Christopher Tonkin

Depletion of a Toxoplasma porin leads to defects in mitochondrial morphology and contacts with the ER.

Natalia Mallo, Jana Ovciarikova, Erica S Martins-Duarte, Stephan C Baehr, Marco Biddau, Mary-Louise Wilde, Alessandro D Uboldi, Leandro Lemgruber, Christopher J Tonkin, Jeremy G Wideman, Clare R Harding, Lilach Sheiner

Journal article  |  2021  |  J Cell Sci

The Voltage Dependent Anion channel (VDAC) is a ubiquitous channel in the outer membrane of the mitochondrion with multiple roles ..

Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

Shengbo Zhang, Hannah D Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M Lew, Yifan Zhan, Christopher J Tonkin, Jose A Villadangos, Gordon K Smyth, Michael Chopin, Stephen L Nutt

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

The functional diversification of dendritic cells (DCs) is a key step in establishing protective immune responses. Despite the imp..

Direct Nanopore Sequencing of mRNA Reveals Landscape of Transcript Isoforms in Apicomplexan Parasites.

V Vern Lee, Louise M Judd, Aaron R Jex, Kathryn E Holt, Christopher J Tonkin, Stuart A Ralph

Journal article  |  2021  |  mSystems

Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the ge..

Environmental sensing and regulation of motility in Toxoplasma

Alessandro D Uboldi, Mary-Louise Wilde, Stefanie M Bader, Christopher J Tonkin

Journal article  |  2020  |  MOLECULAR MICROBIOLOGY

Toxoplasma and other apicomplexan parasites undergo a unique form of cellular locomotion referred to as "gliding motility." Glidin..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Catastrophic consequences: can the feline parasiteToxoplasma gondiiprompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  JOURNAL OF NEUROINFLAMMATION

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior

Shiraz Tyebji, Anthony J Hannan, Christopher J Tonkin

Journal article  |  2020  |  CELL REPORTS

Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environmen..

Metabolomic Analysis of Toxoplasma gondii Tachyzoites

Elizabeth FB King, Simon A Cobbold, Alessandro D Uboldi, Christopher J Tonkin, Malcolm J McConville

Journal article  |  2020  |  TOXOPLASMA GONDII: METHODS AND PROTOCOLS

This protocol describes the use of 13C-stable isotope labeling, combined with metabolite profiling, to investigate the metabolism ..

Metabolic networks and metabolomics

Joachim Kloehn, Aarti Krishnan, Christopher J Tonkin, Malcolm J McConville, Dominique Soldati-Favre

Book Chapter  |  2020

Calcium and cyclic nucleotide signaling networks in Toxoplasma gondii

Kevin M Brown, Christopher J Tonkin, Oliver Billker, L David Sibley

Book Chapter  |  2020