Joanne Davis

A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma.

undefined Jake Shortt, Peter Galettis, Chan Y Cheah, Joanne Davis, Mandy Ludford-Menting, Emma K Link, Jennifer H Martin, Rachel Koldej, David Ritchie

Journal article  |  2023  |  Clin Epigenetics

BACKGROUND: N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applicati..

Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence

Joanne E Davis, Chia Sharpe, Kylie Mason, Constantine S Tam, Rachel M Koldej, David S Ritchie

Journal article  |  2021  |  JOURNAL OF TRANSLATIONAL MEDICINE

BACKGROUND: The development of Bruton's tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL)..

Venetoclax or Ruxolitinib in Pre-Transplant Conditioning Lowers the Engraftment Barrier by Different Mechanisms in Allogeneic Stem Cell Transplant Recipients

Joanne E Davis, Kelei Du, Mandy J Ludford-Menting, Ashvind Prabahran, Eric Wong, Nicholas D Huntington, Rachel M Koldej, David S Ritchie

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Allogeneic stem cell transplantation (alloSCT) is utilised to cure haematological malignancies through a combination of conditioni..

Immune recovery in patients with mantle cell lymphoma receiving long-term ibrutinib and venetoclax combination therapy

Joanne E Davis, Sasanka M Handunnetti, Mandy Ludford-Menting, Chia Sharpe, Piers Blombery, Mary Ann Anderson, Andrew W Roberts, John F Seymour, Constantine S Tam, David S Ritchie, Rachel M Koldej

Journal article  |  2020  |  BLOOD ADVANCES

Combination venetoclax plus ibrutinib for the treatment of mantle cell lymphoma (MCL) has demonstrated efficacy in the relapsed or..

Long Term Responses to Venetoclax and Ibrutinib in Mantle Cell Lymphoma Are Associated with Immunological Recovery and Prognostic Changes in Inflammatory Biomarkers

Joanne Davis, Sasanka M Handunnetti, Chia Sharpe, Gillian Turner, Mary Ann Anderson, Andrew W Roberts, John F Seymour, Constantine S Tam, David Ritchie, Rachel Koldej

Conference Proceedings  |  2019  |  BLOOD

Combination Ibrutinib (IB) plus Venetoclax (Ven) for the treatment of Mantle Cell Lymphoma (MCL) has demonstrated efficacy in the ..

Nivolumab induces dynamic alterations in CD8 T-cell function and TIM-3 expression when used to treat relapsed acute myeloid leukemia after allogeneic stem cell transplantation

Eric Wong, Joanne Davis, Rachel Koldej, Jeff Szer, Andrew Grigg, David Ritchie

Journal article  |  2019  |  LEUKEMIA & LYMPHOMA

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  CELL DEATH AND DIFFERENTIATION

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

Strategies to enhance the graft versus tumour effect after allogeneic haematopoietic stem cell transplantation

Eric Wong, Joanne E Davis, Andrew Grigg, Jeff Szer, David Ritchie

Journal article  |  2019  |  BONE MARROW TRANSPLANTATION

Relapse of haematological malignancies after allogeneic haematopoietic stem cell transplant is a major cause of mortality. The imm..

Comparison of gene expression and flow cytometry for immune profiling in chronic lymphocytic leukaemia

Chia Sharpe, Joanne Davis, Kylie Mason, Constantine Tam, David Ritchie, Rachel Koldej

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGICAL METHODS

Understanding how cancer and cancer therapies affect the immune system is integral to the rational application of immunotherapies...

More Than a BTK Inhibitor; Ibrutinib Profoundly Impacts the Function of Cell Mediated Immunity

Chia Sharpe, Joanne Davis, Kylie D Mason, Dale I Godfrey, Adam Uldrich, Constantine S Tam, Rachel Koldej, David Ritchie

Conference Proceedings  |  2018  |  BLOOD

Abstract Background: Chronic lymphocytic leukaemia (CLL) is associated with profound immune dysfunction, which is o..