Jessica Howell

Use of controlled temperature chain and compact prefilled auto-disable devices to reach 2030 hepatitis B birth dose vaccination targets in LMICs: a modelling and cost-optimisation study

Christopher P Seaman, Christopher Morgan, Jess Howell, Yinzong Xiao, C Wendy Spearman, Mark Sonderup, Olufunmilayo Lesi, Monique I Andersson, Margaret E Hellard, Nick Scott

Journal article  |  2020  |  The Lancet Global Health

BACKGROUND: Hepatitis B causes more than 800 000 deaths globally each year. Perinatal infections are a major driver of this burden..

The impact of universal access to direct-acting antiviral therapy on the hepatitis C cascade of care among individuals attending primary and community health services

Michael W Traeger, Alisa E Pedrana, Daniela K van Santen, Joseph S Doyle, Jessica Howell, Alexander J Thompson, Carol El-Hayek, Jason Asselin, Victoria Polkinghorne, Dean Membrey, Fran Bramwell, Allison Carter, Rebecca Guy, Mark A Stoove, Margaret E Hellard

Journal article  |  2020  |  PLOS ONE

BACKGROUND: Hepatitis C elimination will require widespread access to treatment and responses at the health-service level to incre..

Closing the Stable Door After the Horse Has Bolted: Should We Be Treating People With Immune-Tolerant Chronic Hepatitis B to Prevent Hepatocellular Carcinoma? COMMENT

Jessica Howell, Henry LY Chan, Jordan J Feld, Margaret E Hellard, Alexander J Thompson

Journal article  |  2020  |  Gastroenterology

A cost-effectiveness analysis of primary versus hospital-based specialist care for direct acting antiviral hepatitis C treatment

Anna Y Palmer, Amanda J Wade, Bridget Draper, Jessica Howell, Joseph S Doyle, Dennis Petrie, Alexander J Thompson, David P Wilson, Margaret E Hellard, Nick Scott

Journal article  |  2020  |  International Journal of Drug Policy

BACKGROUND: Hepatitis C virus elimination may be possible by scaling up direct-acting antiviral (DAA) treatment. Due to the safety..

Enhancing the hepatitis B care cascade in Australia: A cost-effectiveness model

Yinzong Xiao, Jessica Howell, Caroline van Gemert, Alexander J Thompson, Christopher P Seaman, Karen McCulloch, Nick Scott, Margaret E Hellard

Journal article  |  2020  |  Journal of Viral Hepatitis

'Think Hep B' in primary care A before-and-after evaluation of a self-guided learning package

Yinzong Xiao, Caroline van Gemert, Jess Howell, Emily Adamson, Vanessa Towell, Benjamin C Cowie, Alex J Thompson, Margaret Hellard

Journal article  |  2020  |  Australian Journal of General Practice

BACKGROUND AND OBJECTIVES: In Australia, over a third of individuals living with chronic hepatitis B (CHB) remain undiagnosed. Evi..

'Teach-back' is a simple communication tool that improves disease knowledge in people with chronic hepatitis B - a pilot randomized controlled study

Sophie Tran, Gabrielle Bennett, Jacqui Richmond, Nguyen Tin, Marno Ryan, Thai Hong, Jessica Howell, Barbara Demediuk, Paul Desmond, Sally Bell, Alexander Thompson

Journal article  |  2019  |  BMC Public Health

BACKGROUND: The low diagnosis rate and poor access to clinical care among people with CHB is a major barrier to reducing HBV-relat..

Point-of-care hepatitis C testing from needle and syringe programs: An Australian feasibility study

Bridget Williams, Jessica Howell, Joseph Doyle, Alexander J Thompson, Bridget Draper, Chloe Layton, Ned Latham, Frances Bramwell, Dean Membrey, Maggie Mcpherson, Janine Roney, Mark Stoove, Margaret E Hellard, Alisa Pedrana

Journal article  |  2019  |  International Journal of Drug Policy

BACKGROUND: Achieving hepatitis C elimination requires novel approaches to engage people at highest risk of infection into care pa..

