Stephen Leslie

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

Richard Ahn, Damjan Vukcevic, Allan Motyer, Joanne Nititham, David McG Squire, Jill A Hollenbach, Paul J Norman, Eva Ellinghaus, Rajan P Nair, Lam C Tsoi, Jorge Oksenberg, John Foerster, Wolfgang Lieb, Stephan Weidinger, Andre Franke, James T Elder, Eric Jorgenson, Stephen Leslie, Wilson Liao

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands...

Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations

Frauke Degenhardt, Gabriele Mayr, Mareike Wendorff, Gabrielle Boucher, Eva Ellinghaus, David Ellinghaus, Hesham ElAbd, Elisa Rosati, Matthias Huebenthal, Simonas Juzenas, Shifteh Abedian, Homayon Vahedi, BK Thelma, Suk-Kyun Yang, Byong Duk Ye, Jae Hee Cheon, Lisa Wu Datta, Naser Ebrahim Daryani, Pierre Ellul, Motohiro Esaki, et al.

Journal article  |  2021  |  HUMAN MOLECULAR GENETICS

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic association studies have identified the hig..

Equitable Expanded Carrier Screening Needs Indigenous Clinical and Population Genomic Data

Simon Easteal, Ruth M Arkell, Renzo F Balboa, Shayne A Bellingham, Alex D Brown, Tom Calma, Matthew C Cook, Megan Davis, Hugh JS Dawkins, Marcel E Dinger, Michael S Dobbie, Ashley Farlow, Kylie G Gwynne, Azure Hermes, Wendy E Hoy, Misty R Jenkins, Simon H Jiang, Warren Kaplan, Stephen Leslie, Bastien Llamas, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF HUMAN GENETICS

Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA var..

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

Aimee L Hanson, Damjan Vukcevic, Stephen Leslie, Jessica Harris, Kim-Anh Le Cao, Tony J Kenna, Matthew A Brown

Journal article  |  2020  |  PLOS GENETICS

The killer immunoglobulin-like receptors (KIRs), found predominantly on the surface of natural killer (NK) cells and some T-cells,..

Efficient simulation of ancestry in large datasets

Georgia Tsambos, Peter Ralph, Jerome Kelleher, Stephen Leslie, Damjan Vukcevic

Conference Proceedings  |  2020  |  GENETIC EPIDEMIOLOGY

The Interaction of LILRB2 with HLA-B Is Associated with Psoriasis Susceptibility

Rebecca L Yanovsky, Haoyan Chen, Stephen Leslie, Mary Carrington, Wilson Liao

Journal article  |  2020  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Using single cell DNA-seq to decipher disease mechanisms for MS

JP Rubio, A Motyer, S Jackson, DA Markalanda, I Harliwong, C Ye, A Shiu, T Tian, JL Fink, A Harding, M Barnett, SJ Leslie

Conference Proceedings  |  2020  |  MULTIPLE SCLEROSIS JOURNAL

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Paul A Lyons, James E Peters, Federico Alberici, James Liley, Richard MR Coulson, William Astle, Chiara Baldini, Francesco Bonatti, Maria C Cid, Heather Elding, Giacomo Emmi, Joerg Epplen, Loic Guillevin, David RW Jayne, Tao Jiang, Iva Gunnarsson, Peter Lamprecht, Stephen Leslie, Mark A Little, Davide Martorana, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-ne..

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A Patsopoulos, Sergio E Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H Beecham, Tojo James, Joseph Replogle, Ioannis S Vlachos, Cristin McCabe, Tune H Pers, Aaron Brandes, Charles White, Brendan Keenan, Maria Cimpean, Phoebe Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till FM Andlauer, et al.

Journal article  |  2019  |  SCIENCE

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the gene..

GENETIC EVIDENCE OF EOSINOPHIL NUMBER UNDERPINNING PR3-AAV AND PLAUSIBLE HOST GENETIC PREDISPOSITION TO MICROBIAL DRIVERS OF DISEASE

Limy Wong, Federica Mescia, Federico Alberici, Miriam J Ball, Bo Baslund, Paul Brenchley, Annette Bruchfeld, Maria C Cid, Jan Willem Cohen Tervaert, Richard MR Coulson, Neda Farahi, Conleth Feighery, Wolfgang L Gross, Loic Guillevin, Iva Gunnarsson, Lorraine Harper, Julia U Holle, Zdenka Hruskova, David RW Jayne, Peter Lamprecht, et al.

Conference Proceedings  |  2019  |  RHEUMATOLOGY