Maximilien Tailler

TBK1 and IKK epsilon Act Redundantly to Mediate STING-Induced NF-kappa B Responses in Myeloid Cells

Katherine R Balka, Cynthia Louis, Tahnee L Saunders, Amber M Smith, Dale J Calleja, Damian B D'Silva, Fiona Moghaddas, Maximilien Tailler, Kate E Lawlor, Yifan Zhan, Christopher J Burns, Ian P Wicks, Jonathan J Miner, Benjamin T Kile, Seth L Masters, Dominic De Nardo

Journal article  |  2020  |  Cell Reports

Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimm..

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams

Journal article  |  2019  |  Cell Death and Differentiation

Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the no..

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

JJ Sandow, L Dorstyn, LA O'Reilly, M Tailler, S Kumar, A Strasser, PG Ekert

Journal article  |  2014  |  Cell Death & Differentiation