Christopher Love

APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells

Maree C Faux, Lauren E King, Serena R Kane, Christopher Love, Oliver M Sieber, Antony W Burgess

Journal article  |  2021  |  MOLECULAR BIOLOGY OF THE CELL

The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of Wnt signaling; however, APC als..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  CANCER DISCOVERY

ADP-ribosylation is an important posttranslational protein modification that regulates diverse biological processes, controlled by..

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  GASTROENTEROLOGY

BACKGROUND AND AIMS: Proteomics holds promise for individualizing cancer treatment. We analyzed to what extent the proteomic lands..

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Ashleigh R Poh, Christopher G Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L Putoczki, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2017  |  CANCER CELL

Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-i..

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

David Barras, Edoardo Missiaglia, Pratyaksha Wirapati, Oliver M Sieber, Robert N Jorissen, Chris Love, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Peter Gibbs, Justin Guinney, Iris M Simon, Arnaud D Roth, Fred T Bosman, Sabine Tejpar, Mauro Delorenzi

Journal article  |  2017  |  CLINICAL CANCER RESEARCH

PURPOSE: Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a group with particularly p..

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Lauren E King, Christopher G Love, Oliver M Sieber, Maree C Faux, Antony W Burgess

Journal article  |  2016  |  GENOMICS DATA

The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (20..

Experimental approaches to studying the nature and impact of splicing variation in zebrafish

MC Keightley, S Markmiller, CG Love, JEJ Rasko, GJ Lieschke, JK Heath

Journal article  |  2016  |  ZEBRAFISH: GENETICS, GENOMICS, AND TRANSCRIPTOMICS, 4TH EDITION

From a fixed number of genes carried in all cells, organisms create considerable diversity in cellular phenotype through different..

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.

Journal article  |  2015  |  BRITISH JOURNAL OF CANCER

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. MET..

Genomic approach to translational studies in colorectal cancer

Dane Cheasley, Robert N Jorissen, Sheng Liu, Chin Wee Tan, Christopher Love, Michelle Palmieri, Oliver M Sieber

Journal article  |  2015  |  TRANSLATIONAL CANCER RESEARCH

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The pathogenesis of CRC is complex with molecula..