Mark Shackleton

Cancer diagnoses following abnormal cell-free DNA detected via non-invasive prenatal testing: A case series, literature review, and proposed management model

Eryn Dow, Alison Freimund, Kortnye Smith, Rodney J Hicks, Peter Jurcevic, Mark Shackleton, Paul James, Andrew Fellowes, Mark Pertile, George McGillivray, Linda Mileshkin

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Australasian merkel cell carcinoma interest group (AMIGOs) - Improving the outlook for patients with Merkel cell carcinoma

Gerald Fogarty, Elizabeth Paton, Narelle Williams, Mark Shackleton, Jonathan Pincus, Shahneen Sandhu, Wen Xu

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Combination of avelumabwith peptide receptor radionuclide therapy (PRRT) or conventional fractionated radiotherapy (RT) in metastatic merkel cell carcinoma (mMCC) [GoTHAM study]

Shahneen Sandhu, Richard Tothill, Richard Scolyer, Alexander Guminski, Juergen Becker, Michael Poulsen, Victoria Atkinson, Paul Neeson, Mark Shackleton, David Pattison, Narelle Williams, Elizabeth Paton

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma

Xiaomeng Zhang, Jian Zhong Tang, Ismael A Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew Colebatch, Lachlan McIntosh, Katrina A Mitchell, Evangeline Shaw, Helen Rizos, Georgina Long, Nicholas Hayward, Grant A McArthur, Anthony T Papenfuss, Kieran F Harvey, Mark Shackleton

Journal article  |  2019  |  Molecular Cancer Research

Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

L Tan, S Sandhu, RJ Lee, J Li, J Callahan, S Ftouni, N Dhomen, P Middlehurst, A Wallace, J Raleigh, A Hatzimihalis, MA Henderson, M Shackleton, A Haydon, V Mar, DE Gyorki, D Oudit, MA Dawson, RJ Hicks, P Lorigan, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: The advent of effective adjuvant therapies for patients with resected melanoma has highlighted the need to stratify pa..

Bevacizumab as a steroid-sparing agent during immunotherapy for melanoma brain metastases: A case series.

Patricia D Banks, Arian Lasocki, Peter KH Lau, Shahneen Sandhu, Grant McArthur, Mark Shackleton

Journal article  |  2019  |  Health Science Reports

Background: Brain metastases are common in advanced melanoma and often necessitate corticosteroids such as dexamethasone to contro..

Personalised surveillance after treatment for high-risk cancer

C Guo, J Lewin, M Shackleton

Journal article  |  2019  |  Oncotarget

Rheumatic immune-related adverse events secondary to anti-programmed death-1 antibodies and preliminary analysis on the impact of corticosteroids on anti-tumour response: A case series

Emma L Mitchell, Peter Kar Han Lau, Chloe Khoo, David Liew, Jessica Leung, Bonnia Liu, Adam Rischin, Albert G Frauman, Damien Kee, Kortnye Smith, Benjamin Brady, Danny Rischin, Andrew Gibson, Linda Mileshkin, Oliver Klein, Andrew Weickhardt, Surein Arulananda, Mark Shackleton, Grant McArthur, Andrew Ostor, et al.

Journal article  |  2018  |  European Journal of Cancer

"It Takes a Village" - investigator-initiated clinical trials in melanoma and non-melanoma skin cancers (NMSCs)

Elizabeth Paton, Katrina Diamante, Alex Economides, Narelle Williams, Mark Shackleton

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Circulating tumour DNA analysis predicts relapse following resection in stage II and III melanoma

L Tan, SK Sandhu, R Lee, J Li, J Callahan, J Raleigh, A Hatzimihalis, P Middlehurst, M Henderson, M Shackleton, A Haydon, D Gyorki, D Oudit, RJ Hicks, P Lorigan, GA McArthur, R Marais, SQ Wong, S-J Dawson

Conference Proceedings  |  2018  |  Annals of Oncology

Surveillance imaging with FDG-PET/CT in the post-operative follow-up of stage 3 melanoma

J Lewin, L Sayers, D Kee, I Walpole, A Sanelli, L te Marvelde, A Herschtal, J Spillane, D Gyorki, D Speakman, V Estall, S Donahoe, M Pohl, K Pope, M Chua, S Sandhu, GA McArthur, CJ McCormack, M Henderson, RJ Hicks, et al.

