Edmund Crampin

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

Journal article  |  2020  |  Journal of Theoretical Biology

Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..

A few clarifications on MIRIBEL

Matthew Faria, Mattias Bjornmalm, Edmund J Crampin, Frank Caruso

Journal article  |  2020  |  Nature Nanotechnology

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  Journal of Theoretical Biology

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release

David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal

Journal article  |  2019  |  Frontiers in Physiology

Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..

Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.

Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin

Journal article  |  2019  |  Journal of Controlled Release

Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent

Journal article  |  2019  |  ACS Nano

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..

Corrected pair correlation functions for environments with obstacles

Stuart T Johnston, Edmund J Crampin

Journal article  |  2019  |  Physical Review E

Environments with immobile obstacles or void regions that inhibit and alter the motion of individuals within that environment are ..

Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration

Ivo Siekmann, Stefan Bjelosevic, Kerry Landman, Paul Monagle, Vera Ignjatovic, Edmund J Crampin

Journal article  |  2019  |  Scientific Reports

Data-Driven Modelling of the Inositol Trisphosphate Receptor ( $$\text {IP}_3\text {R}$$ ) and its Role in Calcium-Induced Calcium Release (CICR)

Ivo Siekmann, Pengxing Cao, James Sneyd, Edmund J Crampin

Book Chapter  |  2019

Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

Shouryadipta Ghosh, Kenneth Tran, Lea MD Delbridge, Anthony JR Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal

Journal article  |  2018  |  PLOS Computational Biology

Bond Graph Representation of Chemical Reaction Networks

Peter Gawthrop, Edmund J Crampin

Journal article  |  2018  |  IEEE Transactions on NanoBioscience

Minimum information reporting in bio-nano experimental literature

Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso

Journal article  |  2018  |  Nature Nanotechnology

Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT

Joseph Cursons, Katherine A Pillman, Kaitlin G Scheer, Philip A Gregory, Momeneh Foroutan, Soroor Hediyeh-Zadeh, John Toubia, Edmund J Crampin, Gregory J Goodall, Cameron P Bracken, Melissa J Davis

Journal article  |  2018  |  Cell Systems

An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

Stuart T Johnston, Matthew Faria, Edmund J Crampin

Journal article  |  2018  |  Journal of The Royal Society Interface

Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2018  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Vijay Rajagopal, Gregory Bass, Shouryadipta Ghosh, Hilary Hunt, Cameron Walkers, Eric Hanssen, Edmund Crampin, Christian Soeller

Journal article  |  2018  |  Journal of Visualized Experiments

DiSNE Movie Visualization and Assessment of Clonal Kinetics Reveal Multiple Trajectories of Dendritic Cell Development

Dawn S Lin, Andrey Kan, Jerry Gao, Edmund J Crampin, Philip D Hodgkin, Shalin H Naik

Journal article  |  2018  |  Cell Reports

Multi-Cellular Modelling of Cellular Mechanisms Gives Insights on the Maintenance of Epidermal Tissue Structure

Claire Miller, James Osborne, Edmund Crampin

Conference Proceedings  |  2018  |  Biophysical Journal

Biomolecular system energetics

PJ Gawthrop, EJ Crampin

Conference Proceedings  |  2018  |  Simulation Series

© 2018 Society for Modeling & Simulation International (SCS). Efficient energy transduction is one driver of evolution; and thus..

Experimental and modelling evidence of shortening heat in cardiac muscle

Kenneth Tran, June-Chiew Han, Edmund John Crampin, Andrew James Taberner, Denis Scott Loiselle

Journal article  |  2017  |  The Journal of Physiology

Bond graph modelling of chemoelectrical energy transduction

Peter J Gawthrop, Ivo Siekmann, Tatiana Kameneva, Susmita Saha, Michael R Ibbotson, Edmund J Crampin

Journal article  |  2017  |  IET Systems Biology

Energy-based analysis of biomolecular pathways

Peter J Gawthrop, Edmund J Crampin

Journal article  |  2017  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Charge Has a Marked Influence on Hyperbranched Polymer Nanoparticle Association in Whole Human Blood

Joshua J Glass, Liyu Chen, Sheilajen Alcantara, Edmund J Crampin, Kristofer J Thurecht, Robert De Rose, Stephen J Kent

Journal article  |  2017  |  ACS Macro Letters

Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs

Joseph Cursons, Katherine Pillman, Kaitlin Scheer, Philip Gregory, Momeneh Foroutan, Soroor Hediyeh Zadeh, John Toubia, Edmund Crampin, Gregory Goodall, Cameron Bracken, Melissa Davis

Journal article  |  2017

Abstract Epithelial-mesenchymal transition (EMT) is a process whereby cells undergo reversible phenotypic change, losing epithelia..

Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy

Jan Jarosz, Shouryadipta Ghosh, Lea MD Delbridge, Amorita Petzer, Anthony JR Hickey, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal

Journal article  |  2017  |  American Journal of Physiology-Cell Physiology

A Computational Study of the Role of Mitochondrial Organization on Cardiac Bioenergetics

Shouryadipta Ghosh, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal

Conference Proceedings  |  2017  |  2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

A Framework to Account for Sedimentation and Diffusion in Particle-Cell Interactions

Jiwei Cui, Matthew Faria, Mattias Bjornmalm, Yi Ju, Tomoya Suma, Sylvia T Gunawan, Joseph J Richardson, Hamed Heidar, Sara Bals, Edmund J Crampin, Frank Caruso

Journal article  |  2016  |  Langmuir

Systems analysis identifies miR-29b regulation of invasiveness in melanoma

Miles C Andrews, Joseph Cursons, Daniel G Hurley, Matthew Anaka, Jonathan S Cebon, Andreas Behren, Edmund J Crampin

Journal article  |  2016  |  Molecular Cancer

Distributed gene expression modelling for exploring variability in epigenetic function

David M Budden, Edmund J Crampin

Journal article  |  2016  |  BMC Bioinformatics

Modular bond-graph modelling and analysis of biomolecular systems

Peter J Gawthrop, Edmund J Crampin

Journal article  |  2016  |  IET Systems Biology

Information theoretic approaches for inference of biological networks from continuous-valued data

David M Budden, Edmund J Crampin

Journal article  |  2016  |  BMC Systems Biology

Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension

Kenneth Tran, June-Chiew Han, Andrew J Taberner, Carolyn J Barrett, Edmund J Crampin, Denis S Loiselle

Journal article  |  2016  |  American Journal of Physiology-Heart and Circulatory Physiology

Modelling modal gating of ion channels with hierarchical Markov models

Ivo Siekmann, Mark Fackrell, Edmund J Crampin, Peter Taylor

Journal article  |  2016  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Semantics-Based Composition of Integrated Cardiomyocyte Models Motivated by Real-World Use Cases

Maxwell L Neal, Brian E Carlson, Christopher T Thompson, Ryan C James, Karam G Kim, Kenneth Tran, Edmund J Crampin, Daniel L Cook, John H Gennari

Journal article  |  2015  |  PLOS ONE

Network analysis of an in vitro model of androgen-resistance in prostate cancer

Sujitra Detchokul, Aparna Elangovan, Edmund J Crampin, Melissa J Davis, Albert C Frauman

Journal article  |  2015  |  BMC Cancer

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2 Release Patterns in Cardiomyocytes

Vijay Rajagopal, Gregory Bass, Cameron G Walker, David J Crossman, Amorita Petzer, Anthony Hickey, Ivo Siekmann, Masahiko Hoshijima, Mark H Ellisman, Edmund J Crampin, Christian Soeller

Journal article  |  2015  |  PLOS Computational Biology

A spatial model of fluid recycling in the airways of the lung.

K Sharp, E Crampin, J Sneyd

Journal article  |  2015  |  Journal of Theoretical Biology

The genetic disease cystic fibrosis (CF) is a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and..

Regulation of cardiac cellular bioenergetics: mechanisms and consequences

K Tran, DS Loiselle, EJ Crampin

Journal article  |  2015  |  Physiological Reports

The regulation of cardiac cellular bioenergetics is critical for maintaining normal cell function, yet the nature of this regulati..

