We study white blood cells called B cells, which are responsible for immunity to infections.
These are the cells that mediate the protective effects of vaccines.
Defects in B cells also underly diseases including cancers, such as B cell leukaemia, lymphoma and myeloma, as well as autoimmune conditions, such as lupus.
We are using our unique insights into the development and biology of B cells to design and assess new approaches to treating B cell cancers and autoimmunity.
Find out more about Lynn Corcoran's experience
Lynn Corcoran's highlights
Lynn Corcoran's selected work
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiati..
Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Co..
Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partner..
Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Develo..
Displaying the 125 most recent scholarly works by Lynn Corcoran.
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)
Amanda L Patchett, Tim HH Coorens, Jocelyn Darby, Richard Wilson, Matthew J McKay, Karthik S Kamath, Alan Rubin, Matthew Wakefield, Lachlan Mcintosh, Stefano Mangiola, Ruth J Pye, Andrew S Flies, Lynn M Corcoran, A Bruce Lyons, Gregory M Woods, Elizabeth P Murchison, Anthony T Papenfuss, Cesar Tovar
Journal article | 2020 | Cellular and Molecular Life Sciences
Devil facial tumour disease (DFTD) comprises two genetically distinct transmissible cancers (DFT1 and DFT2) endangering the surviv..
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies
Journal article | 2020 | Nature Communications
Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..
Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells
Jai Rautela, Laura F Dagley, Tobias Kratina, Angaleena Anthony, Wilford Goh, Elliot Surgenor, Rebecca B Delconte, Andrew I Webb, Ngaire Elwood, Joanna R Groom, Fernando Souza-Fonseca-Guimaraes, Lynn Corcoran, Nicholas D Huntington
Journal article | 2019 | Molecular Immunology
NK cells are cytotoxic lymphocytes with a key role in limiting tumour metastases. In mice, the NK cell lineage continually express..
Class-Switch Recombination Occurs Infrequently in Germinal Centers
Jonathan A Roco, Luka Mesin, Sebastian C Binder, Christian Nefzger, Paula Gonzalez-Figueroa, Pablo F Canete, Julia Ellyard, Qian Shen, Philippe A Robert, Jean Cappello, Harpreet Vohra, Yang Zhang, Carla R Nowosad, Arien Schiepers, Lynn M Corcoran, Kai-Michael Toellner, Jose M Polo, Michael Meyer-Hermann, Gabriel D Victora, Carola G Vinuesa
Journal article | 2019 | Immunity
Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord
Audrey Harris, Gauhar Masgutova, Amandine Collin, Mathilde Toch, Maria Hidalgo-Figueroa, Benvenuto Jacob, Lynn M Corcoran, Cedric Francius, Frederic Clotman
Journal article | 2019 | Frontiers in Cellular Neuroscience
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT
Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt
Journal article | 2019 | Immunity
Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans
Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf
Journal article | 2019 | NUCLEIC ACIDS RESEARCH
Germline-activating mutations in PIK3CD compromise B cell development and function
Danielle T Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R Hermes, David Zahra, William A Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, et al.
