Con Sonza

Immunogenicity of HIV-1-Based Virus-Like Particles with Increased Incorporation and Stability of Membrane-Bound Env

Christopher A Gonelli, Hannah AD King, Charlene Mackenzie, Secondo Sonza, Rob J Center, Damian FJ Purcell

Journal article  |  2021  |  Vaccines

An optimal prophylactic vaccine to prevent human immunodeficiency virus (HIV-1) transmission should elicit protective antibody res..

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2018  |  Proteomics

The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antig..

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase

Sushama Telwatte, Chanson J Brumme, Anna C Hearps, Catherine F Latham, Joshua A Hayward, Secondo Sonza, Nicolas Sluis-Cremer, P Richard Harrigan, Gilda Tachedjian

Journal article  |  2016  |  AIDS

OBJECTIVE: Synonymous substitutions K65K/K66K in HIV-1 reverse transcriptase alleviate fitness and fidelity defects in HIV-1 molec..

MYB Elongation Is Regulated by the Nucleic Acid Binding of NF kappa B p50 to the Intronic Stem-Loop Region

Lloyd A Pereira, Honor J Hugo, Jordane Malaterre, Huiling Xu, Secondo Sonza, Alina Cures, Damian FJ Purcell, Paul A Ramsland, Steven Gerondakis, Thomas J Gonda, Robert G Ramsay

Journal article  |  2015  |  PLoS One

MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem ..

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Sushama Telwatte, Anna C Hearps, Adam Johnson, Catherine F Latham, Katie Moore, Paul Agius, Mary Tachedjian, Secondo Sonza, Nicolas Sluis-Cremer, P Richard Harrigan, Gilda Tachedjian

Journal article  |  2015  |  Nucleic Acids Research

Resistance to combined antiretroviral therapy (cART) in HIV-1-infected individuals is typically due to nonsynonymous mutations tha..

Vaginal concentrations of lactic acid potently inactivate HIV

Muriel Aldunate, David Tyssen, Adam Johnson, Tasnim Zakir, Secondo Sonza, Thomas Moench, Richard Cone, Gilda Tachedjian

Journal article  |  2013  |  Journal of Antimicrobial Chemotherapy

OBJECTIVES: When Lactobacillus spp. dominate the vaginal microbiota of women of reproductive age they acidify the vagina to pH <4...

Phosphatidylethanolamine Binding Is a Conserved Feature of Cyclotide-Membrane Interactions

Sonia Troeira Henriques, Yen-Hua Huang, Miguel ARB Castanho, Luis A Bagatolli, Secondo Sonza, Gilda Tachedjian, Norelle L Daly, David J Craik

Journal article  |  2012  |  Journal of Biological Chemistry

Cyclotides are bioactive cyclic peptides isolated from plants that are characterized by a topologically complex structure and exce..

SPL7013 Gel (VivaGel (R)) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

Clare F Price, David Tyssen, Secondo Sonza, Ashley Davie, Sonya Evans, Gareth R Lewis, Shirley Xia, Tim Spelman, Peter Hodsman, Thomas R Moench, Andrew Humberstone, Jeremy RA Paull, Gilda Tachedjian

Journal article  |  2011  |  PLoS One

UNLABELLED: SPL7013 Gel (VivaGel(®)) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed r..

Decoding the Membrane Activity of the Cyclotide Kalata B1 THE IMPORTANCE OF PHOSPHATIDYLETHANOLAMINE PHOSPHOLIPIDS AND LIPID ORGANIZATION ON HEMOLYTIC AND ANTI-HIV ACTIVITIES

Sonia Troeira Henriques, Yen-Hua Huang, K Johan Rosengren, Henri G Franquelim, Filomena A Carvalho, Adam Johnson, Secondo Sonza, Gilda Tachedjian, Miguel ARB Castanho, Norelle L Daly, David J Craik

Journal article  |  2011  |  Journal of Biological Chemistry

Cyclotides, a large family of cyclic peptides from plants, have a broad range of biological activities, including insecticidal, cy..

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations.

Nicolas Sluis-Cremer, Katie Moore, Jessica Radzio, Secondo Sonza, Gilda Tachedjian

Journal article  |  2010  |  AIDS

We previously demonstrated that N348I in HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. However, both o..