Nuzhat Ahmed

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer

Elif Kadife, Emily Chan, Rodney Luwor, George Kannourakis, Jock Findlay, Nuzhat Ahmed

Journal article  |  2019  |  Cancers

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan, George Kannourakis

Journal article  |  2018  |  Seminars in Cancer Biology

Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer

Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran

Journal article  |  2018  |  ACS Applied Materials & Interfaces

Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer.

Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  Oncotarget

Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phase..

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression

Ruth M Escalona, Emily Chan, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  International Journal of Molecular Sciences

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Chantel Samardzija, David W Greening, Ruth Escalona, Maoshan Chen, Maree Bilandzic, Rodney Luwor, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2017  |  SCIENTIFIC REPORTS

Surface Profiling of Extracellular Vesicles from Plasma or Ascites Fluid Using DotScan Antibody Microarrays

Larissa Belov, Susannah Hallal, Kieran Matic, Jerry Zhou, Sandra Wissmueller, Nuzhat Ahmed, Sumaiya Tanjil, Stephen P Mulligan, O Giles Best, Richard J Simpson, Richard I Christopherson

Book Chapter  |  2017  |  Methods in Molecular Biology

Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells

Nuzhat Ahmed, David Greening, Chantel Samardzija, Ruth M Escalona, Maoshan Chen, Jock K Findlay, George Kannourakis

Journal article  |  2016  |  Scientific Reports

Coalition of Oct4A and beta 1 integrins in facilitating metastasis in ovarian cancer

Chantel Samardzija, Rodney B Luwor, Michael A Quinn, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2016  |  BMC CANCER

A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer

Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2015  |  MOLECULAR CANCER

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Josiah Ochieng, Gladys N Nangami, Olugbemiga Ogunkua, Isabelle R Miousse, Igor Koturbash, Valerie Odero-Marah, Lisa McCawley, Pratima Nangia-Makker, Nuzhat Ahmed, Yunus Luqmani, Zhenbang Chen, Silvana Papagerakis, Gregory T Wolf, Chenfang Dong, Binhua P Zhou, Dustin G Brown, Annamaria Colacci, Roslida A Hamid, Chiara Mondello, Jayadev Raju, et al.

Journal article  |  2015  |  Carcinogenesis

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

William H Goodson, Leroy Lowe, David O Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K Charles, Andrew R Collins, Andrew Ward, Anna C Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J Barclay, Binhua P Zhou, Carmen Blanco-Aparicio, et al.

Journal article  |  2015  |  Carcinogenesis

Enhanced activation of STAT3 in ascites-derived recurrent ovarian tumors: inhibition of cisplatin-induced STAT3 activation reduced tumorigenicity of ovarian cancer by a loss of cancer stem cell-like characteristics

Khalid Abubaker, Ardian Latifi, Emily Chan, Rodney B Luwor, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2015  |  Journal of Cancer Stem Cell Research

Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NF kappa B-mediated induction of MMP2

Maree Bilandzic, Yao Wang, Nuzhat Ahmed, Rodney B Luwor, Hong Jian Zhu, Jock K Findlay, Kaye L Stenvers

Journal article  |  2014  |  Cancer Letters

Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets

Nuzhat Ahmed, Khalid Abubaker, Jock K Findlay

Journal article  |  2014  |  Molecular Aspects of Medicine

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2014  |  BMC CANCER

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer

J Kumar, FW Fraser, C Riley, N Ahmed, DR McCulloch, AC Ward

Journal article  |  2014  |  British Journal of Cancer

Targeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Ruth Escalona, Orla McNally, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2014  |  FRONTIERS IN ONCOLOGY

Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research.

Nuzhat Ahmed, Kaye L Stenvers

Journal article  |  2013  |  Frontiers in Oncology

More than one third of ovarian cancer patients present with ascites at diagnosis, and almost all have ascites at recurrence. The p..

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

Khalid Abubaker, Ardian Latifi, Rod Luwor, Simon Nazaretian, Hongjian Zhu, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2013  |  Molecular Cancer

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer

Ratana Lim, Martha Lappas, Clyde Riley, Niels Borregaard, Holger J Moller, Nuzhat Ahmed, Gregory E Rice

Journal article  |  2013  |  JOURNAL OF OVARIAN RESEARCH

Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance

Nuzhat Ahmed, Khalid Abubaker, Jock Findlay, Michael Quinn

Journal article  |  2013  |  Journal of Cellular Biochemistry

Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary

Chantel Samardzija, Michael Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2012  |  Journal of Ovarian Research

Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors

Ardian Latifi, Rodney B Luwor, Maree Bilandzic, Simon Nazaretian, Kaye Stenvers, Jan Pyman, Hongjian Zhu, Erik W Thompson, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2012  |  PLoS One

Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment.