Point-of-care Hepatitis C virus testing and linkage to treatment in an Australian inner-city emergency department

J Hutton, J Doyle, R Zordan, T Weiland, A Cocco, J Howell, S Iser, J Snell, S Fry, K New, R Sloane, M Jarman, D Phan, S Tran, A Pedrana, B Williams, J Johnson, S Glasgow, A Thompson

Journal article  |  2019  |  International Journal of Drug Policy

BACKGROUND: In Australia, Hepatitis C Virus (HCV) treatment is declining, despite broad access to direct-acting antiviral medicati..

Innovative strategies for the elimination of viral hepatitis at a national level: A country case series

Sophia E Schroeder, Alisa Pedrana, Nick Scott, David Wilson, Christian Kuschel, Lisa Aufegger, Rifat Atun, Ricardo Baptista-Leite, Maia Butsashvili, Manal El-Sayed, Aneley Getahun, Saeed Hamid, Radi Hammad, Ellen 't Hoen, Sharon J Hutchinson, Jeffrey V Lazarus, Olufunmilayo Lesi, Wangsheng Li, Rosmawati Binti Mohamed, Sigurdur Olafsson, et al.

Journal article  |  2019  |  Liver International

Nurse-led, protocol-driven screening for hepatitis B virus before initiating biological therapy for chronic inflammatory disease is very effective

I Urbano, A Sim, S Oon, J Luong, F Lai, M Sullivan, P Foley, S Anderson, D Courtney, A Macdonald, T Samyue, S Fry, A Stanley, J Ding, W Connell, M Lust, J Schulberg, C Basnayake, M Kamm, E Flanagan, et al.

Conference Proceedings  |  2019  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Eliminating hepatitis C by 2030: Hospital presentation provides opportunities for engagement and treatment of marginalized individuals with chronic hepatitis C

E Freeman, K New, S Glasgow, L Stothers, C Croagh, P Desmond, B Demediuk, J Holmes, T Hong, J Howell, M Ryan, J Doyle, A Thompson

Conference Proceedings  |  2019  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Real-world efficacy of long-term entecavir and tenofovir in patients with chronic hepatitis B

S Le, D Ratnam, R Van Leest, W Kemp, S Roberts, A Nicoll, P Gow, S Bell, S Sood, N Arachchi, J Lubel, M Ryan, J Howell, A Majeed, A Dev

Conference Proceedings  |  2019  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Identification of mutations in circulating cell-free tumour DNA as a biomarker in hepatocellular carcinoma

Jessica Howell, Stephen R Atkinson, David J Pinato, Susanne Knapp, Caroline Ward, Rosalba Minisini, Michela E Burlone, Monica Leutner, Mario Pirisi, Reinhard Buettner, Shahid A Khan, Mark Thursz, Margarete Odenthal, Rohini Sharma

Journal article  |  2019  |  European Journal of Cancer

BACKGROUND: Hepatocellular carcinoma (HCC) is increasing globally. Prognostic biomarkers are urgently needed to guide treatment an..

Community-based, point-of-care hepatitis C testing: perspectives and preferences of people who inject drugs

Ned H Latham, Alisa Pedrana, Joseph S Doyle, Jessica Howell, Bridget Williams, Peter Higgs, Alexander J Thompson, Margaret E Hellard

Journal article  |  2019  |  Journal of Viral Hepatitis

Hepatitis B management during immunosuppression for haematological and solid organ malignancies: an Australian consensus statement

Joseph Doyle, Michelle Raggatt, Monica Slavin, Sue-Anne McLachlan, Simone I Strasser, Joseph J Sasadeusz, Jessica Howell, Krispin Hajkowicz, Harshal Nandurkar, Anna Johnston, Narin Bak, Alexander J Thompson

Journal article  |  2019  |  Medical Journal of Australia

Outcomes of treatment for hepatitis C in prisoners using a nurse-led, statewide model of care