Modelling the conditional regulatory activity of methylated and bivalent promoters

David M Budden, Daniel G Hurley, Edmund J Crampin

Journal article  |  2015  |  Epigenetics & Chromatin

NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks

Daniel G Hurley, Joseph Cursons, Yi Kan Wang, David M Budden, Cristin G Print, Edmund J Crampin

Journal article  |  2015  |  Bioinformatics

Virtual Reference Environments: a simple way to make research reproducible

DG Hurley, DM Budden, EJ Crampin

Journal article  |  2015  |  Briefings in Bioinformatics

Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis

J CURSONS, CE Angel, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EC Crampin

Journal article  |  2015  |  GigaScience

Hierarchical bond graph modelling of biochemical networks

PG Gawthrop, J CURSONS, EJ Crampin

Journal article  |  2015  |  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Predictive modelling of gene expression from transcriptional regulatory elements

DM Budden, DG Hurley, EJ Crampin

Journal article  |  2015  |  Briefings in Bioinformatics

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Journal article  |  2015  |  Cell Communication and Signaling

Regulation of ERK-MAPK signaling in human epidermis

J Cursons, J Gao, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EJ Crampin

Journal article  |  2015  |  BMC Systems Biology

The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells diff..

Predicting expression: the complementary power of histone modification and transcription factor binding data

David M Budden, Daniel G Hurley, Joseph Cursons, John F Markham, Melissa J Davis, Edmund J Crampin

Journal article  |  2014  |  Epigenetics & Chromatin

Energy-based analysis of biochemical cycles using bond graphs

Peter J Gawthrop, Edmund J Crampin

Journal article  |  2014  |  Proceedings of the Royal Society A: Mathematical, Physical & Engineering Sciences

Multiscale modelling of saliva secretion

James Sneyd, Edmund Crampin, David Yule

Journal article  |  2014  |  Mathematical Biosciences

Statistical analysis of modal gating in ion channels

Ivo Siekmann, James Sneyd, Edmund J Crampin

Journal article  |  2014  |  Proceedings of the Royal Society A: Mathematical, Physical & Engineering Sciences

Reply to Response to 'What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?' Maclaren OJ, Sneyd J, Crampin EJ (2013) J Membr Biol 246:297-305

Oliver J Maclaren, James Sneyd, Edmund J Crampin

Journal article  |  2014  |  Journal of Membrane Biology

Effect of a High-Salt Diet on the Mechano-Energetics of Left Ventricular Trabeculae Isolated from Dahl Salt-Sensitive Rats

Kenneth Tran, June-Chiew Han, Carolyn J Barrett, Andrew J Taberner, Denis S Loiselle, Edmund J Crampin

Conference Proceedings  |  2014  |  Biophysical Journal

Integration of Steady-State and Temporal Gene Expression Data for the Inference of Gene Regulatory Networks

Yi Kan Wang, Daniel G Hurley, Santiago Schnell, Cristin G Print, Edmund J Crampin

Journal article  |  2013  |  PLoS One

What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?

Oliver J Maclaren, James Sneyd, Edmund J Crampin

Journal article  |  2013  |  Journal of Membrane Biology

Biclustering reveals breast cancer tumour subgroups with common clinical features and improves prediction of disease recurrence

Yi Kan Wang, Cristin G Print, Edmund J Crampin

Journal article  |  2013  |  BMC Genomics

Multilayer Perceptron Classification of Unknown Volatile Chemicals from the Firing Rates of Insect Olfactory Sensory Neurons and Its Application to Biosensor Design

Luqman R Bachtiar, Charles P Unsworth, Richard D Newcomb, Edmund J Crampin

Journal article  |  2013  |  Neural Computation

MCMC Can Detect Nonidentifiable Models

Ivo Siekmann, James Sneyd, Edmund J Crampin

Journal article  |  2012  |  Biophysical Journal

A quantitative analysis of electrolyte exchange in the salivary duct

Kate Patterson, Marcelo A Catalan, James E Melvin, David I Yule, Edmund J Crampin, James Sneyd

Journal article  |  2012  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Relating components of pressure-volume area in Suga's formulation of cardiac energetics to components of the stress-time integral

J-C Han, AJ Taberner, K Tran, DP Nickerson, MP Nash, PMF Nielsen, EJ Crampin, DS Loiselle

Journal article  |  2012  |  Journal of Applied Physiology

Comparison of the Gibbs and Suga formulations of cardiac energetics: the demise of "isoefficiency"

J-C Han, AJ Taberner, K Tran, S Goo, DP Nickerson, MP Nash, PMF Nielsen, EJ Crampin, DS Loiselle

Journal article  |  2012  |  Journal of Applied Physiology

Myocardial twitch duration and the dependence of oxygen consumption on pressure-volume area: experiments and modelling

