Grace Lidgerwood

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Drew Neavin, Quan Nguyen, Maciej S Daniszewski, Helena H Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W Lukowski, Duncan E Crombie, Grace E Lidgerwood, Damian Hernandez, James C Vickers, Anthony L Cook, Nathan J Palpant, Alice Pebay, Alex W Hewitt, Joseph E Powell

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundati..

The Use of Human Pluripotent Stem Cells (hPSCs) and CRISPR-Mediated Gene Editing in Retinal Diseases

Grace E Lidgerwood, Alex W Hewitt, Alice Pébay, Damián Hernández

Book Chapter  |  2021

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

Journal article  |  2020  |  Genomics Proteomics Bioinformatics

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline KR Walker, Grace E Lidgerwood, Kimberley L Dilworth, Leszek Lisowski, Alice Pebay, Alex W Hewitt

Journal article  |  2020  |  NATURE COMMUNICATIONS

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosi..

Optimization of silk fibroin membranes for retinal implantation

Shuko Suzuki, Audra MA Shadforth, Samuel McLenachan, Dan Zhang, Shang-Chih Chen, Jennifer Walshe, Grace E Lidgerwood, Alice Pebay, Traian Chirila, Fred K Chen, Damien G Harkin

Journal article  |  2019  |  MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS

Silk fibroin membrane displays potential for ocular tissue reconstruction as demonstrated by its ability to support a functioning ..

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Grace E Lidgerwood, Alex W Hewitt, Alice Pebay

Journal article  |  2019  |  CURRENT OPINION IN PHARMACOLOGY

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retin..

An overview of human pluripotent stem cell applications for the understanding and treatment of blindness

Louise Rooney, Duncan Crombie, Grace Lidgerwood, Maciej Daniszewski, Alice Pebay

Book Chapter  |  2019

Human pluripotent stem cells (hPSCs) hold great promise for human therapies including for treatment of eye-related disease. Given ..

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Grace E Lidgerwood, Stuart M Pitson, Claudine Bonder, Alice Pebay

Journal article  |  2018  |  PROGRESS IN LIPID RESEARCH

Stem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem ce..

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Maciej Daniszewski, Nguyen Quan, Hun S Chy, Vikrant Singh, Duncan E Crombie, Tejal Kulkarni, Helena H Liang, Priyadharshini Sivakumaran, Grace E Lidgerwood, Damien Hernandez, Alison Conquest, Louise A Rooney, Sophie Chevalier, Stacey B Andersen, Anne Senabouth, James C Vickers, David A Mackey, Jamie E Craig, Andrew L Laslett, Alex W Hewitt, et al.

Journal article  |  2018  |  ISCIENCE

We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex an..

Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors

Grace E Lidgerwood, Andrew J Morris, Alison Conquest, Maciej Daniszewski, Louise A Rooney, Shiang Y Lim, Damian Hernandez, Helena H Liang, Penelope Allen, Paul P Connell, Robyn H Guymer, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The human retina is a complex structure of organised layers of specialised cells that support the transmission of light signals to..