Timothy Papaluca, Lucy McDonald, Anne Craigie, Annabelle Gibson, Paul Desmond, Darren Wong, Rebecca Winter, Nick Scott, Jessica Howell, Joseph Doyle, Alisa Pedrana, Andrew Lloyd, Mark Stoove, Margaret Hellard, David Iser, Alexander Thompson

Journal article  |  2019  |  Journal of Hepatology

The emerging burden of liver disease in cystic fibrosis patients: A UK nationwide study

MB Toledano, SK Mukherjee, J Howell, D Westaby, SA Khan, D Bilton, NJ Simmonds

Journal article  |  2019  |  PLOS ONE

OBJECTIVE: Cystic fibrosis associated liver disease (CFLD) is the third largest cause of mortality in CF. Our aim was to define th..

The impact of community-based rapid point-of-care testing on enhancing uptake of hepatitis C treatment for people who inject drugs in needle and syringe services

Jessica Howell, Bridget Williams, Alisa Pedrana, Michael Traeger, Joseph Doyle, Ned Latham, Bridget Draper, Chloe Layton, Frances Bramwell, Dean Membrey, Margaret Mcpherson, Janine Roney, Alexander Thompson, Margaret Hellard

Conference Proceedings  |  2019  |  Journal of Hepatology

Low rate of treatment uptake amongst recently released prisoners with active HCV infection

Tim Papaluca, George Tambakis, Anne Craigie, Lucy Mcdonald, Amy Edwards, David Iser, Jessica Howell, Paul Desmond, Mark Stoove, Margaret Hellard, Joseph Doyle, Alexander Thompson

Conference Proceedings  |  2019  |  Journal of Hepatology

Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission

Graham S Cooke, Isabelle Andrieux-Meyer, Tanya L Applegate, Rifat Atun, Jessica R Burry, Hugo Cheinquer, Geoff Dusheiko, Jordan J Feld, Charles Gore, Max G Griswold, Saeed Hamid, Margaret E Hellard, JinLin Hou, Jess Howell, Jidong Jia, Natalia Kravchenko, Jeffrey V Lazarus, Maud Lemoine, Olufunmilayo A Lesi, Liudmyla Maistat, et al.

Journal article  |  2019  |  The Lancet Gastroenterology & Hepatology

Eliminating hepatitis C Part 4. Ongoing care after hepatitis C treatment

K Chan, M Gooey, M Hellard, B Greenwood-Smith, R Chaney, D Baker, A Pedrana, J Doyle, J Howell

Journal article  |  2019  |  Medicine Today

Tracking the uptake of outcomes of hepatitis B virus testing using laboratory data in Victoria, 2011-16: a population-level cohort study

Caroline van Gemert, Wayne Dimech, Mark Stoove, Rebecca Guy, Jess Howell, Scott Bowden, Suellen Nicholson, Stella Pendle, Basil Donovan, Margaret Hellard, Carol El-Hayek, Denton Callandar, Jason Asselin, Clarissa Moreira, Lucy Watchirs Smith, Nguyen Long, Gijo Thomas

Journal article  |  2019  |  Sexual Health

Eliminating hepatitis C Part 5. Practical steps in your practice

D Baker, A Balcomb, J O'Loan, J Howell

Journal article  |  2019  |  Medicine Today

Eliminating hepatitis C Part 1. Finding your patients with hepatitis C

B Draper, C Layton, J Doyle, J Howell, D Baker, M Stoové, A Pedrana

Journal article  |  2019  |  Medicine Today

Eliminating hepatitis C: Part 2. Assessing your patient for antiviral treatment

C Layton, J Richmond, D Baker, L Owen, G Matthews, E Oliver-Landry, J Howell, J Doyle

Journal article  |  2019  |  Medicine Today

Aiming for the elimination of viral hepatitis in Australia, New Zealand, and the Pacific Islands and Territories: Where are we now and barriers to meeting World Health Organization targets by 2030

