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Dr

Mark Shackleton

Honorary
Clinical Pathology
science & technology
life sciences & biomedicine
oncology
humans
melanoma
female
animals
mice
skin neoplasms
Mark Shackleton's Profile Picture
Dr

Mark Shackleton

 
Division
Medicine, Dentistry and Health Sciences
Mark Shackleton's Profile Picture
Dr

Mark Shackleton

 
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Mark's  Short Profile
 

Projects

Displaying the 10 most recent projects by Mark Shackleton.

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THE HIPPO PATHWAY AND MELANOMA GROWTH

An exciting area of drug discovery involves targeting Hippo pathway proteins, particularly one called YAP, which were discovered by members ..

2018 - 2021
Active
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ACRF TUMOUR HETEROGENEITY PROGRAM

2017 - 2024
Active
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NOVEL APPROACHES FOR OVERCOMING RESISTANCE TO THERAPIES FOR ADVANCED MELANOMA

2017 - 2022
Active
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CIRCULATING TUMOUR DNA AS A NONINVASIVE BIOMARKER IN MELANOMA

The expanding repertoire of treatment options in melanoma is bringing into focus the need for improved ways to accurately monitor treatment ..

2016 - 2020
Completed
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DECIPHERING MECHANISMS OF DISEASE EVOLUTION IN MELANOMA

In many patients, cancers are ever-changing, even after they have formed. This explains why many cancers can spread beyond the point of cure..

2015 - 2017
Completed
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ESTABLISHMENT OF ACRF ADVANCED CENTRE FOR CANCER CELL ISOLATION AND IMAGING

2013 - 2020
Completed
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Overcoming Receptor Tyrosine Kinase mediated resistance to BRAF Inhibitors in metastatic melanoma, colorectal and lung cancers.

The drug Vemurafenib results in good responses in melanoma patients. However, patients become resistant to treatment. We have identified spe..

2013 - 2017
Completed
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A NEW SURFACE ADHESION MOLECULE FOR VASCULAR PROGENITOR CELLS

Collectively, diseases of the blood vascular system contribute immensely to the burden of health care in Australia. Notably, abnormal blood ..

2012 - 2014
Completed
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IDENTIFYING DETERMINANTS OF HUMAN MELANOMA PROGRESSION

2011 - 2015
Completed
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Clonal evolution in human melanoma

Cancers can progress in patients by developing genetic changes that favor the growth, survival and spread of cancer cells. However, the rate..

2011 - 2013
Completed

10

Projects

Project Types

10

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Mark Shackleton.

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Impact of Radiotherapy on the Efficacy and Toxicity of anti-PD-1 Inhibitors in Metastatic NSCLC.

Evangeline Samuel, Gabrielle Lie, Adithya Balasubramanian, Alison Hiong, Yeojeong So, Mark Voskoboynik, Maggie Moore, Mark Shackleton, Andrew Haydon, Tom John, Paul LR Mitchell, Ben Markman, Peter Briggs, Sagun Parakh

Journal article  |  2021  |  Clinical Lung Cancer

BACKGROUND: The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors (ICIs) in patients with m..

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Feasibility and Acceptability of Fear-Less: A Stepped-Care Program to Manage Fear of Cancer Recurrence in People with Metastatic Melanoma

Fiona A Lynch, Lynda Katona, Michael Jefford, Allan Ben Smith, Joanne Shaw, Haryana M Dhillon, Steve Ellen, Jo Phipps-Nelson, Julia Lai-Kwon, Donna Milne, Lahiru Russell, Victoria Dax, Justine Diggens, Holly Kent, Alison Button-Sloan, Jane Elliott, Mark Shackleton, Hayley Burridge, Maria Ftanou

Journal article  |  2020  |  Journal of Clinical Medicine

Immunotherapies and targeted therapies have revolutionised treatment of metastatic melanoma and improved survival rates. However, ..

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The Hippo pathway in melanoma.

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

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Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24 CD29/CD49fhi in mice

Genevieve Dall, Jessica Vieusseux, Yashar Seyed-Razavi, Nathan Godde, Mandy Ludford-Menting, Sarah M Russell, Alan Ashworth, Robin L Anderson, Gail P Risbridger, Mark Shackleton, Kara L Britt

Journal article  |  2020  |  Breast Cancer Research and Treatment

BACKGROUND: Breast cancer (BCa) mortality is decreasing with early detection and improvement in therapies. The incidence of BCa, h..

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The Hippo pathway in melanoma

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  Oral Presentations - Invited Abstracts

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Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  Nature

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

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Australasian merkel cell carcinoma interest group (AMIGOs) - Improving the outlook for patients with Merkel cell carcinoma

Gerald Fogarty, Elizabeth Paton, Narelle Williams, Mark Shackleton, Jonathan Pincus, Shahneen Sandhu, Wen Xu

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

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Cancer diagnoses following abnormal cell-free DNA detected via non-invasive prenatal testing: A case series, literature review, and proposed management model

Eryn Dow, Alison Freimund, Kortnye Smith, Rodney J Hicks, Peter Jurcevic, Mark Shackleton, Paul James, Andrew Fellowes, Mark Pertile, George McGillivray, Linda Mileshkin

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

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Combination of avelumabwith peptide receptor radionuclide therapy (PRRT) or conventional fractionated radiotherapy (RT) in metastatic merkel cell carcinoma (mMCC) [GoTHAM study]

Shahneen Sandhu, Richard Tothill, Richard Scolyer, Alexander Guminski, Juergen Becker, Michael Poulsen, Victoria Atkinson, Paul Neeson, Mark Shackleton, David Pattison, Narelle Williams, Elizabeth Paton

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

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Estrogen receptor positive luminal progenitors the cancer cell origin for Estrogen receptor positive breast cancer

Genevieve Dall, Serene Yeow, Jessica Vieusseux, Yashar Seyed-Razavi, Nathan Godde, Mandy Ludford-Menting, Sarah M Russell, Alan Ashworth, Robin Anderson, Kelly Phillips, Gail Risbridger, Mark Shackleton, Kara Britt

Conference Proceedings  |  2019  |  Oncology Abstracts

49

Scholarly Works

Keyword Analysis

Oncology and Carcinogenesis
Clinical Health
Public Health and Health Services
Biomedical Engineering
Expanding Knowledge
Automotive Engineering
Macromolecular Chemistry
Clinical Sciences
Genetics
Law Enforcement

Credentials

Positions

Honorary

Clinical Pathology