Dimitra Zotos

The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21

Dimitra Zotos, Isaak Quast, Connie SN Li-Wai-Suen, Craig I McKenzie, Marcus J Robinson, Andrey Kan, Gordon K Smyth, Philip D Hodgkin, David M Tarlinton

Journal article  |  2021  |  NATURE COMMUNICATIONS

Humoral immune responses require germinal centres (GC) for antibody affinity maturation. Within GC, B cell proliferation and mutat..

Defining the Role of B Cells in Graft Rejection Following Lung Transplantation

D Zotos, L Goldring, R Farighi, L Sullivan, Y Cristiano, G Snell, D Tarlinton, G Westall

Conference Proceedings  |  2020  |  JOURNAL OF HEART AND LUNG TRANSPLANTATION

PURPOSE: Humoral immunity is maintained by long lived memory B and plasma cells, both of which arise from the activation and diffe..

The Amount of BCL6 in B Cells Shortly after Antigen Engagement Determines Their Representation in Subsequent Germinal Centers

Marcus James Robinson, Zhoujie Ding, Catherine Pitt, Erica Janet Brodie, Isaak Quast, David Mathew Tarlinton, Dimitra Zotos

Journal article  |  2020  |  CELL REPORTS

It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B cells influence the unfolding differentiati..

Atypical chemokine receptor 4 shapes activated B cell fate

Ervin E Kara, Cameron R Bastow, Duncan R McKenzie, Carly E Gregor, Kevin A Fenix, Rachelle Babb, Todd S Norton, Dimitra Zotos, Lauren B Rodda, Jana R Hermes, Katherine Bourne, Derek S Gilchrist, Robert J Nibbs, Mohammed Alsharifi, Carola G Vinuesa, David M Tarlinton, Robert Brink, Geoffrey R Hill, Jason G Cyster, Iain Comerford, et al.

Journal article  |  2018  |  JOURNAL OF EXPERIMENTAL MEDICINE

Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC..

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection

Selma Tuzlak, Robyn L Schenk, Ajithkumar Vasanthakumar, Simon P Preston, Manuel D Haschka, Dimitra Zotos, Axel Kallies, Andreas Strasser, Andreas Villunger, Marco J Herold

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

The physiological role of the pro-survival BCL-2 family member A1 has been debated for a long time. Strong mRNA induction in T cel..

CXCR5( ) follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types..

Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development

Renee Gloury, Dimitra Zotos, Malou Zuidscherwoude, Frederick Masson, Yang Liao, Jhaguaral Hasbold, Lynn M Corcoran, Phil D Hodgkin, Gabrielle T Belz, Wei Shi, Stephen L Nutt, David M Tarlinton, Axel Kallies

Journal article  |  2016  |  JOURNAL OF EXPERIMENTAL MEDICINE

The generation of high-affinity antibodies requires germinal center (GC) development and differentiation of long-lived plasma cell..

Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall

Yu Kato, Ali Zaid, Gayle M Davey, Scott N Mueller, Stephen L Nutt, Dimitra Zotos, David M Tarlinton, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  JOURNAL OF IMMUNOLOGY

Targeting Ags to dendritic cell (DC) surface receptors can induce a variety of responses depending on the DC type targeted, the re..

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies

Journal article  |  2014  |  NATURE MEDICINE

Loss of function of the tumor suppressor gene PRDM1 (also known as BLIMP1) or deregulated expression of the oncogene BCL6 occurs i..

Determining germinal centre B cell fate

Dimitra Zotos, David M Tarlinton

Journal article  |  2012  |  TRENDS IN IMMUNOLOGY

The humoral immune system generates immunological memory comprising affinity matured, long-lived memory B cells and plasma cells (..