Mark van Delft

The BCL-2 Family Proteins: Insights Into Their Mechanism of Action and Therapeutic Potential

Mark F van Delft, Grant Dewson

Book Chapter  |  2023

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

Allan Shuai Huang, Hui San Chin, Boris Reljic, Tirta M Djajawi, Iris KL Tan, Jia-Nan Gong, David A Stroud, David CS Huang, Mark F van Delft, Grant Dewson

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Intrinsic apoptosis is principally governed by the BCL-2 family of proteins, but some non-BCL-2 proteins are also critical to cont..

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Annette Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus JA Kersten, Andre L Samson, Mark F van Delft, David CS Huang, Helene Jousset Sabroux, Guillaume Lessene, John Silke, James M Murphy

Journal article  |  2022  |  CELL DEATH & DISEASE

Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed line..

Too much death can kill you: inhibiting intrinsic apoptosis to treat disease

Kaiming Li, Mark F van Delft, Grant Dewson

Journal article  |  2021  |  EMBO JOURNAL

Apoptotic cell death is implicated in both physiological and pathological processes. Since many types of cancerous cells intrinsic..

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Pasquale L Fedele, Yang Liao, Jia-nan Gong, Yuan Yao, Mark F van Delft, Michael SY Low, Lin Tai, Marco J Herold, Jacob T Jackson, Charis E Teh, Tania Tan, Lorraine A O'Reilly, Julie Tellier, George Grigoriadis, David CS Huang, Wei Shi, Stephen L Nutt, Simon N Willis

Journal article  |  2020  |  LEUKEMIA

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Catia L Pierotti, Maria C Tanzer, Annette Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus JA Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David CS Huang, Peter E Czabotar, John Silke, Mark F van Delft, James M Murphy, et al.

Journal article  |  2020  |  ACS CHEMICAL BIOLOGY

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a m..

MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex

Tirta Mario Djajawi, Lei Liu, Jia-nan Gong, Allan Shuai Huang, Ming-jie Luo, Zhen Xu, Toru Okamoto, Melissa J Call, David CS Huang, Mark F van Delft

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

MCL1, a BCL2 relative, is critical for the survival of many cells. Its turnover is often tightly controlled through both ubiquitin..

Loss of IRF4 Results in Multiple Myeloma Cell Apoptosis through the Transcriptional up-Regulation of the BH3-Only Proteins Bmf and BIM

Pasquale L Fedele, Yang Liao, Jianan Gong, Mark van Delft, Michael SY Low, Lin Tai, Marco J Herold, Julie Tellier, George Grigoriadis, David CS Huang, Wei Shi, Stephen Nutt, Simon Willis

Conference Proceedings  |  2019  |  BLOOD

The transcription factor IRF4 is essential for the survival of both normal plasma cells and the plasma cell malignancy multiple my..

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  NATURE CHEMICAL BIOLOGY

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX..