Kaylene Simpson

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir JN Bykov, Kenji M Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman

Journal article  |  2020  |  EMBO Molecular Medicine

The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..

Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen

Lauren E King, Hui-Hua Zhang, Cathryn M Gould, Daniel W Thomas, Lachlan W Whitehead, Kaylene J Simpson, Antony W Burgess, Maree C Faux

Journal article  |  2020  |  PLoS One

Truncating mutations in the tumour suppressor gene APC occur frequently in colorectal cancers and result in the deregulation of Wn..

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma

Jovana R Gotovac, David SH Liu, Michael J Yates, Julia Milne, Arthi A Macpherson, Kaylene J Simpson, Guy D Eslick, Catherine Mitchell, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2020  |  Journal of Pathology

Efficacious therapeutic approaches are urgently needed to improve outcomes in patients with oesophageal adenocarcinoma (OAC). Howe..

Requirement for cleavage factor IIm in the control of alternative polyadenylation in breast cancer cells

Rachael E Turner, Lee M Henneken, Marije Liem-Weits, Paul F Harrison, Angavai Swaminathan, Robert Vary, Iva Nikolic, Kaylene J Simpson, David R Powell, Traude H Beilharz, Bernhard Dichtl

Journal article  |  2020  |  RNA

Alternative polyadenylation (APA) determines stability, localization and translation potential of the majority of mRNA in eukaryot..

Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells.

Vuk Bortnik, Michelle Wu, Bryan Julcher, Ana Salinas, Iva Nikolic, Kaylene J Simpson, Nigel Aj McMillan, Adi Idris

Journal article  |  2020  |  Journal of Microbiology Immunology and Infection

Human papilloma viruses (HPV) are the main culprit in cervical and oropharyngeal cancers. HPV positive (+) cancers are regarded as..

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer

Laura A Baker, Holly Holliday, Daniel Roden, Christoph Krisp, Sunny Z Wu, Simon Junankar, Aurelien A Serandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan, Andrew MK Law, Andrea McFarland, Peter T Simpson, Sunil Lakhani, Eoin Dodson, Christina Selinger, Lyndal Anderson, Goli Samimi, Neville F Hacker, Elgene Lim, et al.

Journal article  |  2020  |  Breast Cancer Research

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

Michael F Sharp, Vince J Murphy, Sylvie Van Twest, Winnie Tan, Jennii Lui, Kaylene J Simpson, Andrew J Deans, Wayne Crismani

Journal article  |  2020  |  Scientific Reports

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription...

Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Ekaterina Ivanova, Pamela M Pollock, Shivashankar H Nagaraj, Adrian P Wiegmans, Izhak Haviv, Kaylene J Simpson, Erik W Thompson

Journal article  |  2020  |  Cancers

BACKGROUND: Breast cancer (BC) is a heterogeneous disease for which the commonly used chemotherapeutic agents primarily include th..

Lysosomal degradation products induce Coxiella burnetii virulence

Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death and Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..