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Prof

Francis Carbone

Honorary
Microbiology And Immunology
Antigen presentation
herpesviruses
HSV
cross presentation
CTL
MHC
animals
science & technology
mice
Francis Carbone's Profile Picture
Prof

Francis Carbone

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Research into infection and immunity focusing on antigen presentation and cellular immunity to HSV
Francis Carbone's Profile Picture
Prof

Francis Carbone

 

Projects

Displaying the 18 most recent projects by Francis Carbone.

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Subset Determination Of Tissue-Resident T Cell Memory

Immunity relies on white blood cells called T cells that circulate around the body and which are also found permanently lodged at body surfa..

2018 - 2020
Active
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
Project icon

Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
Project icon

Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
Project icon

Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
Project icon

Antigen Presentation, Recognition And The Immune Response

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

2017 - 2021
Active
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A Novel Strategy For T Cell Vaccines

Current vaccines rely on immune components in the blood. We are taking a different approach, which focuses on immunity at the body surfaces...

2015 - 2017
Completed
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Antigen Presentation Recognition And The Immune System

This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techn..

2012 - 2016
Completed
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Antigen Presentation Recognition And The Immune System

This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techn..

2012 - 2016
Completed
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An Advanced Flow Cytometry Facility For The Peter Doherty Institute

The establishment of a flow cytometry facility in the new Peter Doherty Institute for Infection and Immunity will enhance capacity to invest..

2011 - 2012
Completed
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Understanding How Herpes Simplex Virus Hides In The Nervous System

Herpes simplex virus causes cold sores and genital herpes. A person can only catch the virus once in their life, but it stays in their body ..

2011 - 2013
Completed
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Australia Fellowship Full Application - Carbone

Prof Carbone’s laboratory specialises in the study of immunity at the body surfaces. These surfaces include skin and mucosal tissues such as..

2010 - 2015
Completed
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Studies On Peripheral T Cell Memory

Success in vaccination depends on the ability of the immune system to remember prior encounter with an infectious agent. This immune memory ..

2010 - 2014
Completed
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Why Eczema Increases The Severity Of Virus Infections

Eczema (atopic dermatitis) is a frequent allergy in Australia. People with eczema can suffer very severe skin infections with some viruses, ..

2008 - 2010
Completed
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2007 Program Grant - (Antigen Presentation, Recognition And The Immune Response)

The early events in immunity require various molecular interactions. We will examine the structural and biophysical basis for some of these ..

2007 - 2011
Completed
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Antigen Presentation, Recognition And The Immune Response

nan

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Multi-Photon Imaging For Infection, Immunity, And Self Recognition

This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents su..

18

Projects

Project Types

18

Research Grant

Scholarly Works

Displaying the 217 most recent scholarly works by Francis Carbone.

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Immovable memories: the journey to permanent residency.

Francis R Carbone

Journal article  |  2020  |  Nature Immunology

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Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes.

H Frizzell, R Fonseca, SN Christo, M Evrard, S Cruz-Gomez, NG Zanluqui, B von Scheidt, D Freestone, SL Park, HEG McWilliam, JA Villadangos, FR Carbone, LK Mackay

Journal article  |  2020  |  Science Immunology

Tissue-resident memory T (TRM) cells exist throughout the body, where they are poised to mediate local immune responses. Although ..

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Should I stay or should I go-Reconciling clashing perspectives on CD4( ) tissue-resident memory T cells

Francis R Carbone, Thomas Gebhardt

Journal article  |  2019  |  Science Immunology

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Staged development of long-lived T-cell receptor alpha beta T(H)17 resident memory T-cell population to Candida albicans after skin infection

Chang Ook Park, Xiujun Fu, Xiaodong Jiang, Youdong Pan, Jessica E Teague, Nicholas Collins, Tian Tian, John T O'Malley, Ryan O Emerson, Ji Hye Kim, Yookyung Jung, Rei Watanabe, Robert C Fuhlbrigge, Francis R Carbone, Thomas Gebhardt, Rachael A Clark, Charles P Lin, Thomas S Kupper

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

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Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Simone L Park, Ali Zaid, Jyh Liang Hor, Susan N Christo, Julia E Prier, Brooke Davies, Yannick O Alexandre, Julia L Gregory, Tiffany A Russell, Thomas Gebhardt, Francis R Carbone, David C Tscharke, William R Heath, Scott N Mueller, Laura K Mackay

Journal article  |  2018  |  Nature Immunology

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Development of a Novel CD4( ) TCR Transgenic Line That Reveals a Dominant Role for CD8( ) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

Daniel Fernandez-Ruiz, Lei Shong Lau, Nazanin Ghazanfari, Claerwen M Jones, Wei Yi Ng, Gayle M Davey, Dorothee Berthold, Lauren Holz, Yu Kato, Matthias H Enders, Ganchimeg Bayarsaikhan, Sanne H Hendriks, Lianne IM Lansink, Jessica A Engel, Megan SF Soon, Kylie R James, Anton Cozijnsen, Vanessa Mollard, Alessandro D Uboldi, Christopher J Tonkin, et al.

Journal article  |  2017  |  The Journal of Immunology

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Sustained accumulation of antigen-presenting cells after infection promotes local T-cell immunity

Nicholas Collins, Katharina Hochheiser, Francis R Carbone, Thomas Gebhardt

Journal article  |  2017  |  Immunology & Cell Biology

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The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis

Jane Li, Rangsima Reantragoon, Lyudmila Kostenko, Alexandra Jane Corbett, George Varigos, Francis Robert Carbone

Journal article  |  2017  |  Australasian Journal of Dermatology

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Cutting Edge: Tissue-Resident Memory T Cells Generated by Multiple Immunizations or Localized Deposition Provide Enhanced Immunity

Brooke Davies, Julia E Prier, Claerwen M Jones, Thomas Gebhardt, Francis R Carbone, Laura K Mackay

Journal article  |  2017  |  The Journal of Immunology

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Liver-Resident Memory CD8( ) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

Daniel Fernandez-Ruiz, Wei Yi Ng, Lauren E Holz, Joel Z Ma, Ali Zaid, Yik Chun Wong, Lei Shong Lau, Vanessa Mollard, Anton Cozijnsen, Nicholas Collins, Jessica Li, Gayle M Davey, Yu Kato, Sapna Devi, Roghieh Skandari, Michael Pauley, Jonathan H Manton, Dale I Godfrey, Asolina Braun, Szun Szun Tay, et al.

Journal article  |  2016  |  Immunity

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Skin CD4( ) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R Heath, Scott N Mueller, Thomas S Kupper, Thomas Gebhardt, Francis R Carbone

Journal article  |  2016  |  NATURE COMMUNICATIONS

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Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Laura K Mackay, Martina Minnich, Natasja AM Kragten, Yang Liao, Benjamin Nota, Cyril Seillet, Ali Zaid, Kevin Man, Simon Preston, David Freestone, Asolina Braun, Erica Wynne-Jones, Felix M Behr, Regina Stark, Daniel G Pellicci, Dale I Godfrey, Gabrielle T Belz, Marc Pellegrini, Thomas Gebhardt, Meinrad Busslinger, et al.

