Professor Edmund Crampin is Rowden White Chair of Systems Biology at the University of Melbourne. Edmund directs the Systems Biology Lab at the School of Mathematics and Statistics and the Department of Biomedical Engineering, and is Adjunct Professor in the Faculty of Medicine, Dentistry and Health Sciences (School of Medicine).
The Systems Biology Lab is a highly collaborative group using mathematical and computer modelling to investigate cellular regulatory processes and biophysical mechanisms underlying complex human diseases, major challenges in biotechnology, and synthetic biology. The group is pioneering energy-based modelling approaches to describe and analyse cellular processes. Current projects include modelling heart cells to understand the development of heart disease; interactions between cells and nanoparticles; and studying the network of genetic interactions underlying breast and skin cancer. Edmund graduated with a BSc (Hons) in Physics from Imperial College London, and a DPhil in Applied Mathematics at the University of Oxford where his thesis topic was on biological pattern formation, advised by Professor Philip Maini FRS. Edmund was elected to a Junior Research Fellowship at Brasenose College Oxford and awarded a Wellcome Trust Research Fellowship to study mathematical models of heart disease, with Professor Denis Noble FRS. In 2003 Edmund moved from Oxford to New Zealand to establish the Systems Biology group at the Auckland Bioengineering Institute, in collaboration with Institute director Professor Peter Hunter FRS. Edmund moved to the University of Melbourne in 2013 to take up the Chair of Systems Biology.
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Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and M..
Displaying the 12 most recent projects by Edmund Crampin.
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Displaying the 134 most recent scholarly works by Edmund Crampin.
Predicting population extinction in lattice-based birth–death–movement models
Stuart T Johnston, Matthew J Simpson, Edmund J Crampin
Journal article | 2020 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathema..
Isolating the sources of heterogeneity in nano-engineered particle-cell interactions.
Stuart T Johnston, Matthew Faria, Edmund J Crampin
Journal article | 2020 | Journal of The Royal Society Interface
Nano-engineered particles have the potential to enhance therapeutic success and reduce toxicity-based treatment side effects via t..
Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain
Peter J Gawthrop, Peter Cudmore, Edmund J Crampin
Journal article | 2020 | Journal of Theoretical Biology
Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..
A thermodynamic framework for modelling membrane transporters
Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin
Journal article | 2019 | Journal of Theoretical Biology
Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..
Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release
David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal
Journal article | 2019 | Frontiers in Physiology
Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..
Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.
Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin
Journal article | 2019 | Journal of Controlled Release
Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..
Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles
Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent
Journal article | 2019 | ACS Nano
Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..
Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture
Shouryadipta Ghosh, Kenneth Tran, Lea MD Delbridge, Anthony JR Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal
Journal article | 2018 | PLOS COMPUTATIONAL BIOLOGY
Minimum information reporting in bio-nano experimental literature
Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso
Journal article | 2018 | NATURE NANOTECHNOLOGY
Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT
Joseph Cursons, Katherine A Pillman, Kaitlin G Scheer, Philip A Gregory, Momeneh Foroutan, Soroor Hediyeh-Zadeh, John Toubia, Edmund J Crampin, Gregory J Goodall, Cameron P Bracken, Melissa J Davis
Journal article | 2018 | Cell Systems
Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
Vijay Rajagopal, Gregory Bass, Shouryadipta Ghosh, Hilary Hunt, Cameron Walkers, Eric Hanssen, Edmund Crampin, Christian Soeller
Journal article | 2018 | Journal of Visualized Experiments
Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs
Joseph Cursons, Katherine Pillman, Kaitlin Scheer, Philip Gregory, Momeneh Foroutan, Soroor Hediyeh Zadeh, John Toubia, Edmund Crampin, Gregory Goodall, Cameron Bracken, Melissa Davis
Journal article | 2017
Abstract Epithelial-mesenchymal transition (EMT) is a process whereby cells undergo reversible phenotypic change, losing epithelia..
Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy
Jan Jarosz, Shouryadipta Ghosh, Lea MD Delbridge, Amorita Petzer, Anthony JR Hickey, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal
Journal article | 2017 | American Journal of Physiology-Cell Physiology
Myocardial energetics is not compromised during compensated hypertrophy in the Dahl salt-sensitive rat model of hypertension
Kenneth Tran, June-Chiew Han, Andrew J Taberner, Carolyn J Barrett, Edmund J Crampin, Denis S Loiselle
Journal article | 2016 | American Journal of Physiology-Heart and Circulatory Physiology
Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2 Release Patterns in Cardiomyocytes
Vijay Rajagopal, Gregory Bass, Cameron G Walker, David J Crossman, Amorita Petzer, Anthony Hickey, Ivo Siekmann, Masahiko Hoshijima, Mark H Ellisman, Edmund J Crampin, Christian Soeller
Journal article | 2015 | PLOS COMPUTATIONAL BIOLOGY
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson
Journal article | 2015 | Cell Communication and Signaling
Regulation of ERK-MAPK signaling in human epidermis
J Cursons, J Gao, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EJ Crampin
Journal article | 2015 | BMC Systems Biology
The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells diff..