Honor J Hugo, Stephanie Lebret, Eva Tomaskovic-Crook, Nuzhat Ahmed, Tony Blick, Donald F Newgreen, Erik W Thompson, M Leigh Ackland

Journal article  |  2012  |  Cancer Microenvironment

Hyperactive inflammatory responses following cancer initiation have led to cancer being described as a 'wound that never heals'. T..

Cisplatin Treatment of Primary and Metastatic Epithelial Ovarian Carcinomas Generates Residual Cells With Mesenchymal Stem Cell-Like Profile

Ardian Latifi, Khalid Abubaker, Natalie Castrechini, Alister C Ward, Clifford Liongue, Francoise Dobill, Janani Kumar, Erik W Thompson, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2011  |  Journal of Cellular Biochemistry

2D-PAGE of ovarian cancer: Analysis of soluble and insoluble fractions using medium-range immobilized pH gradients

Ratana Lim, Martha Lappas, Nuzhat Ahmed, Michael Permezel, Michael A Quinn, Gregory E Rice

Journal article  |  2011  |  Biochemical and Biophysical Research Communications

Effect of silencing neutrophil gelatinase-associated lipocalin in ovarian cancer cells on epithelio-mesenchymal transition

R Lim, M Lappas, N Ahmed, N Borregaard, MA Quinn, GE Rice

Journal article  |  2011  |  Journal of Molecular Biomarkers & Diagnosis

Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer

Nuzhat Ahmed, Ardian Latifi, Clyde B Riley, Jock K Findlay, Michael A Quinn

Journal article  |  2010  |  Journal of Ovarian Research

Epithelial Mesenchymal Transition and Cancer Stem Cell-Like Phenotypes Facilitate Chemoresistance in Recurrent Ovarian Cancer

N Ahmed, K Abubaker, J Findlay, M Quinn

Journal article  |  2010  |  Current Cancer Drug Targets

Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of alpha 6 beta 1 integrin

Michelle Colomiere, Jock Findlay, Leigh Ackland, Nuzhat Ahmed

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Kristy Shield, M Leigh Ackland, Nuzhat Ahmed, Gregory E Rice

Journal article  |  2009  |  Gynecologic Oncology

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas

M Colomiere, AC Ward, C Riley, MK Trenerry, D Cameron-Smith, J Findlay, L Ackland, N Ahmed

Journal article  |  2009  |  BRITISH JOURNAL OF CANCER

An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours

N Ahmed, C Riley, MA Quinn

Journal article  |  2008  |  British Journal of Cancer

Epithelial-mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: An exception to the norm

Nuzhat Ahmed, Erik W Thompson, Michael A Quinn

Journal article  |  2007  |  Journal of Cellular Physiology

α2β1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

K Shield, C Riley, MA Quinn, GE Rice, ML Ackland, N Ahmed

Journal article  |  2007  |  Journal of Carcinogenesis

Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis.

Kristy Shield, Clyde Riley, Michael A Quinn, Gregory E Rice, Margaret L Ackland, Nuzhat Ahmed

Journal article  |  2007  |  J Carcinog

BACKGROUND: Ovarian cancer is characterized by a wide-spread intra-abdominal metastases which represents a major clinical hurdle i..

Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition

Ratana Lim, Nuzhat Ahmed, Niels Borregaard, Clyde Riley, Razan Wafai, Erik W Thompson, Michael A Quinn, Gregory E Rice

Journal article  |  2007  |  International Journal of Cancer

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium

N Ahmed, S Maines-Bandiera, MA Quinn, WG Unger, S Dedhar, N Auersperg

Journal article  |  2006  |  American Journal of Physiology - Cell Physiology

Translational proteomics: Developing a predictive capacity - A review

GE Rice, HM Georgiou, N Ahmed, G Shi, G Kruppa

Journal article  |  2006  |  Placenta

15 Role of Integrins in Ovarian Cancer

N Ahmed

Journal article  |  2006  |  Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas

Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer

N Ahmed, KT Oliva, G Barker, P Hoffmann, S Reeve, IA Smith, MA Quinn, GE Rice

Journal article  |  2005  |  Proteomics

Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment

N Ahmed, C Riley, G Rice, M Quinn

Journal article  |  2005  |  Clinical and Experimental Metastasis

Ascites induces modulation of alpha 6 beta 1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma

N Ahmed, C Riley, K Oliva, G Rice, M Quinn

Journal article  |  2005  |  British Journal of Cancer

Strategies for revealing lower abundance proteins in two-dimensional protein maps

N Ahmed, GE Rice

Journal article  |  2005  |  Journal of Chromatography B: Biomedical Sciences and Applications

Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma

GY Zhang, N Ahmed, C Riley, K Oliva, G Barker, MA Quinn, GE Rice

Journal article  |  2005  |  British Journal of Cancer

Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer

N Ahmed, G Barker, KT Oliva, P Hoffmann, C Riley, S Reeve, AL Smith, BE Kemp, MA Quinn, GE Rice

Journal article  |  2004  |  British Journal of Cancer

Cell-free 59 kDa immunoreactive integrin-linked kinase: A novel marker for ovarian carcinoma

N Ahmed, K Oliva, GE Rice, MA Quinn

Journal article  |  2004  |  Clinical Cancer Research

Expression and localization of alpha(v)beta(6) integrin in extraplacental fetal membranes: possible role in human parturition

N Ahmed, C Riley, K Oliva, G Barker, MA Quinn, GE Rice

Journal article  |  2004  |  Molecular Human Reproduction

Cell-free 59 kDa immunoreactive integrin-linked kinase

N AHMED, KT OLIVA, GE RICE, MA QUINN

Journal article  |  2004  |  Clinical Cancer Research

Integrin-linked kinase expression increases with ovarian turnour grade and is sustained by peritoneal tumour fluid

N Ahmed, C Riley, K Oliva, E Stutt, GE Rice, MA Quinn

Journal article  |  2003  |  Journal of Pathology

An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum

N Ahmed, G Barker, K Oliva, D Garfin, K Talmadge, H Georgiou, M Quinn, G Rice

Journal article  |  2003  |  Proteomics

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta 1 integrin complex in colon cancer cells

N Ahmed, K Oliva, Y Wang, M Quinn, G Rice

Journal article  |  2003  |  British Journal of Cancer

Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach

N Ahmed, K Oliva, Y Wang, M Quinn, G Rice

Journal article  |  2003  |  Proteomics

alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer

N Ahmed, C Riley, GE Rice, MA Quinn, MS Baker

Journal article  |  2002  |  Journal of Histochemistry & Cytochemistry

Integrin expression in colon cancer ells is regulated by the cytoplasmic domain of the beta 6 integrin subunit

J Niu, DJ Dorahy, XH Gu, RJ Scott, B Draganic, N Ahmed, MV Agrez

Journal article  |  2002  |  International Journal of Cancer

Direct integrin alpha v beta 6-ERK binding: implications for tumour growth

N Ahmed, J Niu, DJ Dorahy, XH Gu, S Andrews, CJ Meldrum, RJ Scott, MS Baker, IG Macreadie, MV Agrez

Journal article  |  2002  |  Oncogene

Overexpression of alpha v beta 6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade

N Ahmed, F Pansino, R Clyde, P Murthi, MA Quinn, GE Rice, MV Agrez, S Mok, MS Baker

Journal article  |  2002  |  Carcinogenesis

αnullvβ6 Integrin-A marker for the malignant potential of epithelial ovarian cancer

N AHMED, C RILEY, GE RICE, MA QUINN, MS BAKER

Journal article  |  2002  |  Journal of Histochemistry and Cytochemistry

Association between alpha v beta 6 integrin expression, elevated p42/44 kDa MAPK, and plasminogen-dependent matrix degradation in ovarian cancer

N Ahmed, F Pansino, M Baker, G Rice, M Quinn

Journal article  |  2002  |  Journal of Cellular Biochemistry

αvβ6 integrin-A marker for the malignant potential of epithelial ovarian cancer

N Ahmed, C Riley, GE Rice, MA Quinn, MS Baker

Journal article  |  2002  |  Journal of Histochemistry and Cytochemistry

The alphaVbeta6 integrin regulates its own expression with cell crowding: implications for tumour progression.

