Rita Busuttil

CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia

Athanasios Koulis, Natasha Di Costanzo, Catherine Mitchell, Stephen Lade, David Goode, Rita A Busuttil, Alex Boussioutas

Journal article  |  2022  |  BMC GASTROENTEROLOGY

BACKGROUND: Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologi..

The Role of Innate Immune Cells in Tumor Invasion and Metastasis

Yu-Kuan Huang, Rita A Busuttil, Alex Boussioutas

Journal article  |  2021  |  CANCERS

Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated wit..

Premalignant lesions of the stomach and management of early neoplastic lesions

A Koulis, RA Busuttil, A Boussioutas

Book Chapter  |  2021

Although the incidence of gastric cancer (GC) is declining, it remains a significant global problem. GC is thought to arise via a ..

SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence

Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, Alex Boussioutas

Journal article  |  2020  |  GASTRIC CANCER

OBJECTIVE: Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined ..

A cohort study and meta-analysis of the evidence for consideration of Lauren subtype when prescribing adjuvant or palliative chemotherapy for gastric cancer

Kunning Wang, Enxiao Li, Rita A Busuttil, Joseph C Kong, Sharon Pattison, Joseph JY Sung, Jun Yu, Emad M El-Omar, Julie A Simpson, Alex Boussioutas

Journal article  |  2020  |  THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY

BACKGROUND: The association between the survival or efficacy of chemotherapy and the Lauren subtype of gastric cancer (GC) remains..

High-dimensional analyses reveal a distinct role of T-cell subsets in the immune microenvironment of gastric cancer

Minyu Wang, Yu-Kuan Huang, Joseph CH Kong, Yu Sun, Daniela G Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha Di Costanzo, Ian R Gordon, Catherine Mitchell, Laura K Mackay, Rita A Busuttil, Paul J Neeson, Alex Boussioutas

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive stu..

Molecular heterogeneity of gastric cancer explained by methylation-driven key regulators.

Seungyeul Yoo, Quan Chen, Li Wang, Wenhui Wang, Ankur Chakravarthy, Rita Busuttil, Alex Boussioutas, Tim R Fenton, Jiangwen Zhang, Xiaodan Fan, Seut-Yi Leung, Jun Zhu

Conference Proceedings  |  2020  |  CANCER IMMUNOLOGY RESEARCH

Abstract Gastric cancer (GC) is a heterogeneous disease in which diverse genetic, genomic, and epigenetic alteratio..

Increased and co-localized CD4 FOXP3 and CD8 T cells is a strong independent prognostic indicator in gastric cancer

Minyu Wang, Yu-Kuan Huang, Joe Kong, Yu Sun, Daniela Tantalo, Han Xian Aw Yeang, Le Ying, Feng Yan, Dakang Xu, Heloise Halse, Natasha di Costanzo, Ian Gordon, Catherine Mitchell, Laura Mackay, Rita Busuttil, Paul Neeson, Alex Boussioutas

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A Hamilton, Rita A Busuttil, Alex Boussioutas

Journal article  |  2019  |  NATURE COMMUNICATIONS

Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to character..

Differential response to adjuvant chemotherapy based on Lauren subtype affects clinical outcome of gastric cancer: A cohort study and meta-analysis.

Kunning Wang, En Xiao Li, Rita A Busuttil, Joseph C Kong, Sharon Tracy Pattison, Joseph JY Sung, Jun Yu, Emad M El-Omar, Julie A Simpson, Alex Boussioutas

Conference Proceedings  |  2018  |  JOURNAL OF CLINICAL ONCOLOGY