Diane Moujalled

Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

Journal article  |  2023  |  Cell Death Differ

The original version of this article contained a mistake. When preparing the revised version of this paper the authors omitted a n..

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah TT Diepstraten, Catherine Chang, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver MM Sieber, Jane Visvader, Gemma LL Kelly, Andreas Strasser

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of ..

Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels.

Amanda E Au, Jason E Corbin, Marion Lebois, Pradnya Gangatirkar, Fatme Yassinson, Stephanie Rose Hyslop, Ping Cannon, Kylie D Mason, Connie Sn Li-Wai-Suen, Alexandra L Garnham, Diane Moujalled, Luisa Cimmino, Warren S Alexander, Emma C Josefsson

Journal article  |  2022  |  Blood Adv

Platelets have been shown to enhance the survival of lymphoma cell lines, but it is unclear if they play a role in lymphoma. Here ..

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells

Diane Moujalled, Adam G Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S Cross, Misty R Jenkins, Duong Nhu, Zilu Wang, Melissa X Shi, Ruth M Kluck, Guillaume Lessene, Stephanie Grabow, Ashley Bush, Andreas Strasser

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer, with treatment options often constrained due..

Molecular mechanisms of cell death in neurological diseases

Diane Moujalled, Andreas Strasser, Jeffrey R Liddell

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and tem..

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X Shi, Michael A Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S Anstee, Boris Reljic, Sarah S Gabriel, Tirta M Djajawi, Chris D Riffkin, Brandon J Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, et al.

Journal article  |  2021  |  BLOOD

Selective targeting of BCL-2 with the BH3-mimetic venetoclax has been a transformative treatment for patients with various leukemi..

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson

Journal article  |  2021  |  CELL DEATH & DISEASE

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). P..

Cu-II(atsm) Attenuates Neuroinflammation

Xin Yi Choo, Jeffrey R Liddell, Mikko T Huuskonen, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E Oikari, Clare Duncan, Simon A James, Lachlan E McInnes, David J Hayne, Paul S Donnelly, Eveliina Pollari, Suvi Vahatalo, Katarina Lejavova, Mikko Kettunen, Tarja Malm, et al.

Journal article  |  2018  |  FRONTIERS IN NEUROSCIENCE

Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, inc..

Effect of Structural Modifications to Glyoxal-bis(thiosemicarbazonato)copper(II) Complexes on Cellular Copper Uptake, Copper-Mediated ATP7A Trafficking, and P-Glycoprotein Mediated Efflux

Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin J Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly

Journal article  |  2018  |  JOURNAL OF MEDICINAL CHEMISTRY

Bis(thiosemicarbazonato)copper(II) complexes are of interest as potential therapeutics for cancer and neurodegenerative diseases a..

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson

Journal article  |  2017  |  SCIENTIFIC REPORTS

Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet..