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Dr

Grace Lidgerwood

Research Fellow
science & technology
life sciences & biomedicine
humans
biochemistry & molecular biology
animals
neural retina
cell differentiation
cells, cultured
science & technology - other topics
Grace Lidgerwood's Profile Picture
Dr

Grace Lidgerwood

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Stem Cell Disease Modelling
Grace Lidgerwood's Profile Picture
Dr

Grace Lidgerwood

 

Grace Lidgerwood received her PhD from the University of Melbourne in 2018. During her PhD, she developed methods for differentiating iPSCs to retinal cell types for disease modelling and explored the role of endogenous signalling lipids and inflammation in retinal homeostasis.



Her current research, based in the Department of Anatomy & Neuroscience at the University of Melbourne, focusses on creating more complex hPSC-derived models of neurodegeneration, including organoid and co-culturing methods, bioengineered matrices and 3D printing.
Dr Lidgerwood is an affiliate Postdoctoral Fellow for the ARC Centre for Personalised Therapeutic Technologies (ARC CPTT), an Honorary Fellow of the Department of Surgery, and the Chair of the Early Career Researcher Committee, Australian Society for Stem Cell Research (ASSCR).

Projects

Displaying the most recent project by Grace Lidgerwood.

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The Jack Brockhoff Early Career Research Grants

2018 - 2019
Completed

1

Projects

Project Types

1

Research Grant

Scholarly Works

Displaying the 17 most recent scholarly works by Grace Lidgerwood.

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Optimization of silk fibroin membranes for retinal implantation

Shuko Suzuki, Audra MA Shadforth, Samuel McLenachan, Dan Zhang, Shang-Chih Chen, Jennifer Walshe, Grace E Lidgerwood, Alice Pebay, Traian Chirila, Fred K Chen, Damien G Harkin

Journal article  |  2019  |  Materials Science and Engineering: C

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Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Grace E Lidgerwood, Alex W Hewitt, Alice Pebay

Journal article  |  2019  |  Current Opinion in Pharmacology

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retin..

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An overview of human pluripotent stem cell applications for the understanding and treatment of blindness

Alice Pebay, Grace Lidgerwood, Louise Rooney, Duncan Crombie, Maciej Daniszewski

Book Chapter  |  2019

Human pluripotent stem cells (hPSCs) hold great promise for human therapies including for treatment of eye-related disease. Given ..

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Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Grace E Lidgerwood, Stuart M Pitson, Claudine Bonder, Alice Pebay

Journal article  |  2018  |  Progress in Lipid Research

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Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Maciej Daniszewski, Nguyen Quan, Hun S Chy, Vikrant Singh, Duncan E Crombie, Tejal Kulkarni, Helena H Liang, Priyadharshini Sivakumaran, Grace E Lidgerwood, Damien Hernandez, Alison Conquest, Louise A Rooney, Sophie Chevalier, Stacey B Andersen, Anne Senabouth, James C Vickers, David A Mackey, Jamie E Craig, Andrew L Laslett, Alex W Hewitt, et al.

Journal article  |  2018  |  iScience

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Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors

Grace E Lidgerwood, Andrew J Morris, Alison Conquest, Maciej Daniszewski, Louise A Rooney, Shiang Y Lim, Damian Hernandez, Helena H Liang, Penelope Allen, Paul P Connell, Robyn H Guymer, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

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Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Duncan E Crombie, Maciej Daniszewski, Helena H Liang, Tejal Kulkarni, Fan Li, Grace E Lidgerwood, Alison Conquest, Damian Hernandez, Sandy S Hung, Katherine P Gill, Elisabeth De Smit, Lisa S Kearns, Linda Clarke, Valentin M Sluch, Xitiz Chamling, Donald J Zack, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  SLAS DISCOVERY: Advancing Life Sciences R&D

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Enriched retinal ganglion cells derived from human embryonic stem cells

Katherine P Gill, Sandy SC Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  Scientific Reports

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Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Grace E Lidgerwood, Shiang Y Lim, Duncan E Crombie, Ray Ali, Katherine P Gill, Damian Hernandez, Josh Kie, Alison Conquest, Hayley S Waugh, Raymond CB Wong, Helena H Liang, Alex W Hewitt, Kathryn C Davidson, Alice Pebay