Journal article | 2018 | Journal of Experimental Medicine
Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
Stephanie Trezise, Alexander Karnowski, Pasquale L Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D'Costa, Andrew J Kueh, Matthew P Hardy, Catherine M Owczarek, Marco J Herold, Andrew Spencer, Wei Shi, Simon N Willis, Stephen L Nutt, Lynn M Corcoran
Journal article | 2018 | International Journal of Molecular Sciences
Immunization Strategies Producing a Humoral IgG Immune Response against Devil Facial Tumor Disease in the Majority of Tasmanian Devils Destined for Wild Release
Ruth Pye, Amanda Patchett, Elspeth McLennan, Russell Thomson, Scott Carver, Samantha Fox, David Pemberton, Alexandre Kreiss, Adriana Baz Morelli, Anabel Silva, Martin J Pearse, Lynn M Corcoran, Katherine Belov, Carolyn J Hogg, Gregory M Woods, A Bruce Lyons
Journal article | 2018 | Frontiers in Immunology
The toll-like receptor ligands Hiltonol (R) (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii)
Amanda L Patchett, Cesar Tovar, Lynn M Corcoran, A Bruce Lyons, Gregory M Woods
Journal article | 2017 | Developmental & Comparative Immunology
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
Cesar Tovar, Ruth J Pye, Alexandre Kreiss, Yuanyuan Cheng, Gabriella K Brown, Jocelyn Darby, Roslyn C Malley, Hannah VT Siddle, Karsten Skjodt, Jim Kaufman, Anabel Silva, Adriana Baz Morelli, Anthony T Papenfuss, Lynn M Corcoran, James M Murphy, Martin J Pearse, Katherine Belov, A Bruce Lyons, Gregory M Woods
Journal article | 2017 | Scientific Reports
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-gamma and Can Be Expressed in the Tumor Microenvironment
Andrew S Flies, A Bruce Lyons, Lynn M Corcoran, Anthony T Papenfuss, James M Murphy, Graeme W Knowles, Gregory M Woods, John D Hayball
Journal article | 2016 | Frontiers in Immunology
Mitogen-activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells
Gabriella K Brown, Cesar Tovar, Anne A Cooray, Alexandre Kreiss, Jocelyn Darby, James M Murphy, Lynn M Corcoran, Silvana S Bettiol, A Bruce Lyons, Gregory M Woods
Journal article | 2016 | Immunology & Cell Biology
Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia
Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone
Journal article | 2016 | Cancer Cell
Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development
Renee Gloury, Dimitra Zotos, Malou Zuidscherwoude, Frederick Masson, Yang Liao, Jhaguaral Hasbold, Lynn M Corcoran, Phil D Hodgkin, Gabrielle T Belz, Wei Shi, Stephen L Nutt, David M Tarlinton, Axel Kallies
Journal article | 2016 | The Journal of Experimental Medicine
RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity
Michael Chopin, Simon P Preston, Aaron TL Lun, Julie Tellier, Gordon K Smyth, Marc Pellegrini, Gabrielle T Belz, Lynn M Corcoran, Jane E Visvader, Li Wu, Stephen L Nutt
Journal article | 2016 | Cell Reports
NF kappa B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
Elisha de Valle, George Grigoriadis, Lorraine A O'Reilly, Simon N Willis, Mhairi J Maxwell, Lynn M Corcoran, Evelyn Tsantikos, Jasper KS Cornish, Kirsten A Fairfax, Ajithkumar Vasanthakumar, Mark A Febbraio, Margaret L Hibbs, Marc Pellegrini, Ashish Banerjee, Philip D Hodgkin, Axel Kallies, Fabienne Mackay, Andreas Strasser, Steve Gerondakis, Raffi Gugasyan
Journal article | 2016 | Journal of Experimental Medicine
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
Rebecca B Delconte, Wei Shi, Priyanka Sathe, Takashi Ushiki, Cyril Seillet, Martina Minnich, Tatiana B Kolesnik, Lucille C Rankin, Lisa A Mielke, Jian-Guo Zhang, Meinrad Busslinger, Mark J Smyth, Dana S Hutchinson, Stephen L Nutt, Sandra E Nicholson, Warren S Alexander, Lynn M Corcoran, Eric Vivier, Gabrielle T Belz, Sebastian Carotta, et al.
