Louise Randall

Innate immune responses to malaria-infected erythrocytes in pregnant women: Effects of gravidity, malaria infection, and geographic location

Marzieh Jabbarzare, Madi Njie, Anthony Jaworowski, Alexandra J Umbers, Maria Ome-Kaius, Wina Hasang, Louise M Randall, Bill Kalionis, Stephen J Rogerson

Journal article  |  2020  |  PLOS ONE

BACKGROUND: Malaria in pregnancy causes maternal, fetal and neonatal morbidity and mortality, and maternal innate immune responses..

Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women

Andrew Teo, Louise M Randall, Mwayiwawo Madanitsa, Victor Mwapasa, Linda Kalilani Phiri, Carole Khairallah, Christelle Buffet, Amalia Karahalios, David L Narum, Feiko O Ter Kuile, Stephen J Rogerson

Journal article  |  2019  |  SCIENTIFIC REPORTS

In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermitte..

Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection

Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson

Journal article  |  2019  |  SCIENTIFIC REPORTS

Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) and SP plus azithromycin (SPAZ) reduces low birthweight (<2..

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

Shinya Hidano, Louise M Randall, Lucas Dawson, Hans K Dietrich, Christoph Konradt, Peter J Klover, Beena John, Tajie H Harris, Qun Fang, Bradley Turek, Takashi Kobayashi, Lothar Hennighausen, Daniel P Beiting, Anita A Koshy, Christopher A Hunter

Journal article  |  2016  |  MBIO

The local production of gamma interferon (IFN-γ) is important to control Toxoplasma gondii in the brain, but the basis for these p..

Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Andrew Teo, Wina Hasang, Louise M Randall, Holger W Unger, Peter M Siba, Ivo Mueller, Graham V Brown, Stephen J Rogerson

Journal article  |  2015  |  MALARIA JOURNAL

BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic..

Simvastatin Prevents and Reverses Depigmentation in a Mouse Model of Vitiligo

Priti Agarwal, Mehdi Rashighi, Kingsley I Essien, Jillian M Richmond, Louise Randall, Hamidreza Pazoki-Toroudi, Christopher A Hunter, John E Harris

Journal article  |  2015  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitiligo is a common autoimmune disease of the skin that results in disfiguring white spots. There are no Food and Drug Administra..

Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women

Andrew Teo, Wina Hasang, Louise M Randall, Gaoqian Feng, Lauren Bell, Holger Unger, Christine Langer, James G Beeson, Peter M Siba, Ivo Mueller, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

Journal article  |  2014  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of pr..

Low Antibody Levels to Pregnancy-specific Malaria Antigens and Heightened Cytokine Responses Associated With Severe Malaria in Pregnancy

Upeksha P Chandrasiri, Louise M Randall, Alfarazdeg A Saad, Ahmed M Bashir, Stephen J Rogerson, Ishag Adam

Journal article  |  2014  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND:  Pregnant women living in unstable malaria transmission settings may develop severe malaria (SM). The pathogenesis of ..

The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells

Sagie Wagage, Beena John, Bryan L Krock, Aisling O'Hara Hall, Louise M Randall, Christopher L Karp, M Celeste Simon, Christopher A Hunter

Journal article  |  2014  |  JOURNAL OF IMMUNOLOGY

The cytokine IL-10 has an important role in limiting inflammation in many settings, including toxoplasmosis. In the present studie..

Pivotal Advance: Peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4( ) T cells

David Parra, Aja M Rieger, Jun Li, Yong-An Zhang, Louise M Randall, Christopher A Hunter, Daniel R Barreda, J Oriol Sunyer

Journal article  |  2012  |  JOURNAL OF LEUKOCYTE BIOLOGY

Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells f..