Journal article  |  2016  |  Science

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Laser Capture Microdissection Reveals Transcriptional Abnormalities in Alopecia Areata before, during, and after Active Hair Loss

Jane Li, Catherine van Vliet, Nicholas W Rufaut, Leslie N Jones, Rodney D Sinclair, Francis R Carbone

Journal article  |  2016  |  Journal of Investigative Dermatology

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Transcriptional Analysis of T Cells Resident in Human Skin

Jane Li, Moshe Olshansky, Francis R Carbone, Joel Z Ma

Journal article  |  2016  |  PLOS ONE

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T-box Transcription Factors Combine with the Cytokines TGF-beta and IL-15 to Control Tissue-Resident Memory T Cell Fate

Laura K Mackay, Erica Wynne-Jones, David Freestone, Daniel G Pellicci, Lisa A Mielke, Dane M Newman, Asolina Braun, Frederick Masson, Axel Kallies, Gabrielle T Belz, Francis R Carbone

Journal article  |  2015  |  Immunity

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A NK complex-linked locus restricts the spread of herpes simplex virus type 1 in the brains of C57BL/6 mice

Lorne F Kastrukoff, Allen S Lau, Fumio Takei, Francis R Carbone, Anthony A Scalzo

Journal article  |  2015  |  Immunology & Cell Biology

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Skin-resident T cells keep parasites on a Leish

Laura K Mackay, Francis R Carbone

Journal article  |  2015  |  Journal of Experimental Medicine

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Tissue-Resident Memory T Cells and Fixed Immune Surveillance in Nonlymphoid Organs

Francis R Carbone

Journal article  |  2015  |  The Journal of Immunology

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Unpleasant memories: tissue-embedded T cell memory drives skin hypersensitivity

Thomas Gebhardt, Francis R Carbone

Journal article  |  2015  |  Nature Medicine

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Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

Laura K Mackay, Asolina Braun, Bethany L Macleod, Nicholas Collins, Christina Tebartz, Sammy Bedoui, Francis R Carbone, Thomas Gebhardt

Journal article  |  2015  |  The Journal of Immunology

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CD4 Helpers Put Tissue-Resident Memory Cells in Their Place

Laura K Mackay, Francis R Carbone

Journal article  |  2014  |  Immunity

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A neighborhood watch upholds local immune protection

Francis R Carbone, Thomas Gebhardt

Journal article  |  2014  |  Science

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Tissue-resident T cells: dynamic players in skin immunity

Scott N Mueller, Ali Zaid, Francis R Carbone

Journal article  |  2014  |  Frontiers in Immunology

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Lytic Gene Expression Is Frequent in HSV-1 Latent Infection and Correlates with the Engagement of a Cell-Intrinsic Transcriptional Response

Joel Z Ma, Tiffany A Russell, Tim Spelman, Francis R Carbone, David C Tscharke

Journal article  |  2014  |  PLoS Pathogens

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Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection

Angus T Stock, Jeffrey M Smith, Francis R Carbone

Journal article  |  2014  |  Journal of Experimental Medicine

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Hair follicles retain memory CD4 T cells in skin following infection with herpes simplex virus-1

Nicholas Collins, Thomas Gebhardt, Francis Carbone

Conference Proceedings  |  2014  |  JOURNAL OF IMMUNOLOGY

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CD8( ) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lei Shong Lau, Daniel Fernandez-Ruiz, Vanessa Mollard, Angelika Sturm, Michelle A Neller, Anton Cozijnsen, Julia L Gregory, Gayle M Davey, Claerwen M Jones, Yi-Hsuan Lin, Ashraful Haque, Christian R Engwerda, Catherine Q Nie, Diana S Hansen, Kenneth M Murphy, Anthony T Papenfuss, John J Miles, Scott R Burrows, Tania de Koning-Ward, Geoffrey I McFadden, et al.

Journal article  |  2014  |  PLOS PATHOGENS

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Persistence of skin-resident memory T cells within an epidermal niche

Ali Zaid, Laura K Mackay, Azad Rahimpour, Asolina Braun, Marc Veldhoen, Francis R Carbone, Jonathan H Manton, William R Heath, Scott N Mueller

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

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The developmental pathway for CD103( )CD8( ) tissue-resident memory T cells of skin

Laura K Mackay, Azad Rahimpour, Joel Z Ma, Nicholas Collins, Angus T Stock, Ming-Li Hafon, Javier Vega-Ramos, Pilar Lauzurica, Scott N Mueller, Tijana Stefanovic, David C Tscharke, William R Heath, Michael Inouye, Francis R Carbone, Thomas Gebhardt

Journal article  |  2013  |  Nature Immunology

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The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

William R Heath, Francis R Carbone

Journal article  |  2013  |  Nature Immunology

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Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues

Francis R Carbone, Laura K Mackay, William R Heath, Thomas Gebhardt

Journal article  |  2013  |  Current Opinion in Immunology

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Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice

Gayle M Davey, Scott N Mueller, Catherine van Vliet, Michelle Gigowski, Ali Zaid, Brooke Davies, Francis R Carbone, William R Heath

Journal article  |  2013  |  Molecular Immunology

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'Licensed' Natural Killer (NK) Cells Dominate the Response to Herpes Simplex Virus Type 1 (HSV-1) Infection of the Central Nervous System (CNS)

Lorne Kastrukoff, Allen Lau, Fumio Takei, Mark Smyth, Francis Carbone

Conference Proceedings  |  2013  |  NEUROLOGY

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Memory T Cell Subsets, Migration Patterns, and Tissue Residence

Scott N Mueller, Thomas Gebhardt, Francis R Carbone, William R Heath

Journal article  |  2013  |  Annual Review of Immunology

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Peripheral tissue surveillance and residency by memory T cells

Thomas Gebhardt, Scott N Mueller, William R Heath, Francis R Carbone

Journal article  |  2013  |  Trends in Immunology (formerly Immunology Today)

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A NK complex-linked locus restricts the spread of herpes simplex virus type 1 (HSV-1) in the central nervous system (CNS)

Lorne Kastrukoff, Allen Lau, Fumio Takei, Anthony Scalzo, Francis Carbone

Conference Proceedings  |  2012  |  JOURNAL OF NEUROIMMUNOLOGY

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Indiscriminate Memories during Infection Control

Sammy Bedoui, Francis R Carbone

Journal article  |  2012  |  Immunity

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Trafficking and functions of memory CD4 and CD8 T cell populations in peripheral tissues

S Mueller, WR Heath, T Gebhardt, FR Carbone

Conference Proceedings  |  2012  |  IMMUNOLOGY

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Long-lived epithelial immunity by tissue-resident memory T (T-RM) cells in the absence of persisting local antigen presentation

Laura K Mackay, Angus T Stock, Joel Z Ma, Claerwen M Jones, Stephen J Kent, Scott N Mueller, William R Heath, Francis R Carbone, Thomas Gebhardt

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

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Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics

Liv Eidsmo, Angus T Stock, William R Heath, Sammy Bedoui, Francis R Carbone

Journal article  |  2012  |  Journal of Pathology

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Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection

Laura K Mackay, Linda Wakim, Catherine J van Vliet, Claerwen M Jones, Scott N Mueller, Oliver Bannard, Douglas T Fearon, William R Heath, Francis R Carbone

