Michael Clarkson

MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Patrick McCoy, Stefano Mangiola, Geoff Macintyre, Ryan Hutchinson, Ben Tran, Bernard Pope, Peter Georgeson, Matthew KH Hong, Natalie Kurganovs, Sebastian Lunke, Michael J Clarkson, Marek Cmero, Michael Kerger, Ryan Stuchbery, Ken Chow, Izhak Haviv, Andrew Ryan, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Recent publications have shown patients with defects in the DNA mismatch repair (MMR) pathway driven by either MSH2 or..

Detection of ctDNA in plasma of patients with clinically localised prostate cancer is associated with rapid disease progression

Edmund Lau, Patrick McCoy, Fairleigh Reeves, Ken Chow, Michael Clarkson, Edmond M Kwan, Kate Packwood, Helen Northen, Miao He, Zoya Kingsbury, Stefano Mangiola, Michael Kerger, Marc A Furrer, Helen Crowe, Anthony J Costello, David J McBride, Mark T Ross, Bernard Pope, Christopher M Hovens, Niall M Corcoran

Journal article  |  2020  |  GENOME MEDICINE

BACKGROUND: DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be ..

Preparation of fluorescent in situ hybridisation probes without the need for optimisation of fragmentation

Patrick J McCoy, Anthony J Costello, Niall M Corcoran, Christopher M Hovens, Michael J Clarkson

Journal article  |  2019  |  METHODSX

DNA-fluorescence in situ hybridisation (DNA-FISH) allows visualisation of chromosome organisation and rearrangement. FISH probes a..

Periprostatic fat tissue transcriptome reveals a signature diagnostic for high-risk prostate cancer

Stefano Mangiola, Ryan Stuchbery, Geoff Macintyre, Michael J Clarkson, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran

Journal article  |  2018  |  ENDOCRINE-RELATED CANCER

Evidence suggests that altered adipose tissue homeostasis may be an important contributor to the development and/or progression of..

Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis

Niall M Corcoran, Michael J Clarkson, Ryan Stuchbery, Christopher M Hovens

Journal article  |  2016  |  CLINICAL CANCER RESEARCH

The maintenance of a pristine genome, free from errors, is necessary to prevent cellular transformation and degeneration. When err..

A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance

Nikhil Sapre, Geoff Macintyre, Michael Clarkson, Haroon Naeem, Marek Cmero, Adam Kowalczyk, Paul D Anderson, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2016  |  BRITISH JOURNAL OF CANCER

BACKGROUND: The objective of this study was to determine whether microRNA (miRNA) profiling of urine could identify the presence o..