Stephen Leslie

The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility.

Rebecca L Yanovsky, Haoyan Chen, Stephen Leslie, Mary Carrington, Wilson Liao

Journal article  |  2019  |  Journal of Investigative Dermatology

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A Patsopoulos, Sergio E Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H Beecham, Tojo James, Joseph Replogle, Ioannis S Vlachos, Cristin McCabe, Tune H Pers, Aaron Brandes, Charles White, Brendan Keenan, Maria Cimpean, Phoebe Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till FM Andlauer, et al.

Journal article  |  2019  |  Science

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis

Di Yan, Richard Ahn, Stephen Leslie, Wilson Liao

Journal article  |  2018  |  Dermatology and Therapy

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O'Connell, Adrian Cortes, Samantha Welsh, Alan Young, Mark Effingham, Gil McVean, Stephen Leslie, Naomi Allen, Peter Donnelly, Jonathan Marchini

Journal article  |  2018  |  Nature

Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.

DJ Pappas, A Lizee, V Paunic, KR Beutner, A Motyer, D Vukcevic, S Leslie, J Biesiada, J Meller, KD Taylor, X Zheng, LP Zhao, P-A Gourraud, JA Hollenbach, SJ Mack, M Maiers

Journal article  |  2018  |  The Pharmacogenomics Journal

Four single nucleotide polymorphism (SNP)-based human leukocyte antigen (HLA) imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAG..

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

Fleur C Garton, Peter J Houweling, Damjan Vukcevic, Lyra R Meehan, Fiona XZ Lee, Monkol Lek, Kelly N Roeszler, Marshall W Hogarth, Chrystal F Tiong, Diana Zannino, Nan Yang, Stephen Leslie, Paul Gregorevic, Stewart I Head, Jane T Seto, Kathryn N North

Journal article  |  2018  |  The American Journal of Human Genetics

Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank

Adrian Cortes, Calliope A Dendrou, Allan Motyer, Luke Jostins, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Stephen Leslie, Lars Fugger, Gil McVean

Journal article  |  2017  |  Nature Genetics

Genome-wide genetic data on ~500,000 UK Biobank participants

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrian Cortes, Samantha Welsh, Gil McVean, Stephen Leslie, Peter Donnelly, Jonathan Marchini

Journal article  |  2017  |  bioRxiv

Abstract The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across the United Kingdom, aged b..

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, Y-A Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira

Journal article  |  2017  |  Clinical & Experimental Allergy

Practical Use of Methods for Imputation of HLA Alleles from SNP Genotype Data

Allan Motyer, Damjan Vukcevic, Alexander Dilthey, Peter Donnelly, Gil McVean, Stephen Leslie

Journal article  |  2016  |  BioRxiv

Abstract The human leukocyte antigen (HLA) genes play an essential role in immune function. Typing of HLA alleles is critical for ..

Class II HLA interactions modulate genetic risk for multiple sclerosis

Loukas Moutsianas, Luke Jostins, Ashley H Beecham, Alexander T Dilthey, Dionysia K Xifara, Maria Ban, Tejas S Shah, Nikolaos A Patsopoulos, Lars Alfredsson, Carl A Anderson, Katherine E Attfield, Sergio E Baranzini, Jeffrey Barrett, Thomas MC Binder, David Booth, Dorothea Buck, Elisabeth G Celius, Chris Cotsapas, Sandra D'Alfonso, Calliope A Dendrou, et al.

Journal article  |  2015  |  Nature Genetics

Imputation of KIR Types from SNP Variation Data

Damjan Vukcevic, James A Traherne, Sigrid Naess, Eva Ellinghaus, Yoichiro Kamatani, Alexander Dilthey, Mark Lathrop, Tom H Karlsen, Andre Franke, Miriam Moffatt, William Cookson, John Trowsdale, Gil McVean, Stephen Sawcer, Stephen Leslie

Journal article  |  2015  |  The American Journal of Human Genetics

The fine-scale genetic structure of the British population

Stephen Leslie, Bruce Winney, Garrett Hellenthal, Dan Davison, Abdelhamid Boumertit, Tammy Day, Katarzyna Hutnik, Ellen C Royrvik, Barry Cunliffe, Daniel J Lawson, Daniel Falush, Colin Freeman, Matti Pirinen, Simon Myers, Mark Robinson, Peter Donnelly, Walter Bodmer

Journal article  |  2015  |  Nature

High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Philippe Goyette, Gabrielle Boucher, Dermot Mallon, Eva Ellinghaust, Luke Jostins, Hailiang Huang, Stephan Ripke, Elena S Gusareva, Vito Annese, Stephen L Hauser, Jorge R Oksenberg, Ingo Thomsent, Stephen Leslie, Mark J Daly, Kristel Van Steen, Richard H Duerr, Jeffrey C Barrett, Dermot PB McGovern, L Philip Schumm, James A Traherne, et al.

