Lynn Corcoran

Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.

Agata K Krzyzanowska, Rashade AH Haynes Ii, Damian Kovalovsky, Hsin-Ching Lin, Louis Osorio, Karen L Edelblum, Lynn M Corcoran, Arnold B Rabson, Lisa K Denzin, Derek B Sant'Angelo

Journal article  |  2022  |  Sci Immunol

The expression of BTB-ZF transcription factors such as ThPOK in CD4+ T cells, Bcl6 in T follicular helper cells, and PLZF in natur..

Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)

Amanda L Patchett, Tim HH Coorens, Jocelyn Darby, Richard Wilson, Matthew J McKay, Karthik S Kamath, Alan Rubin, Matthew Wakefield, Lachlan Mcintosh, Stefano Mangiola, Ruth J Pye, Andrew S Flies, Lynn M Corcoran, A Bruce Lyons, Gregory M Woods, Elizabeth P Murchison, Anthony T Papenfuss, Cesar Tovar

Journal article  |  2020  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Devil facial tumour disease (DFTD) comprises two genetically distinct transmissible cancers (DFT1 and DFT2) endangering the surviv..

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE COMMUNICATIONS

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord

Gauhar Masgutova, Audrey Harris, Benvenuto Jacob, Lynn M Corcoran, Frederic Clotman

Journal article  |  2019  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

Spinal dorsal interneurons, which are generated during embryonic development, relay and process sensory inputs from the periphery ..

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington

Journal article  |  2019  |  MOLECULAR IMMUNOLOGY

NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A Roco, Luka Mesin, Sebastian C Binder, Christian Nefzger, Paula Gonzalez-Figueroa, Pablo F Canete, Julia Ellyard, Qian Shen, Philippe A Robert, Jean Cappello, Harpreet Vohra, Yang Zhang, Carla R Nowosad, Arien Schiepers, Lynn M Corcoran, Kai-Michael Toellner, Jose M Polo, Michael Meyer-Hermann, Gabriel D Victora, Carola G Vinuesa

Journal article  |  2019  |  IMMUNITY

Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isot..

Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord

Audrey Harris, Gauhar Masgutova, Amandine Collin, Mathilde Toch, Maria Hidalgo-Figueroa, Benvenuto Jacob, Lynn M Corcoran, Cedric Francius, Frederic Clotman

Journal article  |  2019  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Acquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cor..

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  IMMUNITY

Dendritic cells (DCs) are can be broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. Despite the importance of..

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many..

Germline-activating mutations in PIK3CD compromise B cell development and function

Danielle T Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R Hermes, David Zahra, William A Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, et al.

Journal article  |  2018  |  JOURNAL OF EXPERIMENTAL MEDICINE

Gain-of-function (GOF) mutations in PIK3CD, encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary i..