J Niu, X Gu, N Ahmed, S Andrews, J Turton, R Bates, M Agrez

Journal article  |  2001  |  International Journal of Cancer

Expression of the growth-promoting integrin alphavbeta6 in colon cancer cells induces gelatinase B secretion and activation, the i..

The a V b6 integrin regulates its own expression with cell crowding: implications for tumour progression

J NIU, X GU, N AHMED, S ANDREWS, J TURTON, R BATES, M AGREZ

Journal article  |  2001  |  International Journal of Cancer

Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils

N Ahmed, MV Berridge

Journal article  |  2000  |  Pharmacology and Toxicology

N-glycosylation of glucose transporter-1 (Glut-1) is associated with increased transporter affinity for glucose in human leukemic cells.

N Ahmed, MV Berridge

Journal article  |  1999  |  Leukemia Research

To elucidate the role of N-glycosylation in the functional activity of the universal glucose transporter, Glut-1, we investigated ..

Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line.

N Ahmed, MV Berridge

Journal article  |  1999  |  Biochemical Pharmacology

Growth factors and oncogenes promote glucose uptake, but the extent to which increased uptake is regulated at the level of glucose..

IL-3 induces apoptosis in a ras-transformed myeloid cell line

N Ahmed, SM Anderson, MV Berridge

Journal article  |  1999  |  APOPTOSIS

Telomerase activity in a specific cell subset co-expressing integrinbeta1/EGFR but not p75NGFR/bcl2/integrin beta4 in normal human epithelial cells.

C Kunimura, K Kikuchi, N Ahmed, A Shimizu, S Yasumoto

Journal article  |  1998  |  Oncogene

Telomerase activity is correlated with the immortality of various cultured cells and cancer cells. The activity, however, is also ..

Acute regulation of glucose transport after activation of human peripheral blood neutrophils by phorbol myristate acetate, fMLP, and granulocyte-macrophage colony-stimulating factor.

AS Tan, N Ahmed, MV Berridge

Journal article  |  1998  |  Blood

Activation of human peripheral blood neutrophils by pathogens or by phorbol myristate acetate (PMA), fMLP, or myeloid growth facto..

Transforming oncogenes regulate glucose transport by increasing transporter affinity for glucose: contrasting effects of oncogenes and heat stress in a murine marrow-derived cell line.

N Ahmed, MV Berridge

Journal article  |  1998  |  Life Sciences

Transforming oncogenes often overcome the growth factor requirements of cells by activating growth factor signal transduction path..

Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst.

N Ahmed, M Kansara, MV Berridge

Journal article  |  1997  |  Biochemical Journal

Activation of the respiratory burst imposes acute metabolic demands on phagocytic cells. These are met by mobilizing internal ener..

The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters.

KD McCoy, N Ahmed, AS Tan, MV Berridge

Journal article  |  1997  |  Journal of Biological Chemistry

Most mammalian cells rely on an external supply of glucose for survival, proliferation, and function. Glucose enters cells through..

Regulation of glucose transport by interleukin-3 in growth factor-dependent and oncogene-transformed bone marrow-derived cell lines.

N Ahmed, MV Berridge

Journal article  |  1997  |  Leukemia Research

Growth factors maintain cell viability and promote cell growth by stimulating glucose transport into cells and by progressing cell..

Interaction of reactive nitrogen and oxygen intermediates in HL60 and dimethylsulphoxide-differentiated HL60 cells.

N Ahmed, MJ Weidemann

Journal article  |  1996  |  Leukemia Research

The interaction of reactive nitrogen intermediates (RNI) with reactive oxygen intermediates (ROI) was inferred from the effect of ..

Glycolytic, glutaminolytic and pentose-phosphate pathways in promyelocytic HL60 and DMSO-differentiated HL60 cells.

N Ahmed, JF Williams, MJ Weidemann

Journal article  |  1993  |  Biochemistry and Molecular Biology International

The human leukaemic cell line HL60 undergoes differentiation to granulocyte-like cells in response to dimethylsulphoxide (DMSO). T..

The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate.

N Ahmed, JF Williams, MJ Weidemann

Journal article  |  1991  |  Biochemistry International

The release of the reactive oxygen species that accompanies the oxidative burst was studied in HL60 cells differentiated with eith..