Mark Shackleton

Impact of Radiotherapy on the Efficacy and Toxicity of anti-PD-1 Inhibitors in Metastatic NSCLC.

Evangeline Samuel, Gabrielle Lie, Adithya Balasubramanian, Alison Hiong, Yeojeong So, Mark Voskoboynik, Maggie Moore, Mark Shackleton, Andrew Haydon, Tom John, Paul LR Mitchell, Ben Markman, Peter Briggs, Sagun Parakh

Journal article  |  2021  |  Clin Lung Cancer

BACKGROUND: The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors (ICIs) in patients with m..

Feasibility and Acceptability of Fear-Less: A Stepped-Care Program to Manage Fear of Cancer Recurrence in People with Metastatic Melanoma

Fiona A Lynch, Lynda Katona, Michael Jefford, Allan Ben Smith, Joanne Shaw, Haryana M Dhillon, Steve Ellen, Jo Phipps-Nelson, Julia Lai-Kwon, Donna Milne, Lahiru Russell, Victoria Dax, Justine Diggens, Holly Kent, Alison Button-Sloan, Jane Elliott, Mark Shackleton, Hayley Burridge, Maria Ftanou

Journal article  |  2020  |  JOURNAL OF CLINICAL MEDICINE

Immunotherapies and targeted therapies have revolutionised treatment of metastatic melanoma and improved survival rates. However, ..

The Hippo pathway in melanoma.

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24 CD29/CD49fhi in mice

Genevieve Dall, Jessica Vieusseux, Yashar Seyed-Razavi, Nathan Godde, Mandy Ludford-Menting, Sarah M Russell, Alan Ashworth, Robin L Anderson, Gail P Risbridger, Mark Shackleton, Kara L Britt

Journal article  |  2020  |  BREAST CANCER RESEARCH AND TREATMENT

BACKGROUND: Breast cancer (BCa) mortality is decreasing with early detection and improvement in therapies. The incidence of BCa, h..

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey

Journal article  |  2020  |  ONCOGENE

Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younge..

The Hippo pathway in melanoma

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  NATURE

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Patterns of somatic structural variation in human cancer genomes

Yilong Li, Nicola D Roberts, Jeremiah A Wala, Ofer Shapira, Steven E Schumacher, Kiran Kumar, Ekta Khurana, Sebastian Waszak, Jan O Korbel, James E Haber, Marcin Imielinski, Joachim Weischenfeldt, Rameen Beroukhim, Peter J Campbell, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Paul C Boutros, David DL Bowtell, Benedikt Brors, et al.

Journal article  |  2020  |  NATURE

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments th..

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E Maruvka, Ciyue Shen, et al.

Journal article  |  2020  |  NATURE

The discovery of drivers of cancer has traditionally focused on protein-coding genes1-4. Here we present analyses of driver point ..

Combined burden and functional impact tests for cancer driver discovery using DriverPower.

Shimin Shuai, undefined PCAWG Drivers and Functional Interpretation Working Group, Steven Gallinger, Lincoln Stein, undefined PCAWG Consortium

Journal article  |  2020  |  Nat Commun

The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-C..