Francis Carbone

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaelle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M Jones, Bernard Malissen, Laura K Mackay, Aziz Moqrich, Francis R Carbone, Sophie Ugolini

Journal article  |  2021  |  NATURE COMMUNICATIONS

Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune res..

Immovable memories: the journey to permanent residency

Francis R Carbone

Journal article  |  2020  |  NATURE IMMUNOLOGY

Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection (vol 45, pg 889, 2016)

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2019  |  IMMUNITY

(Immunity 45, 889–902; October 18, 2016) The authors noticed an error in this paper in which an amino acid sequence of the NVY mim..

Should I stay or should I go-Reconciling clashing perspectives on CD4( ) tissue-resident memory T cells

Francis R Carbone, Thomas Gebhardt

Journal article  |  2019  |  SCIENCE IMMUNOLOGY

Two recent studies on CD4+ T cells in nonlymphoid tissues reveal a combination of memory cell retention and emigration.

Comparative analysis reveals a role for TGF-beta in shaping the residency-related transcriptional signature in tissue-resident memory CD8( ) T cells

Artika P Nath, Asolina Braun, Scott C Ritchie, Francis R Carbone, Laura K Mackay, Thomas Gebhardt, Michael Inouye

Journal article  |  2019  |  PLOS ONE

Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important ro..

Staged development of long-lived T-cell receptor alpha beta T(H)17 resident memory T-cell population to Candida albicans after skin infection

Chang Ook Park, Xiujun Fu, Xiaodong Jiang, Youdong Pan, Jessica E Teague, Nicholas Collins, Tian Tian, John T O'Malley, Ryan O Emerson, Ji Hye Kim, Yookyung Jung, Rei Watanabe, Robert C Fuhlbrigge, Francis R Carbone, Thomas Gebhardt, Rachael A Clark, Charles P Lin, Thomas S Kupper

Journal article  |  2018  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Candida albicans is a dimorphic fungus to which human subjects are exposed early in life, and by adulthood, it is part..

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  NATURE IMMUNOLOGY

Although tissue-resident memory T cells (TRM cells) are critical in fighting infection, their fate after local pathogen re-encount..

Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  JOURNAL OF IMMUNOLOGY

We describe an MHC class II (I-Ab)-restricted TCR transgenic mouse line that produces CD4+ T cells specific for Plasmodium species..