Bill Chang

Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro

HMP Dilrukshi Herath, Aya C Taki, Nguyen Nghi, Jose Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill CH Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser

Journal article  |  2020  |  Molecules

Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ce..

The developmental phosphoproteome of Haemonchus contortus

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Andreas J Stroehlein, Neil D Young, Andreas Hofmann, Bill CH Chang, Nicholas A Williamson, Robin B Gasser

Journal article  |  2020  |  Journal of Proteomics

Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics..

Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport

Marziyeh Anari, Andreas J Stroehlein, Ross S Hall, Bill CH Chang, Robin B Gasser, Neil D Young

Journal article  |  2020  |  Parasites & Vectors

BACKGROUND: The parasitic flatworm Clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. This par..

Global prevalence of Toxocara infection in dogs.

Ali Rostami, Seyed Mohammad Riahi, Andreas Hofmann, Guangxu Ma, Tao Wang, Hamed Behniafar, Ali Taghipour, Yadolah Fakhri, Adel Spotin, Bill CH Chang, Calum NL Macpherson, Peter J Hotez, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

Dogs serve as the most important definitive hosts for Toxocara canis-a causative agent of human toxocariasis and one of the most w..

A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here?

Yaqing Jiao, Sarah Preston, Andreas Hofmann, Aya Taki, Jonathan Baell, Bill CH Chang, Abdul Jabbar, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide. Anthelmintic treatment is central..

Human toxocariasis - A look at a neglected disease through an epidemiological 'prism'

Ali Rostami, Guangxu Ma, Tao Wang, Anson Koehler, Andreas Hofmann, Bill CH Chang, Calum N Macpherson, Robin B Gasser

Journal article  |  2019  |  Infection, Genetics and Evolution

Selected alpha-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

HMP Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Russell S Addison, Sasha Hayes, Topul Rali, Tao Wang, Anson Koehler, Bill CH Chang, Andreas Hofmann, Rohan A Davis, Robin B Gasser

Journal article  |  2019  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro

Yaqing Jiao, Sarah Preston, Jose F Garcia-Bustos, Jonathan B Baell, Sabatino Ventura, Thuy Le, Nicole McNamara, Nghi Nguyen, Antony Botteon, Cameron Skinner, Jill Danne, Sarah Ellis, Anson Koehler, Tao Wang, Bill CH Chang, Andreas Hofmann, Abdul Jabbar, Robin B Gasser

Journal article  |  2019  |  International Journal for Parasitology: Drugs and Drug Resistance

Novel 1-Methyl-1H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity

Thuy G Le, Abhijit Kundu, Atanu Ghoshal, Nghi H Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill CH Chang, Jose Garcia-Bustos, Timothy NC Wells, Michael J Palmer, Abdul Jabbar, Robin B Gasser, Jonathan B Baell

Journal article  |  2019  |  Journal of Medicinal Chemistry

A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode H..

ENVirT: inference of ecological characteristics of viruses from metagenomic data

Duleepa Jayasundara, Damayanthi Herath, Damith Senanayake, Isaam Saeed, Cheng-Yu Yang, Yuan Sun, Bill C Chang, Sen-Lin Tang, Saman K Halgamuge

Journal article  |  2019  |  BMC Bioinformatics

Background: Estimating the parameters that describe the ecology of viruses,particularly those that are novel, can be made possible..

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Thuy G Le, Abhijit Kundu, Atanu Ghoshal, Nghi H Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill CH Chang, Jose Garcia-Bustos, Timothy NC Wells, Michael J Palmer, Abdul Jabbar, Robin B Gasser, Jonathan B Baell

Journal article  |  2019  |  Journal of Medicinal Chemistry

Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host

Guangxu Ma, Tao Wang, Pasi K Korhonen, Shuai Nie, Gavin E Reid, Andreas J Stroehlein, Anson V Koehler, Bill CH Chang, Andreas Hofmann, Neil D Young, Robin B Gasser

Journal article  |  2019  |  Parasit Vectors

Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus

H Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Aya Taki, Russell Addison, Sasha Hayes, Karren Beattie, Sean McGee, Sheree Martin, Merrick Ekins, John Hooper, Bill Chang, Andreas Hofmann, Rohan Davis, Robin Gasser

Journal article  |  2019  |  Marine Drugs

There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importanc..

Optimization of Novel 1-Methyl-1H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm

Thuy G Le, Abhijit Kundu, Atanu Ghoshal, Nghi H Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill CH Chang, Jose Garcia-Bustos, Abdul Jabbar, Timothy NC Wells, Michael J Palmer, Robin B Gasser, Jonathan B Baell

Journal article  |  2018  |  Journal of Medicinal Chemistry

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus conforms in vitro

HMP Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill CH Chang, Anson V Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B Gasser

Journal article  |  2018  |  International Journal for Parasitology: Drugs and Drug Resistance

Due to widespread drug resistance in parasitic nematodes, there is a need to develop new anthelmintics. Given the cost and time in..

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro.

HMP Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill CH Chang, Anson V Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B Gasser

Journal article  |  2018  |  International Journal for Parasitology: Drugs and Drug Resistance

Due to widespread drug resistance in parasitic nematodes, there is a need to develop new anthelmintics. Given the cost and time in..

PhalDB:A comprehensive database for molecular mining of the Phalaenopsis genome, transcriptome and miRNome

CY Lee, KK Viswanath, JZ Huang, CP Lee, CP Lin, TC Cheng, BC Chang, SW Chin, FC Chen

Journal article  |  2018  |  Genetics and Molecular Research

The development of functional mapping by three sex-related loci on the third whorl of different sex types of Carica papaya L.

Chen-Yu Lee, Hui-Jun Lin, Kotapati Kasi Viswanath, Chih-Peng Lin, Bill Chia-Han Chang, Pei-Hsun Chiu, Chan-Tai Chiu, Ren-Huang Wang, Shih-Wen Chin, Fure-Chyi Chen

Journal article  |  2018  |  PLOS ONE

Carica papaya L. is an important economic crop worldwide and is used as a model plant for sex-determination research. To study the..

A termite symbiotic mushroom maximizing sexual activity at growing tips of vegetative hyphae

HM Hsieh, MC Chung, PY Chen, FM Hsu, WW Liao, AN Sung, CR Lin, CJR Wang, YH Kao, MJ Fang, CY Lai, CC Huang, JC Chou, WN Chou, BCH Chang, YM Ju

Journal article  |  2017  |  Botanical Studies

Whipworm kinomes reflect a unique biology and adaptation to the host animal

Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill CH Chang, Peter Nejsum, Edoardo Pozio, Giuseppe La Rosa, Paul W Sternberg, Robin B Gasser

Journal article  |  2017  |  International Journal for Parasitology

Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of genome-wide high-throughput analysis of hepatitis B virus.

Wen-Chun Liu, I-Chin Wu, Yen-Chien Lee, Chih-Peng Lin, Ji-Hong Cheng, Yih-Jyh Lin, Chia-Jui Yen, Pin-Nan Cheng, Pei-Fu Li, Yi-Ting Cheng, Pei-Wen Cheng, Koun-Tem Sun, Shu-Ling Yan, Jia-Jhen Lin, Jui-Chu Yang, Kung-Chao Chang, Cheng-Hsun Ho, Vincent S Tseng, Bill Chia-Han Chang, Jaw-Ching Wu, et al.

Journal article  |  2017  |  The Journal of Pathology

This study investigated hepatitis B virus (HBV) single-nucleotide variants (SNVs) and deletion mutations linked with hepatocellula..

yy Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser

Journal article  |  2017  |  The FASEB Journal

Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus

HMP Dilrukshi Herath, Sarah Preston, Andreas Hofmann, Rohan A Davis, Anson V Koehler, Bill CH Chang, Abdul Jabbar, Robin B Gasser

Journal article  |  2017  |  Veterinary Parasitology

Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus

Yaqing Jiao, Sarah Preston, Anson V Koehler, Andreas J Stroehlein, Bill CH Chang, Kaylene J Simpson, Karla J Cowley, Michael J Palmer, Benoit Laleu, Timothy NC Wells, Abdul Jabbar, Robin B Gasser

Journal article  |  2017  |  PARASITES & VECTORS

Analyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain

Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill CH Chang, Paul W Sternberg, Giuseppe La Rosa, Edoardo Pozio, Robin B Gasser

Journal article  |  2016  |  G3-GENES GENOMES GENETICS

The genome and transcriptome of Phalaenopsis yield insights into floral organ development and flowering regulation

Jian-Zhi Huang, Chih-Peng Lin, Ting-Chi Cheng, Ya-Wen Huang, Yi-Jung Tsai, Shu-Yun Cheng, Yi-Wen Chen, Chueh-Pai Lee, Wan-Chia Chung, Bill Chia-Han Chang, Shih-Wen Chin, Chen-Yu Lee, Fure-Chyi Chen

Journal article  |  2016  |  PeerJ

Phylogenomic and biogeographic reconstruction of the Trichinella complex

Pasi K Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill CH Chang, Anson V Koehler, Eric P Hoberg, Peter R Boag, Patrick Tan, Aaron R Jex, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser

Journal article  |  2016  |  NATURE COMMUNICATIONS

Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus.

Wen-Chun Liu, Chih-Peng Lin, Chun-Pei Cheng, Cheng-Hsun Ho, Kuo-Lun Lan, Ji-Hong Cheng, Chia-Jui Yen, Pin-Nan Cheng, I-Chin Wu, I-Chen Li, Bill Chia-Han Chang, Vincent S Tseng, Yen-Cheng Chiu, Ting-Tsung Chang

Journal article  |  2016  |  Hepatology International

BACKGROUND: Hepatitis B virus (HBV) quasispecies are crucial in the pathogenesis of chronic liver disease. Next-generation sequenc..

