Cody Allison

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

Simon P Preston, Cody C Allison, Jan Schaefer, William Clow, Stefanie M Bader, Sophie Collard, Wasan O Forsyth, Michelle P Clark, Alexandra L Garnham, Connie SN Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2023  |  CELL DEATH & DISEASE

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue da..

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation.

Salimeh Ebrahimnezhaddarzi, Catherina H Bird, Cody C Allison, Daniel E Tuipulotu, Xenia Kostoulias, Christophe Macri, Michael D Stutz, Gilu Abraham, Dion Kaiserman, Siew Siew Pang, Si Ming Man, Justine D Mintern, Thomas Naderer, Anton Y Peleg, Marc Pellegrini, James C Whisstock, Phillip I Bird

Journal article  |  2022  |  Immunol Cell Biol

To control infections phagocytes can directly kill invading microbes. Macrophage-expressed gene 1 (Mpeg1), a pore-forming protein ..

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M Bader, Simon P Preston, Katie Saliba, Adam Lipszyc, Zoe L Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M Murphy, Cody C Allison, Marc Pellegrini, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including infla..

Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection.

Dylan Sheerin, undefined Abhimanyu, Nashied Peton, William Vo, Cody Charles Allison, Xutao Wang, W Evan Johnson, Anna Kathleen Coussens

Journal article  |  2022  |  iScience

Current and previous tuberculosis (TB) increase the risk of COVID-19 mortality and severe disease. To identify mechanisms of immun..

Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage

Charis E Teh, Simon P Preston, Alissa K Robbins, Michael D Stutz, James Cooney, Michelle P Clark, Antonia N Policheni, Cody C Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C Rankin, Peggy P Teh, Gabrielle T Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel HD Gray

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Targeting the potent immunosuppressive properties of FOXP3+ regulatory T cells (Tregs) has substantial therapeutic potential for t..

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Adam K Wheatley, Phillip Pymm, Robyn Esterbauer, Melanie H Dietrich, Wen Shi Lee, Damien Drew, Hannah G Kelly, Li-Jin Chan, Francesca L Mordant, Katrina A Black, Amy Adair, Hyon-Xhi Tan, Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Ester Lopez, Kevin J Selva, Ebene R Haycroft, James P Cooney, Hariprasad Venugopal, et al.

Journal article  |  2021  |  CELL REPORTS

Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of ..

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J Herold, Andreas Strasser, Nicholas P West, Marc Pellegrini

Journal article  |  2021  |  IMMUNITY

Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche..

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Cody C Allison, Ester Lopez, Ebene R Haycroft, Matthew T O'Neill, Li Lynn Tan, Melanie H Dietrich, Damien Drew, Marcel Doerflinger, Michael A Dengler, Nichollas E Scott, Adam K Wheatley, Nicholas A Gherardin, Hariprasad Venugopal, Deborah Cromer, Miles P Davenport, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVI..

The role of MKK4 in T-cell development and immunity to viral infections

Simon P Preston, Marcel Doerflinger, Hamish W Scott, Cody C Allison, Miles Horton, James Cooney, Marc Pellegrini

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The stress-activated protein kinases (SAPKs)/c-Jun-N-terminal-kinases (JNK) are members of the mitogen-activated protein kinase fa..