J-C Han, K Tran, AJ Taberner, DP Nickerson, RS Kirton, PMF Nielsen, M-L Ward, MP Nash, EJ Crampin, DS Loiselle

Journal article  |  2012  |  Journal of Physiology

A Kinetic Model for Type I and II IP3R Accounting for Mode Changes

Ivo Siekmann, Larry E Wagner, David Yule, Edmund J Crampin, James Sneyd

Journal article  |  2012  |  Biophysical Journal

Modelling the effects of calcium waves and oscillations on saliva secretion

Laurence Palk, James Sneyd, Kate Patterson, Trevor J Shuttleworth, David I Yule, Oliver Maclaren, Edmund J Crampin

Journal article  |  2012  |  Journal of Theoretical Biology

Cell Cycle Gene Networks Are Associated with Melanoma Prognosis

Li Wang, Daniel G Hurley, Wendy Watkins, Hiromitsu Araki, Yoshinori Tamada, Anita Muthukaruppan, Louis Ranjard, Eliane Derkac, Seiya Imoto, Satoru Miyano, Edmund J Crampin, Cristin G Print

Journal article  |  2012  |  PLoS One

Gene network inference and visualization tools for biologists: application to new human transcriptome datasets

Daniel Hurley, Hiromitsu Araki, Yoshinori Tamada, Ben Dunmore, Deborah Sanders, Sally Humphreys, Muna Affara, Seiya Imoto, Kaori Yasuda, Yuki Tomiyasu, Kosuke Tashiro, Christopher Savoie, Vicky Cho, Stephen Smith, Satoru Kuhara, Satoru Miyano, D Stephen Charnock-Jones, Edmund J Crampin, Cristin G Print

Journal article  |  2012  |  Nucleic Acids Research

Bioenergetic Supply and Demand in the Cardiomyocyte

Kenneth Tran, Denis S Loiselle, Edmund J Crampin

Conference Proceedings  |  2012  |  Biophysical Journal

Human Epidermis as a Model System for the Investigation of Intracellular Signaling Pathways, In Situ

Joseph Cursons, Edmund J Crampin, Marc D Jacobs

Conference Proceedings  |  2012  |  Biophysical Journal

Reconciling Aquaporin Knockout Studies with Epithelial Permeability: Insights from Modelling the Salivary Gland

Oliver J Maclaren, James Sneyd, Edmund J Crampin

Conference Proceedings  |  2012  |  Biophysical Journal

Efficiency of Primary Saliva Secretion: An Analysis of Parameter Dependence in Dynamic Single-Cell and Acinus Models, with Application to Aquaporin Knockout Studies

Oliver J Maclaren, James Sneyd, Edmund J Crampin

Journal article  |  2012  |  Journal of Membrane Biology

A Graphical User Interface for a Method to Infer Kinetics and Network Architecture (MIKANA)

Marcio A Mourao, Jeyaraman Srividhya, Patrick E McSharry, Edmund J Crampin, Santiago Schnell

Journal article  |  2011  |  PLoS One

Comments on Point:Counterpoint: Muscle lactate and H production do/do not have a 1:1 association in skeletal muscle. Lactate and acidosis yet again?

EJ Crampin

Journal article  |  2011  |  Journal of Applied Physiology

LACTATE AND ACIDOSIS YET AGAIN?

Edmund J Crampin

Journal article  |  2011  |  JOURNAL OF APPLIED PHYSIOLOGY

MCMC Estimation of Markov Models for Ion Channels

Ivo Siekmann, Larry E Wagner, David Yule, Colin Fox, David Bryant, Edmund J Crampin, James Sneyd

Journal article  |  2011  |  Biophysical Journal

Minimum Information About a Simulation Experiment (MIASE)

Dagmar Waltemath, Richard Adams, Daniel A Beard, Frank T Bergmann, Upinder S Bhalla, Randall Britten, Vijayalakshmi Chelliah, Michael T Cooling, Jonathan Cooper, Edmund J Crampin, Alan Garny, Stefan Hoops, Michael Hucka, Peter Hunter, Edda Klipp, Camille Laibe, Andrew K Miller, Ion Moraru, David Nickerson, Poul Nielsen, et al.