Jess Howell, Alisa Pedrana, Benjamin C Cowie, Joseph Doyle, Aneley Getahun, James Ward, Ed Gane, Chris Cunningham, Jack Wallace, Alice Lee, Jioji Malani, Alex Thompson, Margaret E Hellard

Journal article  |  2019  |  Journal of Gastroenterology and Hepatology

Salvage Therapy with Sofosbuvir, Elbasvir, Grazoprevir and Ribavirin for Daa Non-Responders - High Efficacy in GT3 and GT1/4 HCV Infection

Tim Papaluca, Susanne Glasgow, Kate New, Anne Craigie, Lucy McDonald, Lisa Stothers, David Iser, Paul Desmond, Sally Bell, Barbara Demediuk, Kumar Visvanathan, Marno Ryan, Jessica Howell, Thai Hong, Catherine Croagh, Marie Sinclair, Peter W Angus, Niranjan Arachchi, Jacinta O'Keefe, Scott Bowden, et al.

Conference Proceedings  |  2018  |  HEPATOLOGY

Increasing hepatitis C testing uptake with point of care testing from the needle and syringe exchange desk - lessons learned from the Rapid-EC Feasibility Study

B Williams, A Pedrana, J Howell, J Doyle, A Thompson, F Bramwell, D Membrey, M McPherson, C Layton, B Draper, J Roney, N Latham, M Hellard

Conference Proceedings  |  2018  |  JOURNAL OF VIRAL HEPATITIS

In hepatitis C patients with cirrhosis who achieve SVR with treatment, reduction in transient elastography measures does not translate to reduced risk of hepatocellular carcinoma: A prospective cohort study

J Howell, T Papaluca, S Glasgow, K New, T Hong, J Snell, D Iser, M Ryan, S Bell, P Desmond, SLCY Mei, C Croagh, T Nguyen, Z Valaydon, G Shaw, B Demediuk, L Mcdonald, A Craigie, L Stothers, M Lust, et al.

Conference Proceedings  |  2018  |  Journal of Hepatology

The Rapid-EC study - A feasibility study of point-of-care testing in community clinics targeted to people who inject drugs in Melbourne, Australia

B Williams, A Pedrana, J Howell, J Doyle, A Thompson, F Bramwell, D Membrey, M Mcpherson, C Layton, B Draper, J Roney, N Latham, M Hellard

Conference Proceedings  |  2018  |  Journal of Hepatology

"B in IT" - a community-based model for the management of hepatitis B patients in primary care clinics using a novel web-based clinical tool.

Debra A O'Leary, Eleanor Cropp, David Isaac, Paul V Desmond, Sally Bell, Tin Nguyen, Darren Wong, Jessica Howell, Jacqui Richmond, Jenny O'Neill, Alexander J Thompson

Journal article  |  2018  |  Hepatology, Medicine and Policy

Background: The current model of care for the treatment of chronic hepatitis B (CHB) in Australia is through specialist Hepatology..

Reaching hepatitis C virus elimination targets requires health system interventions to enhance the care cascade

Nick Scott, Joseph S Doyle, David P Wilson, Amanda Wade, Jess Howell, Alisa Pedrana, Alexander Thompson, Margaret E Hellard

Journal article  |  2017  |  International Journal of Drug Policy

Knowledge and practices of chronic hepatitis B virus testing by general practitioners in Victoria, Australia, 2014-15

Caroline van Gemert, Jess Howell, Julie Wang, Mark Stoove, Benjamin Cowie, Nicole Allard, Chris Enright, Elisabeth Dunn, Vanessa Towell, Margaret Hellard

Journal article  |  2017  |  Australian Family Physician

Review article: delivering precision oncology in intermediate-stage liver cancer

DJ Pinato, J Howell, R Ramaswami, R Sharma

Journal article  |  2017  |  Alimentary Pharmacology & Therapeutics

BACKGROUND: Intermediate-stage hepatocellular carcinoma (HCC), for which trans-arterial chemoembolization (TACE) constitutes the s..

