Nuzhat Ahmed

Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma

Revati Sharma, Elif Kadife, Mark Myers, George Kannourakis, Prashanth Prithviraj, Nuzhat Ahmed

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay of treatment for patients with ad..

The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence

Tamsin Wesley, Stuart Berzins, George Kannourakis, Nuzhat Ahmed

Journal article  |  2021  |  CELL COMMUNICATION AND SIGNALING

The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especiall..

TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells

Ruth M Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2020  |  BMC CANCER

BACKGROUND: The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential prote..

In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer Xenograft Model

Jiali Zhai, Fiona H Tan, Rodney B Luwor, T Srinivasa Reddy, Nuzhat Ahmed, Calum J Drummond, Nhiem Tran

Journal article  |  2020  |  ACS APPLIED BIO MATERIALS

Cubosomes with an internal three-dimensional (3D) periodic and porous particulate nanostructure have emerged as a promising drug d..

Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods

Nuzhat Ahmed, Elif Kadife, Ali Raza, Mary Short, Paul T Jubinsky, George Kannourakis

Journal article  |  2020  |  Cells

Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related deat..

Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer

Elif Kadife, Emily Chan, Rodney Luwor, George Kannourakis, Jock Findlay, Nuzhat Ahmed

Journal article  |  2019  |  CANCERS

Approximately seventy percent of ovarian cancer patients succumb to the disease within the first 5 years of diagnosis, even after ..

Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells

Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan, George Kannourakis

Journal article  |  2018  |  SEMINARS IN CANCER BIOLOGY

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therap..

Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer

Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran

Journal article  |  2018  |  ACS APPLIED MATERIALS & INTERFACES

Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer..

Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer.

Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  Oncotarget

Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phase..

The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression

Ruth M Escalona, Emily Chan, George Kannourakis, Jock K Findlay, Nuzhat Ahmed

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated ..