage repair proficient castrate-resistant prostate cancer to PARP inhibition.

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  Mol Cancer Ther

Monotherapy with poly (ADP-ribose) polymerase (PARP) inhibitors is effective for the subset of castrate-resistant prostate cancer ..

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells

Vuk Bortnik, Michelle Wu, Bryan Julcher, Ana Salinas, Iva Nikolic, Kaylene J Simpson, Nigel Aj McMillan, Adi Idris

Journal article  |  2021  |  JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Human papilloma viruses (HPV) are the main culprit in cervical and oropharyngeal cancers. HPV positive (+) cancers are regarded as..

SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status.

Kenji M Fujihara, Mariana Corrales Benitez, Carlos S Cabalag, Bonnie Z Zhang, Hyun S Ko, David S Liu, Kaylene J Simpson, Ygal Haupt, Lara Lipton, Sue Haupt, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2021  |  Mol Cancer Ther

APR-246 (eprenetapopt) is in clinical development with a focus on hematologic malignancies and is promoted as a mutant-p53 reactiv..

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M Winter, Luke A Selth, Amy R Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E Hickey, Wayne D Tilley, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence, Kaylene J Simpson

Journal article  |  2021  |  SLAS DISCOVERY

New treatments are required for advanced prostate cancer; however, there are fewer preclinical models of prostate cancer than othe..

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Genome-wide genetic screen identifies host ubiquitination as important for Legionella pneumophila Dot/Icm effector translocation

Sze Ying Ong, Ralf Schuelein, Rachelia R Wibawa, Daniel W Thomas, Yanny Handoko, Saskia Freytag, Melanie Bahlo, Kaylene J Simpson, Elizabeth L Hartland

Journal article  |  2021  |  CELLULAR MICROBIOLOGY

The Dot/Icm system of Legionella pneumophila is essential for virulence and delivers a large repertoire of effectors into infected..

High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins

Hendrika M Duivenvoorden, Natasha K Brockwell, Cameron J Nowell, Kaylene J Simpson, Belinda S Parker

Journal article  |  2021  |  SCIENTIFIC DATA

Understanding how cancer cells interact with the surrounding microenvironment early in breast cancer development can provide insig..

Next Generation Cell Culture Tools Featuring Micro- and Nanotopographies for Biological Screening

James Carthew, Hazem H Abdelmaksoud, Karla J Cowley, Margeaux Hodgson-Garms, Roey Elnathan, Joachim P Spatz, Juergen Brugger, Helmut Thissen, Kaylene J Simpson, Nicolas H Voelcker, Jessica E Frith, Victor J Cadarso

Journal article  |  2021  |  ADVANCED FUNCTIONAL MATERIALS

Cells are able to perceive complex mechanical cues across both the micro- and nanoscale which can influence their development. Whi..

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir JN Bykov, Kenji M Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman

Journal article  |  2020  |  EMBO MOLECULAR MEDICINE

The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..