Gene network inference and visualization tools for biologists: application to new human transcriptome datasets
Daniel Hurley, Hiromitsu Araki, Yoshinori Tamada, Ben Dunmore, Deborah Sanders, Sally Humphreys, Muna Affara, Seiya Imoto, Kaori Yasuda, Yuki Tomiyasu, Kosuke Tashiro, Christopher Savoie, Vicky Cho, Stephen Smith, Satoru Kuhara, Satoru Miyano, D Stephen Charnock-Jones, Edmund J Crampin, Cristin G Print
Journal article | 2012 | Nucleic Acids Research
Minimum Information About a Simulation Experiment (MIASE)
Dagmar Waltemath, Richard Adams, Daniel A Beard, Frank T Bergmann, Upinder S Bhalla, Randall Britten, Vijayalakshmi Chelliah, Michael T Cooling, Jonathan Cooper, Edmund J Crampin, Alan Garny, Stefan Hoops, Michael Hucka, Peter Hunter, Edda Klipp, Camille Laibe, Andrew K Miller, Ion Moraru, David Nickerson, Poul Nielsen, et al.
Journal article | 2011 | PLoS Computational Biology
Cardiac cell modelling: Observations from the heart of the cardiac physiome project
Martin Fink, Steven A Niederer, Elizabeth M Cherry, Flavio H Fenton, Jussi T Koivumaki, Gunnar Seemann, Ruediger Thul, Henggui Zhang, Frank B Sachse, Dan Beard, Edmund J Crampin, Nicolas P Smith
Journal article | 2011 | Progress in Biophysics & Molecular Biology
Using Artificial Neural Networks to Classify Unknown Volatile Chemicals from the Firings of Insect Olfactory Sensory Neurons
Luqman R Bachtiar, Charles P Unsworth, Richard D Newcomb, Edmund J Crampin
Conference Proceedings | 2011 | The proceedings of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Predicting Odorant Chemical Class from Odorant Descriptor Values With an Assembly of Multi-Layer Perceptrons
Luqman R Bachtiar, Charles P Unsworth, Richard D Newcomb, Edmund J Crampin
Conference Proceedings | 2011 | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
A Global Sensitivity Tool for Cardiac Cell Modeling: Application to Ionic Current Balance and Hypertrophic Signaling
Anna A Sher, Michael T Cooling, Blair Bethwaite, Jefferson Tan, Tom Peachey, Colin Enticott, Slavisa Garic, David J Gavaghan, Denis Noble, David Abramson, Edmund J Crampin
Conference Proceedings | 2010 | Proceedings of the 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Minimum information requested in the annotation of biochemical models (MIRIAM)
N Le Novere, A Finney, M Hucka, US Bhalla, F Campagne, J Collado-Vides, EJ Crampin, M Halstead, E Klipp, P Mendes, P Nielsen, H Sauro, B Shapiro, JL Snoep, HD Spence, BL Wanner
Journal article | 2005 | Nature Biotechnology
Reaction and diffusion on growing domains: scenarios for robust pattern formation.
EJ Crampin, EA Gaffney, PK Maini
Journal article | 1999 | Bulletin of mathematical biology
We investigate the sequence of patterns generated by a reaction-diffusion system on a growing domain. We derive a general evolutio..
Longitudinal single cell fate of hematopoiesis in vivo using cellular barcoding and DiSNE movie visualization
Jerry Gao, Dawn S Lin, Edmund Crampin, Shalin H Naik
AbstractIdentifying the progeny of many single progenitor cells simultaneously can be achieved by tagging progenitors with unique ..
Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development
Dawn Lin, Andrey Kan, Jerry Gao, Edmund Crampin, Philip D Hodgkin, Shalin H Naik
SUMMARYA thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individ..
Honours, Awards and Fellowships
Oxygen Group of 10 New Science Leaders
Early Career Research Excellence Award
Faculty Teaching Award
Junior Research Fellowship
Granville Prize for Physics (top physics degree in the University of London)
Logica Prize in Computational Physics
Governors' Prize in Physics (top physics degree at Imperial College)
British Association Exhibition Scholarship
Imperial College Scholarship
Rowden White Chair Of Systems Biology
Mathematics And Statistics
Melbourne Medical School
Rowden White Chair,Systems & Computational Biology
DOCTOR OF PHILOSOPHY (MATHEMATICAL SCIENCES) - UNIVERSITY OF OXFORD
University of Oxford
BACHELOR OF SCIENCE (HONS) - PHYSICS - IMPERIAL COLLEGE LONDON
Imperial College London