Journal article | 2016 | Immunity
Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
Wei Shi, Yang Liao, Simon N Willis, Nadine Taubenheim, Michael Inouye, David M Tarlinton, Gordon K Smyth, Philip D Hodgkin, Stephen L Nutt, Lynn M Corcoran
Journal article | 2015 | Nature Immunology
The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
Sebastian Carotta, Simon N Willis, Jhagvaral Hasbold, Michael Inouye, Swee Heng Milon Pang, Dianne Emslie, Amanda Light, Michael Chopin, Wei Shi, Hongsheng Wang, Herbert C Morse, David M Tarlinton, Lynn M Corcoran, Philip D Hodgkin, Stephen L Nutt
Journal article | 2014 | Journal of Experimental Medicine
The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
Stephane Chevrier, Dianne Emslie, Wei Shi, Tobias Kratina, Cameron Wellard, Alexander Karnowski, Erdem Erikci, Gordon K Smyth, Kamal Chowdhury, David Tarlinton, Lynn M Corcoran
Journal article | 2014 | Journal of Experimental Medicine
Identification of Dendritic Cells, B Cell and T Cell Subsets in Tasmanian Devil Lymphoid Tissue; Evidence for Poor Immune Cell Infiltration into Devil Facial Tumors
Lauren J Howson, Katrina M Morris, Takumi Kobayashi, Cesar Tovar, Alexandre Kreiss, Anthony T Papenfuss, Lynn Corcoran, Katherine Belov, Gregory M Woods
Journal article | 2014 | The Anatomical Record
Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism
Simon N Willis, Kim L Good-Jacobson, Joan Curtis, Amanda Light, Julie Tellier, Wei Shi, Gordon K Smyth, David M Tarlinton, Gabrielle T Belz, Lynn M Corcoran, Axel Kallies, Stephen L Nutt
Journal article | 2014 | Journal of Immunology
Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas
Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies
Journal article | 2014 | Nature Medicine
MiR-210 Is Induced by Oct-2, Regulates B Cells, and Inhibits Autoantibody Production
Yingting Mok, Vera Schwierzeck, David C Thomas, Elena Vigorito, Tim F Rayner, Lorna B Jarvis, Haydn M Prosser, Allan Bradley, David R Withers, Inga-Lill Martensson, Lynn M Corcoran, Cherie Blenkiron, Eric A Miska, Paul A Lyons, Kenneth GC Smith
Journal article | 2013 | The Journal of Immunology
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
Alex Karnowski, Stephane Chevrier, Gabrielle T Belz, Adele Mount, Dianne Emslie, Kathy D'Costa, David M Tarlinton, Axel Kallies, Lynn M Corcoran
Journal article | 2012 | Journal of Experimental Medicine
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Dimitra Zotos, Jonathan M Coquet, Yang Zhang, Amanda Light, Kathy D'Costa, Axel Kallies, Lynn M Corcoran, Dale I Godfrey, Kai-Michael Toellner, Mark J Smyth, Stephen L Nutt, David M Tarlinton
Journal article | 2010 | Journal of Experimental Medicine
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.
Ye Zheng, Ashutosh Chaudhry, Arnold Kas, Paul deRoos, Jeong M Kim, Tin-Tin Chu, Lynn Corcoran, Piper Treuting, Ulf Klein, Alexander Y Rudensky
Journal article | 2009 | Nature
In the course of infection or autoimmunity, particular transcription factors orchestrate the differentiation of T(H)1, T(H)2 or T(..
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
Stephane Chevrier, Celine Genton, Axel Kallies, Alexander Karnowski, Luc A Otten, Bernard Malissen, Marie Malissen, Marina Botto, Lynn M Corcoran, Stephen L Nutt, Hans Acha-Orbea
Journal article | 2009 | Proceedings of the National Academy of Sciences of the United States of America
A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation.
Elias Theodorou, George Dalembert, Christopher Heffelfinger, Eric White, Sherman Weissman, Lynn Corcoran, Michael Snyder
Journal article | 2009 | Genes & Development
Neuronal differentiation is a complex process that involves a plethora of regulatory steps. To identify transcription factors that..
Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells
Dianne Emslie, Kathy D'Costa, Jhagvaral Hasbold, Donald Metcalf, Kiyoshi Takatsu, Philip O Hodgkin, Lynn M Corcoran
Journal article | 2008 | Journal of Experimental Medicine
Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: Predominant role of IL-21 produced by CXCR5( ) T follicular helper cells
Vanessa L Bryant, Cindy S Ma, Danielle T Avery, Ying Li, Kim L Good, Lynn M Corcoran, Rene de Waal Malefyt, Stuart G Tangye
Journal article | 2007 | The Journal of Immunology
Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
Axel Kallies, Jhagvaral Hasbold, Kirsten Fairfax, Clare Pridans, Dianne Emslie, Brent S McKenzie, Andrew M Lew, Lynn M Corcoran, Philip D Hodgkin, David M Tarlinton, Stephen L Nutt
Journal article | 2007 | Immunity
Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients.
