Lisa Mielke

Abstract PR007: Intestinal intraepithelial T cells limit colorectal cancer progression

Sonia Ghilas, Dinesh Raghu, Kelly Tran, Yang Liao, Bhupinder Pal, Shoukat Sterle, Christine Dijkstra, Marina Yakou, Pavitha Parathan, John Mariadason, Matthias Ernst, Andreas Behren, Grant Drummond, Wei Shi, Lisa A Mielke

Journal article  |  2022  |  Cancer Research

Abstract Homeostasis in the gut is achieved by impeccable functioning of tissue resident immune cells that reside a..

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

Ian Y Luk, Laura J Jenkins, Kael L Schoffer, Irvin Ng, Janson WT Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D Burrows, Robin L Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F Richardson, Oliver M Sieber, Yang Liao, Jennifer K Mooi, Natalia Vukelic, Camilla M Reehorst, Shoukat Afshar-Sterle, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecular underpinnin..

Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease.

Sonia Ghilas, Ryan O'Keefe, Lisa Anna Mielke, Dinesh Raghu, Michael Buchert, Matthias Ernst

Journal article  |  2022  |  Front Immunol

The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for hi..

Dendritic cells shape TCF1( )CD8( ) progenitor T cell heterogeneity

Sonia Ghilas, Lisa A Mielke

Journal article  |  2021  |  TRENDS IN IMMUNOLOGY

In two elegant studies, Tyler Jacks' group and colleagues unveil crucial interactions between dendritic cells and TCF1+CD8+ progen..

Unique cellular sources of CXCR3 ligands direct intranodal T cell positioning and effector/stem-like memory fates following viral infection

Fanny Lafouresse, Brigette C Duckworth, Verena C Wimmer, Benjamin J Brommfield, Lennard Dalit, Yannick Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  NATURE IMMUNOLOGY

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival

Qiutong Huang, Nicolas Jacquelot, Adele Preaudet, Soroor Hediyeh-zadeh, Fernando Souza-Fonseca-Guimaraes, Andrew NJ McKenzie, Philip M Hansbro, Melissa J Davis, Lisa A Mielke, Tracy L Putoczki, Gabrielle T Belz

Journal article  |  2021  |  CANCERS

Chronic inflammation of the gastrointestinal (GI) tract contributes to colorectal cancer (CRC) progression. While the role of adap..

Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of Signal Transducer and Activator of Transcription 1 to Promote Gastric Tumorigenesis in Mice

Jun T Low, Michael Christie, Matthias Ernst, Laure Dumoutier, Adele Preaudet, Yanhong Ni, Michael DW Griffin, Lisa A Mielke, Andreas Strasser, Tracy L Putoczki, Lorraine A O'Reilly

Journal article  |  2020  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Activity of nuclear factor κB transcription factors and signaling via signal transducer and activator of transc..

Innate Lymphoid Cells in Colorectal Cancers: A Double-Edged Sword

Qiutong Huang, Wang Cao, Lisa Anna Mielke, Cyril Seillet, Gabrielle T Belz, Nicolas Jacquelot

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

The immune system plays a fundamental role at mucosal barriers in maintaining tissue homeostasis. This is particularly true for th..

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and canc..