Journal article  |  2018  |  Annals of Oncology

Whole-genome landscapes of major melanoma subtypes

Nicholas K Hayward, James S Wilmott, Nicola Waddell, Peter A Johansson, Matthew A Field, Katia Nones, Ann-Marie Patch, Hojabr Kakavand, Ludmil B Alexandrov, Hazel Burke, Valerie Jakrot, Stephen Kazakoff, Oliver Holmes, Conrad Leonard, Radhakrishnan Sabarinathan, Loris Mularoni, Scott Wood, Qinying Xu, Nick Waddell, Varsha Tembe, et al.

Journal article  |  2017  |  Nature

Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma

Fumihito Noguchi, Shigeki Inui, Clare Fedele, Mark Shackleton, Satoshi Itami

Journal article  |  2017  |  Molecular Cancer Therapeutics

Patient-Derived Xenografting of Human Melanoma

SE Boyle, CG Fedele, M Shackleton

Book Chapter  |  2017

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

Journal article  |  2016  |  Oncogene

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis

Lisa M Ebert, Lih Y Tan, M Zahied Johan, Kay Khine Myo Min, Michaelia P Cockshell, Kate A Parham, Kelly L Betterman, Paceman Szeto, Samantha Boyle, Lokugan Silva, Angela Peng, YouFang Zhang, Andrew Ruszkiewicz, Andrew CW Zannettino, Stan Gronthos, Simon Koblar, Natasha L Harvey, Angel F Lopez, Mark Shackleton, Claudine S Bonder

Journal article  |  2016  |  Angiogenesis

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Ugur Eskiocak, Vijayashree Ramesh, Jennifer G Gill, Zhiyu Zhao, Stacy W Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Timothy M Johnson, Ralph J DeBerardinis, Sean J Morrison

Journal article  |  2016  |  Nature Communications

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

Lih Yin Tan, Chris Mintoff, M Zahied Johan, Brenton W Ebert, Clare Fedele, You Fang Zhang, Pacman Szeto, Karen E Sheppard, Grant A McArthur, Erwin Foster-Smith, Andrew Ruszkiewicz, Michael P Brown, Claudine S Bonder, Mark Shackleton, Lisa M Ebert

Journal article  |  2016  |  Oncotarget

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

Samantha E Boyle, Clare G Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard J Young, Annie Wong, Robert Fuller, John Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A Henderson, Ricky W Johnstone, Anthony T Papenfuss, Mark Shackleton

Journal article  |  2016  |  Cancer Research

The use of ipilimumab in patients with rheumatoid arthritis and metastatic melanoma

B Lee, A Wong, D Kee, P Neeson, M Shackleton, G McArthur, S Sandhu

Journal article  |  2016  |  Annals of Oncology

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth

Michael Dewaele, Tommaso Tabaglio, Karen Willekens, Marco Bezzi, Shun Xie Teo, Diana HP Low, Cheryl M Koh, Florian Rambow, Mark Fiers, Aljosja Rogiers, Enrico Radaelli, Muthafar Al-Haddawi, Soo Yong Tan, Els Hermans, Frederic Amant, Hualong Yan, Manikandan Lakshmanan, Ratnacaram Chandrahas Koumar, Soon Thye Lim, Frederick A Derheimer, et al.

Journal article  |  2016  |  Journal of Clinical Investigation

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

Stephen Q Wong, Kelly Waldeck, Ismael A Vergara, Jan Schroeder, Jason Madore, James S Wilmott, Andrew J Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J Helen Leonard, George Hruby, Graham J Mann, John F Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, et al.

Journal article  |  2015  |  Cancer Res

Tumour procurement, DNA extraction, coverage analysis and optimisation of mutation-detection algorithms for human melanoma genomes

James S Wilmott, Matthew A Field, Peter A Johansson, Hojabr Kakavand, Ping Shang, Ricardo De Paoli-Iseppi, Ricardo E Vilain, Gulietta M Pupo, Varsha Tembe, Valerie Jakrot, Catherine A Shang, Jonathan Cebon, Mark Shackleton, Anna Fitzgerald, John F Thompson, Nicholas K Hayward, Graham J Mann, Richard A Scolyer

