Vivek Rathi

ALK-Rearranged Non-SmallCell Lung Cancer in 2020:Real-WorldTriumphs in an Era of MultigenerationALK-InhibitorSequencing Informed by Drug Resistance Profiling

Malinda Itchins, Brandon Lau, Amanda L Hudson, Helen Westman, Cathy Yi Xia, Sarah A Hayes, Viive M Howell, Michael Rodriguez, Wendy A Cooper, Heng Wei, Michael Buckland, Bob T Li, Mark Li, Vivek Rathi, Stephen B Fox, Anthony J Gill, Stephen J Clarke, Michael J Boyer, Nick Pavlakis

Journal article  |  2020  |  ONCOLOGIST

Since its discovery in 2007, we have seen the lives of patients diagnosed with advanced anaplastic lymphoma kinase (ALK)-rearrange..

Slim electrodes for improved targeting in deep brain stimulation

Joel Villalobos, Hugh J McDermott, Peter McNeill, Aharon Golod, Vivek Rathi, Sebastien H Bauquier, James B Fallon

Journal article  |  2020  |  JOURNAL OF NEURAL ENGINEERING

OBJECTIVE: The efficacy of deep brain stimulation can be limited by factors including poor selectivity of stimulation, targeting e..

Molecular profile of long-term survivors of glioblastoma: A scoping review of the literature

L Gately, SA McLachlan, J Philip, V Rathi, A Dowling

Journal article  |  2019  |  JOURNAL OF CLINICAL NEUROSCIENCE

Molecular aberrations of malignancy are becoming widely recognized as important predictive and prognostic markers for treatment re..

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A Best, Sheryl Ding, Ariena Kersbergen, Xueyi Dong, Ji-Ying Song, Yi Xie, Boris Reljic, Kaiming Li, James E Vince, Vivek Rathi, Gavin M Wright, Matthew E Ritchie, Kate D Sutherland

Journal article  |  2019  |  NATURE COMMUNICATIONS

The KRAS oncoprotein, a critical driver in 33% of lung adenocarcinoma (LUAD), has remained an elusive clinical target due to its p..

FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium

Sarah A Best, Cassandra R Harapas, Ariena Kersbergen, Vivek Rathi, Marie-Liesse Asselin-Labat, Kate D Sutherland

Journal article  |  2018  |  ONCOGENE

Structural rearrangements of the genome can drive lung tumorigenesis through the generation of fusion genes with oncogenic propert..

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  CELL METABOLISM

The lung presents a highly oxidative environment, which is tolerated through engagement of tightly controlled stress response path..

Correlation between molecular analysis, diagnosis according to the 2015 WHO classification of unresected lung tumours and TTF1 expression in small biopsies and cytology specimens from 344 non-small cell lung carcinoma patients

Prudence A Russell, Toni-Maree Rogers, Benjamin Solomon, Naveed Alam, Stephen A Barnett, Vivek Rathi, Richard A Williams, Gavin M Wright, Matthew Conron

Journal article  |  2017  |  PATHOLOGY

We investigated correlations between diagnosis according to the 2015 World Health Organization (WHO) classification of unresected ..

Clinical validation of the 50 gene AmpliSeq Cancer Panel V2 for use on a next generation sequencing platform using formalin fixed, paraffin embedded and fine needle aspiration tumour specimens

Vivek Rathi, Gavin Wright, Diana Constantin, Siok Chang, Huong Pham, Kerryn Jones, Atha Palios, Sue-Anne Mclachlan, Matthew Conron, Penny Mckelvie, Richard Williams

Journal article  |  2017  |  PATHOLOGY

The advent of massively parallel sequencing has caused a paradigm shift in the ways cancer is treated, as personalised therapy bec..

National Working Group Meeting on ALK diagnostics in lung cancer

Wendy Cooper, Stephen Fox, Sandra O'Toole, Adrienne Morey, Glenn Frances, Nick Pavlakis, Kenneth O'Byrne, Andrew Dettrick, Trishe Leong, Vivek Rathi, Dominic Spagnolo, Chris Hemmings, Mahendra Singh, David Moffat, Ming-Sound Tsao, Keith Wilner, Richard Buller, Susan Pitman Lowenthal, Shams Arifeen, Justin Binko, et al.

Journal article  |  2014  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

The global landscape of molecular testing is rapidly changing, with the recent publication of the International Association for th..

Mapping of actionable mutations to histologic subtype domains in lung adenocarcinoma: implications for precision medicine

GM Wright, Hongdo Do, Jonathan Weiss, Naveed Z Alam, Vivek Rathi, Marzena Walkiewicz, Thomas John, Prudence A Russell, Alexander Dobrovic

Journal article  |  2014  |  Oncotarget

Precision medicine depends on the accurate identification of actionable mutations in a tumor sample. It is unknown how heterogeneo..