Journal article  |  2012  |  Journal of Immunology

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T Cell Receptor Antagonist Peptides Induce Positive Selection

Kristin A Hogquist, Stephen C Jameson, William R Heath, Jane L Howard, Michael J Bevan, Francis R Carbone

Journal article  |  2012  |  Journal of Immunology

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Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8( ) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery

Lei Shong Lau, Daniel Fernandez Ruiz, Gayle M Davey, Tania F de Koning-Ward, Anthony T Papenfuss, Francis R Carbone, Andrew G Brooks, Brendan S Crabb, William R Heath

Journal article  |  2011  |  Journal of Infectious Diseases

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Different patterns of peripheral migration by memory CD4( ) and CD8( ) T cells

Thomas Gebhardt, Paul G Whitney, Ali Zaid, Laura K Mackay, Andrew G Brooks, William R Heath, Francis R Carbone, Scott N Mueller

Journal article  |  2011  |  Nature

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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

Francois-Xavier Hubert, Sarah A Kinkel, Gayle M Davey, Belinda Phipson, Scott N Mueller, Adrian Liston, Anna I Proietto, Ping ZF Cannon, Simon Forehan, Gordon K Smyth, Li Wu, Christopher C Goodnow, Francis R Carbone, Hamish S Scott, William R Heath

Journal article  |  2011  |  Blood

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Rapid recruitment and activation of CD8( ) T cells after herpes simplex virus type 1 skin infection

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2011  |  Immunology and Cell Biology

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Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8( ) T cells

Sophie A Valkenburg, E Bridie Day, Natasha G Swan, Hayley A Croom, Francis R Carbone, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Journal article  |  2010  |  European Journal of Immunology

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Cross-Priming: Its Beginnings

Francis R Carbone, William R Heath

Journal article  |  2010  |  Journal of Immunology

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Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells

Rachel J Lundie, Louise J Young, Gayle M Davey, Jose A Villadangos, Francis R Carbone, William R Heath, Brendan S Crabb

Journal article  |  2010  |  European Journal of Immunology

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Redundancy in the immune system restricts the spread of HSV-1 in the central nervous system (CNS) of C57BL/6 mice

Lorne F Kastrukoff, Allen S Lau, Fumio Takei, Mark J Smyth, Claerwen M Jones, Sally RM Clarke, Francis R Carbone

Journal article  |  2010  |  Virology

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Cutting Edge: Priming of CD8 T Cell Immunity to Herpes Simplex Virus Type 1 Requires Cognate TLR3 Expression In Vivo

Gayle M Davey, Magdalena Wojtasiak, Anna I Proietto, Francis R Carbone, William R Heath, Sammy Bedoui

Journal article  |  2010  |  Journal of Immunology

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Dendritic cell subsets in primary and secondary T cell responses at body surfaces

William R Heath, Francis R Carbone

Journal article  |  2009  |  Nature Immunology

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IMMUNOLOGY A helpers' guide to infection

Thomas Gebhardt, Francis R Carbone

Journal article  |  2009  |  Nature

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Cross-presentation of viral and self antigens by skin-derived CD103( ) dendritic cells

Sammy Bedoui, Paul G Whitney, Jason Waithman, Liv Eidsmo, Linda Wakim, Irina Caminschi, Rhys S Allan, Magdalena Wojtasiak, Ken Shortman, Francis R Carbone, Andrew G Brooks, William R Heath

Journal article  |  2009  |  Nature Immunology

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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Thomas Gebhardt, Linda M Wakim, Liv Eidsmo, Patrick C Reading, William R Heath, Francis R Carbone

Journal article  |  2009  |  Nature Immunology

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

Ian A Parish, Jason Waithman, Gayle M Davey, Gabrielle T Belz, Justine D Mintern, Christian Kurts, Robyn M Sutherland, Francis R Carbone, William R Heath

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

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Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection

Liv Eidsmo, Rhys Allan, Irina Caminschi, Nico van Rooijen, William R Heath, Francis R Carbone

Journal article  |  2009  |  Journal of Immunology

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Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

Linda M Wakim, Thomas Gebhardt, William R Heath, Francis R Carbone

Journal article  |  2008  |  Journal of Immunology

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CD8( ) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection

Linda M Wakim, Claerwen M Jones, Thomas Gebhardt, Christopher M Preston, Francis R Carbone

Journal article  |  2008  |  Immunology and Cell Biology

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Blood-stage Plasmodium infection induces CD8( ) T lymphocytes to parasite-expressed antigens, largely regulated by CD8 alpha( ) dendritic cells

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Lei Shong Lau, Justine D Mintern, Gabrielle T Belz, Louis Schofield, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

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Langerhans cells and viral immunity

Anthony L Cunningham, Francis Carbone, Teunis BH Geijtenbeek

Journal article  |  2008  |  European Journal of Immunology

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Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoinimunity

Jason Waithman, Thomas Gebhardt, Gayle M Davey, William R Heath, Francis R Carbone

Journal article  |  2008  |  Journal of Immunology

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Dendritic cell-induced memory T cell activation in nonlymphoid tissues

Linda M Wakim, Jason Waithman, Nico van Rooijen, William R Heath, Francis R Carbone

Journal article  |  2008  |  Science

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Neonatal CD8( ) T cells are slow to develop into lytic effectors after HSV infection in vivo

Marian A Fernandez, Ingrid AC Evans, Eddy H Hassan, Francis R Carbone, Cheryl A Jones

Journal article  |  2008  |  European Journal of Immunology

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Induction of antigen-specific T cell responses following blood-stage Plasmodium infection occurs mainly via CD8 alpha dendritic cells but is short-lived.

Rachel J Lundie, Tania F de Koning-Ward, Gayle M Davey, Catherine Q Nie, Diana S Hansen, Louis Schofield, Gabrielle T Belz, Francis R Carbone, Jose A Villadangos, Brendan S Crabb, William R Heath

Conference Proceedings  |  2008  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

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Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance

Justine D Mintern, Carole Guillonneau, Francis R Carbone, Peter C Doherty, Stephen J Turner

Journal article  |  2007  |  Journal of Immunology

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Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells

Jason Waithman, Rhys S Allan, Hiroshi Kosaka, Hiroaki Azukizawa, Ken Shortman, Manfred B Lutz, William R Heath, Francis R Carbone, Gabrielle T Belz

Journal article  |  2007  |  Journal of Immunology

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Minimal activation of memory CD8 T cell by tissue-derived dendritic cells favors the stimulation of naive CD8 T cells

Gabrielle T Belz, Sammy Bedoui, Fiona Kupresanin, Francis R Carbone, William R Heath

Journal article  |  2007  |  Nature Immunology

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Optimization of TCR transgenic T cells for in vivo tracking of immune responses

Angus T Stock, Scott N Mueller, Lauren M Kleinert, William R Heath, Francis R Carbone, Claerwen M Jones

Journal article  |  2007  |  Immunology and Cell Biology

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A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection

Daniel P Barr, Gabrielle T Belz, Patrick C Reading, Magdalena Wojtasiak, Paul G Whitney, William R Heath, Francis R Carbone, Andrew G Brooks