A De Novo Floral Transcriptome Reveals Clues into Phalaenopsis Orchid Flower Development

Jian-Zhi Huang, Chih-Peng Lin, Ting-Chi Cheng, Bill Chia-Han Chang, Shu-Yu Cheng, Yi-Wen Chen, Chen-Yu Lee, Shih-Wen Chin, Fure-Chyi Chen

Journal article  |  2015  |  PLOS ONE

Evaluation and application of the strand-specific protocol for next-generation sequencing.

Kuo-Wang Tsai, Bill Chang, Cheng-Tsung Pan, Wei-Chen Lin, Ting-Wen Chen, Sung-Chou Li

Journal article  |  2015  |  BioMed Research International

Next-generation sequencing (NGS) has become a powerful sequencing tool, applied in a wide range of biological studies. However, th..

Mitochondrial genomes of Trichinella species and genotypes - a basis for diagnosis, and systematic and epidemiological explorations

Namitha Mohandas, Edoardo Pozio, Giuseppe La Rosa, Pasi K Korhonen, Neil D Young, Anson V Koehler, Ross S Hall, Paul W Sternberg, Peter R Boag, Aaron R Jex, Bill CH Chang, Robin B Gasser

Journal article  |  2014  |  International Journal for Parasitology

De novo transcriptome sequence assembly from coconut leaves and seeds with a focus on factors involved in RNA-directed DNA methylation.

Ya-Yi Huang, Chueh-Pai Lee, Jason L Fu, Bill Chia-Han Chang, Antonius JM Matzke, Marjori Matzke

Journal article  |  2014  |  G3: Genes|Genomes|Genetics

Coconut palm (Cocos nucifera) is a symbol of the tropics and a source of numerous edible and nonedible products of economic value...

Global analyses of small interfering RNAs derived from Bamboo mosaic virus and its associated satellite RNAs in different plants.

Kuan-Yu Lin, Chi-Ping Cheng, Bill Chia-Han Chang, Wei-Chi Wang, Ying-Wen Huang, Yun-Shien Lee, Hsien-Da Huang, Yau-Heiu Hsu, Na-Sheng Lin

Journal article  |  2010  |  PLoS ONE

BACKGROUND: Satellite RNAs (satRNAs), virus parasites, are exclusively associated with plant virus infection and have attracted mu..

Gene functionality's influence on the second codon: A large-scale survey of second codon composition in three domains

Sen-Lin Tang, Bill CH Chang, Saman K Halgamuge

Journal article  |  2010  |  Genomics

Identification of repressed gene transcript accumulation in three albino mutants of Bambusa edulis Munro by cDNA microarray analysis

FH Wu, NT Liu, SJ Chou, SC Shen, BCH Chang, CY Pan, CS Lin

Journal article  |  2009  |  Journal of the Science of Food and Agriculture

Questionable 16S ribosomal RNA gene annotations are frequent in completed microbial genomes.

Yu-Hsiang Lin, Bill CH Chang, Pei-Wen Chiang, Sen-Lin Tang

Journal article  |  2008  |  Gene

According to recent reports, many ribosomal RNA gene annotations are still questionable, and the use of inappropriate tools for an..

Fast splice site detection using information content and feature reduction

AKMA Baten, SK Halgamuge, BCH Chang

Journal article  |  2008  |  BMC Bioinformatics

Correction: Splice site identification using probabilistic parameters and SVM classification (vol 8, pg 241, 2007)

AKMA Baten, BCH Chang, SK Halgamuge, Jason Li

Journal article  |  2007  |  BMC Bioinformatics

Biological sequence data preprocessing for classification: A case study in splice site identirication

AKMA Baten, SK Halgamuge, B Chang, N Wickramarachchi

Conference Proceedings  |  2007  |  Advances in Neural Networks - ISNN 2007 (Lecture Notes in Computer Science)

Analysis of SD sequences in completed microbial genomes: Non-SD-led genes are as common as SD-led genes

Bill Chang, Saman Halgamuge, Sen-Lin Tang

Journal article  |  2006  |  Gene

Splice site identification using probabilistic parameters and SVM classification

AKMA Baten, BCH Chang, SK Halgamuge, Jason Li

Journal article  |  2006  |  BMC Bioinformatics

Particle swarm optimisation for protein Motif discovery

BCH Chang, A Ratnaweera, SK Halgamuge, HC Watson

Journal article  |  2004  |  Genetic Programming and Evolvable Machines

Approximate symbolic pattern matching for protein sequence data

BCH Chang, SK Halgamuge

Journal article  |  2003  |  International Journal of Approximate Reasoning

Protein motif extraction with neuro-fuzzy optimization

BCH Chang, SK Halgamuge

Journal article  |  2002  |  Bioinformatics

Fuzzy Sequence Pattern Matching in Zinc Finger domain proteins

BCH Chang, SK Halgamuge

Conference Proceedings  |  2001  |  Proceedings Joint 9-th IFSA World Congress and 20-th NAFIPS International Conference

Pre-filter design for high speed contouring machines

BCH Chang, RC Ko, SK Halgamuge

Conference Proceedings  |  1999  |  ICONIP'99. ANZIIS'99 & ANNES'99 & ACNN'99. 6th International Conference on Neural Information Processing. Proceedings (Cat. No.99EX378)