Katie Ganio

Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae

Marina L Zupan, Zhenyao Luo, Katherine Ganio, Victoria G Pederick, Stephanie L Neville, Evelyne Deplazes, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Streptococcus pneumoniae scavenges essential zinc ions from the host during colonization and infection. This is achieved by the AT..

The structural basis of bacterial manganese import

Stephanie L Neville, Jennie Sjoehamn, Jacinta A Watts, Hugo MacDermott-Opeskin, Stephen J Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P McGrath, Andrew J Hayes, Tess R Malcolm, Mark R Davies, Norimichi Nomura, So Iwata, Megan L O'Mara, Megan J Maher, Christopher A McDevitt

Journal article  |  2021  |  SCIENCE ADVANCES

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC) permeases serve as the primary import p..

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

Zhenyao Luo, Jacqueline R Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G Pederick, James C Paton, Thorben Cordes, Jeffrey R Harmer, Bostjan Kobe, Christopher A McDevitt

Journal article  |  2021  |  MBIO

Zinc is an essential element in all domains of life. Nonetheless, how prokaryotes achieve selective acquisition of zinc from the e..

Structural and functional characterizations of the C-terminal domains of CzcD proteins

Saumya R Udagedara, Daniel M La Porta, Christian Spehar, Ghruta Purohit, Matthew JA Hein, Monique E Fatmous, G Patricia Casas Garcia, Katherine Ganio, Christopher A McDevitt, Megan J Maher

Journal article  |  2020  |  JOURNAL OF INORGANIC BIOCHEMISTRY

Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist ..

Extraction of α-neurotoxins from equine plasma by receptor based affinity purification.

Mark Timms, Katherine Ganio, Rohan Steel

Journal article  |  2020  |  Drug Test Anal

Venoms were first identified as potential doping agents by the racing industry in 2007 when three vials of cobra venom were seized..

Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity

Kyle P Grim, Jana N Radin, Paola K Parraga Solorzano, Jacqueline R Morey, Katie A Frye, Katherine Ganio, Stephanie L Neville, Christopher A McDevitt, Thomas E Kehl-Fie

Journal article  |  2020  |  JOURNAL OF BACTERIOLOGY

The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas ..

Expanding beyond ICP-MS to better understand selenium biochemistry

Barbara R Cardoso, Katherine Ganio, Blaine R Roberts

Journal article  |  2019  |  METALLOMICS

Selenium is an essential trace element in human health and therefore its concentration in biological samples (biofluids and tissue..

A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS.

Mark Timms, Katherine Ganio, Rohan Steel

Journal article  |  2019  |  Drug Test Anal

CJC-1295 is a peptide-based drug that stimulates the production of growth hormone (GH) from the pituitary gland. It incorporates a..

An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma

Mark Timms, Katherine Ganio, Grace Forbes, Simon Bailey, Rohan Steel

Journal article  |  2019  |  DRUG TESTING AND ANALYSIS

CJC-1295 is a 30 amino acid peptide-based drug that stimulates the release of growth hormone (GH) from the pituitary gland. It is ..

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, et al.

Journal article  |  2017  |  MOLECULAR PSYCHIATRY

Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke ti..