Journal article  |  2007  |  European Journal of Immunology

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Outside looking in: the inner workings of the crosspresentation pathway within dendritic cells

Jose A Villadangos, William R Heath, Francis R Carbone

Journal article  |  2007  |  Trends in Immunology (formerly Immunology Today)

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CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2006  |  Immunology and Cell Biology

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Central nervous system (CNS) involvement by herpes simplex virus 1 (HSV 1) is restricted in C57BL6 (BL6) mice

LF Kastrukoff, AS Lau, E Wilson, F Takei, FR Carbone

Conference Proceedings  |  2006  |  JOURNAL OF NEUROIMMUNOLOGY

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Cutting edge: Central memory T cells do not show accelerated proliferation or tissue infiltration in response to localized herpes simplex virus-1 infection

Angus T Stock, Claerwen M Jones, William R Heath, Francis R Carbone

Journal article  |  2006  |  The Journal of Immunology

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The dominant role of CD8( ) dendritic cells in cross-presentation is not dictated by antigen capture

Petra Schnorrer, Georg MN Behrens, Nicholas S Wilson, Joanne L Pooley, Christopher M Smith, Dima EI-Sukkari, Gayle Davey, Fiona Kupresanin, Ming Li, Eugene Maraskovsky, Gabrielle T Belz, Francis R Carbone, Ken Shortman, William R Heath, Jose A Villadangos

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

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Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming

Rhys S Allan, Jason Waithman, Sammy Bedoui, Claerwen M Jones, Jose A Villadangos, Yifan Zhan, Andrew M Lew, Ken Shortman, William R Heath, Francis R Carbone

Journal article  |  2006  |  Immunity

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CD4 T cells can protect APC from CTL-mediated elimination

Scott N Mueller, Claerwen M Jones, Angus T Stock, Mark Suter, William R Heath, Francis R Carbone

Journal article  |  2006  |  Journal of Immunology

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NKT cells are not critical for HSV-1 disease resolution

AL Cornish, R Keating, K Kyparissoudis, MJ Smyth, FR Carbone, DI Godfrey

Journal article  |  2006  |  Immunology and Cell Biology

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Bone marrow-derived cells expand memory CD8( ) T cells in response to viral infections of the lung and skin

GT Belz, NS Wilson, CM Smith, AM Mount, FR Carbone, WR Heath

Journal article  |  2006  |  European Journal of Immunology

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Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

NS Wilson, GMN Behrens, RJ Lundie, CM Smith, J Waithman, L Young, SP Forehan, A Mount, RJ Steptoe, KD Shortman, TF de Koning-Ward, GT Belz, FR Carbone, BS Crabb, WR Heath, JA Villadangos

Journal article  |  2006  |  NATURE IMMUNOLOGY

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Central memory T cells do not show accelerated proliferation or tissue infiltration in response to localised herpes simples virus-1 infection

AT STOCK, C JONES, W Heath, F CARBONE

Journal article  |  2006  |  Journal of Immunology

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Latent infection with herpes simplex virus is associated with ongoing CD8 T-cell stimulation by parenchymal cells within sensory ganglia

AL van Lint, L Kleinert, SRM Clarke, A Stock, WR Heath, FR Carbone

Journal article  |  2005  |  Journal of Virology

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Rapidity of recall by memory CD8 T cells to herpes simplex virus infection

AT Stock, CM Jones, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Self tolerance to organ-specific antigens

WR Heath, IA Parish, J Waithman, GM Davey, GT Belz, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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SOCS-1 deficiency results in IL-15 dependent proliferation of antigen naive CD8 T cells

GM Davey, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, R Starr, WR Heath

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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CTL immunity limits HSV-1 replication and disease, but not the establishment of a latent infection capable of reactivation

LM Wakim, AL Van Lint, CM Jones, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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The unique ability of CD8 DC to cross-present is not due to selective antigen capture

P Schnorrer, GMN Behrens, NS Wilson, JL Pooley, GT Belz, FR Carbone, K Shortman, WR Heath, JA Villadangos

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Dendritic cell presentation of skin derived self-antigen

J Waithman, WR Heath, GT Belz, FR Carbone

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Neonatal dendritic cells primed in vitro display an adult like capacity to induce a CD8( ) cytotoxic T cell (CTL) response to herpes simplex virus (HSV) in adult but not neonatal recipients

M Fernandez, IA Evans, F Carbone, CA Jones

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

GM Davey, R Starr, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, WR Heath

Journal article  |  2005  |  Journal of Experimental Medicine

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Antigen independent persistence of 'effector' memory CD8 T cells

AT Stock, FR Carbone

Conference Proceedings  |  2005  |  FASEB JOURNAL

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Coupling and cross-presentation

WR Heath, FR Carbone

Journal article  |  2005  |  Nature

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Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

FR Carbone, GT Belz, WR Heath

Journal article  |  2004  |  Trends in Immunology (formerly Immunology Today)

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Cognate CD4( ) T cell licensing of dendritic cells in CD8( ) T cell immunity

CM Smith, NS Wilson, J Waithman, JA Villadangos, FR Carbone, WR Heath, GT Belz

Journal article  |  2004  |  NATURE IMMUNOLOGY

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Erratum: The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance (Journal of Immunology (2004) 173 (402-409))

AI Webb, NA Borg, MA Dunstone, L Kjer-Nielsen, T Beddoe, J McCluskey, FR Carbone, SP Bottomley, MI Aguilar, AW Purcell, J Rossjohn

Journal article  |  2004  |  Journal of Immunology

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Herpes simplex virus 1 (HSV1)-induced central nervous system (CNS) demyelination

LF Kastrukoff, CM Jones, FR Carbone

Conference Proceedings  |  2004  |  JOURNAL OF NEUROIMMUNOLOGY

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Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals

M Wojtasiak, CM Jones, LC Sullivan, AC Winterhalter, FR Carbone, AG Brooks

Journal article  |  2004  |  International Immunology

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Cutting edge: Prolonged antigen presentation after herpes simplex virus-1 skin infection

AT Stock, SN Mueller, AL van Lint, WR Heath, FR Carbone

Journal article  |  2004  |  JOURNAL OF IMMUNOLOGY

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The structure of H-2K(b) and K-bm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

AI Webb, NA Borg, MA Dunstone, L Kjer-Nielsen, T Beddoe, J McCluskey, FR Carbone, SP Bottomley, MI Aguilar, AW Purcell, J Rossjohn

Journal article  |  2004  |  Journal of Immunology

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

GT Belz, CM Smith, L Kleinert, P Reading, A Brooks, K Shortman, FR Carbone, WR Heath

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

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Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens

WR Heath, GT Belz, GMN Behrens, CM Smith, SP Forehan, IA Parish, GM Davey, NS Wilson, FR Carbone, JA Villadangos

Journal article  |  2004  |  Immunological Reviews

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Helper requirements for generation of effector CTL to islet beta cell antigens

GMN Behrens, M Li, GM Davey, J Allison, RA Flavell, FR Carbone, WR Heath

Journal article  |  2004  |  Journal of Immunology

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Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

CM Dyer, YF Zhan, JL Brady, FR Carbone, MJ Smyth, AM Lew

Journal article  |  2004  |  Blood

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Cutting edge: Conventional CD8 alpha( ) dendritic cells are generally involved in priming CTL immunity to viruses

