Bill Chang

High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus

Aya C Taki, Joseph J Byrne, Tao Wang, Brad E Sleebs, Nghi Nguyen, Ross S Hall, Pasi K Korhonen, Bill CH Chang, Paul Jackson, Abdul Jabbar, Robin B Gasser

Journal article  |  2021  |  PHARMACEUTICALS

Parasitic worms cause very significant diseases in animals and humans worldwide, and their control is critical to enhance health, ..

Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro

Aya C Taki, Abdul Jabbar, Thomas Kurz, Beate Lungerich, Guangxu Ma, Joseph J Byrne, Marc Pflieger, Yodita Asfaha, Fabian Fischer, Bill CH Chang, Brad E Sleebs, Robin B Gasser

Journal article  |  2021  |  MOLECULES

Due to widespread multi-drug resistance in parasitic nematodes of livestock animals, there is an urgent need to discover new anthe..

Dipylidium caninum draft genome-a new resource for comparative genomic and genetic explorations of flatworms

Guo-Hua Liu, Pasi K Korhonen, Neil D Young, Jiang Lu, Tao Wang, Yi-Tian Fu, Anson V Koehler, Andreas Hofmann, Bill CH Chang, Shuai Wang, Nan Li, Chu-Yu Lin, Hui Zhang, Lingzi Xiangli, Lin Lin, Wei-Min Liu, Nan Li, Hua-Wei Li, Robin B Gasser, Xing-Quan Zhu

Journal article  |  2021  |  GENOMICS

Here, we present a draft genome of the tapeworm Dipylidium caninum (family Dipylidiidae) and compare it with other cestode genomes..

High-quality reference genome for Clonorchis sinensis

Neil D Young, Andreas J Stroehlein, Liina Kinkar, Tao Wang, Woon-Mok Sohn, Bill CH Chang, Parwinder Kaur, David Weisz, Olga Dudchenko, Erez Lieberman Aiden, Pasi K Korhonen, Robin B Gasser

Journal article  |  2021  |  GENOMICS

The Chinese liver fluke, Clonorchis sinensis, causes the disease clonorchiasis, affecting ~35 million people in regions of China, ..

Nanopore Sequencing Resolves Elusive Long Tandem-Repeat Regions in Mitochondrial Genomes

Liina Kinkar, Robin B Gasser, Bonnie L Webster, David Rollinson, D Timothy J Littlewood, Bill CH Chang, Andreas J Stroehlein, Pasi K Korhonen, Neil D Young

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long non-coding, tandem-repetitive regions in mitochondrial (mt) genomes of many metazoans have been notoriously difficult to char..

1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity

Sarah Preston, Jose Garcia-Bustos, Liam G Hall, Sheree D Martin, Thuy G Le, Abhijit Kundu, Atanu Ghoshal, Nghi H Nguyen, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Bill CH Chang, Sean L McGee, Timothy NC Wells, Michael J Palmer, Abdul Jabbar, Robin B Gasser, Jonathan B Baell

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

A series of 1-methyl-1H-pyrazole-5-carboxamides were synthesized as potent inhibitors of the parasitic nematode of sheep, Haemonch..

Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus

Aya C Taki, Robert Brkljaca, Tao Wang, Anson Koehler, Guangxu Ma, Jill Danne, Sarah Ellis, Andreas Hofmann, Bill CH Chang, Abdul Jabbar, Sylvia Urban, Robin B Gasser

Journal article  |  2020  |  PATHOGENS

Eight secondary metabolites (1 to 8) were isolated from a marine sponge, a marine alga and three terrestrial plants collected in A..

Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro

HMP Dilrukshi Herath, Aya C Taki, Nguyen Nghi, Jose Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill CH Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser

Journal article  |  2020  |  MOLECULES

Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ce..

The developmental phosphoproteome of Haemonchus contortus

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Andreas J Stroehlein, Neil D Young, Andreas Hofmann, Bill CH Chang, Nicholas A Williamson, Robin B Gasser

Journal article  |  2020  |  JOURNAL OF PROTEOMICS

Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics..

Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport

Marziyeh Anari, Andreas J Stroehlein, Ross S Hall, Bill CH Chang, Robin B Gasser, Neil D Young

Journal article  |  2020  |  PARASITES & VECTORS

BACKGROUND: The parasitic flatworm Clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. This par..