Lisa Mielke

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  NATURE IMMUNOLOGY

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Loss of NFKB1 Results in Expression of Tumor Necrosis Factor and Activation of Signal Transducer and Activator of Transcription 1 to Promote Gastric Tumorigenesis in Mice

Jun T Low, Michael Christie, Matthias Ernst, Laure Dumoutier, Adele Preaudet, Yanhong Ni, Michael DW Griffin, Lisa A Mielke, Andreas Strasser, Tracy L Putoczki, Lorraine A O'Reilly

Journal article  |  2020  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Activity of nuclear factor κB transcription factors and signaling via signal transducer and activator of transc..

Innate Lymphoid Cells in Colorectal Cancers: A Double-Edged Sword

Qiutong Huang, Wang Cao, Lisa Anna Mielke, Cyril Seillet, Gabrielle T Belz, Nicolas Jacquelot

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

The immune system plays a fundamental role at mucosal barriers in maintaining tissue homeostasis. This is particularly true for th..

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and canc..

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  IMMUNITY

Dendritic cells (DCs) are can be broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. Despite the importance of..

Plasmacytoid dendritic cell heterogeneity is defined by CXCL10 expression following TLR7 stimulation

Casper Marsman, Fanny Lafouresse, Yang Liao, Tracey M Baldwin, Lisa A Mielke, Yifang Hu, Matthias Mack, Paul J Hertzog, Carolyn A de Graaf, Wei Shi, Joanna R Groom

Journal article  |  2018  |  IMMUNOLOGY AND CELL BIOLOGY

Plasmacytoid dendritic cells (pDCs) play a critical role in bridging the innate and adaptive immune systems. pDCs are specialized ..

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide ..

Characterization of Blimp-1 function in effector regulatory T cells

Erika Cretney, Patrick SK Leung, Stephanie Trezise, Dane M Newman, Lucille C Rankin, Charis E Teh, Tracy L Putoczki, Daniel HD Gray, Gabrielle T Belz, Lisa A Mielke, Sheila Dias, Stephen L Nutt

Journal article  |  2018  |  JOURNAL OF AUTOIMMUNITY

Regulatory T (Treg) cells maintain immunological tolerance in steady-state and after immune challenge. Activated Treg cells can un..

Loss of NF-kappa B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Adele Preaudet, Marco J Herold, Kelvin Yaprianto, Lin Tai, Andrew Kueh, Guido Pacini, Richard L Ferrero, Raffi Gugasyan, Yifang Hu, Michael Christie, Stephen Wilcox, Raelene Grumont, Michael DW Griffin, Liam O'Connor, Gordon K Smyth, et al.

Journal article  |  2018  |  IMMUNITY

Polymorphisms in NFKB1 that diminish its expression have been linked to human inflammatory diseases and increased risk for epithel..

The TNF Receptor Superfamily-NF-kappa B Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, et al.

Journal article  |  2017  |  CELL REPORTS

After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the gene..