Joanna Groom

A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity.

Yannick O Alexandre, Dominik Schienstock, Hyun Jae Lee, Luke C Gandolfo, Cameron G Williams, Sapna Devi, Bhupinder Pal, Joanna R Groom, Wang Cao, Susan N Christo, Claire L Gordon, Graham Starkey, Rohit D'Costa, Laura K Mackay, Ashraful Haque, Burkhard Ludewig, Gabrielle T Belz, Scott N Mueller

Journal article  |  2022  |  Sci Immunol

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Spatial determinates of effector and memory CD8( ) T cell fates

Brigette C Duckworth, Raymond Z Qin, Joanna R Groom

Journal article  |  2021  |  IMMUNOLOGICAL REVIEWS

The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign pathogens, and can..

CXCL10( ) peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

Hen Prizant, Nilesh Patil, Seble Negatu, Noor Bala, Alexander McGurk, Scott A Leddon, Angela Hughson, Tristan D McRae, Yu-Rong Gao, Alexandra M Livingstone, Joanna R Groom, Andrew D Luster, Deborah J Fowell

Journal article  |  2021  |  CELL REPORTS

Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, ..

Diversity in science requires mentoring for all, by all

Joanna R Groom

Journal article  |  2021  |  NATURE IMMUNOLOGY

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  NATURE IMMUNOLOGY

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Mechanisms of regulate gene expression during immune cell differentiation and development Conversations that count: Cellular interactions that drive T cell fate

Brigette C Duckworth, Joanna R Groom

Journal article  |  2021  |  IMMUNOLOGICAL REVIEWS

The relationship between the extrinsic environment and the internal transcriptional network is circular. Naive T cells first engag..

The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R Groom, Colby Zaph, Kim L Good-Jacobson

Journal article  |  2020  |  CELL REPORTS

Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The rec..

Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment

Amania A Sheikh, Joanna R Groom

Journal article  |  2020  |  CELLULAR & MOLECULAR IMMUNOLOGY

During viral infection, immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses..

Hhex drives B cells down memory lane

Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2020  |  NATURE IMMUNOLOGY