Integration of the cancer-related inflammatory response as a stratifying biomarker of survival in hepatocellular carcinoma treated with sorafenib

Jessica A Howell, David J Pinato, Ramya Ramaswami, Tadaaki Arizumi, Carlotta Ferrari, Antonello Gibbin, Michela E Burlone, Giulia Guaschino, Pierluigi Toniutto, James Black, Laura Sellers, Masatoshi Kudo, Mario Pirisi, Rohini Sharma

Journal article  |  2017  |  Oncotarget

Hepatocellular Carcinoma After Sustained Virologic Response: Leave No One Behind

Jessica Howell, Alexander J Thompson

Journal article  |  2017  |  Gastroenterology

The clinical role of circulating free tumor DNA in gastrointestinal malignancy

Jessica A Howell, Shahid A Khan, Susanne Knapp, Mark R Thursz, Rohini Sharma

Journal article  |  2017  |  Translational Research

Circulating cell-free DNA (cfDNA) is DNA released from necrotic or apoptotic cells into the bloodstream. While both healthy cells ..

On-target sorafenib toxicity predicts improved survival in hepatocellular carcinoma: a multi-centre, prospective study

J Howell, DJ Pinato, R Ramaswami, D Bettinger, T Arizumi, C Ferrari, C Yen, A Gibbin, ME Burlone, G Guaschino, L Sellers, J Black, M Pirisi, M Kudo, R Thimme, J-W Park, R Sharma

Journal article  |  2017  |  Alimentary Pharmacology & Therapeutics

BACKGROUND: Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and has high mortality despite treatment. Whi..

The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma

David J Pinato, Rohini Sharma, Elias Allara, Clarence Yen, Tadaaki Arizumi, Keiichi Kubota, Dominik Bettinger, Jeong Won Jang, Carlo Smirne, Young Woon Kim, Masatoshi Kudo, Jessica Howell, Ramya Ramaswami, Michela E Burlone, Vito Guerra, Robert Thimme, Mitsuru Ishizuka, Justin Stebbing, Mario Pirisi, Brian I Carr

Journal article  |  2017  |  Journal of Hepatology

BACKGROUND & AIMS: Overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC) due to the mutual infl..

Identification of actionable mutations in circulating cell-free tumour DNA as a prognostic biomarker in hepatocellular carcinoma

J Howell, S Atkinson, DJ PInato, S Knapp, C Ward, R Minisini, M Burlone, M Leutner, M Pirisi, S Khan, M Odenthal, M Thursz, R Sharma

Conference Proceedings  |  2017  |  Journal of Hepatology

Treatment-stage migration maximizes survival outcomes in patients with hepatocellular carcinoma treated with sorafenib: an observational study

C Yen, R Sharma, L Rimassa, T Arizumi, D Bettinger, J Evans, T Pressiani, ME Burlone, M Pirisi, L Giordano, J Howell, M Kudo, R Thimme, J-W Park, DJ Pinato

Conference Proceedings  |  2017  |  Journal of Hepatology

Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

Maud Lemoine, Yusuke Shimakawa, Ramou Njie, Makie Taal, Gibril Ndow, Isabelle Chemin, Sumantra Ghosh, Harr F Njai, Adam Jeng, Amina Sow, Coumba Toure-Kane, Souleymane Mboup, Penda Suso, Saydiba Tamba, Abdullah Jatta, Louise Sarr, Aboubacar Kambi, William Stanger, Shevanthi Nayagam, Jessica Howell, et al.

Journal article  |  2016  |  The Lancet Global Health

BACKGROUND: Despite the introduction of immunisation for hepatitis B virus (HBV) in the 1990s, HBV-related morbidity and mortality..

PROLIFICA: a story of West African clinical and research collaborations to target hepatitis B-related hepatocellular carcinoma in West Africa.

