Joanna Groom

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  Nature Immunology

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Mechanisms of regulate gene expression during immune cell differentiation and development Conversations that count: Cellular interactions that drive T cell fate

Brigette C Duckworth, Joanna R Groom

Journal article  |  2021  |  Immunological Reviews

The relationship between the extrinsic environment and the internal transcriptional network is circular. Naive T cells first engag..

The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R Groom, Colby Zaph, Kim L Good-Jacobson

Journal article  |  2020  |  Cell Reports

Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The rec..

Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment

Amania A Sheikh, Joanna R Groom

Journal article  |  2020  |  Cellular and Molecular Immunology

Hhex drives B cells down memory lane

Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2020  |  Nature Immunology

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  JCI Insight

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ann Ly, Yang Liao, Halina Pietrzak, Lisa J Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z Qin, Joanna R Groom, Gabrielle T Belz, Kim L Good-Jacobson, Wei Shi, Axel Kallies, Diana S Hansen

Journal article  |  2019  |  Cell Reports

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity agai..

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington

Journal article  |  2019  |  Molecular Immunology

NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Amania A Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C Duckworth, Nicholas D Huntington, James J Moon, Marc Pellegrini, Stephen L Nutt, Gabrielle T Belz, Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2019  |  Cell Reports

Regulators of T-cell fate: Integration of cell migration, differentiation and function

Joanna R Groom

Journal article  |  2019  |  Immunological Reviews