GT Belz, CM Smith, D Eichner, K Shortman, G Karupiah, FR Carbone, WK Heath

Journal article  |  2004  |  Journal of Immunology

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Helper T cells, dendritic cells and CTL immunity

G Behrens, M Li, CM Smith, GT Belz, J Mintern, FR Carbone, WR Heath

Journal article  |  2004  |  Immunology and Cell Biology

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Herpes simplex virus-specific CD8( ) T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation

A van Lint, M Ayers, AG Brooks, RM Coles, WR Heath, FR Carbone

Journal article  |  2004  |  Journal of Immunology

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Immunology - Dangerous liaisons

WR Heath, FR Carbone

Journal article  |  2003  |  Nature

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Epidermal viral immunity induced by CD8 alpha( ) dendritic cells but not by Langerhans cells

RS Allan, CM Smith, GT Belz, AL van Lint, LM Wakim, WR Heath, FR Carbone

Journal article  |  2003  |  Science

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The role of dendritic cell subsets in immunity to viruses

FR Carbone, WR Heath

Journal article  |  2003  |  Current Opinion in Immunology

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Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes

RM Coles, CM Jones, AG Brooks, PU Cameron, WR Heath, FR Carbone

Journal article  |  2003  |  European Journal of Immunology

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Cutting edge: Conventional CD8 alpha( ) dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1

CM Smith, GT Belz, NS Wilson, JA Villadangos, K Shortman, FR Carbone, WR Heath

Journal article  |  2003  |  Journal of Immunology

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Hide and seek: The immunology of HSV persistence

FR Carbone, PG Speck

Journal article  |  2003  |  Immunity

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The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8( ) T cells

SN Mueller, CM Jones, WS Chen, Y Kawaoka, MR Castrucci, WR Heath, FR Carbone

Journal article  |  2003  |  Journal of Virology

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Hide and Seek: The Immunology of HSV Persistence

FR CARBONE, PG SPECK

Journal article  |  2003  |  Immunity

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Detection of low-avidity CD4( ) T cells using recombinant artificial APC: Following the antiovalbumin immune response

VI Mallet-Designe, T Stratmann, D Homann, F Carbone, MBA Oldstone, L Teyton

Journal article  |  2003  |  Journal of Immunology

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The CD8 alpha( ) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens

GT Belz, GMN Behrens, CM Smith, JFAP Miller, C Jones, K Lejon, CG Fathman, SN Mueller, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

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Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim

GM Davey, C Kurts, JFAP Miller, P Bouillet, A Strasser, AG Brooks, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Experimental Medicine

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The role of dendritic cell subsets in selection between tolerance and immunity

GT Belz, WR Heath, FR Carbone

Journal article  |  2002  |  Immunology and Cell Biology

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CD36 is differentially expressed by CD8( ) splenic dendritic cells but is not required for cross-presentation in vivo

GT Belz, D Vremec, M Febbraio, L Corcoran, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  Journal of Immunology

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Characterization of two TCR transgenic mouse lines specific for herpes simplex virus

SN Mueller, WR Heath, JD McLain, FR Carbone, CM Jones

Journal article  |  2002  |  Immunology and Cell Biology

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Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice

JD Mintern, RM Sutherland, AM Lew, K Shortman, FR Carbone, WR Heath

Journal article  |  2002  |  European Journal of Immunology

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The cross-priming APC requires a Rel-dependent signal to induce CTL

JD Mintern, G Belz, S Gerondakis, FR Carbone, WR Heath

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus

SN Mueller, CM Jones, CM Smith, WR Heath, FR Carbone

Journal article  |  2002  |  JOURNAL OF EXPERIMENTAL MEDICINE

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Cutting edge: Precursor frequency affects the helper dependence of cytotoxic T cells

JD Mintern, GM Davey, GT Belz, FR Carbone, WR Heath

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1

RM Coles, SN Mueller, WR Heath, FR Carbone, AG Brooks

Journal article  |  2002  |  JOURNAL OF IMMUNOLOGY

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Cross-presentation of antigens by dendritic cells

GT Belz, FR Carbone, WR Heath

Journal article  |  2002  |  Critical Reviews in Immunology

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Cross-presentation in viral immunity and self-tolerance

William R Heath, Francis R Carbone

Journal article  |  2001  |  Nature Reviews Immunology

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Cross-presentation in viral immunity and self-tolerance

WR Heath, FR Carbone

Journal article  |  2001  |  Nature Reviews Immunology

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MHC class II expression is regulated in dendritic cells independently of invariant chain degradation

JA Villadangos, M Cardoso, RJ Steptoe, D van Berkel, J Pooley, FR Carbone, K Shortman

Journal article  |  2001  |  Immunity

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A key role for ICAM-I in generating effector cells mediating inflammatory responses

SA Camacho, WR Heath, FR Carbone, N Sarvetnick, A LeBon, L Karlsson, PA Peterson, SR Webb

Journal article  |  2001  |  NATURE IMMUNOLOGY

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Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo

M Li, GM Davey, RM Sutherland, C Kurts, AM Lew, C Hirst, FR Carbone, WR Heath

Journal article  |  2001  |  Journal of Immunology

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Cross-presentation, dendrttic cells, tolerance and immunity

WR Heath, FR Carbone

Journal article  |  2001  |  Annual Review of Immunology

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Erratum: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells (Nature (1999) 398: (341-344))

C Kurts, FR Carbone, MF Krummel, KM Koch, JFAP Miller, WR Heath

Journal article  |  2000  |  Nature

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Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1

ME Wallace, M Bryden, SC Cose, RM Coles, TN Schumacher, A Brooks, FR Carbone

Journal article  |  2000  |  Immunity

The enormous diversity of the T cell pool makes it difficult to determine whether inherent biases in the naive TCR repertoire can ..

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Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

SRM Clarke, M Barnden, C Kurts, FR Carbone, JF Miller, WR Heath

Journal article  |  2000  |  Immunology and Cell Biology

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A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4( ) and CD8( ) T cells

E Blanas, GM Davey, FR Carbone, WR Heath

Journal article  |  2000  |  The Journal of Immunology

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Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection

CM Jones, SC Cose, RM Coles, AC Winterhalter, AG Brooks, WR Heath, FR Carbone

Journal article  |  2000  |  Journal of Virology

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Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus

CM Jones, SC Cose, JM McNally, SR Jennings, WR Heath, FR Carbone

Journal article  |  2000  |  Journal of General Virology

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Cytotoxic T lymphocytes and cross-priming

WR Heath, SMR Clarke, GM Davey, C Kurts, AM Lew, M Li, J Mintern, RM Sutherland, FR Carbone, JFAP Miller

Journal article  |  2000  |  Immunologist

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The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo

J Mintern, M Li, GM Davey, E Blanas, C Kurts, FR Carbone, WR Heath

Journal article  |  1999  |  Immunology and Cell Biology

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

C Kurts, RM Sutherland, G Davey, M Li, AM Lew, E Blanas, FR Carbone, JFAP Miller, WR Heath

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

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The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant

ME Wallace, R Keating, WR Heath, FR Carbone

Journal article  |  1999  |  Journal of Virology

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Inhibition of naive class I-restricted T cells by altered peptide ligands

C Koniaras, FR Carbone, WR Heath, AM Lew

Journal article  |  1999  |  Immunology and Cell Biology

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CD30 prevents T-cell responses to non-lymphoid tissues

WR Heath, C Kurts, I Caminschi, FR Carbone, JFAP Miller

Journal article  |  1999  |  Immunological Reviews

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Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

C Kurts, FR Carbone, MF Krummel, KM Koch, JFAP Miller, WR Heath

Journal article  |  1999  |  Nature

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T-cell receptor contact and MHC binding residues of a major rye grass pollen allergen T-cell epitope.