Journal article  |  2011  |  PLoS Computational Biology

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

Martin Fink, Steven A Niederer, Elizabeth M Cherry, Flavio H Fenton, Jussi T Koivumaki, Gunnar Seemann, Ruediger Thul, Henggui Zhang, Frank B Sachse, Dan Beard, Edmund J Crampin, Nicolas P Smith

Journal article  |  2011  |  Progress in Biophysics & Molecular Biology

Using Artificial Neural Networks to Classify Unknown Volatile Chemicals from the Firings of Insect Olfactory Sensory Neurons

Luqman R Bachtiar, Charles P Unsworth, Richard D Newcomb, Edmund J Crampin

Conference Proceedings  |  2011  |  The proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Gene Network Analysis and Application

Hiromitsu ARAKI, Daniel HURLEY, Edmund CRAMPIN, Cristin PRINT, Satoru KUHARA

Journal article  |  2011  |  Seibutsu Butsuri

Predicting Odorant Chemical Class from Odorant Descriptor Values With an Assembly of Multi-Layer Perceptrons

Luqman R Bachtiar, Charles P Unsworth, Richard D Newcomb, Edmund J Crampin

Conference Proceedings  |  2011  |  Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

The Role of Airway Epithelium in Replenishment of Evaporated Airway Surface Liquid From the Human Conducting Airways

NJ Warren, EJ Crampin, MH Tawhai

Journal article  |  2010  |  Annals of Biomedical Engineering

Physiome Mark-Up Languages for Systems Biology: Model Modularization and Re-Use

MT Cooling, EJ Crampin, PJ Hunter

Book Chapter  |  2010

A Bayesian Search for Transcriptional Motifs

Andrew K Miller, Cristin G Print, Poul MF Nielsen, Edmund J Crampin

Journal article  |  2010  |  PLoS One

A dynamic model of saliva secretion

Laurence Palk, James Sneyd, Trevor J Shuttleworth, David I Yule, Edmund J Crampin

Journal article  |  2010  |  Journal of Theoretical Biology

The effect of intracellular calcium oscillations on fluid secretion in airway epithelium

NJ Warren, MH Tawhai, EJ Crampin

Journal article  |  2010  |  Journal of Theoretical Biology

Systems Biology: An Approach

P Kohl, EJ Crampin, TA Quinn, D Noble

Journal article  |  2010  |  Clinical Pharmacology and Therapeutics

Why has reversal of the actin-myosin cross-bridge cycle not been observed experimentally?

Denis S Loiselle, Kenneth Tran, Edmund J Crampin, Nancy A Curtin

Journal article  |  2010  |  Journal of Applied Physiology

THE ROLE OF OESTROGEN SIGNALLING IN BREAST CANCER

A Muthukaruppan, BA Michael, LD Miller, Y Tamada, TM Allen, KJ Woad, Y Wang, EJ Crampin, AN Shelling, CG Print

Conference Proceedings  |  2010  |  ANNALS OF ONCOLOGY

Enzyme catalyzed reactions: From experiment to computational mechanism reconstruction

Jeyaraman Srividhya, Marcio A Mourao, Edmund J Crampin, Santiago Schnell

Journal article  |  2010  |  Computational Biology and Chemistry

A Metabolite-Sensitive, Thermodynamically Constrained Model of Cardiac Cross-Bridge Cycling: Implications for Force Development during Ischemia

Kenneth Tran, Nicolas P Smith, Denis S Loiselle, Edmund J Crampin

Journal article  |  2010  |  Biophysical Journal

Mathematical modelling of calcium wave propagation in mammalian airway epithelium: evidence for regenerative ATP release

NJ Warren, MH Tawhai, EJ Crampin

Journal article  |  2010  |  Experimental Physiology

A Global Sensitivity Tool for Cardiac Cell Modeling: Application to Ionic Current Balance and Hypertrophic Signaling

Anna A Sher, Michael T Cooling, Blair Bethwaite, Jefferson Tan, Tom Peachey, Colin Enticott, Slavisa Garic, David J Gavaghan, Denis Noble, David Abramson, Edmund J Crampin

Conference Proceedings  |  2010  |  Proceedings of the 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Inference of an in situ Epidermal Intracellular Signaling Cascade

Joseph Cursons, Daniel Hurley, Catherine E Angel, Rod Dunbar, Edmund J Crampin, Marc D Jacobs