Journal article  |  2015  |  Nature Genetics

Development of a global network of induced pluripotent stem cell haplobanks

Ian Wilmut, Stephen Leslie, Nicholas G Martin, Marc Peschanski, Mahendra Rao, Alan Trounson, David Turner, Marc L Turner, Shinya Yamanaka, Craig J Taylor

Journal article  |  2015  |  Regenerative Medicine

Toward the Development of a Global Induced Pluripotent Stem Cell Library

Marc Turner, Stephen Leslie, Nicholas G Martin, Marc Peschanski, Mahendra Rao, Craig J Taylor, Alan Trounson, David Turner, Shinya Yamanaka, Ian Wilmut

Journal article  |  2013  |  Cell Stem Cell

Multi-Population Classical HLA Type Imputation

Alexander Dilthey, Stephen Leslie, Loukas Moutsianas, Judong Shen, Charles Cox, Matthew R Nelson, Gil McVean

Journal article  |  2013  |  PLoS Computational Biology

Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

Benjamin P Fairfax, Seiko Makino, Jayachandran Radhakrishnan, Katharine Plant, Stephen Leslie, Alexander Dilthey, Peter Ellis, Cordelia Langford, Fredrik O Vannberg, Julian C Knight

Journal article  |  2012  |  Nature Genetics

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.

Michelle MA Fernando, Jan Freudenberg, Annette Lee, David Lester Morris, Lora Boteva, Benjamin Rhodes, María Francisca Gonzalez-Escribano, Miguel Angel Lopez-Nevot, Sandra V Navarra, Peter K Gregersen, Javier Martin, undefined IMAGEN, Timothy J Vyse

Journal article  |  2012  |  Annals of the Rheumatic Diseases

OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic multisystem genetically complex autoimmune disease characterised by th..

People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population

Bruce Winney, Abdelhamid Boumertit, Tammy Day, Dan Davison, Chikodi Echeta, Irina Evseeva, Katarzyna Hutnik, Stephen Leslie, Kristin Nicodemus, Ellen C Royrvik, Susan Tonks, Xiaofeng Yang, James Cheshire, Paul Longley, Pablo Mateos, Alexandra Groom, Caroline Relton, D Tim Bishop, Kathryn Black, Emma Northwood, et al.

Journal article  |  2012  |  European Journal of Human Genetics

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

David M Evans, Chris CA Spencer, Jennifer J Pointon, Zhan Su, David Harvey, Grazyna Kochan, Udo Opperman, Alexander Dilthey, Matti Pirinen, Millicent A Stone, Louise Appleton, Loukas Moutsianis, Stephen Leslie, Tom Wordsworth, Tony J Kenna, Tugce Karaderi, Gethin P Thomas, Michael M Ward, Michael H Weisman, Claire Farrar, et al.

Journal article  |  2011  |  Nature Genetics

Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3

Loukas Moutsianas, Victor Enciso-Mora, Yussanne P Ma, Stephen Leslie, Alexander Dilthey, Peter Broderick, Amy Sherborne, Rosie Cooke, Alan Ashworth, Anthony J Swerdlow, Gilean McVean, Richard S Houlston

Journal article  |  2011  |  Blood

HLA*IMP-an integrated framework for imputing classical HLA alleles from SNP genotypes

Alexander T Dilthey, Loukas Moutsianas, Stephen Leslie, Gil McVean

Journal article  |  2011  |  Bioinformatics

MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

Fay J Hosking, Stephen Leslie, Alexander Dilthey, Loukas Moutsianas, Yufei Wang, Sara E Dobbins, Elli Papaemmanuil, Eamonn Sheridan, Sally E Kinsey, Tracy Lightfoot, Eve Roman, Julie AE Irving, James M Allan, Malcolm Taylor, Mel Greaves, Gilean McVean, Richard S Houlston

Journal article  |  2011  |  Blood

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

undefined Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Amy Strange, Francesca Capon, Chris CA Spencer, Jo Knight, Michael E Weale, Michael H Allen, Anne Barton, Gavin Band, Céline Bellenguez, Judith GM Bergboer, Jenefer M Blackwell, Elvira Bramon, Suzannah J Bumpstead, Juan P Casas, Michael J Cork, Aiden Corvin, Panos Deloukas, Alexander Dilthey, Audrey Duncanson, et al.

Journal article  |  2010  |  Nature Genetics

To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individua..

Integrating common and rare genetic variation in diverse human populations

David M Altshuler, Richard A Gibbs, Leena Peltonen, Emmanouil Dermitzakis, Stephen F Schaffner, Fuli Yu, Penelope E Bonnen, Paul IW de Bakker, Panos Deloukas, Stacey B Gabriel, Rhian Gwilliam, Sarah Hunt, Michael Inouye, Xiaoming Jia, Aarno Palotie, Melissa Parkin, Pamela Whittaker, Kyle Chang, Alicia Hawes, Lora R Lewis, et al.

Journal article  |  2010  |  Nature

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

undefined International MHC and Autoimmunity Genetics Network, John D Rioux, Philippe Goyette, Timothy J Vyse, Lennart Hammarström, Michelle MA Fernando, Todd Green, Philip L De Jager, Sylvain Foisy, Joanne Wang, Paul IW de Bakker, Stephen Leslie, Gilean McVean, Leonid Padyukov, Lars Alfredsson, Vito Annese, David A Hafler, Qiang Pan-Hammarström, Ritva Matell, Stephen J Sawcer, et al.

Journal article  |  2009  |  Proceedings of the National Academy of Sciences

The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predi..

A statistical method for predicting classical HLA alleles from SNP data.

Stephen Leslie, Peter Donnelly, Gil McVean

Journal article  |  2008  |  The American Journal of Human Genetics

Genetic variation at classical HLA alleles is a crucial determinant of transplant success and susceptibility to a large number of ..