Miranda Smith

Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies

Jillian SY Lau, Miranda Z Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R Lewin, James H McMahon

Journal article  |  2020  |  AIDS RESEARCH AND THERAPY

BACKGROUND: Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing ..

Time for revolution? Enhancing meaningful involvement of people living with HIV and affected communities in HIV cure-focused science

Jillian SY Lau, Miranda Z Smith, Brent Allan, Karine Dube, A Toni Young, Jennifer Power

Journal article  |  2020  |  JOURNAL OF VIRUS ERADICATION

Introduction: Involving affected communities and people living with HIV (PLHIV) in HIV cure-focused clinical trials has ethical an..

Perspectives on Analytical Treatment Interruptions in People Living with HIV and Their Health Care Providers in the Landscape of HIV Cure-Focused Studies

Jillian SY Lau, Miranda Z Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R Lewin, James H McMahon

Journal article  |  2019  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

Analytical treatment interruptions (ATIs) aim to assess effects of HIV cure-focused interventions, but poses potential risks. Unde..

Clinical trials of antiretroviral treatment interruption in HIV-infected individuals

Jillian SY Lau, Miranda Z Smith, Sharon R Lewin, James H McMahon

Journal article  |  2019  |  AIDS

: Despite the benefits of antiretroviral therapy (ART) for people living with HIV, there has been a long-standing research interes..

DEVELOPING RESEARCH PRIORITIES FOR AUSTRALIA'S RESPONSE TO INFECTIOUS DISEASE EMERGENCIES

Sharon R Lewin, Ross Andrews, Jodie McVernon, Julie Milland, Miranda Z Smith, Tania C Sorrell

Journal article  |  2017  |  COMMUNICABLE DISEASES INTELLIGENCE

Persistence of integrated HIV DNA in CXCR3 CCR6 memory CD4( ) T cells in HIV-infected individuals on antiretroviral therapy

Gabriela Khoury, Jenny L Anderson, Remi Fromentin, Wendy Hartogenesis, Miranda Z Smith, Peter Bacchetti, Frederick M Hecht, Nicolas Chomont, Paul U Cameron, Steven G Deeks, Sharon R Lewin

Journal article  |  2016  |  AIDS

BACKGROUND: HIV latent infection can be established in vitro by treating resting CD4 T cells with chemokines that bind to chemokin..

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

Julian H Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J Cameron, Miranda Z Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H Prince, Jennifer F Hoy, Nicolas Chomont, Remi Fromentin, Francesco A Procopio, Joumana Zeidan, Sarah Palmer, et al.

Journal article  |  2014  |  PLOS PATHOGENS

UNLABELLED: Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier t..

CD8( ) T Cells Are Activated in an Antigen-Independent Manner in HIV-Infected Individuals

Sonia Bastidas, Frederik Graw, Miranda Z Smith, Herbert Kuster, Huldrych F Guenthard, Annette Oxenius

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY

Hyperactivation of T cells, particularly of CD8(+) T cells, is a hallmark of chronic HIV 1 (HIV-1) infection. Little is known abou..

Impact of antigen specificity on CD4( ) T cell activation in chronic HIV-1 infection

Miranda Z Smith, Sonia Bastidas, Urs Karrer, Annette Oxenius

Journal article  |  2013  |  BMC INFECTIOUS DISEASES

BACKGROUND: HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes o..

HIV Reservoirs and Strategies for Eradication

Miranda Z Smith, Fiona Wightman, Sharon R Lewin

Journal article  |  2012  |  CURRENT HIV/AIDS REPORTS

Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in HIV-infected patients but therapy i..