Edmund Crampin

Ca2 Release via IP3 Receptors Shapes the Cardiac Ca2 Transient for Hypertrophic Signaling.

Hilary Hunt, Agnė Tilūnaitė, Greg Bass, Christian Soeller, H Llewelyn Roderick, Vijay Rajagopal, Edmund J Crampin

Journal article  |  2020  |  Biophysical Journal

Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocyte..

Ca2 release via IP3Rs increases RyR mediated Ca2 spark frequency in ventricular cardiomyocytes without altering spark amplitude and duration

Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Llewelyn Roderick, Edmund Crampin, Vijay Rajagopal

Journal article  |  2020

Abstract Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbe..

Predicting population extinction in lattice-based birth–death–movement models

Stuart T Johnston, Matthew J Simpson, Edmund J Crampin

Journal article  |  2020  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathema..

Insights From Computational Modeling Into the Contribution of Mechano-Calcium Feedback on the Cardiac End-Systolic Force-Length Relationship

Megan E Guidry, David P Nickerson, Edmund J Crampin, Martyn P Nash, Denis S Loiselle, Kenneth Tran

Journal article  |  2020  |  Frontiers in Physiology

Isolating the sources of heterogeneity in nano-engineered particle-cell interactions.

Stuart T Johnston, Matthew Faria, Edmund J Crampin

Journal article  |  2020  |  Journal of the Royal Society Interface

Nano-engineered particles have the potential to enhance therapeutic success and reduce toxicity-based treatment side effects via t..

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

Journal article  |  2020  |  Journal of Theoretical Biology

Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..

A few clarifications on MIRIBEL

Matthew Faria, Mattias Bjornmalm, Edmund J Crampin, Frank Caruso

Journal article  |  2020  |  NATURE NANOTECHNOLOGY

We are inspired by the responses1,2,3,4 to our recently proposed ‘reporting standards’ for bio–nano research (Minimum Information ..

Predicting population extinction in lattice-based birth-death-movement models

ST Johnston, MJ Simpson, EJ Crampin

Journal article  |  2020  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  Journal of Theoretical Biology

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release

David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal

Journal article  |  2019  |  Frontiers in Physiology

Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..