MD Burton, B Blaher, C Suphioglu, RE O'Hehir, FR Carbone, JM Rolland

Journal article  |  1999  |  Journal of Allergy and Clinical Immunology

BACKGROUND: T cells are pivotal in the elicitation of allergic diseases. Analogues of T-cell epitope peptides with a modification ..

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T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs.

SH Stotz, L Bolliger, FR Carbone, E Palmer

Journal article  |  1999  |  Journal of Experimental Medicine

Antagonist peptides inhibit T cell responses by an unknown mechanism. By coexpressing two independent T cell receptors (TCRs) on a..

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Identification of a gastritogenic epitope of the H/K ATPase beta-subunit

HD De Silva, PA Gleeson, BH Toh, IR Van Driel, FR Carbone

Journal article  |  1999  |  Immunology

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B cells directly tolerize CD8( ) T cells

SRM Bennett, FR Carbone, T Toy, JFAP Miller, WR Heath

Journal article  |  1998  |  Journal of Experimental Medicine

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Induction of peripheral CD8( ) T-cell tolerance by cross-presentation of self antigens

JFAP Miller, C Kurts, J Allison, H Kosaka, F Carbone, WR Heath

Journal article  |  1998  |  Immunological Reviews

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Cross-presentation: A general mechanism for CTL immunity and tolerance

FR Carbone, C Kurts, SRM Bennett, JFAP Miller, WR Heath

Journal article  |  1998  |  Immunology Today

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Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction

C Kurts, JFAP Miller, RM Subramaniam, FR Carbone, WR Heath

Journal article  |  1998  |  Journal of Experimental Medicine

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The peripheral deletion of autoreactive CD8( ) T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1)

C Kurts, WR Heath, H Kosaka, JFAP Miller, FR Carbone

Journal article  |  1998  |  Journal of Experimental Medicine

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling

SRM Bennett, FR Carbone, F Karamalis, RA Flavell, JFAP Miller, WR Heath

Journal article  |  1998  |  Nature

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Cross-tolerance: A pathway for inducing tolerance to peripheral tissue antigens

WR Heath, C Kurts, JFAP Miller, FR Carbone

Journal article  |  1998  |  Journal of Experimental Medicine

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A dominant V beta bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR beta-chain CDR3.

SJ Turner, FR Carbone

Journal article  |  1998  |  Molecular Immunology

Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vbeta- and/or..

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Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements

MJ Barnden, J Allison, WR Heath, FR Carbone

Journal article  |  1998  |  Immunology and Cell Biology

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Cross-presentation of self antigens to CD8 T cells: the balance between tolerance and autoimmunity.

C Kurts, WR Heath, FR Carbone, H Kosaka, JF Miller

Journal article  |  1998  |  Novartis Foundation symposium

Upon encounter with foreign antigen, tissue-associated antigen-presenting cells (APCs) migrate to draining lymph nodes to prime sp..

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Loss of antiviral cytotoxic T-lymphocyte activity during high-level antigen stimulation

MS Rolph, KI Matthaei, FR Carbone, WR Heath, IA Ramshaw

Journal article  |  1998  |  Viral Immunology

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CD4( ) T cell help impairs CD8( ) T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

C Kurts, FR Carbone, M Barnden, E Blanas, J Allison, WR Heath, JFAP Miller

Journal article  |  1997  |  Journal of Experimental Medicine

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Activation and migration of CD8 T cells in the intestinal mucosa

SK Kim, DS Reed, WR Heath, F Carbone, L Lefrancois

Journal article  |  1997  |  Journal of Immunology

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Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ

C Koniaras, SRM Bennett, FR Carbone, WR Heath, AM Lew

Journal article  |  1997  |  International Immunology

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Antigen-specific CD8( ) T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection

SC Cose, CM Jones, ME Wallace, WR Heath, FR Carbone

Journal article  |  1997  |  European Journal of Immunology

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Evidence for cooperation between TCR V region and junctional sequences in determining a dominant cytotoxic T lymphocyte response to herpes simplex virus glycoprotein B.

CM Jones, SC Cose, FR Carbone

Journal article  |  1997  |  International Immunology

TCR repertoire availability has the potential to influence the immune response to foreign antigens. Here we have analysed how chan..

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Functional mapping of the orientation for TCR recognition of an H2-Kb-restricted ovalbumin peptide suggests that the beta-chain subunit can dominate the determination of peptide side chain specificity.

SJ Turner, SC Jameson, FR Carbone

Journal article  |  1997  |  Journal of Immunology

T cells recognize a complex of antigenic peptide bound to the class I or class II products of the MHC. Crystallographic analysis o..

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Carbohydrates and antigen recognition by T cells

FR Carbone, PA Gleeson

Journal article  |  1997  |  Glycobiology

T Lymphocytes (T cells) recognize short antigenic peptides bound to either MHC I or II molecules, in contrast to antibodies which ..

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8( ) T cells

C Kurts, H Kosaka, FR Carbone, JFAP Miller, WR Heath

Journal article  |  1997  |  Journal of Experimental Medicine

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Induction of a CD8( ) cytotoxic T lymphocyte response by cross-priming requires cognate CD4( ) T cell help

SRM Bennett, FR Carbone, F Karamalis, JFAP Miller, WR Heath

Journal article  |  1997  |  Journal of Experimental Medicine

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Down-modulation of CD8 beta-chain in response to an altered peptide ligand enables developing thymocytes to escape negative selection

MJ Barnden, WR Heath, FR Carbone

Journal article  |  1997  |  Cellular Immunology

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Erratum: CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes (Nature (1996) 384 (577-581))

KC Garcia, CA Scott, A Brunmark, FR Carbone, PA Peterson, IA Wilson, L Teyton

Journal article  |  1997  |  Nature

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CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.

KC Garcia, CA Scott, A Brunmark, FR Carbone, PA Peterson, IA Wilson, L Teyton

Journal article  |  1996  |  Nature

T-cell antigen receptors (TCR) generally interact with moderate affinity with the complex formed by major histocompatibility compl..

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Induction of autoimmune diabetes by oral administration of autoantigen

E Blanas, FR Carbone, J Allison, JFAP Miller, WR Heath

Journal article  |  1996  |  Science

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T cell receptor α-chain usage can determine ant igen-selected tcr 3-chain repertoire diversity

SJ Turner, FR Carbone

Journal article  |  1996  |  FASEB Journal

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TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.