J Howell, NG Ladep, S Nayagam, M Lemoine, DA Garside, MME Crossey, E Okeke, R Njie, MM Ka, M Taal, MR Thursz, SD Taylor-Robinson

Journal article  |  2016  |  QJM

The increasing burden of potentially preventable liver disease among adult liver transplant recipients: A comparative analysis of liver transplant indication by era in Australia and New Zealand

Jessica Howell, Glenda Balderson, Margaret Hellard, Paul Gow, Simone Strasser, Katherine Stuart, Alan Wigg, Gary Jeffrey, Ed Gane, Peter W Angus

Journal article  |  2016  |  Journal of Gastroenterology and Hepatology

Prevention of Liver Fibrosis and Cancer in Africa: The PROLIFICA project - a collaborative study of hepatitis B-related liver disease in West Africa

Jessica Howell, Nimzing G Ladep, Maud Lemoine, Shevanthi Nayagam, Papa Souleymane Toure, Magatte Madoky Diop, Joao Armindo Daveiga, Amina Sow Sall, Gora Lo, Mary ME Crossey, Mark R Thursz, Simon D Taylor-Robinson, Mamadou Mourtalla Ka

Journal article  |  2015  |  South African Medical Journal

An overview of hepatitis B prevalence, prevention, and management in the Pacific Islands and Territories

Jessica Howell, Caroline Van Gemert, Maud Lemoine, Mark Thursz, Margaret Hellard

Journal article  |  2014  |  Journal of Gastroenterology and Hepatology

Prevention of materno-foetal transmission of hepatitis B in sub-Saharan Africa: the evidence, current practice and future challenges

J Howell, M Lemoine, M Thursz

Journal article  |  2014  |  Journal of Viral Hepatitis

Role of toll-like receptors in liver transplantation

Jessica Howell, Paul Gow, Peter Angus, Kumar Visvanathan

Journal article  |  2014  |  Liver Transplantation

Hepatitis C recurrence: the Achilles heel of liver transplantation

J Howell, P Angus, P Gow

Journal article  |  2014  |  Transplant Infectious Disease

Identifying the superior measure of rapid fibrosis for predicting premature cirrhosis after liver transplantation for hepatitis C

J Howell, R Sawhney, P Angus, M Fink, R Jones, BZ Wang, K Visvanathan, P Crowley, P Gow

Journal article  |  2013  |  Transplant Infectious Disease

Paracetamol overdose in Victoria remains a significant health-care burden

Siddharth Sood, Jessica Howell, Vijaya Sundararajan, Peter W Angus, Paul J Gow

Journal article  |  2013  |  Journal of Gastroenterology and Hepatology

Toll-like receptors in hepatitis C infection: Implications for pathogenesis and treatment

Jessica Howell, Peter Angus, Paul Gow, Kumar Visvanathan

Journal article  |  2013  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Toll-Like Receptor 3 and 7/8 Function Is Impaired in Hepatitis C Rapid Fibrosis Progression Post-Liver Transplantation

J Howell, R Sawhney, N Skinner, P Gow, P Angus, D Ratnam, K Visvanathan

Journal article  |  2013  |  American Journal of Transplantation

The role of natural killer cells in hepatitis C infection

Jessica Howell, Kumar Visvanathan

Journal article  |  2013  |  Antiviral Therapy

Type 2 Diabetes does not worsen prognosis in hepatocellular carcinoma

J Howell, M Yiu, R Gibson, B Thomson, D Stella, A Gorelik, PJ Prichard, AJ Nicoll

Journal article  |  2011  |  Clinics and Research in Hepatology and Gastroenterology

A novel role for human leukocyte antigen-DP in chronic hepatitis B infection: a genomewide association study.

Jessica A Howell, Kumar Visvanathan

Journal article  |  2009  |  Hepatology

Amiodarone hepatoxicity

J Howell, A Nicoll

Journal article  |  2009  |  Medicine Today

Education and imaging. Gastrointestinal: beef tapeworm (Taenia saginata).

J Howell, G Brown

Journal article  |  2008  |  Journal of Gastroenterology and Hepatology