Journal article  |  2016  |  Stem Cell Reviews and Reports

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Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43

Diane Moujalled, Janine L James, Shu Yang, Katharine Zhang, Clare Duncan, Donia M Moujalled, Sarah J Parker, Aphrodite Caragounis, Grace Lidgerwood, Bradley J Turner, Julie D Atkin, Alexandra Grubman, Jeffrey R Liddell, Christian Proepper, Tobias M Boeckers, Katja M Kanninen, Ian Blair, Peter J Crouch, Anthony R White

Journal article  |  2015  |  Human Molecular Genetics

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A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein, Grace Lidgerwood, Donald P Cameron, Jason Ellul, Gregory J Goodall, Lee H Wong, Amardeep S Dhillon, Nourdine Hamdane, Lawrence I Rothblum, Richard B Pearson, Izhak Haviv, Tom Moss, Ross D Hannan

Journal article  |  2015  |  Genome Research

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Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Alexandra Grubman, Grace E Lidgerwood, Clare Duncan, Laura Bica, Jiang-Li Tan, Sarah J Parker, Aphrodite Caragounis, Jodi Meyerowitz, Irene Volitakis, Diane Moujalled, Jeffrey R Liddell, James L Hickey, Malcolm Horne, Shoshanah Longmuir, Jari Koistinaho, Paul S Donnelly, Peter J Crouch, Imke Tammen, Anthony R White, Katja M Kanninen

Journal article  |  2014  |  Acta Neuropathologica Communications

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Erratum: Copper modulates the large dense core vesicle secretory pathway in PC12 cells (Metallomics (2013) 5 (700-714) DOI:10.1039/C3MT20231C)

C Duncan, L Bica, PJ Crouch, A Caragounis, GE Lidgerwood, SJ Parker, J Meyerowitz, I Volitakis, JR Liddell, R Raghupathi, BM Paterson, MD Duffield, R Cappai, PS Donnelly, A Grubman, J Camakaris, DJ Keating, AR White

Journal article  |  2013  |  Metallomics

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Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Diane Moujalled, Janine L James, Sarah J Parker, Grace E Lidgerwood, Clare Duncan, Jodi Meyerowitz, Takashi Nonaka, Masato Hasegawa, Katja M Kanninen, Alexandra Grubman, Jeffrey R Liddell, Peter J Crouch, Anthony R White

Journal article  |  2013  |  PLoS One

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Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

Katja M Kanninen, Alexandra Grubman, Aphrodite Caragounis, Clare Duncan, Sarah J Parker, Grace E Lidgerwood, Irene Volitakis, George Ganio, Peter J Crouch, Anthony R White

Journal article  |  2013  |  Biology Open

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Copper modulates the large dense core vesicle secretory pathway in PC12 cells

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  Metallomics: integrated biometal science

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Copper modulates the large dense core vesicle secretory pathway in PC12 cells (vol 5, pg 700, 2013)

Clare Duncan, Laura Bica, Peter J Crouch, Aphrodite Caragounis, Grace E Lidgerwood, Sarah J Parker, Jodi Meyerowitz, Irene Volitakis, Jeffrey R Liddell, Ravinarayan Raghupathi, Brett M Paterson, Michael D Duffield, Roberto Cappai, Paul S Donnelly, Alexandra Grubman, James Camakaris, Damien J Keating, Anthony R White

Journal article  |  2013  |  METALLOMICS

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Scholarly Works

Keyword Analysis

Expanding Knowledge
Clinical Health (organs, Diseases and Abnormal Conditions)
Biochemistry and Cell Biology
Ophthalmology and Optometry
Clinical Sciences
Medical Biotechnology
Other Health
Medical Biochemistry and Metabolomics
Neurosciences
Genetics

Credentials

Positions

Research Fellow

Anatomy And Neuroscience

Casual

Medical Education

Elected Professional Development And Junior Investigators Subcommittee Chair.

Australian Society for Stem Cell Research (ASSCR)

Centre For Personalised Therapeutics Technologies

Australian Research Council Centre for Personalised Therapeutics Technologies (ARC CPTT)

Member

Australian Society for Stem Cell Research (ASSCR)

Education

Doctor of Philosophy

University of Melbourne

Bachelor of Science (Honours)

University of Melbourne

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