Conference Proceedings  |  2010  |  Conference Proceedings of the IEEE Engineering in Medicine and Biology Society

A method for visualizing CellML models

SM Wimalaratne, MDB Halstead, CM Lloyd, MT Cooling, EJ Crampin, PF Nielsen

Journal article  |  2009  |  Bioinformatics

Biophysical annotation and representation of CellML models

SM Wimalaratne, MDB Halstead, CM Lloyd, EJ Crampin, PF Nielsen

Journal article  |  2009  |  Bioinformatics

A mathematical model of calcium-induced fluid secretion in airway epithelium

NJ Warren, MH Tawhai, EJ Crampin

Journal article  |  2009  |  Journal of Theoretical Biology

Facilitating modularity and reuse: guidelines for structuring CellML 1.1 models by isolating common biophysical concepts

SM Wimalaratne, MDB Halstead, CM Lloyd, MT Cooling, EJ Crampin, PF Nielsen

Journal article  |  2009  |  Experimental Physiology

Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes

Michael T Cooling, Peter Hunter, Edmund J Crampin

Journal article  |  2009  |  Biophysical Journal

A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca2 (SERCA) Pump

Kenneth Tran, Nicolas P Smith, Denis S Loiselle, Edmund J Crampin

Journal article  |  2009  |  Biophysical Journal

Energetic consequences of mechanical loads (vol 97, pg 348, 2008)

DS Loiselle, EJ Crampin, SA Niederer, NP Smith, CJ Barclay

Journal article  |  2009  |  Progress in Biophysics and Molecular Biology

Bioinformatics, multiscale modeling and the IUPS physiome project

Peter J Hunter, Edmund J Crampin, Poul MF Nielsen

Journal article  |  2008  |  Briefings in Bioinformatics

Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction

Jonna R Terkildsen, Steven Niederer, Edmund J Crampin, Peter Hunter, Nicolas P Smith

Journal article  |  2008  |  Experimental Physiology

Energetic consequences of mechanical loads

DS Loiselle, EJ Crampin, SA Niederer, NP Smith, CJ Barclay

Journal article  |  2008  |  Progress in Biophysics & Molecular Biology

Modelling biological modularity with CellML

MT Cooling, P Hunter, EJ Crampin

Journal article  |  2008  |  IET Systems Biology

Modeling hypertrophic IP3 transients in the cardiac myocyte

Michael Cooling, Peter Hunter, Edmund J Crampin

Journal article  |  2007  |  Biophysical Journal

The balance between inactivation and activation of the Na -K pump underlies the triphasic accumulation of extracellular K during myocardial ischemia

Jonna R Terkildsen, Edmund J Crampin, Nicolas P Smith

Journal article  |  2007  |  American Journal of Physiology - Heart and Circulatory Physiology

A mathematical model of fluid secretion from a parotid acinar cell

Elan Gin, Edmund J Crampin, David A Brown, Trevor J Shuttleworth, David I Yule, James Sneyd

Journal article  |  2007  |  Journal of Theoretical Biology

Computational biology of cardiac myocytes: proposed standards for the physiome

Nicolas P Smith, Edmund J Crampin, Steven A Niederer, James B Bassingthwaighte, Daniel A Beard

Journal article  |  2007  |  Journal of Experimental Biology

Reconstructing biochemical pathways from time course data

Jeyaraman Srividhya, Edmund J Crampin, Patrick E McSharry, Santiago Schnell

Journal article  |  2007  |  Proteomics

Mode transitions in a model reaction-diffusion system driven by domain growth and noise

Iain Barrass, Edmund J Crampin, Philip K Maini

Journal article  |  2006  |  Bulletin of Mathematical Biology

Reconstructing gene regulatory networks: from random to scale-free connectivity

J Wildenhain, EJ Crampin

Journal article  |  2006  |  IEE Proceedings of Systems Biology

Acidosis in models of cardiac ventricular myocytes

EJ Crampin, NP Smith, AE Langham, RH Clayton, CH Orchard

Journal article  |  2006  |  Philosophical Transactions of the Royal Society of London Series A - Mathematical, Physical and Engineering Sciences

A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes

EJ Crampin, NP Smith

Journal article  |  2006  |  Biophysical Journal

Integrative models of pH regulation and intracellular Ca2 handling during cardiac acidosis