SJ Turner, SC Cose, FR Carbone

Journal article  |  1996  |  Journal of Immunology

There is considerable variation in the TCR repertoire diversity selected by different peptide Ags. Certain responses show limited ..

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

C Kurts, WR Heath, FR Carbone, J Allison, JFAP Miller, H Kosaka

Journal article  |  1996  |  The Journal of Experimental Medicine

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Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.

CA Scott, KC Garcia, FR Carbone, IA Wilson, L Teyton

Journal article  |  1996  |  The Journal of Experimental Medicine

Structural studies of cellular receptor molecules involved in immune recognition require the production of large quantities of the..

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Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias.

SC Cose, JM Kelly, FR Carbone

Journal article  |  1995  |  Journal of Virology

The glycoprotein B (gB) from herpes simplex virus type I is a major target of cytotoxic T lymphocytes (CTL) in C57BL/6 mice. The m..

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EXPRESSION OF 2 T-CELL RECEPTOR-ALPHA CHAINS ON THE SURFACE OF NORMAL MURINE T-CELLS

WR HEATH, FR CARBONE, P BERTOLINO, J KELLY, S COSE, JFAP MILLER

Journal article  |  1995  |  European Journal of Immunology

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Intermediate steps in positive selection: differentiation of CD4 8int TCRint thymocytes into CD4-8 TCRhi thymocytes.

K Lundberg, W Heath, F Köntgen, FR Carbone, K Shortman

Journal article  |  1995  |  The Journal of Experimental Medicine

The differentiation potential of putative intermediates between CD4+8+ thymocytes and mature T cells has been examined. Such inter..

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Contrast between class I and class II MHC-mediated differentiation of a CD4 CD8 T cell line: implications for lineage commitment.

J DeKoning, FR Carbone, J Kaye

Journal article  |  1995  |  International Immunology

Experiments in transgenic mice have demonstrated that thymocyte differentiation into the mature CD4+ helper or CD8+ cytotoxic T ce..

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T cell receptor V alpha bias can be determined by TCR-contact residues within an MHC-bound peptide.

SJ Sterry, JM Kelly, SJ Turner, FR Carbone

Journal article  |  1995  |  Immunology and Cell Biology

Many antigen-specific T cell responses show profound V-region biases in one or both chains of the TCR alpha beta heterodimer. We h..

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PEPTIDE ANTAGONISTS THAT PROMOTE POSITIVE SELECTION ARE INEFFICIENT AT T-CELL ACTIVATION AND THYMOCYTE DELETION

MJ BARNDEN, WR HEATH, S RODDA, FR CARBONE

Journal article  |  1994  |  European Journal of Immunology

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T-CELL RECEPTOR ANTAGONIST PEPTIDES INDUCE POSITIVE SELECTION

KA HOGQUIST, SC JAMESON, WR HEATH, JL HOWARD, MJ BEVAN, FR CARBONE

Journal article  |  1994  |  Cell

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Circulating insulin-like growth factors-I and -II and substrates in fetal sheep following restriction of placental growth.

JA Owens, KL Kind, F Carbone, JS Robinson, PC Owens

Journal article  |  1994  |  Journal of Endocrinology

To determine the relationship between placental delivery of oxygen and glucose, circulating insulin-like growth factors (IGFs) and..

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Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant.

JM Kelly, SJ Sterry, S Cose, SJ Turner, J Fecondo, S Rodda, PJ Fink, FR Carbone

Journal article  |  1993  |  European Journal of Immunology

We have analyzed the T cell receptor (TCR) repertoire found in the major histocompatibility complex class I-restricted cytotoxic T..

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SALMONELLA-TYPHIMURIUM DELTA-AROA DELTA-AROD MUTANTS EXPRESSING A FOREIGN RECOMBINANT PROTEIN INDUCE SPECIFIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RESTRICTED CYTOTOXIC T-LYMPHOCYTES IN MICE

SJ TURNER, FR CARBONE, RA STRUGNELL

Journal article  |  1993  |  Infection and Immunity

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Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

SC Jameson, FR Carbone, MJ Bevan

Journal article  |  1993  |  The Journal of Experimental Medicine

A previous report showed that the proliferative response of helper T cells to class II major histocompatibility complex (MHC)-rest..

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ELECTROPORATION AND COMMERCIAL LIPOSOMES EFFICIENTLY DELIVER SOLUBLE-PROTEIN INTO THE MHC CLASS-I PRESENTATION PATHWAY - PRIMING INVITRO AND INVIVO FOR CLASS I-RESTRICTED RECOGNITION OF SOLUBLE-ANTIGEN

WS CHEN, FR CARBONE, J MCCLUSKEY

Journal article  |  1993  |  Journal of Immunological Methods

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CHANGES AT PEPTIDE RESIDUES BURIED IN THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-I BINDING CLEFT INFLUENCE T-CELL RECOGNITION - A POSSIBLE ROLE FOR INDIRECT CONFORMATIONAL ALTERATIONS IN THE MHC CLASS-I OR BOUND PEPTIDE IN DETERMINING T-CELL RECOGNITION

W CHEN, J MCCLUSKEY, S RODDA, FR CARBONE

Journal article  |  1993  |  JOURNAL OF EXPERIMENTAL MEDICINE

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Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4 and CD8 T cells.

PJ Fink, K Swan, G Turk, MW Moore, FR Carbone

Journal article  |  1992  |  The Journal of Experimental Medicine

Murine T cells expressing V beta 5 are characterized by (a) intrathymic deletion in the presence of I-E and products of endogenous..

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Induction of antigen-specific class I-restricted cytotoxic T cells by soluble proteins in vivo.

S Raychaudhuri, M Tonks, F Carbone, T Ryskamp, WJ Morrow, N Hanna

Journal article  |  1992  |  Proceedings of the National Academy of Sciences

Cytotoxic T lymphocytes (CTL) are induced specifically against viral and tumor antigens presented by major histocompatibility comp..

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T cell receptor alpha-chain pairing determines the specificity of residue 262 within the Kb-restricted, ovalbumin257-264 determinant.

FR Carbone, SJ Sterry, J Butler, S Rodda, MW Moore

Journal article  |  1992  |  International Immunology

Ovalbumin-specific, Kb-restricted T cells recognize the minimal fully active synthetic peptide ovalbumin (OVA)257-264. This sequen..

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Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor.

O Kanagawa, BA Nussrallah, ME Wiebenga, KM Murphy, HC Morse, FR Carbone

Journal article  |  1992  |  Journal of Immunology

A B cell line, B6-1710, that expresses the defective virus known to induce murine AIDS stimulates a large fraction of nonprimed sp..

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Conformational difference of T cell antigen receptors revealed by monoclonal antibodies to mouse V beta 5 T cell receptor for antigen determinants.

O Kanagawa, Y Utsunomiya, J Bill, E Palmer, MW Moore, FR Carbone

Journal article  |  1991  |  Journal of Immunology

The mAb MR9-4 and MR9-8 react with T cells expressing the V beta 5.1 and -5.2 chains of the TCR. T cells expressing V beta 5.1 TCR..

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pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein.

R Reddy, F Zhou, L Huang, F Carbone, M Bevan, BT Rouse

Journal article  |  1991  |  Journal of Immunological Methods

Exogenous antigens are normally endocytosed and enter the class II pathway of processing and presentation. It had been shown earli..