Nadine Taubenheim, Marcus von Hornung, Anne Durandy, Klaus Warnatz, Lynn Corcoran, Hans-Hartmut Peter, Hermann Eibel
Journal article | 2005 | The Journal of Immunology
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by defective Ab production and recurrent bacteri..
The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells.
Lynn Corcoran, Isabel Ferrero, David Vremec, Karen Lucas, Jason Waithman, Meredith O'Keeffe, Li Wu, Anne Wilson, Ken Shortman
Journal article | 2003 | The Journal of Immunology
There has been controversy over the possible lymphoid origin of certain dendritic cell (DC) subtypes. To resolve this issue, DC an..
Nerve growth factor-regulated properties of sensory neurones in Oct-2 null mutant mice.
NN Ninkina, VL Buchman, AN Akopian, SN Lawson, M Yamamoto, E Campbell, L Corcoran, JN Wood
Journal article | 1995 | Molecular Brain Research
The POU-domain transcription factor Oct-2 is expressed in both B lymphocytes and sensory neurones, where its expression is regulat..
Plasmodium falciparum: mapping the membrane-binding domain in the ring-infected erythrocyte surface antigen.
M Foley, L Corcoran, L Tilley, R Anders
Journal article | 1994 | Experimental Parasitology
The ring-infected erythrocyte surface antigen (RESA) associates with spectrin in the erythrocyte membrane (Foley, M., Tilley, L., ..
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.
MS Schlissel, LM Corcoran, D Baltimore
Journal article | 1991 | The Journal of Experimental Medicine
Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highl..
The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.
MP Kamps, L Corcoran, JH LeBowitz, D Baltimore
Journal article | 1990 | Molecular and Cellular Biology
The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site t..
The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
RG Clerc, LM Corcoran, JH LeBowitz, D Baltimore, PA Sharp
Journal article | 1988 | Genes & Development
Transcription of promoters of immunoglobulin genes is controlled by an octanucleotide sequence element. The sequence of a cDNA enc..
IMMUNIZATION TRIALS WITH THE RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM IN OWL MONKEYS (AOTUS-VOCIFERANS)
WE COLLINS, M PAPPAIOANOU, RF ANDERS, GH CAMPBELL, GV BROWN, DJ KEMP, JR BRODERSON, RL COPPEL, JC SKINNER, PM PROCELL, JM FAVALORO, LM CORCORAN, NSF MA, GF MITCHELL, CC CAMPBELL
Journal article | 1988 | The American Journal of Tropical Medicine and Hygiene
IMMUNIZATION OF AOTUS MONKEYS WITH RECOMBINANT PROTEINS OF AN ERYTHROCYTE SURFACE-ANTIGEN OF PLASMODIUM-FALCIPARUM
WE COLLINS, RF ANDERS, M PAPPAIOANOU, GH CAMPBELL, GV BROWN, DJ KEMP, RL COPPEL, JC SKINNER, PM ANDRYSIAK, JM FAVALORO, LM CORCORAN, JR BRODERSON, GF MITCHELL, CC CAMPBELL
Journal article | 1986 | Nature
Genes For Antigens of Plasmodium Falciparum
DJ Kemp, RL Coppel, HD Stahl, AE Bianco, LM Corcoran, P McIntyre, CJ Langford, JM Favaloro, PE Crewther, GV Brown, GF Mitchell, JG Culvenor
Journal article | 1986 | Parasitology
Sporozoites ofP. falciparumand other Plasmodia appear to be fairly simple antigenically, in that there is a dominant antigen, the ..
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas
JM Adams, S Gerondakis, E Webb, LM Corcoran, S Cory
Journal article | 1983 | Proceedings of the National Academy of Sciences of the United States of America
Medical Biology (W.E.H.I.)
Doctor of Philosophy
University of Melbourne