Silvia Alvarez-Diaz

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

Silvia Alvarez-Diaz, Adele Preaudet, Andre L Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L Garnham, Warren S Alexander, Andreas Strasser, Matthias Ernst, Tracy L Putoczki, James M Murphy

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Chronic inflammation of the large intestine is associated with an increased risk of developing colorectal cancer (CRC), the second..

Loss of RIPK3 does not impact MYC-driven lymphomagenesis or chemotherapeutic drug-induced killing of malignant lymphoma cells

Rachel Thijssen, Silvia Alvarez-Diaz, Clea Grace, Ming-yuan Gao, David H Segal, Zhen Xu, Andreas Strasser, David CS Huang

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Physiological role of linear ubiquitination: more to it than meets the eye

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Lucia Taraborrelli, Amanda Fisher, Tobias L Haas, Yutaka Shimizu, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Ciaran Hutchinson, Charlotta Boiers, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, et al.

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, et al.

Journal article  |  2018  |  NATURE

The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon acti..

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive ..

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  IMMUNITY

The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathwa..

Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression

Gemma Ferrer-Mayorga, Silvia Alvarez-Diaz, Noelia Valle, Javier De Las Rivas, Marta Mendes, Rodrigo Barderas, Francesc Canals, Olga Tapia, J Ignacio Casal, Miguel Lafarga, Alberto Munoz

Journal article  |  2015  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Cystatin D is an inhibitor of lysosomal and secreted cysteine proteases. Strikingly, cystatin D has been found to inhibit prolifer..

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Paul J Baker, Dave Boucher, Damien Bierschenk, Christina Tebartz, Paul G Whitney, Damian B D'Silva, Maria C Tanzer, Mercedes Monteleone, Avril AB Robertson, Matthew A Cooper, Silvia Alvarez-Diaz, Marco J Herold, Sammy Bedoui, Kate Schroder, Seth L Masters

Journal article  |  2015  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase-4 and caspase-5. When activated, these trigger pyropt..

Is SIRT2 required for necroptosis?

Kim Newton, Joanne M Hildebrand, Zhirong Shen, Diego Rodriguez, Silvia Alvarez-Diaz, Sean Petersen, Saumil Shah, Debra L Dugger, Chunzi Huang, Johan Auwerx, Peter Vandenabeele, Douglas R Green, Avi Ashkenazi, Vishva M Dixit, William J Kaiser, Andreas Strasser, Alexei Degterev, John Silke

Journal article  |  2014  |  NATURE

Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular proce..

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  IMMUNITY

Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein complex that triggers tumor necrosis f..