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Peptide presentation by class-I major histocompatibility complex molecules.

J Nikolić-Zugić, FR Carbone

Journal article  |  1991  |  Immunologic Research

MHC class-I molecules express distinct peptide-binding pockets within their antigen-binding groove. These are critically involved ..

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Conformational constraints involved in MHC class I restricted antigen presentation.

FR Carbone

Journal article  |  1991  |  International Reviews of Immunology

The realization that class I-restricted antigen presentation can be mimicked using synthetic peptides and the description of the c..

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The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant.

J Nikolić-Zugić, FR Carbone

Journal article  |  1990  |  European Journal of Immunology

The H-2Kb-restricted cytotoxic T lymphocyte (CTL) response directed against ovalbumin (OVA) is specific for a region contained wit..

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Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

FR Carbone, MJ Bevan

Journal article  |  1990  |  The Journal of Experimental Medicine

MHC class I-restricted T lymphocyte responses are usually directed to cellular antigenic components resulting from endogenous gene..

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PEPTIDE-DEPENDENT RECOGNITION OF H-2KB BY ALLOREACTIVE CYTO-TOXIC LYMPHOCYTES-T

WR HEATH, ME HURD, FR CARBONE, LA SHERMAN

Journal article  |  1989  |  Nature

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Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

FR Carbone, MJ Bevan

Journal article  |  1989  |  The Journal of Experimental Medicine

CTL recognize peptide forms of processed, foreign antigens in association with class I molecules encoded by the MHC and are usuall..

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Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides.

NA Hosken, MJ Bevan, FR Carbone

Journal article  |  1989  |  Journal of Immunology

Previous studies have shown that glutaraldehyde-fixed cells can present fragmented, but not native, Ag to class II-restricted T ce..

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Class I MHC-restricted cytotoxic responses to soluble protein antigen.

FR Carbone, NA Hosken, MW Moore, MJ Bevan

Conference Proceedings  |  1989  |  Cold Spring Harbor Symposia on Quantitative Biology

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Introduction of soluble protein into the class I pathway of antigen processing and presentation.

MW Moore, FR Carbone, MJ Bevan

Journal article  |  1988  |  Cell

In order to investigate how peptides associate with class I major histocompatibility complex (MHC) glycoproteins intracellularly, ..

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The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant.

H Bhayani, FR Carbone, Y Paterson

Journal article  |  1988  |  Journal of Immunology

We recently demonstrated that the sequence 95-104 contains all the residues necessary for direct recognition of the I-Ek restricte..

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Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.

FR Carbone, MW Moore, JM Sheil, MJ Bevan

Journal article  |  1988  |  The Journal of Experimental Medicine

Antigen-specific cytotoxic T cells can be generated by primary in vitro stimulation of spleen cells from C57BL/6 mice with appropr..

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Processing of a minimal antigenic peptide alters its interaction with MHC molecules.

BS Fox, FR Carbone, RN Germain, Y Paterson, RH Schwartz

Journal article  |  1988  |  Nature

Before their recognition by T lymphocytes, protein antigens generally require processing by antigen-presenting cells. In a poorly ..

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Effects of protein restriction, melatonin administration, and short daylength on brain benzodiazepine receptors in prepubertal male rats.

DJ Kennaway, P Royles, H Webb, F Carbone

Journal article  |  1988  |  Journal of Pineal Research

The possibility that there are changes in brain benzodiazepine binding sites controlled by photoperiod was investigated in two str..

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Structure-activity studies of melatonin analogues in prepubertal male rats.

DJ Kennaway, HM Hugel, S Clarke, A Tjandra, DW Johnson, P Royles, HA Webb, F Carbone

Journal article  |  1988  |  Australian Journal of Biological Sciences

Comparison has been made between the activity of the pineal hormone melatonin, and several analogues and metabolites in inhibiting..

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Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

MF Kagnoff, YJ Paterson, PJ Kumar, DD Kasarda, FR Carbone, DJ Unsworth, RK Austin

Journal article  |  1987  |  Gut

We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate ..

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A new T helper cell specificity within the pigeon cytochrome c determinant 95-104.

FR Carbone, UD Staerz, Y Paterson

Journal article  |  1987  |  European Journal of Immunology

A T cell hybridoma with unusual antigen specificity has been isolated from B10.BR mice immunized with pigeon cytochrome c. Using s..

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The use of hydrophobic, alpha-helix-defined peptides in delineating the T cell determinant for pigeon cytochrome c.

FR Carbone, BS Fox, RH Schwartz, Y Paterson

Journal article  |  1987  |  Journal of Immunology

The B10.A T cell proliferative response to pigeon cytochrome c is largely directed to a single site in the molecule located at the..

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Phase delay of the rhythm of 6-sulphatoxy melatonin excretion by artificial light.

DJ Kennaway, CR Earl, PF Shaw, P Royles, F Carbone, H Webb

Journal article  |  1987  |  Journal of Pineal Research

The purpose of this study was to investigate the effect of bright artificial light exposure on the rhythms of 6-sulphatoxy melaton..

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STUDIES OF REPEATING SYNTHETIC PEPTIDES DESIGNED TO ADOPT A CROSS-BETA CONFORMATION .1. CONFORMATIONAL-ANALYSIS OF THE BETA-BEND REGION

FR CARBONE, SJ LEACH

Journal article  |  1985  |  International Journal of Peptide and Protein Research

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Monoclonal antibodies to horse cytochrome c expressing four distinct idiotypes distribute among two sites on the native protein.

FR Carbone, Y Paterson

Journal article  |  1985  |  Journal of Immunology

Antibody-secreting hybridoma cell lines produced from BALB/c mice that had been immunized with horse cytochrome c (cyt c) conjugat..

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STUDIES OF REPEATING SYNTHETIC PEPTIDES DESIGNED TO ADOPT A CROSS-BETA CONFORMATION .2. CONFORMATIONAL-ANALYSIS OF THE REPEATING POLYMERS

FR CARBONE, SJ LEACH

Journal article  |  1985  |  International Journal of Peptide and Protein Research

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2 LARGE IMMUNOGENIC AND ANTIGENIC MYOGLOBIN PEPTIDES AND THE EFFECTS OF CYCLIZATION

DS DOROW, PT SHI, FR CARBONE, E MINASIAN, PEE TODD, SJ LEACH

Journal article  |  1985  |  Molecular Immunology

Peptides corresponding to sequences (72-88) and (26-54) of beef myoglobin have been synthesised in their open-chain and cyclised f..

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Scholarly Works

Keyword Analysis

Immunology
Clinical (organs, Diseases and Abnormal Conditions)
Clinical Health (organs, Diseases and Abnormal Conditions)
Biochemistry and Cell Biology
Medical Microbiology
Expanding Knowledge
Microbiology

Honours, Awards and Fellowships

2007

Australian-American Fulbright Senior Scholar Award

Australian-American Fulbright Commission
2010

FAA - Fellow of the Australian Academy of Science

2

Awards

Credentials

Positions

Honorary

Microbiology And Immunology

Member

American Association of Immunologist

Member

Australasian Society for Immunology

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science

University of Melbourne

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