Geraldine Mitchell

Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids

Kiryu K Yap, Yi-Wen Gerrand, Aaron M Dingle, George C Yeoh, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2020  |  BIOMATERIALS

The structural and physiological complexity of currently available liver organoids is limited, thereby reducing their relevance fo..

Vascular Pedicle and Microchannels: Simple Methods Toward Effective In Vivo Vascularization of 3D Scaffolds

Jelena Rnjak-Kovacina, Yi-wen Gerrand, Lindsay S Wray, Beryl Tan, Habib Joukhdar, David L Kaplan, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  ADVANCED HEALTHCARE MATERIALS

Poor vascularization remains a key limiting factor in translating advances in tissue engineering to clinical applications. Vascula..

Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment

Nadeeka Bandara, Saliya Gurusinghe, Anne Kong, Geraldine Mitchell, Le-Xin Wang, Shiang Y Lim, Padraig Strappe

Journal article  |  2019  |  JOURNAL OF CELLULAR PHYSIOLOGY

Enhancing differentiation of mesenchymal stem cells (MSCs) to endothelial cells may improve their ability to vascularize tissue an..

Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle

Anne M Kong, Kiryu K Yap, Shiang Y Lim, Diego Marre, Alice Pebay, Yi-wen Gerrand, Jarmon G Lees, Jason A Palmer, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  ACTA BIOMATERIALIA

Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a ..

Methods for Assessing Scaffold Vascularization In Vivo

Jiang-Hui Wang, Jinying Chen, Shyh-Ming Kuo, Geraldine M Mitchell, Shiang Y Lim, Guei-Sheung Liu

Journal article  |  2019  |  SKIN TISSUE ENGINEERING: METHODS AND PROTOCOLS

The success of tissue engineering hinges on the rapid and sufficient vascularization of the neotissue. For efficient vascular netw..

Epigenetic and Transcriptome Profiling Identifies a Population of Visceral Adipose-Derived Progenitor Cells with the Potential to Differentiate into an Endocrine Pancreatic Lineage

Michael D Williams, Mugdha Joglekar, Sarang N Satoor, Wilson Wong, Effie Keramidaris, Amanda Rixon, Philip O'Connell, Wayne J Hawthorne, Geraldine M Mitchell, Anandwardhan A Hardikar

Journal article  |  2019  |  CELL TRANSPLANTATION

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing β-cells in the pancreas. T1D can be treated using cadaveri..

The Vascularised Chamber as an In Vivo Bioreactor

Kiryu K Yap, George C Yeoh, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2018  |  TRENDS IN BIOTECHNOLOGY

Vascularisation is key to developing large transplantable tissue constructs capable of providing therapeutic benefits. The vascula..

Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering

AM Dingle, KK Yap, Y-W Gerrand, CJ Taylor, E Keramidaris, Z Lokmic, AM Kong, HL Peters, WA Morrison, GM Mitchell

Journal article  |  2018  |  ANGIOGENESIS

BACKGROUND: The liver sinusoidal capillaries play a pivotal role in liver regeneration, suggesting they may be beneficial in liver..

Melatonin promotes survival of nonvascularized fat grafts and enhances the viability and migration of human adipose-derived stem cells via down-regulation of acute inflammatory cytokines

Shaun S Tan, Weiqing Zhan, Christopher J Poon, Xiaolian Han, Diego Marre, Sholeh Boodhun, Jason A Palmer, Geraldine M Mitchell, Wayne A Morrison

Journal article  |  2018  |  JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Nonvascularized fat grafting is a valuable technique for soft tissue reconstruction but poor survival of fat in the host environme..

Hypoxic preconditioning of myoblasts implanted in a tissue engineering chamber significantly increases local angiogenesis via upregulation of myoblast vascular endothelial growth factor-A expression and downregulation of miRNA-1, miRNA-206 and angiopoietin-1

CJ Taylor, JE Church, MD Williams, Y-W Gerrand, E Keramidaris, JA Palmer, LA Galea, AJ Penington, WA Morrison, GM Mitchell

Journal article  |  2018  |  JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Vascularization is a major hurdle for growing three-dimensional tissue engineered constructs. This study investigated the mechanis..