Joanna Groom

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

The transcription factor Myc is critically important in driving cell proliferation, a function that is frequently dysregulated in ..

IL-1 alpha-releasing T(H)17 cells live long and prosper

Joanna R Groom, James E Vince

Journal article  |  2023  |  NATURE IMMUNOLOGY

Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable

Miles B Horton, HoChan Cheon, Ken R Duffy, Daniel Brown, Shalin H Naik, Carolina Alvarado, Joanna R Groom, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2022  |  IMMUNITY

To optimize immunity to pathogens, B lymphocytes generate plasma cells with functionally diverse antibody isotypes. By lineage tra..

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Isabella Y Kong, Stephanie Trezise, Amanda Light, Izabela Todorovski, Gisela Mir Arnau, Sreeja Gadipally, David Yoannidis, Kaylene J Simpson, Xueyi Dong, Lachlan Whitehead, Jessica C Tempany, Anthony J Farchione, Amania A Sheikh, Joanna R Groom, Kelly L Rogers, Marco J Herold, Vanessa L Bryant, Matthew E Ritchie, Simon N Willis, Ricky W Johnstone, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell fu..

CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection

Lennard Dalit, Carolina Alvarado, Lisan Kuijper, Andrew J Kueh, Ashley Weir, Angela D'Amico, Marco J Herold, James E Vince, Stephen L Nutt, Joanna R Groom

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

The chemokine receptor CXCR3 is expressed on immune cells to co-ordinate lymphocyte activation and migration. CXCR3 binds three ch..

Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S Simpson, Jiyi Pang, Ashley Weir, Isabella Y Kong, Melanie Fritsch, Maryam Rashidi, James P Cooney, Kathryn C Davidson, Mary Speir, Tirta M Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A Conos, Hazel Tye, Seong H Chow, et al.

Journal article  |  2022  |  IMMUNITY

Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to ..

Editorial overview: Collaboration in the immune system

Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2022  |  CURRENT OPINION IN IMMUNOLOGY

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The spleen is a compartmentalized organ that serves as a blood filter and safeguard of systemic immune surveillance. Labyrinthine ..

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles

Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Hannah G Kelly, Kathleen M Wragg, Penny Konstandopoulos, Sheilajen Alcantara, Carolina Alvarado, Robert Jones, Graham Starkey, Boa Zhong Wang, Osamu Yoshino, Thomas Tiang, M Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, David Masopust, et al.

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Recent studies have established that memory B cells, largely thought to be circulatory in the blood, can take up long-term residen..

Spatial determinates of effector and memory CD8( ) T cell fates

Brigette C Duckworth, Raymond Z Qin, Joanna R Groom

Journal article  |  2021  |  IMMUNOLOGICAL REVIEWS

The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign pathogens, and can..