Christopher Tonkin

Environmental sensing and regulation of motility in Toxoplasma

Alessandro D Uboldi, Mary-Louise Wilde, Stefanie M Bader, Christopher J Tonkin

Journal article  |  2020  |  Molecular Microbiology

Toxoplasma and other apicomplexan parasites undergo a unique form of cellular locomotion referred to as "gliding motility." Glidin..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  Cell

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Catastrophic consequences: can the feline parasiteToxoplasma gondiiprompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  Journal of Neuroinflammation

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior

Shiraz Tyebji, Anthony J Hannan, Christopher J Tonkin

Journal article  |  2020  |  Cell Reports

Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environmen..

Metabolomic Analysis of Toxoplasma gondii Tachyzoites.

Elizabeth FB King, Simon A Cobbold, Alessandro D Uboldi, Christopher J Tonkin, Malcolm J McConville

Journal article  |  2020  |  Methods in molecular biology (Clifton, N.J.)

This protocol describes the use of 13C-stable isotope labeling, combined with metabolite profiling, to investigate the metabolism ..

Preface

CJ Tonkin

Book  |  2020  |  Methods in Molecular Biology

Metabolic networks and metabolomics

Joachim Kloehn, Aarti Krishnan, Christopher J Tonkin, Malcolm J McConville, Dominique Soldati-Favre

Book Chapter  |  2020

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes

Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K Thompson, Alexei A Kouzmitchev, Hayley E Bullen, Paul R Gilson, Alan F Cowman, Christopher J Tonkin

Journal article  |  2019  |  mBio

Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial ..

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

Shiraz Tyebji, Simona Seizova, Alexandra L Garnham, Anthony J Hannan, Christopher J Tonkin

Journal article  |  2019  |  Brain, Behavior, and Immunity

Toxoplasma gondii (T. gondii) is a neurotropic parasite that is associated with various neuropsychiatric disorders. Rodents infect..

Toxoplasma gondii bradyzoites induce transcriptional changes to host cells and prevent IFNγ-mediated cell death

Simona Seizova, Alexandra Garnham, Michael Coffey, Lachlan Whitehead, Kelly Rogers, Christopher Tonkin

Journal article  |  2019

Summary Toxoplasma gondii , the causative agent of toxoplasmosis, lies dormant for life and is a reservoir for disease reactivatio..