Silvia Alvarez-Diaz

Physiological role of linear ubiquitination: more to it than meets the eye

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Lucia Taraborrelli, Amanda Fisher, Tobias L Haas, Yutaka Shimizu, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Ciaran Hutchinson, Charlotta Boiers, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, et al.

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, et al.

Journal article  |  2018  |  Nature

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  Immunity

Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression

Gemma Ferrer-Mayorga, Silvia Alvarez-Diaz, Noelia Valle, Javier De Las Rivas, Marta Mendes, Rodrigo Barderas, Francesc Canals, Olga Tapia, J Ignacio Casal, Miguel Lafarga, Alberto Munoz

Journal article  |  2015  |  Journal of Biological Chemistry

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul J Baker, Dave Boucher, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Damian B D'Silva, Maria C Tanzer, Mercedes Monteleone, Avril AB Robertson, Matthew A Cooper, Silvia Alvarez-Diaz, Marco J Herold, Sammy Bedoui, Kate Schroder, Seth L Masters

Journal article  |  2015  |  European Journal of Immunology

Is SIRT2 required for necroptosis?

Kim Newton, Joanne M Hildebrand, Zhirong Shen, Diego Rodriguez, Silvia Alvarez-Diaz, Sean Petersen, Saumil Shah, Debra L Dugger, Chunzi Huang, Johan Auwerx, Peter Vandenabeele, Douglas R Green, Avi Ashkenazi, Vishva M Dixit, William J Kaiser, Andreas Strasser, Alexei Degterev, John Silke

Journal article  |  2014  |  Nature

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

Synthesis and Biological Evaluation of 1 alpha,25-Dihydroxyvitamin D-3 Analogues with a Long Side Chain at C12 and Short C17 Side Chains

Diego M Carballa, Samuel Seoane, Flavia Zacconi, Xenxo Perez, Antonio Rumbo, Silvia Alvarez-Diaz, Maria Jesus Larriba, Roman Perez-Fernandez, Alberto Munoz, Miguel Maestro, Antonio Mourino, Mercedes Torneiro

Journal article  |  2012  |  Journal of Medicinal Chemistry

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells

Silvia Alvarez-Diaz, Noelia Valle, Gemma Ferrer-Mayorga, Luis Lombardia, Mercedes Herrera, Orlando Dominguez, Miguel F Segura, Felix Bonilla, Eva Hernando, Alberto Munoz

Journal article  |  2012  |  Human Molecular Genetics

The effects of 1,25-dihydroxyvitamin D-3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling

Paloma Ordonez-Moran, Silvia Alvarez-Diaz, Noelia Valle, Maria Jesus Larriba, Felix Bonilla, Alberto Munoz

Journal article  |  2010  |  The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Proteases, protease inhibitors and cancer

Silvia Alvarez-Diaz, Maria Jesus Larriba, Carlos Lopez-Otin, Alberto Munoz

Journal article  |  2010  |  Cell Cycle

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Silvia Alvarez-Diaz, Noelia Valle, Jose Miguel Garcia, Cristina Pena, Jose MP Freije, Victor Quesada, Aurora Astudillo, Felix Bonilla, Carlos Lopez-Otin, Alberto Munoz

Journal article  |  2009  |  Journal of Clinical Investigation

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

Miguel F Segura, Douglas Hanniford, Silvia Menendez, Linsey Reavie, Xuanyi Zou, Silvia Alvarez-Diaz, Jan Zakrzewski, Elen Blochin, Amy Rose, Dusan Bogunovic, David Polsky, Jianjun Wei, Peng Lee, Ilana Belitskaya-Levy, Nina Bhardwaj, Iman Osman, Eva Hernando

Journal article  |  2009  |  Proceedings of the National Academy of Sciences

Vitamin D-3 and colorectal cancer

MJ Larriba, N Valle, S Alvarez, A Munoz

Conference Proceedings  |  2008  |  Advances in Experimental Medicine and Biology

The inhibition of Wnt/beta-catenin signalling by 1 alpha,25-dihydroxyvitamin D-3 is abrogated by Snail1 in human colon cancer cells

Maria Jesus Larriba, Noelia Valle, Hector G Palmer, Paloma Ordonez-Moran, Silvia Alvarez-Diaz, Karl-Friedrich Becker, Carlos Gamallo, Antonio Garcia de Herreros, Jose Manuel Gonzalez-Sancho, Alberto Munoz

Journal article  |  2007  |  Endocrine-Related Cancer