Grace Lidgerwood

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

Journal article  |  2020  |  Genomics Proteomics & Bioinformatics

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline KR Walker, Grace E Lidgerwood, Kimberley L Dilworth, Leszek Lisowski, Alice Pebay, Alex W Hewitt

Journal article  |  2020  |  Nature Communications

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosi..

Optimization of silk fibroin membranes for retinal implantation

Shuko Suzuki, Audra MA Shadforth, Samuel McLenachan, Dan Zhang, Shang-Chih Chen, Jennifer Walshe, Grace E Lidgerwood, Alice Pebay, Traian Chirila, Fred K Chen, Damien G Harkin

Journal article  |  2019  |  Materials Science and Engineering C

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Grace E Lidgerwood, Alex W Hewitt, Alice Pebay

Journal article  |  2019  |  Current Opinion in Pharmacology

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retin..

An overview of human pluripotent stem cell applications for the understanding and treatment of blindness

Louise Rooney, Duncan Crombie, Grace Lidgerwood, Maciej Daniszewski, Alice Pebay

Book Chapter  |  2019

Human pluripotent stem cells (hPSCs) hold great promise for human therapies including for treatment of eye-related disease. Given ..

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Grace E Lidgerwood, Stuart M Pitson, Claudine Bonder, Alice Pebay

Journal article  |  2018  |  Progress in Lipid Research

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Maciej Daniszewski, Nguyen Quan, Hun S Chy, Vikrant Singh, Duncan E Crombie, Tejal Kulkarni, Helena H Liang, Priyadharshini Sivakumaran, Grace E Lidgerwood, Damien Hernandez, Alison Conquest, Louise A Rooney, Sophie Chevalier, Stacey B Andersen, Anne Senabouth, James C Vickers, David A Mackey, Jamie E Craig, Andrew L Laslett, Alex W Hewitt, et al.

Journal article  |  2018  |  ISCIENCE

Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors

Grace E Lidgerwood, Andrew J Morris, Alison Conquest, Maciej Daniszewski, Louise A Rooney, Shiang Y Lim, Damian Hernandez, Helena H Liang, Penelope Allen, Paul P Connell, Robyn H Guymer, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Duncan E Crombie, Maciej Daniszewski, Helena H Liang, Tejal Kulkarni, Fan Li, Grace E Lidgerwood, Alison Conquest, Damian Hernandez, Sandy S Hung, Katherine P Gill, Elisabeth De Smit, Lisa S Kearns, Linda Clarke, Valentin M Sluch, Xitiz Chamling, Donald J Zack, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  SLAS DISCOVERY Advancing the Science of Drug Discovery

Poster sessions WTH Wednesday/Thursday

Journal article  |  2017  |  Journal of Neurochemistry