Journal article  |  2015  |  Pathology

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Rachel Ramsdale, Robert N Jorissen, Frederic Z Li, Sheren Al-Obaidi, Teresa Ward, Karen E Sheppard, Patricia E Bukczynska, Richard J Young, Samantha E Boyle, Mark Shackleton, Gideon Bollag, Georgina V Long, Eugene Tulchinsky, Helen Rizos, Richard B Pearson, Grant A McArthur, Amardeep S Dhillon, Petranel T Ferrao

Journal article  |  2015  |  Science Signaling

Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression

Igor Puzanov, Ravi K Amaravadi, Grant A McArthur, Keith T Flaherty, Paul B Chapman, Jeffrey A Sosman, Antoni Ribas, Mark Shackleton, Patrick Hwu, Bartosz Chmielowski, Keith B Nolop, Paul S Lin, Kevin B Kim

Journal article  |  2015  |  European Journal of Cancer

Post-operative survival following metastasectomy for patients receiving BRAF inhibitor therapy is associated with duration of pre-operative treatment and elective indication

Mike He, Jane Lovell, Bee Ling Ng, John Spillane, David Speakman, Michael A Henderson, Mark Shackleton, David E Gyorki

Journal article  |  2015  |  Journal of Surgical Oncology

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin, et al.

Journal article  |  2015  |  Nature

Current management of advanced melanoma: a transformed landscape

David E Gyorki, John Spillane, David Speakman, Mark Shackleton, Michael A Henderson

Journal article  |  2014  |  ANZ Journal of Surgery

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads

Jan Schroeder, Arthur Hsu, Samantha E Boyle, Geoff Macintyre, Marek Cmero, Richard W Tothill, Ricky W Johnstone, Mark Shackleton, Anthony T Papenfuss

Journal article  |  2014  |  Bioinformatics

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

Elsa Quintana, Elena Piskounova, Mark Shackleton, Daniel Weinberg, Ugur Eskiocak, Douglas R Fullen, Timothy M Johnson, Sean J Morrison

Journal article  |  2012  |  Science Translational Medicine

MDM4 is a key therapeutic target in cutaneous melanoma

Agnieszka Gembarska, Flavie Luciani, Clare Fedele, Elisabeth A Russell, Michael Dewaele, Stephanie Villar, Aleksandra Zwolinska, Sue Haupt, Job de Lange, Dana Yip, James Goydos, Jody J Haigh, Ygal Haupt, Lionel Larue, Aart Jochemsen, Hubing Shi, Gatien Moriceau, Roger S Lo, Ghanem Ghanem, Mark Shackleton, et al.

Journal article  |  2012  |  Nature Medicine

Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors

Anjali Tikoo, Vincent Roh, Karen G Montgomery, Ivan Ivetac, Paul Waring, Rebecca Pelzer, Lauren Hare, Mark Shackleton, Patrick Humbert, Wayne A Phillips

Journal article  |  2012  |  PLoS One

Pulling RANK: Are Some Melanoma Cells More Malignant than Others?

Mark Shackleton

Journal article  |  2011  |  Journal of Investigative Dermatology

Melanoma stem cells - are there devils in the detail?

Mark Shackleton

Journal article  |  2010  |  Pigment Cell & Melanoma Research

Moving Targets That Drive Cancer Progression

Mark Shackleton

Journal article  |  2010  |  New England Journal of Medicine

Normal stem cells and cancer stem cells: similar and different

Mark Shackleton

Journal article  |  2010  |  Seminars in Cancer Biology

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Nature Cell Biology

Generation of a functional mammary gland from a single stem cell

M Shackleton, F Vaillant, KJ Simpson, J Stingl, GK Smyth, ML Asselin-Labat, L Wu, GJ Lindeman, JE Visvader

Journal article  |  2006  |  Nature

Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenza peptides in subjects with advanced malignant melanoma.

Jonathan Cebon, Elke Jäger, Mark J Shackleton, Peter Gibbs, Ian D Davis, Wendie Hopkins, Sharen Gibbs, Qiyuan Chen, Julia Karbach, Heather Jackson, Duncan P MacGregor, Sue Sturrock, Hilary Vaughan, Eugene Maraskovsky, Antje Neumann, Eric Hoffman, Mathew L Sherman, Alexander Knuth

Journal article  |  2003  |  Cancer Immunity

Preclinical studies have shown that low dose IL-12 can potentiate cytotoxic lymphocyte responses. Since previous trials have demon..