NP Smith, EJ Crampin

Conference Proceedings  |  2006  |  FASEB JOURNAL

Minimum information requested in the annotation of biochemical models (MIRIAM)

N Le Novere, A Finney, M Hucka, US Bhalla, F Campagne, J Collado-Vides, EJ Crampin, M Halstead, E Klipp, P Mendes, P Nielsen, H Sauro, B Shapiro, JL Snoep, HD Spence, BL Wanner

Journal article  |  2005  |  Nature Biotechnology

Integrative models of pH regulation and intracellular Ca2 handling during acidosis in cardiac myocytes

E Crampin, N Smith

Conference Proceedings  |  2005  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modelling the kinetics of Ca2 and Mg2 binding to cardiac troponin

SA Niederer, E Crampin, NP Smith

Conference Proceedings  |  2005  |  FASEB JOURNAL

A model of pH regulation and acidosis in the myocyte

EJ Crampin, NP Smith

Conference Proceedings  |  2005  |  FASEB JOURNAL

Multi-scale modelling and the IUPS physiome project

EJ Crampin, NP Smith, PJ Hunter

Journal article  |  2004  |  Journal of Molecular Histology

Mathematical and computational techniques to deduce complex biochemical reaction mechanisms

EJ Crampin, S Schnell, PE McSharry

Journal article  |  2004  |  Progress in Biophysics & Molecular Biology

New approaches to modelling and analysis of biochemical reactions, pathways and networks

EJ Crampin, S Schnell

Journal article  |  2004  |  Progress in Biophysics & Molecular Biology

Modelling cellular and tissue function

NP Smith, EJ Crampin

Journal article  |  2004  |  Progress in Biophysics and Molecular Biology

Development of models of active ion transport for whole-cell modelling: cardiac sodium-potassium pump as a case study

NP Smith, EJ Crampin

Journal article  |  2004  |  Progress in Biophysics & Molecular Biology

Computational physiology and the physiome project

EJ Crampin, M Halstead, P Hunter, P Nielsen, D Noble, N Smith, M Tawhai

Journal article  |  2004  |  Experimental Physiology

Extracting biochemical reaction kinetics from time series data

EJ Crampin, PE McSharry, S Schnell

Journal article  |  2004  |  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Multiscale computational modelling of the heart

NP Smith, DP Nickerson, EJ Crampin, PJ Hunter

Journal article  |  2004  |  Acta Numerica

Pattern formation in reaction-diffusion models with nonuniform domain growth

EJ Crampin, WW Hackborn, PK Maini

Journal article  |  2002  |  Bulletin of Mathematical Biology

Mode-doubling and tripling in reaction-diffusion patterns on growing domains: A piecewise linear model

EJ Crampin, EA Gaffney, PK Maini

Journal article  |  2002  |  Journal of Mathematical Biology

The heart cell in silico: successes, failures and prospects.

Denis Noble

Conference Proceedings  |  2002  |  Novartis Foundation Symposium

The development of computer models of heart cells is used to illustrate the interaction between simulation and experimental work. ..

Reaction-diffusion models for biological pattern formation

EJ Crampin, PK Maini

Journal article  |  2001  |  Methods and Applications of Analysis

Reaction-diffusion patterns on growing domains

EJ Crampin

Book  |  2000

Reaction and diffusion on growing domains: scenarios for robust pattern formation.

EJ Crampin, EA Gaffney, PK Maini

Journal article  |  1999  |  Bulletin of mathematical biology

We investigate the sequence of patterns generated by a reaction-diffusion system on a growing domain. We derive a general evolutio..

Incorporation of silver in DyBa2Cu3O7-δ ceramics. Correlation between superconducting properties and microstructure

C Nguyen-van-Huong, E Crampin, JY Laval, A Dubon

Journal article  |  1997  |  Superconductor Science and Technology

Longitudinal single cell fate of hematopoiesis in vivo using cellular barcoding and DiSNE movie visualization

Jerry Gao, Dawn S Lin, Edmund Crampin, Shalin H Naik

Journal article

AbstractIdentifying the progeny of many single progenitor cells simultaneously can be achieved by tagging progenitors with unique ..

Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development

Dawn Lin, Andrey Kan, Jerry Gao, Edmund Crampin, Philip D Hodgkin, Shalin H Naik

Journal article

SUMMARYA thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individ..